期刊
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
卷 82, 期 9, 页码 1140-1148出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.82.1140
关键词
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资金
- Global COE [B-09]
- JSPS
- JST-CREST
- ACCMS
- IIMC
- Kyoto University
- Grants-in-Aid for Scientific Research [21685002] Funding Source: KAKEN
Human red (HR), green (HG), and blue (HB) cone pigments are responsible for human color vision, and their photoabsorption wavelengths spread uniquely over the three primary colors. These pigments, however, include only one common chromophore, retinal. Here, we report physical basis of the color tuning in human vision on the basis of SAC-CI calculations for excited states of the cone pigments. The dominant origin of the red-green-blue distinction lies in differences in electrostatic interactions between retinal and its surrounding proteins. Structural distortion effect of the retinal chromophore is important in human blue pigment. Detailed analysis on individual roles of amino acids; within these proteins has clarified elaborate mechanisms of the color tuning, in accordance with previous mutagenesis experiments. Furthermore, the color tuning is regulated by amino acids at specific positions in the proteins, suggesting some genetic origins for the color tuning.
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