Article
Chemistry, Physical
Frank Betancourt, Alyssa Valente, Hongbin Yan
Summary: The synthesis and evaluation of four 4-aryl-N-methoxyethyl-1,8-naphthalimide derivatives showed high fluorescence in chloroform but significant fluorescence quenching in polar solvents. One derivative in particular exhibited a drastic fluorescence quenching in methanol. Dilution of DMSO solutions of other derivatives with water also led to fluorescence quenching. In aqueous solutions, the presence of bovine serum albumin resulted in significant increases in fluorescence intensity for two of the derivatives.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Zhong-jie Xu, Ying-jie Zhou, Jia-hao Wang, Long-fei Mao, Wei Li, Gui-qing Xu
Summary: In this study, acenaphthylene was used as the raw material to synthesize a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives, which were then tested for their anti-tumor activities. Compound 5e exhibited good activity against H1975 lung cancer cells, with an IC50 of 16.56 mu M.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Gui-Bin Liang, Jian-Hua Wei, Hong Jiang, Ri-Zhen Huang, Jing-Ting Qin, Hui-Ling Wang, Heng-Shan Wang, Ye Zhang
Summary: The newly synthesized antitumor agents compounds 6b and 7b demonstrated effective antiproliferative activity in vitro and in vivo by targeting DNA, inducing DNA damage, inhibiting Topo I, causing cell cycle arrest at the S phase, and inducing apoptosis.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Conor Geraghty, Conor Wynne, Robert B. P. Elmes
Summary: Fluorescent probes are essential tools in studying biological systems, and the 1,8-naphthalimide fluorophore is commonly used for detecting enzymatic conversions. With advancements in synthetic methods, the sensitivity and selectivity of these probes continue to improve.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Sonia Kotowicz, Mateusz Korzec, Katarzyna Malarz, Aleksandra Krystkowska, Anna Mrozek-Wilczkiewicz, Sylwia Golba, Mariola Siwy, Sebastian Mackowski, Ewa Schab-Balcerzak
Summary: A new series of 1,8-naphtalimides containing an imine bond at the 3-position of the naphthalene ring was synthesized and studied for their properties and bioimaging capabilities. These compounds showed specific melting temperature ranges and underwent thermal decomposition, as well as exhibited unique electrochemical behavior and photoluminescence activities in various environments. Despite some challenges like incomplete energy transfer, the compounds have potential applications in biological studies and diagnostic imaging.
Article
Biochemistry & Molecular Biology
Sebastian Rykowski, Dorota Gurda-Wozna, Marta Orlicka-Plocka, Agnieszka Fedoruk-Wyszomirska, Malgorzata Giel-Pietraszuk, Eliza Wyszko, Aleksandra Kowalczyk, Pawel Staczek, Andrzej Bak, Agnieszka Kiliszek, Wojciech Rypniewski, Agnieszka B. Olejniczak
Summary: A series of novel 3-carboranyl-1,8-naphthalimide derivatives were synthesized and their effects on cytotoxicity, cell cycle arrest, and apoptosis in a HepG2 cancer cell line were investigated. The compounds were found to induce various cellular responses, with conjugate 35 showing strong apoptosis induction and ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Chao Ge, Lu Liu, Yanqing Wang, Xiaojiao Di, Xiangjie Luo, Hongke Liu, Yong Qian
Summary: This study focuses on the cytotoxicity and mode of action of naphthalimide derivatives, particularly the anticancer activity and demethylase inhibition by compounds 1 and 7.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Review
Materials Science, Textiles
Mohammad Dodangeh, Ivo Grabchev, Desislava Staneva, Kamaladin Gharanjig
Summary: This review discusses the use of 1,8-naphthalimide derivatives as dyes for textile and polymeric materials, exploring their influence on dyeability as disperse dyes, acid dyes, and cationic dyes. It also covers their role as fluorophores for dyeing synthetic polymers, along with mentioning polymerizing 1,8-naphthalimide derivatives used for dyeing synthetic polymer materials during preparation.
FIBERS AND POLYMERS
(2021)
Article
Chemistry, Analytical
Jesus L. Pablos, Esther Hernandez, Fernando Catalina, Teresa Corrales
Summary: Novel water-swollen photo-crosslinked membranes with pH sensitive fluorescence probes were synthesized and characterized. These membranes exhibited sensitive fluorescence changes and reversible behavior, making them suitable for acidity detection in aqueous environments.
Article
Chemistry, Applied
Yiqiu Xie, Lei Du, Xuyang Li, Bo Yuan, Guoqing Bao, Limin Wang
Summary: This study synthesized a series of 1,8-naphthalimide derivatives with different quaternary ammonium groups and investigated their performance in tin plating. The results showed that the aromatic ring quaternary ammonium group with higher positive charge density and larger conjugate area could increase cathodic polarization, leading to a reduced deposition rate of tin ions and hydrogen evolution. Among them, the substituted naphthalimide NI4 exhibited the best performance, with a current density suppression effect of 90% and a negative shift in tin deposition and hydrogen evolution potential. In actual application, the tin layer surface under NI4 electrolyte was smoother, without leakage or agglomeration, and showed a higher nuclei density and smaller feature size.
Article
Chemistry, Physical
Sonia Kotowicz, Mateusz Korzec, Jan Grzegorz Malecki, Sylwia Golba, Mariola Siwy, Sebastian Mackowski, Ewa Schab-Balcerzak
Summary: In this research, six novel unsymmetrical imino-1,8-naphthalimides (AzNI) were synthesized and characterized. The compounds exhibited thermal stability and showed different emission colors in solution and in the solid-state. The electrochemical analysis revealed their reduction and oxidation processes.
Article
Chemistry, Applied
Xu-Chen Feng, Gang Zhang, Ru Sun, Yu-Jie Xu, Jian-Feng Ge
Summary: This study designed and synthesized three new Golgi markers for monitoring the normal functioning of the Golgi apparatus. The experiments showed that these markers were able to rapidly and accurately label the Golgi apparatus, and they had low cytotoxicity.
Review
Materials Science, Multidisciplinary
Sneha Kagatikar, Dhanya Sunil
Summary: Organic light-emitting devices (OLEDs) have attracted significant research attention due to their potential applications in full-color flat panel displays and eco-friendly solid-state lighting. The molecular design of 1,8-naphthalimide (NI) derivatives shows promise in producing light-emitting materials for OLEDs with a wide range of colors and potential for reducing energy consumption. Further exploration is needed to improve research in this promising field.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Wo Nie, Jiahui Wu, Jian Yang, Liu Hu
Summary: A facile method for imparting fluorescent and hydrophobic characteristics to cotton fabrics was developed using novel fluorescent molecules. Three fluorescent dyes with carboxyl reactive groups and different carbon chain lengths were synthesized and covalently fixed onto the cotton fabrics. The fabricated fabrics exhibited strong yellow-green fluorescence and excellent hydrophobic properties, making them promising for green and functional textile manufacturing.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Narendra Pratap Tripathi, Sanyam Jain, Rajiv K. Singh, Sanchita Sengupta
Summary: Tripodal donor-acceptor small molecules Tr-Np3 and Tr-T-Np3 consisting of triphenyl triazine and 1,8-naphthalimide have been synthesized and showed promising optical and redox properties. They have demonstrated potential as photocatalysts in organic transformations.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Polymer Science
Fantahun Aklog Yihun, Shinsuke Ifuku, Hiroyuki Saimoto, Hironori Izawa, Minoru Morimoto
Article
Chemistry, Multidisciplinary
Hironori Izawa, Yuta Toyoshima, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: The results show that oriented chitosan films prepared by elongation can be applied to surface wrinkling systems via a horseradish peroxidase-catalyzed surface reaction of ferulic acid and drying, resulting in different wrinkle morphologies influenced by drying compression stress.
Article
Chemistry, Multidisciplinary
Hironori Izawa, Fumika Yasufuku, Toshiki Nokami, Shinsuke Ifuku, Hiroyuki Saimoto, Toru Matsui, Kenji Morihashi, Masato Sumita
Summary: The study investigated the photo-induced colorimetric reaction mechanism of different cationic receptors, suggesting that substituents on the naphthalene ring can facilitate the generation of naphthalimide-based radical anions. Additionally, it was found that the trimethylammonium group plays a crucial role in stabilizing the radical anion species.
Article
Materials Science, Paper & Wood
Mizuki Kishimoto, Hironori Izawa, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: The study successfully obtained chitin nanofibers of different colors using reactive dyes, which are resistant to hot water and detergents and can be mixed to produce a variety of colors. Through evaluation using reflection spectrum and color space, the optimal ratio of reactive dye to chitin was determined to be 5%, while maintaining the morphology of the nanofibers.
Article
Polymer Science
Dagmawi Abebe Zewude, Hironori Izawa, Shinsuke Ifuku
Summary: The alpha-chitin derived from crab shells was partially deacetylated with 30% sodium hydroxide to obtain a deacetylation degree of 36%. Partially deacetylated chitin nanofibers were successfully prepared using weak ultrasonic energy from a domestic ultrasonic cleaner. The optimal conditions for obtaining fine nanofibers with high yield were found to be ultrasonication at 45 kHz frequency for 20 minutes.
Article
Polymer Science
Koichi Tanabe, Hironori Izawa, Shinsuke Ifuku
Summary: Utilizing the emulsion-forming ability of partially deacetylated chitin nanofibers, a composite with polystyrene was prepared, significantly improving the mechanical and thermal properties of polystyrene. The optimal mixing ratio of chitin nanofibers for improving mechanical properties was 7%. The composite material showed good recyclability without a decrease in mechanical properties after hot pressing molding.
Article
Chemistry, Applied
Hironori Izawa, Tomoe Yonemura, Yumi Nakamura, Yuta Toyoshima, Momoka Kawakami, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: This study introduces hierarchical surface wrinkles and bumps fabricated through drying-induced shrinkage. The kappa-carrageenan system shows hierarchical wrinkles, while the iota-carrageenan system exhibits hierarchical bumps.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Hujun Li, Saori Yoshida, Naofumi Mitani, Mayumi Egusa, Momoko Takagi, Hironori Izawa, Teruyuki Matsumoto, Hironori Kaminaka, Shinsuke Ifuku
Summary: This study investigated the potential use of spent mushroom substrate (SMS) in agriculture and successfully isolated chitin/cellulose nanofiber complex (CCNFC) from SMS. Further research revealed that low concentration CCNFC water dispersion exhibited significant plant disease resistance and plant growth promotion activities.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Dagmawi Abebe Zewude, Takako Noguchi, Kimihiko Sato, Hironori Izawa, Shinsuke Ifuku
Summary: In this study, chitin nanoparticles were successfully prepared by alkaline treatment and regeneration, which showed small particle size, high dispersibility, and high heat resistance. Compared to nanofibers, nanoparticles had lower viscosity, allowing for preparation at higher concentrations, and can be easily redispersed in water after concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Organic
Hironori Izawa, Fumika Yasufuku, Tomoko Matsumoto, Shinsuke Ifuku, Hiroyuki Saimoto, Masato Sumita
Summary: A novel colorimetric sensor system utilizing the photo-induced colorimetric reaction of TENDI is demonstrated for the detection and quantification of carboxylate derivatives. The presence of CH3COONa induces a photo-induced colorimetric reaction in the TENDI solution under UV irradiation, enabling the detection of carboxylate derivatives. Additionally, TENDI has the ability to distinguish the structural features of carboxylate derivatives based on color tone.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Hironori Izawa, Shota Ishisaka, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: The effects of the physical properties of skin layers and substrates on drying-induced surface wrinkling were investigated. It was found that the size of surface wrinkles formed by different polymers on skin layers varied. The hardness of the skin layers was the primary factor determining wrinkle size.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Materials Science, Composites
Dagmawi Abebe Zewude, Hironori Izawa, Shinsuke Ifuku
Summary: Chitin nanofibers were prepared by mechanically grinding chitin using a ball mill. The optimal conditions for efficient preparation were determined by analyzing the resulting water dispersion and cast film. The length and width of the nanofibers were measured, and it was found that the size of the balls, total ball weight, and milling time all had an impact on the grinding efficiency and fiber properties.
JOURNAL OF COMPOSITES SCIENCE
(2022)
Article
Materials Science, Composites
Kana Kishida, Toshifumi Mizuta, Hironori Izawa, Shinsuke Ifuku
Summary: Crickets are gaining attention as a low environmental impact nutrient source. In this study, chitin isolated from crickets was successfully converted into nanochitin, which had larger fiber width and smaller crystal size compared to crab shells. The shape differences affected the physical properties of the dispersion.
JOURNAL OF COMPOSITES SCIENCE
(2022)
Article
Polymer Science
Hironori Izawa, Ayaka Yagi, Ryo Umemoto, Shinsuke Ifuku
Summary: In this study, water-soluble guanidinylated chitosan (WGCS) is introduced as a potential material for protein delivery systems to improve the cellular internalization of protein/peptide drugs. WGCS, composed mainly of guanidinylated chitosan, chitosan, and chitin units, showed higher internalization into HeLa cells compared to common chitosan. The increased internalization was attributed to the guanidinylation and electrostatic interactions between WGCS and the protein.
Article
Engineering, Biomedical
Nowshin Farzana Khan, Hideaki Nakamura, Hironori Izawa, Shinsuke Ifuku, Daisuke Kadowaki, Masaki Otagiri, Makoto Anraku
Summary: Researchers evaluated the in vivo safety of GCS and observed no deleterious effects after a single oral administration of an excessive dose. They also found that GCS had a slower migration rate in the gastrointestinal tract and exhibited mucoadhesive properties. Future studies will focus on using GCS to improve absorption of poorly water-soluble and poorly membrane-permeable drugs.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)