Article
Engineering, Biomedical
Jing Qiao, Zhi Liu, Shuolin Cui, Tamas Nagy, May P. Xiong
Summary: This study investigated a triple combination approach targeting P. aeruginosa by selectively disrupting its outer membrane and enhancing bacterial sensitivity to antibiotics. The lead polymer pGQ-DG demonstrated selective antibacterial activity against P. aeruginosa and synergistic properties when combined with VAN, effectively clearing the infection and accelerating wound healing in mice. This strategy could potentially serve as an alternative to colistin against multidrug resistant bacteria.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Floriana Cappiello, Sudhir Verma, Xiao Lin, Isabel Y. Moreno, Bruno Casciaro, Debarun Dutta, Alison M. McDermott, Mark Willcox, Vivien J. Coulson-Thomas, Maria Luisa Mangoni
Summary: The corneal epithelium is essential for both vision and immune defense. Corneal abrasion can lead to severe eye infections, but recent research has discovered peptides that not only treat keratitis but also promote corneal wound healing, which could have potential clinical applications.
Article
Medicine, Research & Experimental
Reem Binsuwaidan, Engy Elekhnawy, Walaa S. Elseady, Walaa A. Keshk, Nagwa A. Shoeib, Nashwah G. M. Attallah, Fatma A. Mokhtar, Soha R. Abd El Hadi, Eman Ahmed, Sameh Magdeldin, Walaa A. Negm
Summary: Patients with diabetes often suffer from chronic wounds, which can lead to significant medical, economic, and social problems. This study investigated the wound healing and antibacterial effects of Cycas thouarsii n-butanol fraction (CTBF) for the first time. The results showed that CTBF has antibacterial activity against Pseudomonas aeruginosa and can promote wound healing in diabetic rats. This research provides important insights into potential therapeutic alternatives for chronic wounds in diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Bouke Boekema, Matthea Stoop, Marcel Vlig, Jos van Liempt, Ana Sobota, Magda Ulrich, Esther Middelkoop
Summary: Cold atmospheric plasma (CAP) devices can be used as an alternative antimicrobial treatment for chronic wounds, showing good efficacy against Staphylococcus aureus but less effective on dermal samples. CAP treatment did not affect cellular activity or DNA integrity of human dermal samples. Treatment with CAP can lead to a temporarily increased local skin temperature and increased erythema.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tingting Cui, Jiafei Yu, Cai-Feng Wang, Su Chen, Qing Li, Kun Guo, Renkun Qing, Gefei Wang, Jianan Ren
Summary: This work presents a microfluidic assembly technique to fabricate micro-gel ensembles that can precisely tune the pH value of wound surface and accelerate wound healing. By regulating the wound pH, the physiological processes are greatly facilitated, resulting in much accelerated healing of chronic wounds.
Review
Microbiology
Sang Phan, Cafrey He Feng, Raymond Huang, Zeng X. Lee, Yer Moua, Olivia J. Phung, Justin R. Lenhard
Summary: Pseudomonas aeruginosa is commonly found in chronic wound infections worldwide, except in South America, where it is less prevalent. It is the second most common organism in each continent, with Staphylococcus aureus being the most abundant pathogen overall. In Southeast Asia nations including India and Malaysia, P. aeruginosa is the most frequently isolated organism in chronic wound infections. The presence of P. aeruginosa in diabetic foot infections is lower in North America, Europe, and Africa compared to other types of chronic wound infections. The isolation of P. aeruginosa using the Levine wound swab technique may not be a reliable predictor of the patient's clinical course.
Article
Pharmacology & Pharmacy
Fiorenza Rancan, Jana Jurisch, Cemre Guenday, Emre Tuereli, Ulrike Blume-Peytavi, Annika Vogt, Christoph Schaudinn, Nazende Guenday-Tuereli
Summary: The study found that surfactants significantly improved the penetration of PLGA particles in wound tissue and enhanced the antimicrobial efficacy of antibiotics, offering a potential safe and effective option for topical antimicrobial management of chronic wound infections.
Article
Chemistry, Multidisciplinary
Huan Peng, Daniele Rossetto, Sheref S. Mansy, Maria C. Jordan, Kenneth P. Roos, Irene A. Chen
Summary: Infections caused by drug-resistant bacteria are difficult to treat, but a study found that engineered phage-nanomaterial conjugates can effectively treat infected wounds caused by Gram-negative pathogens in mice. The treatment rapidly reduced bacterial load and promoted wound healing, outperforming standard-of-care antibiotics. The phage-nanomaterial treatment also worked against a strain resistant to last-line antibiotics, with no detectable toxicity or systemic effects.
Review
Biochemistry & Molecular Biology
Firas Diban, Silvia Di Lodovico, Paola Di Fermo, Simonetta D'Ercole, Sara D'Arcangelo, Mara Di Giulio, Luigina Cellini
Summary: Chronic wounds have detrimental effects on patients and healthcare systems. The search for effective compounds to treat these wounds has been ongoing, with a focus on combating microbial colonization by multidrug resistant pathogens. The development of an in vitro model, such as the Lubbock chronic wound biofilm model, has facilitated the study of wound poly-microbial biofilms and the evaluation of innovative treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Samantha Rae Loggenberg, Danielle Twilley, Marco Nuno De Canha, Debra Meyer, Ephraim Cebisa Mabena, Namrita Lall
Summary: This study evaluated the potential wound healing activity of Greyia radlkoferi Szyszyl (GR) and its effect on growth factors regulating angiogenesis. The results showed that the GR extract had antibacterial and antioxidant activity, but significantly inhibited wound closure. Additionally, the extract also regulated angiogenesis by inhibiting the expression of PDGF-AA. Thus, the GR extract may have potential anti-angiogenic and anti-metastatic properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Weng Kit Ban, Isabel Lim Fong, Heng Yen Khong, Joyce Hui Yie Phung
Summary: Clinacanthus nutans and Strobilanthes crispus have multiple beneficial properties, including antimicrobial and wound healing activities. Strobilanthes crispus exhibits superior antimicrobial and wound healing activities.
Article
Immunology
Derek Fleming, Brandon Niese, Whitni Redman, Emily Vanderpool, Vernita Gordon, Kendra P. Rumbaugh
Summary: The absence of the exopolysaccharides Pel and Psl in Pseudomonas aeruginosa did not significantly affect the severity or wound closure rates of wound infections in a mouse model. However, the size and distribution of biofilm aggregates in the wound tissue were different, and the mutants' ability to survive antibiotic treatment was impaired.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Engineering, Biomedical
Hori Ghaneialvar, Airat Kayumov, Elham Aboualigalehdari, Iraj Pakzad, Nader Tanideh, Naser Abbasi, Mohammad Hossein Haddadi
Summary: In this study, chitosan-alginate (CA) membranes loaded with DHA and MSCs were developed with excellent antibacterial and antibiofilm activities. In vivo experiments showed that these membranes accelerated the healing of burn wounds and reduced inflammation.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Pharmacology & Pharmacy
Weibin Zhang, Zhe An, Yuqi Bai, Ying Zhou, Fangyi Chen, Ke-Jian Wang
Summary: Antimicrobial resistance (AMR) is a significant global threat to human health. In this study, a novel cationic antimicrobial peptide (AMP) named Scyreptin1-30 was identified, which showed broad-spectrum antimicrobial activity against bacteria and fungi, including the clinically isolated multidrug-resistant bacteria Pseudomonas aeruginosa. Scyreptin1-30 exhibited rapid bactericidal kinetics and destroyed bacterial membranes. It also demonstrated no discernible cytotoxicity and promoted wound healing in vivo. The findings suggest that Scyreptin1-30 holds promise as an effective antibacterial agent against multidrug-resistant bacterial infections.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Erik Gerner, Sofia Almqvist, Peter Thomsen, Maria Werthen, Margarita Trobos
Summary: Inhibition of quorum sensing by sodium salicylate in Pseudomonas aeruginosa strains influences biofilm formation and tolerance to silver, making biofilms more susceptible to silver and reducing levels of virulence factors associated with biofilm development. This suggests that sodium salicylate allows antiseptics to become more readily available to cells by reducing cell aggregation in biofilms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Hasan Fallah Huseini, Amir Hossein Abdolghaffari, Maryam Ahwazi, Eghbal Jasemi, Maryam Yaghoobi, Mojtaba Ziaee
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2020)
Article
Multidisciplinary Sciences
Golnar Rahimzadeh, Majid Saeedi, Mahmood Moosazadeh, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei, Mohammad Sadegh Rezai, Kosar Kamel, Kofi Asare-Addo, Ali Nokhodchi
Summary: The study found that the chitosan encapsulated bacteriophage cocktail can effectively treat gastrointestinal infections, preventing weight loss in rats and reducing group weight changes, as well as shortening the time needed for positive stool cultures.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Hamed Cheraghmakani, Mohammad Sadegh Rezai, Reza Valadan, Golnar Rahimzadeh, Mona Moradi, Vahid Jahanfekr, Mahmood Moosazadeh, Nasim Tabrizi
Summary: The study revealed that short-term treatment with ciprofloxacin can significantly alter the gut microbiota pattern of patients and reduce seizure frequency, especially in patients with symptomatic generalized epilepsy.
Article
Dermatology
Hasan Fallah Huseini, Maryam Yaghoobi, Farhad Fallahi, Farzaneh Boroumand, Mohammad Hassan Ezzati, Seyyed Mohammad Tabatabaei, Homa Sotvan, Maryam Ahvazi, Shapour Badiee Aval, Mojtaba Ziaee
Summary: The study confirms that the addition of topical T. polium ointment significantly improves the healing time of diabetic non-infected foot ulcers as a supplementary to standard treatment.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2021)
Article
Engineering, Environmental
Golnar Rahimzadeh, Mohammad Ali Zazouli, Mohammad Sadegh Rezai
Summary: The study aimed to evaluate the potential of phage in controlling Pseudomonas aeruginosa on infected hard surfaces. The results showed that phage can effectively reduce the number of Pseudomonas aeruginosa on contaminated surfaces.
JOURNAL OF ENVIRONMENTAL HEALTH SCIENCE AND ENGINEERING
(2022)
Article
Medicine, General & Internal
Mohammad Sadegh Rezai, Fatemeh Ahangarkani, Andrew Hill, Leah Ellis, Manya Mirchandani, Alireza Davoudi, Gohar Eslami, Fatemeh Roozbeh, Farhang Babamahmoodi, Nima Rouhani, Ahmad Alikhani, Narges Najafi, Roya Ghasemian, Hossein Mehravaran, Azin Hajialibeig, Mohammad Reza Navaeifar, Leila Shahbaznejad, Golnar Rahimzadeh, Majid Saeedi, Reza Alizadeh-Navai, Mahmood Moosazadeh, Shahab Saeedi, Seyedeh-Kiana Razavi-Amoli, Shaghayegh Rezai, Fereshteh Rostami-Maskopaee, Fatemeh Hosseinzadeh, Faezeh Sadat Movahedi, John S. Markowitz, Reza Valadan
Summary: The study results indicate that ivermectin as a treatment for COVID-19 did not have a significant effect on improving clinical symptoms or reducing hospital admissions and mortality rates.
FRONTIERS IN MEDICINE
(2022)
Article
Materials Science, Biomaterials
Arefe Zargari, Pooria Gill, Golnar Rahimzadeh, Fatemeh Ghadami, Adele Rafati, Pedram Ebrahimnejad
Summary: In this study, Aloe vera nanofibers containing Pseudomonas sp. bacteriophages were fabricated using an electrospinning machine. The nanofibers were characterized using atomic force microscopy (AFM), tensile test system (TTS), and simultaneous thermal analyzer (STA). The addition of phages significantly changed the morphology, roughness, and topographical ultra-structures of the nanofibers, as well as improved their thermal stability, flexibility, and antimicrobial properties. These findings suggest that the nanofibers can be utilized as hybrid nanomaterials for food packaging.
Article
Chemistry, Applied
Hiva Hashemi, Golnar Rahimzadeh, Majid Saeedi, Fatemeh Ghadami, Adele Rafati, Pooria Gill
Summary: This study investigates the mechanical, thermodynamic, and morphological changes of Aloe vera-based nanofibers as nanocarriers of MRSA. The results show that the addition of phages improves the thermal stability and elongation percentage of the nanofibers, making them suitable for wound dressing.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Golnar Rahimzadeh, Majid Saeedi, Ali Nokhodchi, Mahmood Moosazadeh, Maryam Ghasemi, Seyyed Sohrab Rostamkalaei, Parham Mortazavi, Mohammad Eghbali, Reza Pourbakhshian, Mohammad Sadegh Rezai, Ebrahim Nemati Hevelaee
Summary: The in-situ gel-forming ophthalmic formulation containing phage showed therapeutic effectiveness in the treatment of P. aeruginosa keratoconjunctivitis, reducing edema and abscesses while promoting re-epithelialization and normal corneal structure.
Article
Nutrition & Dietetics
Saeed Mehrzadi, Reza Mirzaei, Mojtaba Heydari, Maryam Sasani, Bahman Yaqoobvand, Hasan Fallah Huseini
Summary: Traditional herbal combination may effectively improve glycemic control in type II diabetic patients with relatively low risk of adverse effects, as shown in a study conducted in Iran.
JOURNAL OF DIETARY SUPPLEMENTS
(2021)
Article
Pediatrics
Leila Shahbaznejad, Mohammad Reza Navaeifar, Ali Abbaskhanian, Fatemeh Hosseinzadeh, Golnar Rahimzadeh, Mohammad Sadegh Rezai
Article
Pharmacology & Pharmacy
Soosan Abdollahi, Zahra Tofighi, Tahereh Babaee, Mohammad Shamsi, Ghazal Rahimzadeh, Hossein Rezvanifar, Elaheh Saeidi, Morteza Mohajer Amiri, Yasaman Saffari Ashtiani, Nasrin Samadi
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2020)
Article
Medicine, General & Internal
Golnar Rahimzadeh, Gregory Resch, Mohammad Sadegh Rezai, Ebrahim Nemati Hevelaee
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Endocrinology & Metabolism
Hossein Mirmiranpour, Hasan Fallah Huseini, Hoda Derakhshanian, Zohreh Khodaii, Bahareh Tavakoli-Far
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2020)
Article
Food Science & Technology
Elaheh Jozve-Zargarabadi, Vajiheh Fadaei-Noghani, Hasan Fallah Huseini
APPLIED FOOD BIOTECHNOLOGY
(2020)