Article
Biochemistry & Molecular Biology
Amalia Ruiz-Serrano, Josep M. Monne Rodriguez, Julia Gunter, Samantha P. M. Sherman, Agnieszka E. Jucht, Pascal Fluechter, Yulia L. Volkova, Svende Pfundstein, Giovanni Pellegrini, Carsten A. Wagner, Christoph Schneider, Roland H. Wenger, Carsten C. Scholz
Summary: OTUB1 is a highly expressed deubiquitinase that plays a role in lung development and pathogenesis, but its physiological function remains unknown. Deletion of Otub1 in mice leads to perinatal lethality due to respiratory failure, indicating its essential role in lung development and homeostasis. Additionally, Otub1 deletion enhances cell proliferation and mTOR signaling in lung tissues, suggesting OTUB1 is a negative regulator of mTOR signaling with crucial functions in lung biology and respiratory regulation.
Editorial Material
Hematology
Alpana Waghmare, Sina A. Gharib
Summary: In this study, Zinter et al sequenced the metatranscriptome of BALF from asymptomatic pediatric HCT candidates, and the results were published in the journal Blood.
Article
Health Care Sciences & Services
Himadri Mukherjee, Priyanka Sreerama, Ankita Dhar, Sk. Md. Obaidullah, Kaushik Roy, Mufti Mahmud, K. C. Santosh
Summary: This study developed a tool to detect respiratory sounds from infected patients, achieving a high accuracy of 99.22% using LPCC-based features and MLP classifier. The results outperformed common works in the literature, showcasing the effectiveness of the developed method.
JOURNAL OF MEDICAL SYSTEMS
(2021)
Article
Biology
Theodore Lerios, Jennifer L. Knopp, Lui Holder-Pearson, Ella F. S. Guy, J. Geoffrey Chase
Summary: This study examines the changes in expiratory resistance in healthy lungs and lungs of COPD patients. The results show that the severity of COPD is associated with increased nonlinearity in expiratory resistance. These findings suggest that a nonlinear model can accurately capture the progression of COPD from regular breathing data, offering potential clinical applications for patient-specific diagnosis and monitoring.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Sorcha Daly, Andrew O'Sullivan, Ronan MacLoughlin
Summary: Cellular immunotherapies have emerged as cutting-edge strategies for the prevention and treatment of cancer and infectious diseases, showing promising potential in addressing respiratory viral infections as well. While initially focused on cancer treatment, recent studies have highlighted the efficacy of these therapies in combating respiratory viruses, especially when administered via inhalation routes.
Article
Pediatrics
Arun Sett, Kelly R. Kenna, Rebecca J. Sutton, Elizabeth J. Perkins, Magdy Sourial, Jack D. Chapman, Susan M. Donath, Arun Sasi, Sheryle R. Rogerson, Brett J. Manley, Peter G. Davis, Prue M. Pereira-Fantini, David G. Tingay
Summary: In preterm newborn lambs, lung ultrasound of the dependent lung was able to detect large changes in total and regional lung volume in real-time and correctly identified opening and closing pressures but lacked the precision to detect small changes in lung volume. Further improvements are needed before translation to clinical practice.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Naziha Khen-Dunlop, Gihad Chalouhi, Augustin Lecler, Afef Bouchouicha, Anne-Elodie Millischer, Bertrand Tavitian, Nathalie Siauve, Daniel Balvay, Laurent J. Salomon
Summary: The study shows that a BOLD response can be observed in the normal fetal lung, indicating appropriate oxygen uptake capacity. This finding may be used in the future to predict the respiratory status of newborns.
EUROPEAN RADIOLOGY
(2021)
Article
Physiology
Nicholas M. J. Smith, Snapper R. M. Magor-Elliott, Christopher J. Fullerton, John H. Couper, Graham Richmond, Gus Hancock, Grant A. D. Ritchie, Peter A. Robbins, Nick P. Talbot, Nayia Petousi
Summary: This study investigated a new technique for assessing gas-exchange inhomogeneity in COPD patients, comparing them with age-matched healthy controls. New indices of lung function were identified to differentiate between varying disease severities in COPD.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dan Wang, Jingyi Cheng, Jia Zhang, Fangyu Zhou, Xiao He, Ying Shi, Yongguang Tao
Summary: The pathogenesis and progression of lung cancer are associated with changes in the respiratory microbiota, which can impact tumor growth and metastasis through various mechanisms such as alterations in metabolism, immune response, inflammation, and angiogenesis. In addition, the microbiota plays a role in modifying the efficacy and toxicity of tumor immunotherapy and chemotherapy, making it a significant factor in cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Medicine, Research & Experimental
Jovile Raudoniute, Daiva Bironaite, Edvardas Bagdonas, Ieva Kulvinskiene, Brigita Jonaityte, Edvardas Danila, Ruta Aldonyte
Summary: The field of microbiome research has gained popularity, focusing on the human microbiome as a new organ and a living community of microorganisms. Microbiome refers to the entire genome of microbiota, including bacteria, archaea, fungi, algae, and protists. Understanding the composition, dynamics, and interactions within the microbiome is essential for future diagnostics and therapies. The study also reviewed the respiratory microbiome, its roles in symbiosis and disease, and the bidirectional relationships with host susceptibility.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Respiratory System
Jan Johnson, Iain Stewart, Simon R. Johnson
Summary: In patients with lymphangioleiomyomatosis, lung function measurements can vary and recognizing the need for treatment can be challenging. This study found that DLCO may decline independently of FEV1, especially in early disease and during mTOR inhibitor treatment. Multiple measurements over a long period of time are needed to accurately estimate lung function trajectories.
Review
Pharmacology & Pharmacy
Isabella Francis, Jesus Shrestha, Keshav Raj Paudel, Philip M. Hansbro, Majid Ebrahimi Warkiani, Suvash C. Saha
Summary: The transition from 2D to 3D models and the recent advances in lung-on-a-chip platforms, their implementation, and the challenges faced are discussed, highlighting the potential applications in respiratory disease research and drug discovery.
DRUG DISCOVERY TODAY
(2022)
Article
Respiratory System
Lihui Zhou, Hongxi Yang, Yuan Zhang, Yuan Wang, Xin Zhou, Tong Liu, Qing Yang, Yaogang Wang
Summary: The study found that lung function measures are associated with cardiovascular disease (CVD). Restrictive and obstructive impairments were found to be associated with an increased risk of CVD compared to normal spirometry. The study suggests that spirometry indicators can be considered in CVD risk assessment.
Article
Multidisciplinary Sciences
Julia Diaz-Escobar, Nelson E. Ordonez-Guillen, Salvador Villarreal-Reyes, Alejandro Galaviz-Mosqueda, Vitaly Kober, Raul Rivera-Rodriguez, Jose E. Lozano Rizk
Summary: The study evaluates and compares deep-learning techniques for detecting COVID-19 infections from lung ultrasound imagery. The findings suggest that the InceptionV3 network provides the most promising predictive results, which can be used to further develop a viable computer-assisted screening tool for COVID-19 based on ultrasound imagery.
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)