期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 149, 期 1, 页码 148-153出版社
SPRINGER
DOI: 10.1007/s10517-010-0895-2
关键词
tissue engineering construction; polylactide carriers; selective laser sintering; multipotent stromal cells; regeneration
资金
- Russian Foundation for Basic Research [07-02-00789, 09-02-00935]
- Russian Ministry of Education and Science [2009-02-1.2-09-08-009]
We studied the biocompatibility of porous polylactide carrier matrices obtained by means of surface selective laser sintering. Carrier matrices had no cytotoxic activity, but maintained adhesion and proliferation of cells. Subcutaneous transplantation of tissue engineering constructions from these carriers and bone marrow-derived multipotent stromal cells did not cause the inflammatory response and pathological changes in rats. The conditions for organotypic regeneration were provided at the site of transplantation (high degree of blood supply and considerable amount of immature precursor cells).
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