期刊
BULLETIN OF MATHEMATICAL BIOLOGY
卷 74, 期 6, 页码 1326-1353出版社
SPRINGER
DOI: 10.1007/s11538-011-9702-0
关键词
Gene regulation networks; Mathematical modelling; Quorum sensing; Reaction-diffusion equations; Staphylococcus aureus
资金
- BBSRC
- MRC
- MRC/EPSRC
- Royal Society
- Wolfson Foundation
- MRC [G1002093, G9219778] Funding Source: UKRI
- Medical Research Council [G9219778, G1002093] Funding Source: researchfish
Staphylococcus aureus uses quorum sensing (QS) to enhance its pathogenicity. An intriguing aspect of this is that different strains are capable of inactivating the QS systems of opposing strains. In Part 1 of this study, we presented a model of this phenomenon in a well-mixed environment; here, we incorporate spatial structure. Two competitive strains occupying adjacent habitats with freely diffusing QS signal molecules (QSSMs) are considered. We investigate the effect of the QSSM diffusion coefficient and the relative size of the two populations on the ability of one population to dominate the other. Regarding population size, a larger population is generally at an advantage (initial conditions permitting), while the implications of different diffusivities are more complex and depend upon the sizes of the populations.
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