Effects of Fenamate on Inhibitory Postsynaptic Currents in Purkinje's Cells

The effects of nonsteroid antiinflammatory drugs of the fenamate group (mefenamic and tolfenamic acids) on spontaneous miniature inhibitory postsynaptic currents in Purkinje's cells were studied in mouse cerebellar slices by the whole cell patch-clamp method. Both drugs in concentrations of 3-30 mu M significantly prolonged miniature inhibitory postsynaptic currents and reduced their amplitude.