Review
Surgery
Guang-Peng Zhou, Yi-Zhou Jiang, Li-Ying Sun, Zhi-Jun Zhu
Summary: This study found no difference in posttransplant survival between NASH and non-NASH patients. Carefully selected NASH patients with hepatocellular carcinoma (HCC) may benefit from liver transplantation. NASH recipients should be managed with caution posttransplant, especially regarding the potentially high risk of sepsis-related death.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Medicine, General & Internal
Lars J. Bjertnaes, Kristian Hindberg, Torvind O. Naesheim, Evgeny V. Suborov, Eirik Reierth, Mikhail Y. Kirov, Konstantin M. Lebedinskii, Torkjel Tveita
Summary: This systematic review and meta-analysis compared outcomes of rewarming after accidental hypothermic cardiac arrest with CPB or/and ECMO, finding that survival rate was significantly higher with ECMO than CPB, and for witnessed compared to unwitnessed cases, with avalanche victims having the lowest survival probability. Male sex, high initial body temperature, low pH, and high s-K+ levels were associated with lower chances of surviving.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Adam Minich, Fakhar Ali Qazi Arisar, Noor-ul Saba Shaikh, Leanne Herman, Amirhossein Azhie, Ani Orchanian-Cheff, Keyur Patel, Sareh Keshavarzi, Mamatha Bhat
Summary: This study conducted a systematic review and meta-analysis to identify clinical variables that predict post-liver transplantation survival in non-alcoholic steatohepatitis (NASH) patients. The findings provide valuable insights for optimizing patient outcomes and decision-making in the limited-resource liver transplantation setting.
Review
Surgery
Yu-Jen Chiu, Yu-Chen Huang, Tai-Wei Chen, Yih-An King, Hsu Ma
Summary: This study found that burn patients receiving extracorporeal membrane oxygenation treatment had a higher risk of death. However, certain patients, including those with inhalation injuries and those with revised Baux scores over 90, would benefit from the treatment.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Medicine, General & Internal
Joseph Mugaanyi, Lei Dai, Changjiang Lu, Shuqi Mao, Jing Huang, Caide Lu
Summary: Machine perfusion, particularly HOPE/D-HOPE and NMP, shows promise as alternatives to static cold storage for the preservation of donor livers. These methods improve graft and patient survival rates and reduce the incidence of biliary complications. They have the potential to address the gap between demand and availability of donor livers by enabling the utilization of marginal livers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Saikat Mitra, Ryan Ruiyang Ling, Chuen Seng Tan, Kiran Shekar, Graeme MacLaren, Kollengode Ramanathan
Summary: This systematic review and meta-analysis analyzed outcomes of patients receiving renal replacement therapy (RRT) on extracorporeal membrane oxygenation (ECMO) from January 2000 to September 2020. The study found that RRT on ECMO was associated with higher mortality rates and longer ICU/hospital stay compared to those without RRT. In the last five years, mortality decreased by 20% in patients receiving RRT, but there is still an increased risk of death. Future research should focus on minimizing renal dysfunction and determining the optimal timing for initiating RRT in ECMO patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Critical Care Medicine
Klementina Ocskay, Anna Kanjo, Noemi Gede, Zsolt Szakacs, Gabriella Par, Balint Eross, Jan Stange, Steffen Mitzner, Peter Hegyi, Zsolt Molnar
Summary: In acute-on-chronic liver failure (ACLF), plasma exchange (PE) appears to be the best liver support therapy currently available, significantly improving patient survival rates and reducing the need for organ transplants according to the results of the network meta-analysis. Additional randomized trials are needed to confirm these findings and potentially introduce new devices.
ANNALS OF INTENSIVE CARE
(2021)
Review
Medicine, General & Internal
Danny Conde Monroy, Milciades Ibanez-Pinilla, Juan Carlos Sabogal, Carlos Rey Chaves, Andres Isaza-Restrepo, Felipe Giron, Marco Vanegas, Rafael Ibanez-Villalba, Lutz Mirow, Timo Siepmann
Summary: This systematic review and meta-analysis evaluated the survival outcomes and predictors of hepatectomy for gastric cancer liver metastasis (GCLM). The results showed that hepatectomy resulted in favorable overall survival rates at one, three, and five years post-surgery. Factors such as metachronous presentation, small tumoral size, R0 resection, and solitary lesions were associated with higher overall survival. Metachronous presentation, smaller primary tumoral size, and solitary metastasis were also linked to longer disease-free survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Nicholas A. Bosma, Alysha R. Keehn, Richard Lee-Ying, Safiya Karim, Anthony R. MacLean, Darren R. Brenner
Summary: Perioperative chemotherapy in patients with resected CRLM improved disease-free survival (DFS) but did not show a benefit in overall survival (OS). Further research is needed to determine the optimal regimen and sequencing of perioperative chemotherapy.
Review
Oncology
D. Wagner, V. Wienerroither, M. Scherrer, M. Thalhammer, F. Faschinger, A. Lederer, H. M. Hau, R. Sucher, P. Kornprat
Summary: This review examines the evidence for sarcopenia as a prognostic parameter in colorectal liver metastases. The results suggest that sarcopenia does not significantly affect overall survival and disease-free survival, but it does have an influence on postoperative complication rates.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pediatrics
Yifu Hou, Xiaoxiao Wang, Hongji Yang, Shan Zhong
Summary: Infant liver transplantation shows modest patient and graft survival rates, but with high rates of infection/sepsis-related complications. More comprehensive evidence is needed from studies with larger sample sizes and longer follow-up duration.
FRONTIERS IN PEDIATRICS
(2021)
Review
Critical Care Medicine
Kollengode Ramanathan, Kiran Shekar, Ryan Ruiyang Ling, Ryan P. Barbaro, Suei Nee Wong, Chuen Seng Tan, Bram Rochwerg, Shannon M. Fernando, Shinhiro Takeda, Graeme MacLaren, Eddy Fan, Daniel Brodie
Summary: A systematic review and meta-analysis of ECMO use in COVID-19 patients with ARDS found venovenous ECMO to be the predominant mode, with age and duration of ECMO support associated with increased mortality. In-hospital mortality for COVID-19 patients receiving ECMO during the first year of the pandemic was 37.1%. Efficacy of venovenous ECMO in selected COVID-19 patients with ARDS was highlighted.
Review
Critical Care Medicine
Abdelaziz Farhat, Ryan Ruiyang Ling, Christopher L. Jenks, Wynne Hsing Poon, Isabelle Xiaorui Yang, Xilong Li, Yulun Liu, Cindy Darnell-Bowens, Kollengode Ramanathan, Ravi R. Thiagarajan, Lakshmi Raman
Summary: The study revealed a rapid expansion in the use of extracorporeal cardiopulmonary resuscitation in pediatric patients, with an overall survival rate of 46% and a 30% rate of favorable neurologic outcomes.
CRITICAL CARE MEDICINE
(2021)
Review
Nutrition & Dietetics
Lynsey N. Spillman, Angela M. Madden, Holly Richardson, Fumiaki Imamura, Danielle Jones, Marilyn Nash, Hong Kai Lim, Holly N. Hellawell, Kirsten L. Rennie, Linda Oude M. Griep, Michael Allison, Simon J. Griffin
Summary: Cardiovascular disease and its concurrent risk factors are common after liver transplant. Most of these risk factors can be improved through diet modification. This study aimed to review the literature on the nutritional intake of liver transplant recipients (LTR) and the factors influencing intake. The findings showed that LTR had a high-energy, low-quality diet with inadequate intake of fruits, vegetables, fiber, and adherence to cardiovascular disease prevention guidelines.
Review
Engineering, Biomedical
Emily Shu Ting Ng, Ryan Ruiyang Ling, Saikat Mitra, Chuen Seng Tan, Graeme MacLaren, Kollengode Ramanathan
Summary: Burns are a major cause of trauma globally, and acute respiratory distress syndrome (ARDS) is a common cause of death for burn patients. In some cases where conventional therapies fail to improve hypoxemia, extracorporeal membrane oxygenation (ECMO) may be used as a rescue treatment. A meta-analysis of studies on ECMO for burns or inhalation injuries found a pooled survival rate of 53.6% and identified age and the proportion of male patients as significant factors affecting survival. The average duration of ECMO cannulation was 8.4 days, ICU stay was 40.4 days, and hospital length of stay was 45.4 days.
Article
Gastroenterology & Hepatology
Gianluca Rompianesi, Reena Ravikumar, Sophie Jose, Michael Allison, Anuja Athale, Felicity Creamer, Bridget Gunson, Derek Manas, Andrea Monaco, Darius Mirza, Nicola Owen, Keith Roberts, Gourab Sen, Parthi Srinivasan, Stephen Wigmore, Giuseppe Fusai, Bimbi Fernando, Andrew Burroughs, Emmanuel Tsochatzis
LIVER INTERNATIONAL
(2019)
Editorial Material
Gastroenterology & Hepatology
Sanket Srinivasa, Stephen J. Wigmore
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Surgery
Kenneth A. McLean, Thomas M. Drake, Alessandro Sgro, Julian Camilleri-Brennan, Stephen R. Knight, Riinu Ots, Anya Adair, Stephen J. Wigmore, Ewen M. Harrison
TRANSPLANT INTERNATIONAL
(2019)
Review
Surgery
Michael J. Hughes, Rosie J. Hackney, Peter J. Lamb, Stephen J. Wigmore, D. A. Christopher Deans, Richard J. E. Skipworth
WORLD JOURNAL OF SURGERY
(2019)
Article
Gastroenterology & Hepatology
Debashis Haldar, Barbara Kern, James Hodson, Matthew James Armstrong, Rene Adam, Gabriela Berlakovich, Josef Fritz, Benedikt Feurstein, Wolfgang Popp, Vincent Karam, Paolo Muiesan, John O'Grady, Neville Jamieson, Stephen J. Wigmore, Jacques Pirenne, Seyed Ali Malek-Hosseini, Ernest Hidalgo, Yaman Tokat, Andreas Paul, Johann Pratschke, Michael Bartels, Pavel Trunecka, Utz Settmacher, Massimo Pinzani, Christophe Duvoux, Philip Noel Newsome, Stefan Schneeberger
JOURNAL OF HEPATOLOGY
(2019)
Article
Multidisciplinary Sciences
Cameron J. Fairfield, Stephen J. Wigmore, Ewen M. Harrison
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Janice Miller, Ahmed Alshehri, Michael Ramage, Nathan A. Stephens, Alexander B. Mullen, Marie Boyd, James A. Ross, Stephen J. Wigmore, David G. Watson, Richard J. E. Skipworth
Article
Medicine, Research & Experimental
Ines Boehm, Janice Miller, Thomas M. Wishart, Stephen J. Wigmore, Richard J. E. Skipworth, Ross A. Jones, Thomas H. Gillingwater
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Gastroenterology & Hepatology
Siobhan C. McKay, Samir Pathak, Richard J. W. Wilkin, Sivesh K. Kamarajah, Stephen J. Wigmore, Jonathan Rees, Declan F. J. Dunne, Giuseppe Garcea, Jawad Ahmad, Nicola de Liguori Carino, Asma Sultana, Mike Silva, Pavlos Lykoudis, David Nasralla, James Milburn, Nehal Shah, Hemant M. Kocher, Ricky Bhogal, Ryan D. Baron, Alex Navarro, James Halle-Smith, Bilal Al-Sarireh, Gourab Sen, Nigel B. Jamieson, Christopher Briggs, David Stell, Somaiah Aroori, Matthew Bowles, Aditya Kanwar, Simon Harper, Krishna Menon, Andreas Prachalias, Parthi Srinivasan, Adam E. Frampton, Claire Jones, Ali Arshad, Iain Tait, Duncan Spalding, Alastair L. Young, Damien Durkin, Manijeh Ghods-Ghorbani, Robert P. Sutcliffe, Keith J. Roberts
Summary: The study shows that the COVID-19 pandemic has greatly affected the treatment capacity of pancreatic specialist centres in the UK. Some centres had limited diagnostic pathways and surgical capabilities during the pandemic, with changes in treatment pathways. Elderly patients and those with COPD were less likely to receive treatment during the pandemic period.
Article
Gastroenterology & Hepatology
Olivia Sgarbura, Graham Mackenzie, Marcus Holmberg, Stephen J. Wigmore, Kjetil Soreide
Summary: The utilization of social media in the field of hepatopancreatobiliary surgery has shown significant growth, with specific HPB hashtag and Twitter handle demonstrating effective engagement. Despite having a global reach, more actors are needed to fully harness its scientific dissemination role.
Review
Gastroenterology & Hepatology
Ruelan Furtado, Osamu Yoshino, Vijayaragavan Muralidharan, Marcos Perini, Stephen J. Wigmore
Summary: Hepatectomy after bile duct injury is a rare but important procedure for the management of vasculo-biliary injury. It can effectively alleviate symptoms in the majority of cases, although postoperative bile leaks and intra-abdominal infection are common.
Article
Education, Scientific Disciplines
Emma E. Howie, Harini Dharanikota, Eilidh Gunn, Olivia Ambler, Roger Dias, Stephen J. Wigmore, Richard J. E. Skipworth, Steven Yule
Summary: This article highlights the importance of considering Cognitive Load (CL) and Cognitive Load Theory (CLT) in surgical training to enhance current strategies and surgical performance. Feedback and assessment methods in surgical training are subjective and at risk of bias, but Surgical Sabermetrics aims to provide objective, real-time feedback through the analysis of surgical and audio-visual data. Real-time measurement of CL can enhance feedback and improve surgical performance. The principles of Cognitive Load and Surgical Sabermetrics can contribute to making surgical training better and providing higher quality care for patients.
JOURNAL OF SURGICAL EDUCATION
(2023)
Article
Oncology
Leo R. Brown, Michael I. Ramage, Ross D. Dolan, Judith Sayers, Nikki Bruce, Lachlan Dick, Sharukh Sami, Donald C. McMillan, Barry J. A. Laird, Stephen J. Wigmore, Richard J. E. Skipworth
Summary: This study aimed to assess CT body composition in patients who had anastomotic leak post-oesophagectomy. The results showed that skeletal muscle index decreased and subcutaneous fat area increased following neoadjuvant treatment and anastomotic leak. Although tissue radiodensity and subcutaneous fat area normalized on late follow-up scans, skeletal muscle index remained below pre-treatment levels.
Review
Medicine, General & Internal
David Martin, Piero Alberti, Stephen J. Wigmore, Nicolas Demartines, Gaetan-Romain Joliat
Summary: Pancreatic cancer is a deadly disease with unknown origins and limited treatment options. Surgical resection, the primary curative treatment, is associated with high morbidity and mortality rates and frequent recurrence. Patient-centered care and understanding patient perspectives are crucial for improving outcomes in pancreatic cancer surgery. Standardized patient-reported outcome and experience measures are needed to assess patient perspectives accurately.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
K. W. Brudvik, S. Yaqub, E. Kemsley, M. M. E. Coolsen, C. H. C. Dejong, S. J. Wigmore, K. Lassen
