Article
Neurosciences
Volker Neugebauer, Peyton Presto, Vadim Yakhnitsa, Nico Antenucci, Brianna Mendoza, Guangchen Ji
Summary: Neuroplasticity in cortico-limbic circuits is important in pain persistence and modulation. The amygdala plays a key role in the emotional dimension of pain, and interactions with prefrontal cortical regions change in pain conditions. Other regions in the limbic system are also involved in pain modulation. The corticolimbic system contains opioids and opioid receptors, and their modulatory effects and potential opposing functions are still not fully understood.
Article
Biochemistry & Molecular Biology
Ye He, Qian Su, Liyun Zhao, Lijuan Zhang, Lu Yu, Jianyou Shi
Summary: Opioids, widely prescribed for pain management, have a long history and are favored due to their effectiveness. However, their non-analgesic effects, such as respiratory depression and addiction potential, raise concerns about their safety. Current research focuses on de-opioidization, individualized pharmacogenomics, and the development of new opioids with fewer side effects. New opioid development has led to the discovery of selective/biased/multi-targeted ligands, including positive allosteric modulators (PAMs), as potential alternatives. This review provides insights into the development of novel opioid analgesics with reduced side effects based on recent studies from 2019 to 2022.
BIOORGANIC CHEMISTRY
(2023)
Article
Behavioral Sciences
Luke A. Jelen, James M. Stone, Allan H. Young, Mitul A. Mehta
Summary: This article reviews the dysregulation of the opioid system in depression and the potential of pharmacological modulators of mu, delta, and kappa opioid receptors for the treatment of depression. The review presents evidence from animal and clinical studies supporting the dysregulation of the opioid system in depression, the modulation of behavioral processes and brain regions associated with depression by opioids, and the modulation of antidepressant responses by opioids. The review also evaluates clinical trials examining the safety and efficacy of opioidergic agents in depression and explores the involvement of the opioid system in the effects of other treatments, such as ketamine, that exert antidepressant effects through non-opioid actions. Furthermore, the review explores the neurochemical and molecular mechanisms underlying the therapeutic effects of opioid system engagement, providing a rationale for further investigation into this relevant target in depression treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldana-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Summary: This study investigates the structure-activity relationships of benzylideneoxymorphone analogs in order to develop analgesics with reduced tolerance and side effects. One compound, nitro-BOM (NBOM), showed high-efficacy antinociception but also exhibited tolerance and toxicity upon repeated administration. Despite these issues, NBOM provides an important tool for understanding MOPr/DOPr pharmacology.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Valeria Catalani, Michelle Botha, John Martin Corkery, Amira Guirguis, Alessandro Vento, Fabrizio Schifano
Summary: This study used computational studies to evaluate the binding affinity of 101 designer benzodiazepines on opioid receptors. The results suggest that some of the benzodiazepines may have the potential to activate opioid receptors, which could enhance their effects and worsen side effects associated with opioid use.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Chemistry, Medicinal
Maree T. Smith, Dehui Kong, Andy Kuo, Mohammad Z. Imam, Craig M. Williams
Summary: The opioid crisis has increased the demand for novel opioid analgesics that have superior profiles compared to morphine. This Perspective reviews and discusses the multitargeted opioid ligand strategy for discovering such analgesics. Dual-targeted mu-opioid/delta-opioid (MOP/DOP) ligands with strong DOP antagonist potency and without DOP or kappa-opioid (KOP) agonist activity are promising candidates. Dual-targeted MOP/NOP partial agonists also show potential. The pharmacologic template of cebranopadol, a full agonist at MOP, DOP, and NOP receptors, and a partial agonist at KOP receptor, should be avoided due to its poor therapeutic indices.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Behavioral Sciences
Jasna Chalangal, Sanoara Mazid, Kyle Windisch, Teresa A. Milner
Summary: The abuse of opioids, particularly among women, has increased over the past two decades. The hippocampal neural circuits, especially the opioid circuits, play a critical role in associative memory formation and encoding of motivational incentives, which are important in the transition from initial drug use to drug abuse/dependence. The anatomical studies in rodents have revealed sex differences in the distribution of opioid peptides and receptors in specific hippocampal circuits, and how these distributions are altered following stress and oxycodone-associative learning processes.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Medicine, Research & Experimental
Yongsheng Zhu, Kejia Wang, Tengfei Ma, Yuanyuan Ji, Yin Lou, Xiaoyu Fu, Ye Lu, Yige Liu, Wei Dang, Qian Zhang, Fangyuan Yin, Kena Wang, Bing Yu, Hongbo Zhang, Jianghua Lai, Yunpen Wang
Summary: This study identified neural pathways involved in controlling depressive-like behaviors and acute withdrawal symptoms after morphine withdrawal. Furthermore, a new DBS treatment protocol was developed to reverse abnormal plasticity and alleviate withdrawal symptoms and depressive-like behaviors.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Behavioral Sciences
C. Sandoval-Caballero, L. Luarte, Y. Jimenez, C. Jaque, F. Cifuentes, G. A. Arenas, M. Figueroa, J. Jara, P. K. Olszewski, J. A. Teske, C. E. Perez-Leighton
Summary: This study conducted a systematic search and meta-analysis of rodent dose-response studies to evaluate the effects of opioid receptor (OR) agonists and antagonists on feeding behaviors and food intake. The results showed overall orexigenic effects of central MOR agonists and anorexigenic effects of OR antagonists. Additionally, peripheral OR agonists selectively increased the intake of fat-preferred foods, while not affecting the intake of sweet carbohydrate-preferred foods. These findings suggest that OR regulation of intake, motivation, and choice is influenced by food macronutrient composition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Peng Xie, Junjie Zhang, Baiyu Chen, Xinwei Li, Wenbo Zhang, Mengdan Zhu, Wei Li, Jianqi Li, Wei Fu
Summary: Opioid receptors are effective targets for treating severe pain. This study investigated the activation mechanisms of opioid receptors and identified key structural determinants using aminomethyl tetrahydronaphthalene compounds.
Review
Medicine, Research & Experimental
Miroslav Adzic, Iva Lukic, Milos Mitic, Emilija Glavonic, Nina Dragicevic, Sanja Ivkovic
Summary: Major depressive disorder (MDD) affects approximately 5% of the world population, and a significant percentage of patients do not achieve complete remission with classical antidepressant medications. Recent evidence suggests that targeting opioid receptors may offer effective therapeutics for stress-related psychiatric disorders. The dysregulation of opioid signaling in depression and the success of opioid modulation in preclinical studies and clinical trials highlight the potential of opioids as adjuvant or alternative treatments for depression. However, further research is needed to fully understand the benefits and weaknesses of opioid system modulation in depression.
Article
Neurosciences
Josue Jaramillo-Polanco, Cintya Lopez-Lopez, Yang Yu, Emma Neary, Alan Hegron, Meritxell Canals, Nigel W. Bunnett, David E. Reed, Alan E. Lomax, Stephen J. Vanner
Summary: This study found that chronic high-dose opioid exposure leads to opioid-induced hyperalgesia (OIH) in the gastrointestinal tract, which is mediated by DOPr signaling and dependent on receptor endocytosis and protein kinase C signaling.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jin Bai, Ting Ye, Yan-bin Wei, Yi Yang, He-min Yang, Yan Lan
Summary: Opioid receptors play important roles in regulating synaptic transmission in the cerebellum, especially at the parallel fiber-Purkinje cell synapses. Activation of mu-opioid receptors and 6-opioid receptors inhibits glutamate release and modulates synaptic transmission, while no significant effects were observed with x-opioid receptor activation. Endogenous opioid peptides also contribute to the modulation of synaptic transmission at these synapses.
NEUROSCIENCE LETTERS
(2022)
Article
Immunology
Anagha Gadepalli, Obulapathi Ummadisetty, Akhilesh, Deepak Chouhan, Anmol, Vinod Tiwari
Summary: This study demonstrates the therapeutic effect of loperamide, a peripherally acting mu-opioid receptor agonist, on neuropathic pain in rats and elucidates its underlying mechanism.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
S. K. Sudakov, N. G. Bogdanova, A. A. Kolpakov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2015)
Article
Medicine, Research & Experimental
S. K. Sudakov, G. A. Nazarova, E. V. Alekseeva, A. A. Kolpakov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2015)
Article
Medicine, Research & Experimental
N. G. Bogdanova, A. A. Kolpakov, S. K. Sudakov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2015)
Article
Medicine, Research & Experimental
V. G. Bashkatova, S. K. Sudakov, H. Prast
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2015)
Article
Medicine, Research & Experimental
S. K. Sudakov, E. V. Alekseeva, N. G. Bogdanova, A. A. Kolpakov, G. A. Nazarova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2016)
Article
Medicine, Research & Experimental
S. K. Sudakov, N. G. Bogdanova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2016)
Article
Food Science & Technology
Sergey K. Sudakov, Natalia G. Bogdanova, Elena V. Alekseeva, Galina A. Nazarova
FOOD SCIENCE & NUTRITION
(2019)
Article
Medicine, Research & Experimental
S. K. Sudakov, N. G. Bogdanova, E. V. Alekseeva, G. A. Nazarova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Behavioral Sciences
Sergey Sudakov, Natalia Bogdanova
Summary: The study explores the role of peripheral opioid receptors in regulating eating behavior, showing that different opioid receptor agonists can have varied effects on food motivation and consumption. The findings suggest that peripheral opioid receptors play a significant role in modulating feeding behavior, influencing food intake and physical activity differently.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Sergey K. Sudakov, Elena Alekseeva, Galina A. Nazarova, Valentina G. Bashkatova
Summary: The study found that as male and female rats aged from 2 to 5 months, there was a decrease in motor and exploratory activities, and an increase in anxiety levels. These age-related changes were influenced by the animals' initial behavioral characteristics.
Article
Medicine, Research & Experimental
S. K. Sudakov, N. G. Bogdanova, N. N. Zolotov
Summary: The aim of this study was to investigate the relationship between adenosine deaminase (ADA) activity and motor activity in the brain, as well as the effects of caffeine on motor activity and ADA activity. The results showed that total motor activity decreased significantly with age, accompanied by a decrease in ADA activity. Caffeine stimulated motor activity in both young and adult animals, but its effect on ADA activity varied with age.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Biology
Sergey K. Sudakov, Natalia G. Bogdanova, Galina A. Nazarova
Summary: This research investigates the influence of epigenetic events at conception on the formation of behavioral features in adult rats. The study examines the first generational inheritance of activity level, anxiety-like behavior, and learning ability. The results show that offspring of parents who mated in the presence of males with high motor activity display higher activity levels, but anxiety-like behavior and learning ability are not inherited in the same way. This discovery may be important for maintaining a specific population's activity levels and counteracting natural selection.
Article
Medicine, Research & Experimental
V. G. Bashkatova, N. G. Bogdanova, G. A. Nazarova, S. K. Sudakov
Summary: Both lamotrigine and LY341495 can prolong the latency of seizures, with lamotrigine showing the most pronounced effect. Both test substances prevent lipid peroxidation intensification induced by hypothermic exposure to varying degrees.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
S. K. Sudakov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
S. K. Sudakov, G. A. Nazarova, E. V. Alekseeva
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2017)
