Article
Health Care Sciences & Services
Hyemi Hwang, Yeonjae Han, Geun-Young Park, Soohwan Lee, Hae-Yeon Park, Sun Im
Summary: This study investigated the effects of tDCS on swallowing function in individuals with different COMT gene polymorphisms. The results showed that individuals with COMT Val/Val polymorphism experienced improvement in swallowing motor function after tDCS, while those with COMT Met carrier group did not show significant changes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Neurosciences
L. Bonetti, S. E. P. Bruzzone, N. A. Sedghi, N. T. Haumann, T. Paunio, K. Kantojarvi, M. Kliuchko, P. Vuust, E. Brattico
Summary: This study explores the influence of different COMT gene variants on auditory prediction processes, demonstrating that catecholamine levels determined by genetics can affect the brain's mechanisms for detecting deviant events.
Article
Neurosciences
Mi Su, Yongyan Song
Summary: This meta-analysis did not find a significant association between COMT Val158Met polymorphism and PTSD. The Hardy-Weinberg equilibrium status of genotype distributions may influence the relationship between the two factors. Further large-scale population-based studies are needed to evaluate the impact of COMT Val158Met polymorphism on the risk of PTSD.
NEUROPSYCHOBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Olga A. Korczeniewska, Fengshen Kuo, Ching-Yu Huang, Cibele Nasri-Heir, Junad Khan, Rafael Benoliel, Craig Hirschberg, Eli Eliav, Scott R. Diehl
Summary: This study investigated the impact of the COMT gene on pain sensitivity and found that the low pain sensitivity haplotype is influenced by genetic variation in gene expression, rather than SNP rs4680. The results suggest that the frequency of the COMT low pain sensitivity haplotype varies widely among global populations.
JOURNAL OF GENE MEDICINE
(2021)
Article
Behavioral Sciences
Gerly Tamm, Kairi Kreegipuu, Jaanus Harro
Summary: This study aimed to describe the interaction between platelet MAO activity and COMT Val158Met genotype in visual working memory updating. The results suggest that the effect of COMT Val158Met on updating efficiency depends on the level of platelet MAO activity.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dong-Fang Zhao, Yu-Fan Fan, Fang-Yuan Wang, Fan-Bin Hou, Frank J. Gonzalez, Shi-Yang Li, Ping Wang, Yang-Liu Xia, Guang-Bo Ge, Ling Yang
Summary: The study identified Scutellariae radix as the most potent inhibitor of hCOMT among 53 herbal products. Specific chemicals like scutellarein, baicalein, and oroxylin A from the extract were found to be potent COMT inhibitors. These findings suggest the potential for developing more effective non-nitrocatechol COMT inhibitors for biomedical applications.
Article
Medicine, General & Internal
Zhonggui Xiong, Jiong Yan, Shuhua Shi
Summary: This study found that Val158Met polymorphisms of the COMT gene and serum concentrations of catecholaminergic neurotransmitters are associated with ADHD children and adolescents, with significant differences between the two groups.
Article
Chemistry, Medicinal
Dong-Fang Zhao, Yu-Fan Fan, Hao-Nan Yu, Fan-bin Hou, Yan-Wei Xiang, Ping Wang, Guang-Bo Ge, Ling Yang, Jian-Guang Xu
Summary: The study revealed that the flavonoids in vine tea exhibit strong inhibition against human catechol-Omethyltransferase, with myricetin being the most potent compound. This finding not only has implications for the drug exposure of catechol drugs, but also provides a promising lead compound for developing more effective hCOMT inhibitors.
Article
Agriculture, Multidisciplinary
Seul Hoo Lee, Bongsang Kim, Kyung-Jin Kim
Summary: The study reported the biochemical and structural analysis of COMT enzyme from Niastella koreensis, revealing that its activity is mainly influenced by magnesium ion, but also shows significant activity with copper and zinc ions. Structural analysis showed that the region near the SAM binding site undergoes conformational changes upon binding of the cosubstrate and the metal ion. Additionally, by developing variants, the activity and selectivity of NkCOMT can be enhanced.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wataru Kadowaki, Ryo Miyata, Misa Fujinami, Yoshizumi Sato, Shigenori Kumazawa
Summary: The study found that Calendula officinalis leaves contain 10 compounds with inhibitory activities against neurotransmitter-related diseases, particularly Parkinson's disease and depression.
Article
Biochemistry & Molecular Biology
Jin-Hee Kim, Jimin Lee, Hyesoo Jeong, Mi Seo Bang, Jin-Hyun Jeong, Minsun Chang
Summary: The study investigated the novel biological activities of NDGA in relation to COMT and how COMT inhibition by NDGA affects 4-OHE2-induced cyto- and genotoxicity in MCF-7 human breast cancer cells. The results showed that NDGA both inhibits COMT-mediated formation of 4-MeOE2 and increases 4-OHE2-induced DNA damage and cytotoxicity, potentially increasing catechol estrogen-induced genotoxicities in mammary tissues.
Article
Clinical Neurology
Joe Yamamoto, Tomohiro Omura, Sachiko Kasamo, Shota Yamamoto, Masayoshi Kawata, Atsushi Yonezawa, Yosuke Taruno, Hisako Endo, Hitoshi Aizawa, Nobukatsu Sawamoto, Kazuo Matsubara, Ryosuke Takahashi, Yoshikazu Tasaki
Summary: In the pharmacotherapy of patients with Parkinson's disease, entacapone can reduce the metabolism of l-dopa, increase its concentration in the body, and improve the treatment. The COMT Val158Met polymorphism affects the response to this treatment, with differences in patients with different genotypes. Concurrent administration of l-dopa with entacapone can suppress the increase in 3-OMD levels, suggesting the polymorphism may be useful for personalized dose adjustment of COMT inhibitors in PD treatment.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Medicine, Research & Experimental
Andrea Polli, Jolien Hendrix, Kelly Ickmans, Jelena Bakusic, Manosij Ghosh, Dora Monteyne, Brigitte Velkeniers, Bram Bekaert, Jo Nijs, Lode Godderis
Summary: The study found associations between COMT haplotypes and DNA methylation, cytokine expression, and symptoms in patients with CFS/FM, but not specific to one condition. Significant differences were observed in increased DNA methylation in the MB-COMT promoter and decreased IFN-gamma expression in patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Medicinal
A. Katherine Hatstat, Grace M. Kennedy, Trevor R. Squires, Gisela Xhafkollari, C. Skyler Cochrane, Mauricio Cafiero, Larryn W. Peterson
Summary: L-DOPA, a dopamine precursor, is commonly used in Parkinson's disease treatment. Inhibiting COMT can prolong the effects of L-DOPA and dopamine, increasing the efficiency of the treatment. Nitrile derivatives with a nitro substituent show the most promise as COMT inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
K. Poonkuzhali, R. Seenivasagan, J. Prabhakaran, A. Karthika
Summary: Chemically engineered PLGA nanospheres inhibiting Catechol-O-methyltransferase (COMT) are a promising technology for treating neurodegenerative disorders. PLGA-MATPM nanospheres, synthesized using PLGA and MATPM, effectively inhibit COMT in a dose-dependent manner. The interaction between COMT and PLGA nanospheres is explained through spectroscopic and molecular dynamics analysis. PLGA-MATPM nanospheres show neurodegenerative recovery by suppressing the growth of neuroblastoma cells and effectively cross the blood-brain barrier.
BIOORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Elena V. Orekhova, Olga V. Sysoeva, Justin F. Schneiderman, Sebastian Lundstrom, Ilia A. Galuta, Dzerasa E. Goiaeva, Andrey O. Prokofyev, Bushra Riaz, Courtney Keeler, Nouchine Hadjikhani, Christopher Gillberg, Tatiana A. Stroganova
SCIENTIFIC REPORTS
(2018)
Article
Genetics & Heredity
Olga Sysoeva, John N. Constantino, Andrey P. Anokhin
Article
Neurosciences
Elena Orekhova, Tatiana A. Stroganova, Justin F. Schneiderman, Sebastian Lundstrom, Bushra Riaz, Darko Sarovic, Olga Sysoeva, Georg Brant, Christopher Gillberg, Nouchine Hadjikhani
HUMAN BRAIN MAPPING
(2019)
Article
Psychiatry
Tufikameni Brima, Sophie Molholm, Ciara J. Molloy, Olga V. Sysoeva, Eric Nicholas, Aleksandra Djukic, Edward G. Freedman, John J. Foxe
TRANSLATIONAL PSYCHIATRY
(2019)
Review
Clinical Neurology
Olga V. Sysoeva, Kirill Smirnov, Tatiana A. Stroganova
CLINICAL NEUROPHYSIOLOGY
(2020)
Article
Psychiatry
Olga V. Sysoeva, Sophie Molholm, Aleksandra Djukic, Hans-Peter Frey, John J. Foxe
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Genetics & Heredity
T. A. Stroganova, K. S. Komarov, O. V. Sysoeva, D. E. Goiaeva, T. S. Obukhova, T. M. Ovsiannikova, A. O. Prokofyev, E. V. Orekhova
Article
Biochemistry & Molecular Biology
Anastasia K. Neklyudova, Galina V. Portnova, Anna B. Rebreikina, Victoria Yu Voinova, Svetlana G. Vorsanova, Ivan Y. Iourov, Olga V. Sysoeva
Summary: SH01 is a 15-year-old girl with a duplication in the SHANK3 gene, exhibiting mild mental retardation, learning disabilities, and smaller vocabulary compared to typically developing children. Despite mild autistic symptoms and microcephaly, she did not meet the criteria for ASD diagnosis. The absence of 40-Hz ASSR in patients with SHANK3 gene duplication suggests deficient temporal resolution of the auditory system, potentially contributing to language problems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kirill Smirnov, Tatiana Stroganova, Sophie Molholm, Olga Sysoeva
Summary: Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutations of the MECP2 gene, resulting in severe deficits in motor, perceptual, and cognitive domains. Despite the use of electroencephalogram (EEG) to provide valuable information, no reliable neurophysiological biomarkers related to the disorder have been identified. Further research is needed to investigate EEG abnormalities and establish potential biomarkers for RTT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Daria F. Kleeva, Anna B. Rebreikina, Gurgen A. Soghoyan, Daria G. Kostanian, Anastacia N. Neklyudova, Olga Sysoeva
Summary: The study found that auditory tetanization can lead to an increase in the P2 ERP component and a decrease in the N1 component, which is not specific to the stimulated tones and can extend to neighboring tones. This effect lasts for at least 30 minutes and can be detected even when participants watched muted videos.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Mathematical & Computational Biology
Gurgen Soghoyan, Alexander Ledovsky, Maxim Nekrashevich, Olga Martynova, Irina Polikanova, Galina Portnova, Anna Rebreikina, Olga Sysoeva, Maxim Sharaev
Summary: Independent Component Analysis (ICA) is commonly used to remove non-brain signals from electroencephalography (EEG), but the process of rejecting independent components (ICs) often requires expert intervention. The ALICE project aims to develop a sustainable algorithm for automatic classification of EEG ICs by accumulating expert knowledge. Through crowdsourced visual labeling, ALICE will improve machine learning algorithms for automatic artifact removal and pattern extraction from EEG signals.
FRONTIERS IN NEUROINFORMATICS
(2021)
Article
Health Care Sciences & Services
Anastasiya A. Rebik, Vyacheslav D. Riga, Kirill S. Smirnov, Olga V. Sysoeva, Inna S. Midzyanovskaya
Summary: The study found that the KM rat strain showed reduced social preference behavior in social preference tests and demonstrated susceptibility to audiogenic seizures. It proposes the KM rat strain as a new animal model for comorbid ASD and epilepsy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Galina Portnova, Anastasia Neklyudova, Victoria Voinova, Olga Sysoeva
Summary: This study compared EEG activity between girls with Rett syndrome and typically developing peers, and identified several EEG parameters that differentiated the groups. Only elevated generalized background slowing and a newly introduced frequency rate index showed significant correlation with Rett syndrome progression and breathing irregularities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Oksana I. Talantseva, Galina V. Portnova, Raisa S. Romanova, Daria A. Martynova, Olga V. Sysoeva, Elena L. Grigorenko
Summary: Potocki-Lupski syndrome (PTLS) is a rare condition caused by a duplication of 17p11.2, which can lead to a variety of congenital abnormalities and behavioral phenotypes. Although autism-specific traits are commonly found in PTLS patients, we present a case of a female adolescent with PTLS but without autism features. Our evaluation focused on clinical, behavioral, and EEG assessments, revealing unique EEG patterns and altered nonlinear EEG dynamics in the patient. Previous studies suggest a bias in the reported occurrence of ASD in PTLS, with more consistent features being intellectual disability and speech/language disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Neurosciences
Olga Sysoeva, Sophie Molholm, Aleksandra Djukic, Hans-Peter Frey, John J. Foxe
BIOLOGICAL PSYCHIATRY
(2020)
