Article
Chemistry, Physical
Chaymae Bourhou, Hind Benouda, Reda Bellaouchi, Mohammed Merzouki, Elmehdi Fraj, Tarik Harit, Allal Challioui, Abdeslam Asehraou, Rachid Touzani, Ismail Ozdemir, Boufelja Bouammali
Summary: This study involves the synthesis of novel Bis(arylidene-2-[(tetrazol-5-yl)]alkane derivatives and their evaluation for antibacterial and antifungal activities. The compounds showed moderate yields and their structures were determined through spectroscopic analyses. In vitro testing revealed antimicrobial properties against various bacterial and fungal strains. Docking study further confirmed the interactions of the compounds with the active site in Staphylococcus aureus.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Microbiology
Ashley L. Cunningham, Orhi Esarte Palomero, Bradley J. Voss, M. Stephen Trent, Bryan W. Davies
Summary: Otilonium bromide, a poorly absorbed oral medication used for irritable bowel syndrome, has been found to have broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. This suggests that otilonium bromide could be a new option for intestinal antimicrobial therapy targeting enteric pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Huimin Miao, Panyong Wang, Yingge Cong, Wenfei Dong, Li Li
Summary: Bacterial infections have become a focus of research in the development of new antimicrobial agents. Ciprofloxacin has strong antibacterial properties but is limited by drug resistance. This study successfully synthesized ciprofloxacin carbon dots (CCDs) and copper-doped ciprofloxacin carbon dots (Cu-CCDs) with enhanced antibacterial activity. The Cu-CCDs showed excellent antibacterial activity against E. coli and S. aureus, indicating their potential in clinical applications as antibacterial nanomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tianxi Li, Lulu Li, Fangyuan Du, Lei Sun, Jichao Shi, Miao Long, Zeliang Chen
Summary: This review focuses on antifungal peptides isolated from various microorganisms, outlining their antifungal activity, toxic effects, and mechanisms of action, as well as common solutions to mitigate their toxicity. This work serves as a useful reference for further clinical research and the development of safe antifungal drugs with high efficiencies and broad application spectra.
Article
Biochemistry & Molecular Biology
Mingxia Song, Yi Hua, Yuxin Liu, Xunli Xiao, Haihong Yu, Xianqing Deng
Summary: The overuse and misuse of antimicrobial drugs have led to a critical global health problem of antibacterial resistance. This study designed, synthesized, and elucidated a novel set of ciprofloxacin-indole/acetophenone hybrids through structural analysis. These hybrids demonstrated excellent inhibitory activity against gram-positive and gram-negative pathogens, including multidrug-resistant clinical isolates. Compound 8b showed higher antibacterial activity and bactericidal capability than ciprofloxacin, making it a promising candidate for further investigations.
Article
Polymer Science
Ryohei Kakuchi, Kota Fukasawa, Li-Chieh Chou, Hyung Kim, Hideki Amii
Summary: Experimental insight into aminolysis postpolymerization modification reactions of polymers featuring alpha,alpha-difluoroacetates reveals primary amines are more efficient than secondary amines, with no negative impact on thermal properties, offering a feasible and useful synthetic tool.
Article
Pharmacology & Pharmacy
Shabnam Yavari, Kayode Olaifa, Darya Shafiee, Reza Rasuli, Mehdi Shafiee
Summary: Microorganisms are emerging contaminants in the environment and pose significant risks to public health. Conventional disinfection methods are often ineffective and have drawbacks. This study presents a method to synthesize nanomaterials with antimicrobial properties and demonstrates their effectiveness against Escherichia coli and Candida albicans. The synthesized nanomaterials show potential for biomedical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Mauricio Osorio, Marcela Carvajal, Alejandra Vergara, Estefania Butassi, Susana Zacchino, Carolina Mascayano, Margarita Montoya, Sophia Mejias, Marcelo Cortez-San Martin, Yesseny Vasquez-Martinez
Summary: Prenylated flavonoids are important natural compounds with significant biological activity, particularly in antimicrobial functions. Compounds 11, 12, and 13 showed strong inhibitory activity against human pathogenic fungi and clinical isolated Staphylococcus aureus MRSA, indicating the key structural requirements for antibacterial activity. Additionally, the combination of prenylated flavonoids with commercial antibiotics significantly enhanced the antibacterial activity against drug-resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wafa Arif, Nosheen Fatima Rana, Iqra Saleem, Tahreem Tanweer, Muhammad Jawad Khan, Sohad Abdulkaleg Alshareef, Huda M. Sheikh, Fatima S. Alaryani, Manal Othman AL-Kattan, Hanan Ali Alatawi, Farid Menaa, Aroosa Younis Nadeem
Summary: A study synthesized a resin composite with antibacterial properties, containing ciprofloxacin-loaded silver nanoparticles. The results showed that this composite exhibited high antibacterial activity and compressive strength, as well as good biocompatibility.
Review
Microbiology
Abdelmoneim K. Abdalla, Mutamed M. Ayyash, Amin N. Olaimat, Tareq M. Osaili, Anas A. Al-Nabulsi, Nagendra P. Shah, Richard Holley
Summary: Exopolysaccharides (EPSs) are metabolites synthesized and excreted by various microorganisms, playing important biological functions in interactions between bacteria and their environments, protection against hostile conditions, and evasion of immune responses. Numerous studies have shown the broad antimicrobial activities of EPS against pathogenic microbes. This review focuses on the in vitro and in vivo antimicrobial activities of different EPSs against foodborne bacterial, fungal, and viral pathogens, as well as the mechanisms of action and methods of measurement.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Yan-Yan Ding, Han Zhou, Bao-Qi Peng-Deng, Bao-Qi Zhang, Zhi-Jun Zhang, Guang-Han Wang, Shao-Yong Zhang, Zheng-Rong Wu, Yi-Rong Wang, Ying-Qian Liu
Summary: Since the isolation of the first natural carbazole alkaloid, murrayanine, from Mwraya Spreng, carbazole alkaloid derivatives have attracted wide attention for their anti-tumor, anti-viral, and anti-bacterial activities. Recent research has shown that carbazole alkaloids and their derivatives exhibit diverse biological activities. This study provides the first comprehensive description of the antifungal and antibacterial activities of carbazole alkaloids in the past decade (2012-2022), including both natural and partially synthesized compounds. The challenges and problems faced by this class of alkaloids are also summarized. This paper will facilitate further exploration of carbazole alkaloids.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Varish Ahmad, Mohammad Omaish Ansari
Summary: Graphene and its nanocomposites have attracted significant interest due to their efficient antimicrobial properties. Graphene has found applications in tissue engineering and has been successfully conjugated with existing drugs to improve therapeutic efficacy. This review discusses the antimicrobial potential, synthesis, and toxicity of graphene-based nanomaterials in biological systems.
Article
Biochemistry & Molecular Biology
Katarzyna Niedzialkowska, Aleksandra Felczak, Iwona E. Glowacka, Dorota G. Piotrowska, Katarzyna Lisowska
Summary: One of the main challenges in medicinal chemistry is the search for new substances with antimicrobial potential. Carbazole-containing compounds have shown promise as antibacterial, antifungal, and antiviral agents. This study examined the antimicrobial potential and toxicity of newly synthesized isomeric fluorinated 4-[4-(benzylamino)butoxy]-9H-carbazole derivatives. The derivatives showed effectiveness in inhibiting the growth of Gram-positive bacteria, particularly Staphylococcus aureus strains. However, Gram-negative strains and human fibroblast cells showed higher resistance and toxicity to these compounds. The results suggest the need for further modification of these structures to enhance their activity against pathogenic microorganisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Ping Yang, Jia-Bao Luo, Zi-Zhou Wang, Li-Lei Zhang, Xiao-Bao Xie, Qing-Shan Shi, Xin-Guo Zhang
Summary: Twelve novel fluoroquinolone derivatives were designed and synthesized by introducing N-acylarylhydrazone to the C-7 position of ciprofloxacin. Compound 3k exhibited more potent antibacterial activity against S. aureus compared to ciprofloxacin, while compound 3g showed activity against methicillin-resistant S. aureus (MRSA). Compound 3g exerted bactericidal effects on S. aureus and E. coli, and displayed a higher affinity to DNA topoisomerase IV than ciprofloxacin. Molecular dynamics simulation results confirmed the stable interaction between receptor 3rae and compound 3g. Furthermore, cytotoxicity and hemolysis assays indicated the minimal risk of toxic effects for compounds 3g and 3k.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Environmental Sciences
Ze-Gang Dong, Fang Xu, Ellen Mitchell, Bo Long
Summary: High-level ab initio calculations and variational transition state theory were used to study the aminolysis of trifluoroacetaldehyde catalyzed by a single water molecule, which significantly reduces the reaction energy barrier. Kinetic calculations showed a wide range of rate coefficients for the reaction. The study also identified a competitive elimination pathway for trifluoroacetaldehyde under certain conditions, which may lead to the growth of secondary organic aerosols.
ATMOSPHERIC ENVIRONMENT
(2021)