期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 158, 期 2, 页码 219-221出版社
SPRINGER
DOI: 10.1007/s10517-014-2726-3
关键词
experimental gestosis; GABA derivatives; thrombus formation; platelet aggregation; hemostasis
Experimental gestosis induced by replacement of drinking water with 1.8% NaCl promoted hypercoagulation, increased the rate and degree of platelet aggregation, and reduced clotting time in pregnant females. GABA derivatives, compounds RGPU-151, RGPU-152, and phenibut normalized parameters of hemostasis and platelet aggregation and the rate of thrombus formation in the animals. The efficiency of the test substances did not significantly differ from that of the reference drug sulodexide.
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