期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 149, 期 3, 页码 347-350出版社
SPRINGER
DOI: 10.1007/s10517-010-0943-y
关键词
urokinase plasminogen activator; tissue plasminogen activator; plasminogen activator inhibitor-1; cancer of the oral mucosa
Enhanced activation of plasminogen by the urokinase pathway (uPA elevation) in patients with cancer of the oral mucosa paralleled by an increase of PAI-1 level in the tumor compared to the adjacent mucosa was shown by enzyme immunoassay. No statistically significant associations of the level of the studied proteins in the tumor with such prognostic factors as location, growth form, histological structure, differentiation degree, size, and dissemination of the primary tumor, involvement of the regional lymph nodes, and stage of the disease were detected.
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