Article
Oncology
Christopher Nutting, Laura Finneran, Justin Roe, Mark A. Sydenham, Matthew Beasley, Shree Bhide, Cheng Boon, Audrey Cook, Emma De Winton, Marie Emson, Bernadette Foran, Robert Frogley, Imran Petkar, Laura Pettit, Keith Rooney, Tom Roques, Devraj Srinivasan, Justine Tyler, DARS Trialist Grp
Summary: The study found that dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) improved swallowing function and reduced radiation dose-related damage in patients with oropharyngeal and hypopharyngeal cancers. Therefore, DO-IMRT should be considered as a new standard treatment for patients receiving radiotherapy for pharyngeal cancers.
Article
Multidisciplinary Sciences
Xiangjun Chen, Reza A. Badian, Havard Hynne, Cecilie Delphin Amdal, Bente Brokstad Herlofson, Oygunn Aass Utheim, Kristine Loken Westgaard, Fredrik Fineide, Janicke Liaaen Jensen, Tor Paaske Utheim
Summary: Patients undergoing IMRT for head and neck cancer may have an increased risk of dry eye disease, with more lid margin abnormalities and worse meibum quality. While their lacrimal gland function seems comparable to controls, patients show significant MG functional and morphological changes, potentially leading to a higher risk of developing dry eye disease.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Guillaume Rougier, Adrien Rochand, Remi Bourdais, Nicolas Meillan, Frederic Tankere, Philippe Herman, Francois Riet, Jean-Jacques Mazeron, Nelly Burnichon, Charlotte Lussey, Julian Jacob, Jean-Marc Simon, Philippe Maingon, Loic Feuvret
Summary: This study aimed to evaluate the safety and efficacy of intensity-modulated radiation therapy in the treatment of Head & Neck paragangliomas. The results showed that IMRT, whether used as an exclusive treatment or post-operative treatment, successfully controlled the paragangliomas with low toxicity.
Article
Oncology
Lucian Zhao, Dominic H. Moon, Vladimir Avkshtol, Caitlin H. Siropaides, Stephanie Terauchi, Andrew T. Day, Baran D. Sumer, Randall Hughes, David J. Sher
Summary: For head and neck squamous cell cancer survivors, risk factors associated with increased chronic opioid use include smoking history, unemployment, prior psychiatric illness, and opiate use before radiotherapy. Early interventions should be targeted at high-risk populations.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Michelle Oud, Sebastiaan Breedveld, Marta Gizynska, Michiel Kroesen, Stefan Hutschemaekers, Steven Habraken, Steven Petit, Zoltan Perko, Ben Heijmen, Mischa Hoogeman
Summary: This study proposes and evaluates a new approach in intensity modulated proton therapy, which involves the daily selection of plans from patient-specific pre-treatment established plan libraries for treatment. Compared to daily online re-planning, this approach is simpler and reduces the risk of xerostomia and dysphagia, while improving adherence to target coverage constraints.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Zachary S. Mayo, Evelyn O. Ilori, Brian Matia, Timothy D. Smile, Christopher W. Fleming, Chandana A. Reddy, Joseph Scharpf, Eric D. Lamarre, Brandon L. Prendes, Jamie Ku, Brian B. Burkey, Nikhil P. Joshi, Neil M. Woody, Shlomo A. Koyfman, Shauna R. Campbell
Summary: H-IMRT for the definitive or postoperative treatment of HNC using . 50 Gy in 20 fractions appears safe and well tolerated with modest toxicity. Locoregional control rate at two years was 87% and median overall survival was 46 months. No grade 4 or 5 toxicities were observed, and only a small percentage of patients experienced moderate toxicities. No patients required feeding tube or tracheostomy placement.
ANTICANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Austin J. Iovoli, Lauren Turecki, Michelle L. Qiu, Michael Khan, Kelsey Smith, Han Yu, Sung Jun Ma, Mark K. Farrugia, Anurag K. Singh
Summary: Oral mucositis is a common adverse effect in head and neck cancer patients receiving radiation therapy. This study aimed to investigate the associations between the severity of oral mucositis and clinical outcomes and quality of life. The results showed that severe oral mucositis was associated with feeding tube placement, hospitalization, opiate use, and weight loss.
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Otorhinolaryngology
Simran Polce, Emile Gogineni, Jeffrey Antone, Maged Ghaly, Douglas Keith Frank, Joshua D. Segal, Bhupesh Parashar
Summary: This study aimed to create dental radiation maps to calculate mean doses to individual teeth, maxilla, and mandible using IMRT. Dosimetric maps of estimated doses to each tooth and each third of the mandible and maxilla were generated for common examples of head and neck cancer. Adoption of these dental maps may improve clinical workflow efficiency.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Yihang Xu, Jonathan Cyriac, Mariluz De Ornelas, Elizabeth Bossart, Kyle Padgett, Michael Butkus, Tejan Diwanji, Stuart Samuels, Michael A. Samuels, Nesrin Dogan
Summary: The study evaluated the performance of a proton-specific knowledge-based planning model in creating optimized IMPT plans for advanced head and neck cancer patients. Results showed that plans generated using the model had better target coverage and organ sparing compared to expert plans, demonstrating greater robustness and improved outcomes for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Paul B. Romesser, Eric J. Sherman, Karissa Whiting, Margaret L. Ho, Ashok R. Shaha, Mona M. Sabra, Nadeem Riaz, Todd E. Waldenberg, Christopher R. Sabol, Ian Ganly, Sean M. McBride, James A. Fagin, Zhigang Zhang, R. Michael Tuttle, Richard J. Wong, Nancy Y. Lee
Summary: The study found that concurrent chemotherapy with intensity-modulated radiation therapy can significantly reduce locoregional failure rates, with acceptable toxicity and positive patient-reported outcomes.
Article
Otorhinolaryngology
Joshua C. Farris, Cole R. Steber, Paul J. Black, Michael D. Chan, James D. Ververs, Christina K. Cramer, James D. Browne, Joshua D. Waltonen, Christopher A. Sullivan, Hafiz S. Patwa, Adrian W. Laxton, Stephen B. Tatter, Bart A. Frizzell, Mercedes Porosnicu, Thomas W. Lycan, Kathryn M. Greven, Ryan T. Hughes
Summary: This study reviewed the use of IMRT/GKRS as a combined modality approach for treating HNC patients, and the results showed excellent disease control and minimal toxicity with IMRT plus GKRS boost.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Elissa Greco, Jolie Ringash, George Tomlinson, Shao Hui Huang, Brian O'Sullivan, John Waldron, Rosemary Martino
Summary: In patients with advanced head and neck cancer receiving intensity-modulated radiation therapy, there were no differences in prophylactic G-tube use during the first 5 years post-IMRT. Overall, the median number of days with a G-tube post-IMRT was 63 days, with patients with hypopharyngeal tumors requiring the longest duration.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Biochemistry & Molecular Biology
Juliana Runnels, Julie R. Bloom, Kristin Hsieh, Daniel R. Dickstein, Yuhao Shi, Brianna M. Jones, Eric J. Lehrer, Richard L. Bakst
Summary: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and deadly disease worldwide. Immunotherapy has shown promise as a treatment option for HNSCC, and combining it with radiation therapy (RT) may enhance effectiveness. This review highlights the advantages of combining RT and immunotherapy, such as improved tumor response rates, increased survival, and reduced toxicity, while also discussing the challenges in redefining the standard of care and the need for further research.
