Article
Transplantation
Amelie K. Muller, Eva Breuer, Kerstin Hubel, Kuno Lehmann, Pietro Cippa, Thomas Schachtner, Christian Oberkofler, Thomas Muller, Markus Weber, Philipp Dutkowski, Pierre-Alain Clavien, Olivier de Rougemont
Summary: This study is the first to demonstrate similar graft survival and function in DCD kidneys compared with DBD kidneys after 35 years of follow-up. DCD grafts are a valuable resource and can be utilized in the same way as DBD grafts.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Andrology
Lu Xu, Wei Yin, Guanghui Li, Jiali Fang, Lei Zhang, Luhao Liu, Yunyi Xiong, Jialin Wu, Guanghui Pan, Junjie Ma, Zheng Chen
Summary: Analysis of 159 DCD donors revealed that the DIC (+) group had a significantly higher kidney rejection rate than the DIC (-) group, with a notable difference in glomerular microthrombus formation rate. Donor-induced DIC may easily lead to renal glomerular microthrombus formation, resulting in an increased kidney rejection rate.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Medicine, General & Internal
Michael Duerr, Lutz Liefeldt, Frank Friedersdorff, Mira Choi, Robert Oellinger, Jorg Hofmann, Klemens Budde, Eva Schrezenmeier, Fabian Halleck
Summary: The study successfully utilized HCV+ donors for transplantation and prevented HCV infection by using PrEP DAA. Transplant recipients showed good graft function and tolerability, with reduced waiting time when accepting HCV+ donors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Michael Olausson, Deepti Antony, Martin Johansson, Galina Travnikova, Nikhil B. Nayakawde, Debashish Banerjee, John Mackay Softeland, Damiano Ognissanti, Moa Andresen Bergstrom, Ola Hammarsten, Goditha U. Premaratne
Summary: In this study, a novel thrombolytic technique was used to salvage kidneys from porcine donors with uncontrolled circulatory deaths. The kidneys were then reconditioned ex vivo and transplanted. The results showed that after 3 months, the transplanted kidneys had similar function and histology compared to kidneys from living donors.
Article
Medicine, General & Internal
S. Ali Husain, Kristen L. King, Navin Sanichar, R. John Crew, Jesse D. Schold, Sumit Mohan
Summary: The study found that living donor kidney transplants from donors biologically related to their recipients had higher rates of allograft failure than transplants from donors unrelated to their recipients after HLA matching was accounted for. This association was mainly observed in recipients without cystic kidney disease and transplants from African American donors. Further research is needed to explore the factors contributing to this finding.
Article
Transplantation
Jacopo Burrello, Silvia Monticone, Alessio Burrello, Sara Bolis, Carlotta Pia Cristalli, Giorgia Comai, Valeria Corradetti, Cristina Grange, Giuseppe Orlando, Massimiliano Bonafe, Gaetano La Manna, Lucio Barile, Benedetta Bussolati
Summary: This study explored the use of extracellular vesicle (EV) surface antigens as potential predictors of kidney transplant outcome. It found that endothelial cells and platelet markers in serum EVs were higher in patients with persistent kidney dysfunction, while mesenchymal progenitor cell markers in urine EVs increased in patients with renal recovery. These markers correlated with kidney function indicators and were able to predict patient outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Florian G. Scurt, Angela Ernst, Ben Hammoud, Tamara Wassermann, Peter R. Mertens, Anke Schwarz, Jan U. Becker, Christos Chatzikyrkou
Summary: This study analyzed the association between donor eGFR values and transplantation outcomes in marginal kidney transplantation. The results showed that the initial, lowest, and terminal eGFR values of the donor can accurately predict delayed graft function. The highest eGFR value is the best predictor of 3-month graft function. For primary non-function, initial and highest eGFR values are the best predictors. There were no differences in the risk associations of each eGFR recording with patient and graft survival.
Article
Urology & Nephrology
Florian G. Scurt, Carl-Ludwig Fischer-Froehlich, Tamara Wassermann, Angela Ernst, Anke Schwarz, Jan U. Becker, Christos Chatzikyrkou
Summary: Despite organ shortages, the discard rate of deceased donor kidneys remains high. This study investigates the reasons for kidney discard and finds that some discarded kidneys were actually of acceptable quality. Procurement biopsies more often lead to discard than to transplantation.
JOURNAL OF NEPHROLOGY
(2023)
Article
Surgery
Nuria Montero, Nestor Toapanta, Natalia Pallares, Marta Crespo, Fritz Diekmann, Lluis Guirado, Rafael Esteban, Sergi Codina, Edoardo Melilli, Anna Buxeda, Gonzalo Velis, Irina B. Torres, Ignacio Revuelta, Alicia Molina Andujar, Carme Facundo, Beatriz Bardaji, Lluis Riera, Maria Fiol, Josep M. Cruzado, Jordi Comas, Magali Giral, Maarten Naesens, Anders Asberg, Francesc Moreso, Oriol Bestard
Summary: This study analyzed 1161 consecutive kidney transplantations and found that using highly expanded criteria donors (ECD) and recipients for controlled circulatory death kidney transplantation (cDCD-KT) resulted in the lowest graft survival rates. Recipient age, gender, dialysis vintage, previous cardiovascular events, and receiving cDCD were predictors of patient death.
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Sile Yu, Jane J. Long, Yifan Yu, Mary G. Bowring, Jennifer D. Motter, Tanveen Ishaque, Niraj Desai, Dorry L. Segev, Jacqueline M. Garonzik-Wang, Allan B. Massie
Summary: The study demonstrates that accepting kidneys from donors aged 50 or older after cardiac death can significantly decrease the mortality risk for recipients, with comparable survival benefits to other donor types. After declining DCD50 kidneys, some candidates still received kidney transplants from other sources at a lower survival rate.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Laurens J. Ceulemans, Cedric Vanluyten, Diethard Monbaliu, Paul Schotsmans, Steffen Fieuws, Christelle M. Vandervelde, Paul De Leyn, Herbert Decaluwe, Hans Van Veer, Lieven Depypere, Jan Van Slambrouck, Jan Gunst, Bart M. Vanaudenaerde, Laurent Godinas, Lieven Dupont, Robin Vos, Geert M. Verleden, Arne P. Neyrinck, Dirk Van Raemdonck
Summary: This study retrospectively analyzed lung transplantation surgeries performed between 2007 and 2020, including organ donations following euthanasia. The results showed that using organs from euthanasia donors for lung transplantation is feasible and safe, with no significant differences in short-term and long-term outcomes compared to other types of organ donation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Immunology
Lukas Frischknecht, Yun Deng, Caroline Wehmeier, Olivier de Rougemont, Jean Villard, Sylvie Ferrari-Lacraz, Dela Golshayan, Monique Gannage, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson
Summary: This study investigates the impact of pre-transplant donor specific antibodies (DSA) on kidney transplantation outcomes. The results show that DSA is associated with increased risk of antibody-mediated rejection, graft loss, and accelerated decline in eGFR. The target HLA antigen and mean fluorescence intensity (MFI) of DSA play significant roles in the outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Eirini Lioudaki, Ariadni Androvitsanea, Ioannis Petrakis, Constantinos Bakogiannis, Emmanuel Androulakis
Summary: Given the high cardiovascular risk in patients with end-stage kidney disease, it is crucial for clinical nephrologists to identify high-risk patients through screening methods and determine the effectiveness of screening asymptomatic transplant candidates in reducing cardiovascular risk. This review emphasizes the need for well-designed studies to provide robust evidence regarding screening criteria and prognostic cardiovascular effects for renal transplant candidates.
Article
Immunology
Fuxun Zhang, Jiayu Liang, Yang Xiong, Fan Zhang, Kan Wu, Wei Wang, Jiuhong Yuan, Tao Lin, Xianding Wang
Summary: Serum uric acid and three other indicators were identified as independent risk factors for treated rejection (TR) after deceased donor kidney transplantation. Patients with higher levels of uric acid were found to have an increased risk of TR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Dong Yu, Eva Malacova, Cameron Hurst, Monica Suet Ying Ng, Andrew John Mallett
Summary: This study evaluates the clinical outcomes of kidney transplant recipients and finds that monogenic primary kidney disease is associated with lower rates of recurrence and graft failure. Donor relatedness has no effect on transplant outcomes.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Linda Sharples, Priya Sastry, Carol Freeman, Colin Bicknell, Yi-Da Chiu, Srinivasa Rao Vallabhaneni, Andrew Cook, Joanne Gray, Andrew McCarthy, Peter McMeekin, Luke Vale, Stephen Large
Summary: The study aimed to observe, describe, and evaluate management and timing of intervention for patients with untreated thoracic aortic aneurysms. It found that the risk of death increased with aneurysm size at baseline and with growth, while hospital admissions also increased with aneurysm size.
EUROPEAN HEART JOURNAL
(2022)
Review
Health Care Sciences & Services
Linda Sharples, Priya Sastry, Carol Freeman, Joanne Gray, Andrew McCarthy, Yi-Da Chiu, Colin Bicknell, Peter McMeekin, S. Rao Vallabhaneni, Andrew Cook, Luke Vale, Stephen Large
Summary: The study investigates the timing and intervention choice for chronic thoracic aortic aneurysms. It found that small aneurysms require close observation, while larger aneurysms require timely intervention. Endovascular stent grafting and open surgical replacement are successful treatments for carefully selected patients. The study also found that factors such as female gender, older age, and increasing diameter have a negative impact on patient survival and quality of life.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Biology
John N. S. Matthews, Sofia Bazakou, Robin Henderson, Linda D. Sharples
Summary: This paper focuses on complete case analysis of complete crossover designs, which can be used to estimate the difference between principal stratum strategy and hypothetical strategy estimands. The results show that the difference between these estimands exceeds 5% only when the trial is severely affected by dropouts or if the within-subject correlation is low.
Article
Immunology
Patrick B. Trotter, John Dark, Andrew J. Fisher, Matthew Robb, Christopher Watson, James Neuberger
Summary: The transplant outcomes for recipients of organs from donors who died from ligature asphyxiation are similar to those from donors who died from other causes. However, the impact on recipients of other solid organ transplants remains uncertain.
Article
Immunology
Gabriel C. Oniscu, Jennifer Mehew, Andrew J. Butler, Andrew Sutherland, Rohit Gaurav, Rachel Hogg, Ian Currie, Mark Jones, Christopher J. E. Watson
Summary: The use of normothermic regional perfusion (NRP) during controlled donation after circulatory death (cDCD) is associated with increased organ recovery and improved transplant outcomes.
Article
Surgery
Claire Albert, Matthew Harris, Jenna DiRito, Audrey Shi, Christopher Edwards, Lauren Harkins, Taras Lysyy, Sanjay Kulkarni, David C. Mulligan, Sarah A. Hosgood, Christopher J. E. Watson, Peter J. Friend, Michael L. Nicholson, Danielle Haakinson, Kourosh Saeb-Parsy, Gregory T. Tietjen
Summary: Transplantation is a life-saving treatment, but the shortage of donor organs and concerns about post-transplant outcomes result in many patients dying while waiting for organs or organs being declined for transplant. This article discusses the need for a new mindset in how we honor organ donation and suggests using transplant-declined organs for translational research to accelerate breakthrough discoveries. The article also addresses the practical challenges of such research and offers potential solutions based on the authors' experiences in their own laboratories.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Ramzi A. Ajjan, Simon R. Heller, Colin C. Everett, Armando Vargas-Palacios, Ruchi Higham, Linda Sharples, Diana A. Gorog, Alice Rogers, Catherine Reynolds, Catherine Fernandez, Pedro Rodrigues, Thozhukat Sathyapalan, Robert F. Storey, Deborah D. Stocken
Summary: This study analyzed the impact of modern glucose-monitoring strategies on glycemic and patient-related outcomes in individuals with type 2 diabetes (T2D) and recent myocardial infarction (MI). The results showed that compared with self-monitoring of blood glucose (SMBG), intermittently scanned continuous glucose monitoring (isCGM) marginally increased time in range and significantly reduced hypoglycemic exposure in T2D individuals with MI, while equally improving HbA(1c). These findings explain the cost effectiveness of isCGM.
Article
Multidisciplinary Sciences
Teresa Brevini, Mailis Maes, Gwilym J. Webb, Binu John, Claudia D. Fuchs, Gustav Buescher, Lu Wang, Chelsea Griffiths, Marnie L. Brown, William E. Scott, Pehuen Pereyra-Gerber, William T. H. Gelson, Stephanie Brown, Scott Dillon, Daniele Muraro, Jo Sharp, Megan Neary, Helen Box, Lee Tatham, James Stewart, Paul Curley, Henry Pertinez, Sally Forrest, Petra Mlcochova, Sagar S. Varankar, Mahnaz Darvish-Damavandi, Victoria L. Mulcahy, Rhoda E. Kuc, Thomas L. Williams, James A. Heslop, Davide Rossetti, Olivia C. Tysoe, Vasileios Galanakis, Marta Vila-Gonzalez, Thomas W. M. Crozier, Johannes Bargehr, Sanjay Sinha, Sara S. Upponi, Corrina Fear, Lisa Swift, Kourosh Saeb-Parsy, Susan E. Davies, Axel Wester, Hannes Hagstrom, Espen Melum, Darran Clements, Peter Humphreys, Jo Herriott, Edyta Kijak, Helen Cox, Chloe Bramwell, Anthony Valentijn, Christopher J. R. Illingworth, Bassam Dahman, Dustin R. Bastaich, Raphaella D. Ferreira, Thomas Marjot, Eleanor Barnes, Andrew M. Moon, Alfred S. Barritt, Ravindra K. Gupta, Stephen Baker, Anthony P. Davenport, Gareth Corbett, Vassilis G. Gorgoulis, Simon J. A. Buczacki, Joo-Hyeon Lee, Nicholas J. Matheson, Michael Trauner, Andrew J. Fisher, Paul Gibbs, Andrew J. Butler, Christopher J. E. Watson, George F. Mells, Gordon Dougan, Andrew Owen, Ansgar W. Lohse, Ludovic Vallier, Fotios Sampaziotis
Summary: Modulating the expression of angiotensin-converting enzyme 2 (ACE2) through farnesoid X receptor (FXR) can reduce susceptibility to SARS-CoV-2 infection, as shown in various tissues and organoids in vitro, in vivo, and ex vivo. The use of z-guggulsterone and ursodeoxycholic acid (UDCA) can downregulate ACE2 and decrease viral infection, including in the nasal epithelium. Clinical data also indicate positive outcomes with UDCA treatment in SARS-CoV-2 infection. These findings suggest that targeting the FXR-ACE2 pathway could be a potential strategy for preventing COVID-19.
Article
Immunology
Christopher J. E. Watson, Stephen MacDonald, Christopher Bridgeman, Rebecca Brais, Sara S. Upponi, Theodora Foukaneli, Lisa Swift, Corrina Fear, Linda Selves, Vasilis Kosmoliaptsis, Michael Allison, Rachel Hogg, Kourosh Saeb Parsy, Will Thomas, Rohit Gaurav, Andrew J. Butler
Summary: This study aimed to determine the underlying cause of biliary complications leading to liver retransplantation and evaluate the role of fibrinolysis. The results showed the presence of fibrin during cold storage and its association with poor posttransplant outcomes. Fibrinolytic therapy may be a promising intervention.
Article
Cardiac & Cardiovascular Systems
Simon Messer, Sally Rushton, Lewis Simmonds, Debbie Macklam, Mubbasher Husain, Anand Jothidasan, Stephen Large, Steven Tsui, Pradeep Kaul, Jennifer Baxter, Mohamed Osman, Vipin Mehta, Derval Russell, Uli Stock, John Dunning, Diana Garcia Saez, Rajamiyer Venkateswaran, Philip Curry, Lynne Ayton, Majid Mukadam, Jorge Mascaro, Jacob Simmonds, Guy Macgowan, Stephen Clark, Jerome Jungschleger, Zdenka Reinhardt, Richard Quigley, Jane Speed, Jayan Parameshwar, David Jenkins, Sarah Watson, Fiona Marley, Ayesha Ali, Dale Gardiner, Antonio Rubino, Julie Whitney, Sarah Beale, Catherine Slater, Ian Currie, Liz Armstrong, Jeanette Foley, Marian Ryan, Sharon Gibson, Karen Quinn, Anna-Maria Macleod, Susan Spence, Christopher J. E. Watson, Pedro Catarino, Anthony Clarkson, John Forsythe, Derek Manas, Marius Berman
Summary: The UK conducted a national pilot program for heart transplantation using DCD hearts, retrieved using the direct procurement and perfusion technique. The outcomes showed comparable posttransplant survival rates between DCD and DBD hearts.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Chris P. Gale, Deborah Stocken, Suleman Aktaa, Catherine Reynolds, Rachael Gilberts, David Brieger, Kathryn Carruthers, Derek P. Chew, Shaun G. Goodman, Catherine Fernandez, Linda Sharples, Andrew Yan, Keith Fox
Summary: This study aimed to determine the effectiveness of risk stratification using the Global Registry of Acute Coronary Events (GRACE) risk score (GRS) for patients with suspected non-ST elevation acute coronary syndrome. The results showed that the use of GRS did not improve adherence to guideline recommended management or reduce cardiovascular events at 12 months.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Surgery
George H. B. Greenhall, Brian A. Rous, Matthew L. Robb, Chloe Brown, Gillian Hardman, Rachel M. Hilton, James M. Neuberger, John H. Dark, Rachel J. Johnson, John L. R. Forsythe, Laurie A. Tomlinson, Chris J. Callaghan, Christopher J. E. Watson
Summary: This cohort study suggests that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought, and long-term transplant outcomes are favorable, providing a possibility for safely expanding organ usage.
Review
Immunology
Stephen O'Neill, Ellie Asgari, Chris Callaghan, Dale Gardiner, Hermien Hartog, Satheesh Iype, Alex Manara, David Nasralla, Gabi C. Oniscu, Chris Watson
Summary: Recipient outcomes after transplantation with organs from donation after circulatory death (DCD) donors can be as good as or even comparable to those after transplantation with organs from donation after brain death donors. The key to success lies in establishing common practices and accepted protocols to safely utilize DCD organs and maximize the use of the DCD donor pool.
TRANSPLANTATION REVIEWS
(2023)
Article
Surgery
James A. Richards, Rohit Gaurav, Sara S. Upponi, Lisa Swift, Corrina Fear, Gwilym J. Webb, Michael E. D. Allison, Christopher J. E. Watson, Andrew J. Butler
Summary: The liver is crucial for life, and without a transplant from a donor, patients with liver failure will die. Unfortunately, limited availability of liver organs results in some patients dying while waiting. This article presents a novel technique that enables resuscitation and testing of potential donor livers, increasing the chances for safe transplantation.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Surgery
George H. B. Greenhall, Maria Ibrahim, Utkarsh Dutta, Carolyn Doree, Susan J. Brunskill, Rachel J. Johnson, Laurie A. Tomlinson, Chris J. Callaghan, Christopher J. E. Watson
Summary: Donor-transmitted cancer has significant implications for organ recipients, particularly in orthotopic transplants. While re-transplantation offers the best chance of cure, there is still a risk of tumor recurrence. Our findings suggest the need for improvements in clinical practice to address this issue.
TRANSPLANT INTERNATIONAL
(2022)
