Review
Respiratory System
Jeremy Anderson, Lien Anh Ha Do, Danielle Wurzel, Zheng Quan Toh, Kim Mulholland, Daniel G. Pellicci, Paul Licciardi
Summary: RSV is the most common viral pathogen causing acute lower respiratory tract infection in young children. Premature birth is a common risk factor for severe RSV disease due to an immature innate immune system, leading to increased susceptibility to RSV. Understanding differences in innate immunity between preterm and term infants is crucial for developing interventions to reduce disease burden in this vulnerable population.
Article
Fisheries
Qiang Fu, Jie Hu, Pei Zhang, Yuqing Li, Shoucong Zhao, Min Cao, Ning Yang, Chao Li
Summary: Seventeen CC and CXC chemokine genes were identified in the turbot genome, making it a valuable resource for comparative immunological studies and functional characterization of chemokines in teleost.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Xing Lv, Qiang Luo, Shiying Xin, Weiwei Zheng, Tianjun Xu, Yuena Sun
Summary: In recent years, there has been an increasing focus on the study of circular RNAs (circRNAs) in noncoding RNAs. While circRNAs are abundant in mammalian studies, research in lower vertebrates has been lacking. In this study, a circRNA called circPlce1 was found to be related to the innate immune response in Miichthys miiuy (miiuy croaker). Experimental results showed that circPlce1 could promote the production of antiviral genes and inflammatory response. It was also observed that circPlce1 can promote cell proliferation and improve cell viability. The study provides a foundation for understanding the biological function of circRNAs in the innate immune response in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Lisen Li, Joao C. R. Cardoso, Rute C. Felix, Ana Patricia Mateus, Adelino V. M. Canario, Deborah M. Power
Summary: The evolution and function of lysozymes in fish show lineage and species-specific adaptations, suggesting differences in maternal innate immune protection among different species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Nguyen Bao Trung, Fan-Hua Nan, Meng-Chou Lee, Jiun-Yan Loh, Hong-Yi Gong, Ming-Wei Lu, Ho Thi Hang, Yu-Lin Lin, Po-Tsang Lee
Summary: TLR18 is expressed in all tissues, with the highest levels in the intestine and the lowest in the liver. It is up-regulated in immune-related organs after bacterial and poly I:C challenges, and in THK cells after LPS stimulation. TLR18 localizes in the intracellular compartment, and interacts with MyD88 and TRIF as adaptors. Constitutively active TLR18 induces the production of various effectors like cytokines and antimicrobial peptides in THK cells.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Yanhong Song, Weiwei Zheng, Shiying Xin, Jiajia Pan, Liyuan Yang, Yuena Sun, Tianjun Xu
Summary: This study identified a novel long noncoding RNA (lncRNA) called LTCONS6801 in Miichthys miiuy, which contributes to the TANK-binding kinase 1 (TBK1) pathway and promotes the host immune function. The overexpression of lncRNA LTCONS6801 was found to enhance cell activity and increase the expression of antiviral genes and TBK1. Furthermore, lncRNA LTCONS6801 was found to regulate the NF-kappa B and IRF3 signaling pathways by modulating TBK1 expression. In conclusion, lncRNA LTCONS6801 positively regulates the host innate immune response by controlling TBK1 expression, highlighting its important role in antiviral immunity of teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Tan Phat Nguyen, Bao Trung Nguyen, Fan-Hua Nan, Meng-Chou Lee, Po-Tsang Lee
Summary: Nile tilapia (Oreochromis niloticus) is an important food fish species mainly cultivated in tropical and subtropical countries. This study focuses on Toll-like receptors (TLRs) and the clonation of OnTLR23 in fish cells. The study also explores the interaction of OnTLR23 with other molecules and its potential role in immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Smruti Mahapatra, Bristy Ganguly, Saswati Pani, Ashis Saha, Mrinal Samanta
Summary: This article provides an overview of various aspects of Toll-like receptors (TLRs) in fish, including their history, classification, structure, function, signaling pathways, and expression patterns. The article highlights the specific contribution of TLRs to the immune response in fish and identifies gaps in research in this area.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ning-Xia Xiong, Sheng-Wei Luo, Zhuang-Wen Mao, Lan-Fen Fan, Kai-Kun Luo, Shi Wang, Fang-Zhou Hu, Ming Wen, Qing-Feng Liu, Shao-Jun Liu
Summary: The study revealed that Ferritin H in hybrid fish plays an important role in regulating fish immunity, with its fusion proteins exhibiting direct binding activity to A. hydrophila and reducing inflammation. These findings suggest that Ferritin H in hybrid fish elicits a similar immune response to A. hydrophila-induced inflammation compared to its parental species.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Bruno Reis, Lourenco Ramos-Pinto, Sara A. Cunha, Manuela Pintado, Joana Laranjeira da Silva, Jorge Dias, Luis Conceicao, Elisabete Matos, Benjamin Costas
Summary: This study evaluated the effects of different feed formulations containing Chlorella vulgaris on the health status and inflammatory response of gilthead seabream. The results showed that Chlorella vulgaris supplementation had an impact on the circulating neutrophils in the fish, but had mild effects on the innate immune and antioxidant functions. In the inflammatory response, the soluble peptide-enriched extract of Chlorella vulgaris seemed to have a protective, anti-stress effect in the gut.
Article
Fisheries
Ning-Xia Xiong, Jin-Fang Huang, Ke-Xin Li, Shi-Yun Li, Jia-Hui Zhao, Rou Wang, Jie Ou, Lan-Fen Fan, Sheng-Wei Luo, Shao-Jun Liu
Summary: The study found that ferritin M in hybrid fish showed a similar immune defense against bacterial infection compared to its parental species, which may have implications for disease control in future fish farming.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Yankai Liu, Jun Xiao, Guoxia Qiao, Qun Wang, Xiao Yang, Xingjian Xu, Jun Li, Jie Zhang, Mingxian Chang, Hao Feng
Summary: In this study, the negative regulatory role of black carp DDX19 (bcDDX19) in the innate immune response was investigated. It was found that bcDDX19 restricts the entry of IRF3 into the nucleus, thereby negatively regulating the RLR/IRF3-mediated type I IFN signaling pathway.
Editorial Material
Immunology
Xinxin Wang, Yuping Lai
Summary: In this study, the authors investigate the mechanism by which pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides to induce inflammation in keratinocytes. They demonstrate that solute carrier 46A2 (SLC46A2) transports DAP-muropeptides into the cytosol, leading to NOD1 activation and subsequent skin inflammation during psoriasis.
Article
Multidisciplinary Sciences
Jennifer Cable, Jie Sun, In Su Cheon, Andrew E. Vaughan, Italo A. Castro, Sydney R. Stein, Carolina B. Lopez, Katelyn M. Gostic, Peter J. M. Openshaw, Ali H. Ellebedy, Andreas Wack, Edward Hutchinson, Mallory M. Thomas, Ryan A. Langlois, Daniel Lingwood, Steven F. Baker, Melanie Folkins, Ellen F. Foxman, Andrew B. Ward, Martin Schwemmle, Alistair B. Russell, Christopher Chiu, Ketaki Ganti, Kanta Subbarao, Timothy P. Sheahan, Pablo Penaloza-MacMaster, Taylor Eddens
Summary: Respiratory viruses, including influenza, RSV, and SARS-CoV-2, pose a significant threat to global public health. Researchers at the Keystone symposium Respiratory Viruses: New Frontiers presented novel insights into viral biology and virus-host interactions, aiming to understand disease mechanisms and develop effective treatment and prevention strategies that are durable and broad.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Fisheries
Ming Xian Chang, Fan Xiong, Xiao Man Wu, Yi Wei Hu
Summary: NLR proteins are immune sensors that recognize pathogen patterns, with different species having varying numbers of NLRs. The zebrafish genome contains almost 400 NLR proteins. These proteins can positively or negatively regulate immune responses and inflammatory signaling cascades.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
