Coordination Compounds of Hydroxamatooxovanadium(IV) Complexes with Nitrogenous Bases and Their Antimicrobial Activities

The coordination compounds of composition [VO(HL1,2)(2)B] (I-IV) (where B = imidazole (C3H4N2) and benzimidazole (C7H6N2); HL1: C6H5OCH2C(O)NHO- (phenoxyacetohydroxamate), HL2: C6H5CH=CHC(O)NHO-(cinnamohydroxamate) have been synthesized from the reactions of [VO(HL1,2)(2)] with equimolar amounts of imidazole and benzimidazole in ethanol. The compounds have been characterized by elemental analyses, molar conductivity, magnetic measurements, IR, UV-vis, ESR, and FAB mass spectral studies. The spectral studies and molecular modeling dynamics suggest a distorted octahedral geometry around vanadium in coordination compounds. The antibacterial and antifungal activities of the newly synthesized coordination compounds, parent complexes, and respective potassium hydroxamate ligands have been screened in vitro against three bacterial strains viz. E. coli, S. aureus, and B. subtilis and two fungal strains viz. C. albicans and A. niger. The MIC values of newly synthesized coordination compounds have shown enhanced activity over parent complexes and respective potassium hydroxamate ligands. The cytotoxicity of the coordination compounds was studied on mammalian transformed cell line Hep2C, a derivative of human cervix carcinoma HeLa cells by MTT assay.