Article
Surgery
Tarek Hassab, Duncan McKinney, Christopher D. D'Adamo, Shane Svoboda, Mark Katlic, Joshua H. Wolf
Summary: This study compared 30-day outcomes for restorative and non-restorative surgery in older adults with ulcerative colitis. Results showed that restorative surgery was associated with increased readmission but otherwise similar rates of post-operative complications compared to non-restorative surgery.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Pediatrics
Elizabeth O'Connor, Ian Sugarman, Yatin Patel, Bruce Jaffray
Summary: The severity of complications after RPC in children is related to the sequence of surgery (two-stage versus three-stage), rather than the underlying diagnosis. Careful consideration should be given to the risk of complications in children undergoing restorative proctocolectomy (RPC).
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Hyo Seon Ryu, Chang Sik Yu, Young Il Kim, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
Summary: Pouch adenomas occur at a fairly high rate in FAP patients after restorative proctocolectomy, and a high colorectal polyp count is associated with pouch adenoma development.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Imerio Angriman, Annaclaudia Colangelo, Claudia Mescoli, Matteo Fassan, Renata D'Inca, Edoardo Savarino, Salvatore Pucciarelli, Romeo Bardini, Cesare Ruffolo, Marco Scarpa
Summary: The study confirmed the accuracy of the Padua Prognostic Score for Colitis (PPSC) in predicting postoperative fistulas or abscesses and pouchitis. Therefore, in clinical practice, patients with a PPSC score greater than 1 should be warned of the risk of possible Crohn's disease diagnosis and pouch failure.
FRONTIERS IN SURGERY
(2022)
Article
Gastroenterology & Hepatology
Amandeep Pooni, Mantaj S. Brar, Erin Kennedy, Zane Cohen, Helen MacRae, Anthony de Buck van Overstraeten
Summary: This study aimed to define long-term IPAA survival outcomes after transabdominal IPAA revision and identify preoperative clinical factors associated with revision failure. The results showed that revisional IPAA can be undertaken with favorable long-term outcomes at high-volume centers, but consideration should be given to indication for revision when counseling patients regarding the risk of failure.
DISEASES OF THE COLON & RECTUM
(2023)
Review
Gastroenterology & Hepatology
M. Machin, H. -C. Younan, A. A. P. Slesser, Y. Mohsen
Summary: Ileoanal pouch-vaginal fistula is a common complication of restorative proctocolectomy, with both local and abdominal approaches showing high failure rates in its management. The review results can guide patient counseling and call for higher quality research in this area.
COLORECTAL DISEASE
(2021)
Review
Surgery
Sameh Hany Emile, Sualeh Muslim Khan, Steven D. Wexner
Summary: Patients with obesity undergoing ileal-pouch anal anastomosis are more likely to have laparotomy instead of laparoscopy, experience longer operation time, more blood loss, increased overall complications, leak and incisional hernia, as well as longer hospital stay. Male sex, longer operation time, and including inflammatory bowel disease patients only were found to be significantly associated with higher complications in the obesity group.
Article
Engineering, Chemical
Yifan Zhang, Jingke Jia, Xinmiao Wang, Jianshe Chen, Hilbert W. van der Glas
Summary: The study aimed to transform 2D scanning data of post-chewing particles into 3D data, and measured particle size using minimal Feret diameter. The estimated X-50 and b values from scanning closely approximated those from sieving, the 'gold standard'.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Medicine, General & Internal
Sang Wook Yi
Summary: This study analyzed the relationship between residual carbon dioxide gas and shoulder pain after laparoscopic adnexal surgery. It found that the use of a drainage tube could safely decrease residual gas volume and shoulder pain score without increasing the risk of postoperative infection.
Review
Gastroenterology & Hepatology
Edward L. Barnes, Stefan D. Holubar, Hans H. Herfarth
Summary: Patients with concomitant primary sclerosing cholangitis and ulcerative colitis undergoing colectomy may have an increased risk of pouchitis. A systematic review and meta-analysis showed that patients with PSC-UC were more likely to experience pouchitis and pouch failure compared to those with UC alone. The study suggests the need for careful consideration of surgical options and further research in this patient population.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Pediatrics
Nathan S. Rubalcava, Samir K. Gadepalli, Cory N. Criss, Natalie A. Moreno, Jeremy Adler, James D. Geiger
Summary: Surgical management for pediatric patients with UC can be done as either 1- or 2-stage operations, with similar short-term, long-term, and functional outcomes. 1-stage RP/IPAA operations without ileostomy are a safe alternative for patients considered for a 2-stage operation.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Carlos Munoz-Lopez, Kieran Lewis, Worapat Attawettayanon, Yosuke Yasuda, Joao Pedro Emrich Accioly, Nityam Rathi, Zaeem Lone, Melissa Boumitri, Rebecca A. Campbell, Andrew Wood, Jihad Kaouk, Georges-Pascal Haber, Mohamad Eltemamy, Venkatesh Krishnamurthi, Robert Abouassaly, Samuel Haywood, Christopher Weight, Steven C. Campbell
Summary: The study aimed to identify factors associated with longitudinal ipsilateral functional decline after partial nephrectomy (PN). The results showed that significant renal comorbidities, age, warm ischaemia, and ipsilateral parenchymal atrophy were the most important predictors of ipsilateral functional decline following establishment of new baseline glomerular filtration rate (NBGFR). Additionally, patients with significant renal comorbidities had significantly increased annual ipsilateral parenchymal atrophy and functional decline compared to those without significant renal comorbidities.
Article
Surgery
Eren Esen, Hasan T. Kirat, Arman Erkan, Erman Aytac, Joanna Esterow, H. Tarik Kani, Michael J. Grieco, Shannon Chang, Feza H. Remzi
Summary: New pouch creation can be safely performed during re-do ileal pouch anal anastomosis, providing acceptable functional and quality of life outcomes if salvage of the existing pouch is not feasible.
Article
Surgery
Eva-Lena Syren, Gabriel Sandblom, Lars Enochsson, Arne Eklund, Bengt Isaksson, Johanna Osterberg, Staffan Eriksson
Summary: This study analyzed the association between endoscopist and center case-volumes and the success and complications of endoscopic retrograde cholangiopancreatography (ERCP). The results suggest that higher case-volumes are associated with higher success rates, lower complication rates, and shorter procedure times.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Surgery
Anne Hendricks, Johannes Diers, Philip Baum, Stephanie Weibel, Carolin Kastner, Sophie Mueller, Johan Friso Lock, Franziska Koehler, Patrik Meybohm, Peter Kranke, Christoph-Thomas Germer, Armin Wiegering
Summary: A systematic review and meta-analysis of over 2 million patients in Germany shows a clear relationship between treatment volume and patient outcomes in abdominal surgical interventions, particularly for complex procedures. High volume hospitals demonstrate significantly lower mortality rates and failure to rescue for patients, highlighting the importance of volume in surgical outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Surgery
George B. Hanna, Hugh Mackenzie, Danilo Miskovic, Melody Ni, Susannah Wyles, Paul Aylin, Amjad Parvaiz, Tom Cecil, Andrew Gudgeon, John Griffith, Jonathan M. Robinson, Chelliah Selvasekar, Tim Rockall, Austin Acheson, Charles Maxwell-Armstrong, John T. Jenkins, Alan Horgan, Chris Cunningham, Ian Lindsey, Tan Arulampalam, Roger W. Motson, Nader K. Francis, Robin H. Kennedy, Mark G. Coleman
Summary: This study examines the impact of The National Training Program for Lapco on the rate of laparoscopic surgery and clinical outcomes. The results show that Lapco increased the rate of laparoscopic surgery and reduced mortality and morbidity.
Article
Health Care Sciences & Services
Alex Bottle, Puji Faitna, Paul P. Aylin
Summary: During England's first wave of COVID-19, there was modest variation in mortality rates between hospitals after risk adjustment and accounting for random variation, in contrast to early media reports. Early-period mortality did not predict late-period mortality.
BMJ QUALITY & SAFETY
(2022)
Article
Gastroenterology & Hepatology
Mohammed Deputy, Kapil Sahnan, Guy Worley, Komal Patel, Violeta Balinskaite, Alex Bottle, Paul Aylin, Elaine M. Burns, Ailsa Hart, Omar Faiz
Summary: The Covid-19 pandemic has had a detrimental effect on inflammatory bowel disease (IBD) services, leading to delays in emergency care and access to investigations and surgeries. A study in England found significant decreases in hospital attendances for acute ulcerative colitis (UC) and acute Crohn's disease (CD), as well as a decrease in the volume of IBD procedures and investigations. The study also highlighted the importance of prioritizing care for patients with IBD to prevent clinical harm and a decrease in quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Nina J. Zhu, Timothy M. Rawson, Siddharth Mookerjee, James R. Price, Frances Davies, Jonathan Otter, Paul Aylin, Russell Hope, Mark Gilchrist, Yeeshika Shersing, Alison Holmes
Summary: The COVID-19 pandemic has affected the patterns of community- and hospital-acquired bloodstream infections in COVID-19 and non-COVID-19 patients. There was a high incidence of hospital-acquired bacteremia during the COVID-19 waves, especially in SARS-CoV-2-negative elective patients.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Max Warner, Samantha Burn, George Stoye, Paul P. Aylin, Alex Bottle, Carol Propper
Summary: Hospital admissions in England saw significant reductions for non-COVID-19 patients between March and December 2020, with larger decreases in areas with higher ethnic minority populations and smaller decreases in more deprived areas. These disparities in care patterns during the COVID-19 pandemic may exacerbate existing health inequalities.
BMJ QUALITY & SAFETY
(2022)
Article
Geriatrics & Gerontology
Mable Nakubulwa, Cornelia Junghans, Vesselin Novov, Clare Lyons-Amos, Derryn Lovett, Azeem Majeed, Paul Aylin, Thomas Woodcock
Summary: This study describes risk factors for long-term adult social care (ASC) in two inner London boroughs and develops a risk prediction model. The findings indicate that age, socioeconomic deprivation, preexisting mental health conditions, and prior health service use are associated with accessing long-term ASC. However, the predictive power of a prognostic model based on risk factors is limited, suggesting the need for a paradigm shift towards more relational, personalized approaches.
Article
Emergency Medicine
Thomas Beaney, Jonathan Clarke, Ahmed Alboksmaty, Kelsey Flott, Aidan Fowler, Jonathan Benger, Paul P. Aylin, Sarah Elkin, Ana Luisa Neves, Ara Darzi
Summary: This study assessed the population-level impact of a national pulse oximetry remote monitoring program for COVID-19 in England. The results showed that the implementation of the program was not associated with mortality, but was associated with increased health service utilization.
EMERGENCY MEDICINE JOURNAL
(2022)
Article
Multidisciplinary Sciences
T. Beaney, A. L. Neves, A. Alboksmaty, H. Ashrafian, K. Flott, A. Fowler, J. R. Benger, P. Aylin, S. Elkin, A. Darzi, J. Clarke
Summary: In this study, the risk of hospitalization and death for all adults in England who tested positive for COVID-19 from October 2020 to April 2021 was investigated. The researchers found that the risk varied substantially over time after accounting for individual risk factors.
NATURE COMMUNICATIONS
(2022)
Article
Respiratory System
Thomas Woodcock, Geva Greenfield, Ajit Lalvani, Azeem Majeed, Paul Aylin
Summary: This study compares posthospitalisation outcomes and health system resource use between patients hospitalised with COVID-19 and influenza. The findings show that COVID-19 patients are more likely to die, have longer hospital stays, and interact more with primary care after discharge compared to influenza patients.
Review
Gastroenterology & Hepatology
Nishani Jayasooriya, Samantha Baillie, Jonathan Blackwell, Alex Bottle, Irene Petersen, Hanna Creese, Sonia Saxena, Richard C. C. Pollok, POP IBD study grp
Summary: This systematic review found that diagnostic delay is associated with negative clinical outcomes in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). The median time to diagnosis was 8.0 months for CD and 3.7 months for UC, with longer diagnostic intervals observed in low-middle-income countries. Furthermore, delayed diagnosis was associated with increased risks of stricturing, penetrating disease, and intestinal surgery in CD, and increased risk of colectomy in UC.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Health Care Sciences & Services
Alex Bottle, Alex Liddle
BMJ QUALITY & SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Alex Bottle, Roger Newson, Puji Faitna, Benedict Hayhoe, Martin R. Cowie
Summary: This study aimed to explore risk prediction models for heart failure based on general practitioners' electronic health records and compare the data from two different cohorts. The results showed that the survival rates were similar in different years, but the later population was older, frailer, and had more comorbidities. The study also found consistent predictors including age, sex, blood pressure, body mass index, GP visits before diagnosis, and some comorbidities.
Article
Primary Health Care
Nishani Jayasooriya, Richard C. Pollok, Jonathan Blackwell, Alex Bottle, Irene Petersen, Hanna Creese, Sonia Saxena
Summary: Rates of discontinuation and adherence to oral 5-ASA in adolescents and young adults with ulcerative colitis were determined in a cohort study. The study found that a significant proportion discontinued within the first year and adherence was lower among young adults compared to adolescents. Risk factors for discontinuation included older age and living in deprived areas, while early corticosteroid use lowered the likelihood of discontinuation.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Emergency Medicine
Thomas Beaney, Jonathan Clarke, Ahmed Alboksmaty, Kelsey Flott, Aidan Fowler, Jonathan Benger, Paul P. Aylin, Sarah Elkin, Ara Darzi, Ana Luisa Neves
Summary: The impact of a national pulse oximetry remote monitoring program on the use of health services and mortality in COVID-19 patients attending Emergency Departments was investigated. The results showed that enrolled patients had a 52% lower death rate, but a 37% and 59% higher probability of ED attendance and hospital admission, respectively. This study suggests that pulse oximetry remote monitoring may be an effective and safe model for early detection and escalation of hypoxia.
EMERGENCY MEDICINE JOURNAL
(2023)