Article
Ecology
J. Lyu, L. S. Yang, Y. Y. Chen, B. X. Ye, L. Zhang, L. Wang
Summary: The study in 12 cities in China found detectable levels of various antibiotics in drinking water, with higher antibiotic exposure in summer and primarily macrolides detected in winter. The total antibiotic exposure varied significantly between cities and seasons, with notable levels in Chaohu, Huainan, Guangzhou, and Mudanjiang. Some antibiotics were found to have health risk quotients exceeding the threshold.
APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mohammad I. Al-Wabel, Munir Ahmad, Jahangir Ahmad, Nahrir M. A. Lubis, Adel R. A. Usman, Abdullah S. F. Al-Farraj
Summary: Application of manure and compost can lead to accumulation of veterinary antibiotics in soil, posing ecological risks. This study investigated the occurrence and potential ecological risk assessment of nine antibiotics residues in soil, manure, and compost samples from Al-Kharj, Saudi Arabia. While most studied antibiotics showed low risk quotient values, oxytetracycline and doxycycline had higher values, indicating possible adverse ecological effects in soil.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Review
Immunology
Annie S. Jasper, Jackson S. Musuuza, Jessica S. Tischendorf, Vanessa W. Stevens, Shantini D. Gamage, Fauzia Osman, Nasia Safdar
Summary: Comparing fluoroquinolone versus macrolide monotherapy in Legionella pneumonia, no significant difference was found in reducing mortality rates, clinical cure, time to apyrexia, length of hospital stay, and occurrence of complications.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Dandara Cassu-Corsi, Fernanda F. Santos, Rodrigo Cayo, Willames M. B. S. Martins, Carolina S. Nodari, Luiz G. P. Almeida, Rafael A. Martins, Roberto J. Carvalho da Silva, Ana Tereza R. Vasconcelos, Antonio C. C. Pignatari, Ana C. Gales
Summary: This study sequenced Neisseria gonorrhoeae isolates collected in Sao Paulo, Brazil and identified different sequence types and resistance mutations. The results contribute to the understanding of N. gonorrhoeae strains circulating in the region.
Article
Microbiology
Martijn Zwama, Kunihiko Nishino
Summary: Recent mutations in RND efflux pumps have increased multidrug resistance. R717L and R717Q substitutions in the AcrB pump of Escherichia coli dramatically enhance resistance to macrolides and fluoroquinolones, while rendering cells more susceptible to novobiocin and cloxacillin. We emphasize the need for antibiotic control, adjustment of treatments, and the development of novel antibiotics and efflux pump inhibitors.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Biology
Alexis J. Vega, Caitlin Smith, Hannah Grace Matejowsky, Katherine J. Thornhill, Grant E. Borne, Chizoba N. Mosieri, Sahar Shekoohi, Elyse M. Cornett, Alan D. Kaye
Summary: The administration of warfarin poses a challenge due to increased patient susceptibility to major bleeding, especially when co-administered with antibiotics capable of modulating its metabolism. Evidence consistently supports an elevated risk of bleeding in patients receiving antibiotics and warfarin therapy. This review highlights the importance of diligent monitoring in patients on warfarin requiring antibiotic therapy and the potential benefits of dose reduction or adjustment for certain antibiotics.
Article
Microbiology
Jade Bokma, Nick Vereecke, Hans Nauwynck, Freddy Haesebrouck, Sebastiaan Theuns, Bart Pardon, Filip Boyen
Summary: This study utilized rapid long-read sequencing to generate high-quality genomes of 100 M. bovis isolates and conducted a GWAS analysis to investigate natural and acquired antimicrobial resistance, identifying potential genetic markers associated with resistance.
MICROBIOLOGY SPECTRUM
(2021)
Article
Immunology
Carolina Cruz, Lucia Rodrigues, Filipa Fernandes, Ricardo Santos, Paulo Paixao, Maria Jesus Chasqueira
Summary: This study aimed to describe the antibiotic susceptibility pattern of environmental Legionella recovered in the south of Portugal. The results showed that fluoroquinolones were the most active antibiotics, while doxycycline was the least sensitive. The minimal inhibitory concentration distributions for all antibiotics were higher than those reported by EUCAST. Interestingly, two phenotypically resistant isolates with high-level quinolone resistance were identified. This is the first investigation of MIC distributions, lpeAB, and tet56 genes in Portuguese environmental isolates of Legionella.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tatsuya Yagi, Buster Mannheimer, Johan Reutfors, Johan Ursing, Diego Hernan Giunta, Helle Kieler, Marie Linder
Summary: The study aims to evaluate the association between the use of fluoroquinolones or macrolides and bleeding events in patients with concomitant DOAC use. The results suggest that the risk of bleeding when combined with DOACs is small for fluoroquinolones, while the use of macrolides is not associated with an increased risk of bleeding.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Infectious Diseases
Andrea Visca, Anna Barra Caracciolo, Paola Grenni, Luisa Patrolecco, Jasmin Rauseo, Giulia Massini, Valentina Mazzurco Miritana, Francesca Spataro
Summary: By investigating three common soil emerging contaminants in a full scale anaerobic plant for one year, this study found that anaerobic digestion can effectively decrease antibiotic residues and antibiotic resistance genes in soil, reducing their potential impact on soil ecosystems.
Article
Food Science & Technology
Masaru Usui, Sho Tateno, Masanobu Onozaki, Naoaki Misawa, Yasuhiko Suzuki, Yutaka Tamura, Chie Nakajima
Summary: The rapid method CAMERA can simultaneously detect C. jejuni/coli and determine their susceptibility to fluoroquinolone/macrolide drugs. This study demonstrated the accuracy and efficiency of CAMERA in detecting and confirming antimicrobial resistance, providing a valuable tool for surveillance and control of resistant C. jejuni/coli contamination.
Article
Infectious Diseases
Carlton Poindexter, Andrea Yarberry, Clifford Rice, Stephanie Lansing
Summary: This study developed a uniform method to extract four classes of antibiotics from different types of manure, providing more accurate data for assessing the risk of antibiotic transport in liquid or solid manure waste.
Article
Chemistry, Multidisciplinary
Yue Wang, Yuan Xu, Ruixia Gao, Xuemeng Tian, Jake Heinlein, Sameer Hussain, Lisa D. Pfefferle, Xiaoyi Chen, Xiaojing Zhang, Yi Hao
Summary: This study develops lightweight hollow double-layer hybrid magnetic molecularly imprinted polymers (HD-MMIPs) using green and sustainable chemistry, which improved the adsorption capacity and the rebinding rate of tetracycline (TC) compared to traditional surface molecularly imprinted polymers (SMIPs). The Fe3O4 nanoparticles embedded in the HD-MMIPs significantly facilitated the separation process. The HD-MMIPs also showed potential in monitoring and controlling TC contamination in real samples.
Article
Pharmacology & Pharmacy
Mahek Garg, Veena Venugopalan, Scott M. Vouri, Vakaramoko Diaby, Nicole M. Iovine, Haesuk Park
Summary: This study investigated the risk of aortic aneurysm or dissection in patients using oral fluoroquinolones compared to macrolides in real-world clinical practice. The results showed that the use of fluoroquinolones was associated with a 34% increased risk of aortic aneurysm or dissection compared to macrolides.
Article
Environmental Sciences
Anne Mehrtens, Wiebke Freund, Pia Luedeke, Tobias Licha, Victoria Burke
Summary: The main route of veterinary antibiotics entering the environment is through the application of liquid manure, and understanding their sorption behavior is crucial for reliable risk assessment. Experimental results demonstrated that sulfonamides were highly mobile regardless of manure presence, while lincomycin transport was significantly delayed in the presence of manure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
