Review
Psychology, Clinical
A. J. Spong, I. C. H. Clare, J. Galante, M. J. Crawford, P. B. Jones
Summary: Short-term psychological interventions for adults with Borderline Personality Disorder (BPD) may be effective, with additional support impacting outcomes, but the sustainability of symptomatic change remains unclear.
CLINICAL PSYCHOLOGY REVIEW
(2021)
Review
Clinical Neurology
Jun Chu, Kaili Zheng, Jinyao Yi
Summary: Aggressive behaviors are prevalent in patients with Borderline Personality Disorder, with neuroimaging studies linking this aggression to alterations in various brain regions, especially in frontal-limbic areas. Studies have highlighted abnormalities in prefrontal cortices and limbic structures, with less focus on parietal and temporal regions. Connectivity studies have shown the importance of frontal-limbic interactions in regulating aggression, while conflicting findings may be due to disparities in controlling variables like gender, anatomical subdivisions, and comorbidities.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Psychiatry
Jutta M. Stoffers-Winterling, Ole Jakob Storebo, Mickey T. Kongerslev, Erlend Faltinsen, Adan Todorovac, Mie Sedoc Jorgensen, Christian P. Sales, Henriette Edemann Callesen, Johanne Pereira Ribeiro, Birgit A. Voellm, Klaus Lieb, Erik Simonsen
Summary: A recent study confirms the efficacy of psychotherapy for borderline personality disorder (BPD). The study evaluated both standalone and add-on psychotherapeutic treatments and found that dialectical behaviour therapy and mentalisation-based treatment had significant effects in standalone treatments, while DBT skills training and other interventions showed beneficial effects in add-on interventions.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Clinical Neurology
Bianca E. Kavanagh, Melanie M. Ashton, Stephanie P. Cowdery, Olivia M. Dean, Alyna Turner, Michael Berk, Stella M. Gwini, Sharon L. Brennan-Olsen, Heli Koivumaa-Honkanen, Andrew M. Chanen, Lana J. Williams
Summary: This study aimed to investigate the impact of personality disorders on pharmacological treatment outcomes in adults with mood disorders. Through a systematic review and meta-analysis of 18 studies, it was found that comorbid personality disorders do not significantly affect the efficacy of pharmacological interventions for mood disorders in adults.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Motahareh Sadat Mirhaj Mohammadabadi, Homa Mohammadsadeghi, Mehrdad Eftekhar Adrebili, Zahra Partovi Kolour, Fatemeh Kashaninasab, Vahid Rashedi, Mohammadreza Shalbafan
Summary: This study aimed to investigate the factors affecting medication and psychotherapy adherence, as well as patients' attitudes toward medication, among individuals with borderline personality disorder. The findings showed that patients had more positive attitudes toward psychotherapy than medication, possibly due to the limited efficacy of medication on the symptoms of borderline personality disorder.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Behavioral Sciences
Tamara May, Pamela D. Pilkington, Rita Younan, Katrina Williams
Summary: The study systematically reviewed the overlap between ASD and BPD, finding similarities in prevalence and clinical characteristics. Despite most samples being small and clinically ascertained, with potential bias, the prevalence of BPD in ASD was approximately 4% and ASD in BPD was about 3%. Neurocognitive differences may explain similar behavioral symptoms, highlighting the need for further research using larger, well-validated samples.
Review
Medicine, General & Internal
Magdalena Wayda-Zalewska, Barbara Kostecka, Katarzyna Kucharska
Summary: This systematic review examines body image disturbances in individuals with BPD, finding higher scores in the three components compared to other groups. Despite being relatively understudied, current research indicates clear disturbances in all three body image components in individuals with BPD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Psychology, Clinical
Buse Beril Durdurak, Nada Altaweel, Rachel Upthegrove, Steven Marwaha
Summary: This study systematically reviewed the available evidence on the factors leading to the emergence of bipolar disorder (BD) and borderline personality disorder (BPD), and identified both common and distinct factors between the two disorders. The findings highlight the importance of prospective studies in understanding the development and complex interplay of BD and BPD.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Alexandre Hudon, Caroline Gaudreau-Menard, Marissa Bouchard-Boivin, Francis Godin, Lionel Cailhol
Summary: The aim of this study was to systematically review the effectiveness of computer-driven technologies for treating BPD patients. The analysis of 11 studies indicates that computer-driven interventions show promising results in treating BPD symptoms. However, the limited number of studies found on this topic highlights the need for further exploration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychiatry
Gerasimos N. Konstantinou, Alisson P. Trevizol, Jonathan Downar, Shelley F. McMain, Fidel Vila-Rodriguez, Zafiris J. Daskalakis, M. Blumberger
Summary: The literature on the application of repetitive transcranial magnetic stimulation (rTMS) in Borderline Personality Disorder (BPD) is unclear, but existing studies suggest that rTMS is a well-tolerated treatment in patients with BPD. Further research is needed to determine the efficacy of rTMS in different symptoms of BPD and to establish the best cortical targets and stimulation protocols. Longitudinal studies combining evidence-based psychotherapy with rTMS may be a promising approach to improve outcomes for this population in the future.
PSYCHIATRY RESEARCH
(2021)
Review
Neurosciences
Joshua Han, Stephen Allison, Jeffrey C. L. Looi, Sherry Kit Wa Chan, Tarun Bastiampillai
Summary: This review examines the effectiveness of clozapine in the treatment of severe borderline personality disorder (BPD) with high risk of suicide, violence or imprisonment, and aims to guide clinical practice in managing severe BPD. The findings from 24 articles suggest that clozapine has benefits for patients with severe BPD at high risk of suicide.
PSYCHOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Mahan Shafie, Elnaz Shahmohamadi, Giulia Cattarinussi, Hossein Sanjari Moghaddam, Shahin Akhondzadeh, Fabio Sambataro, Chiara Moltrasio, Giuseppe Delvecchio
Summary: This review summarizes the findings of resting-state functional magnetic resonance imaging (rsfMRI) studies in individuals with borderline personality disorder (BPD). The results indicate aberrant functional connectivity within and between several brain networks, including the default mode network (DMN), salience network (SN), and central executive network (CEN), as well as selective functional impairments in specific brain regions. However, the generalizability of these results is limited by the observational design, small sample size, and heterogeneity across imaging methodologies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Jon E. Grant, Stephanie Valle, Eve Chesivoir, Dustin Ehsan, Samuel R. Chamberlain
Summary: The study evaluated brexpiprazole for the reduction of borderline personality disorder symptoms and found a significant interaction between treatment and time at week 12. Brexpiprazole was generally well tolerated, but secondary measures did not show significant differences from placebo.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Julija Gecaite-Stonciene, Taryn Williams, Christine Lochner, Jacob Hoffman, Dan J. Stein
Summary: Although OCPD is a prevalent personality disorder, it is understudied. Current evidence suggests that citalopram and fluvoxamine may be effective for OCPD, but more randomized controlled trials are needed to confirm their efficacy.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Kim Donoghue, Laura Hermann, Eileen Brobbin, Colin Drummond
Summary: This study aims to review the rates of adherence reported in randomized controlled clinical trials of acamprosate and determine the reliability of adherence monitoring and measurement methods used in these trials. The results suggest that adherence to acamprosate in clinical trials can be poor, with low confidence in the methods used to measure it. This has implications for determining the efficacy of acamprosate.
Article
Obstetrics & Gynecology
Kai Berner, Marc Hirschfeld, Daniela Weiss, Gerta Ruecker, Jasmin Asberger, Andrea Ritter, Claudia Noethling, Markus Jaeger, Ingolf Juhasz-Boss, Thalia Erbes
Summary: Ovarian cancer is a significant global health issue, with a high mortality rate. This study focused on identifying potential biomarkers for early detection of ovarian cancer by analyzing microRNA expression levels in different cell lines and urine samples. The results showed promise for using specific microRNAs as circulating biomarkers in liquid biopsies for ovarian cancer detection.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Health Care Sciences & Services
Theodoros Papakonstantinou, Georgia Salanti, Dimitris Mavridis, Gerta Rucker, Guido Schwarzer, Adriani Nikolakopoulou
Summary: This study proposes a method for generating treatment hierarchies in network meta-analysis and relates them to clinically relevant decision questions.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Review
Psychiatry
Jutta M. Stoffers-Winterling, Ole Jakob Storebo, Mickey T. Kongerslev, Erlend Faltinsen, Adan Todorovac, Mie Sedoc Jorgensen, Christian P. Sales, Henriette Edemann Callesen, Johanne Pereira Ribeiro, Birgit A. Voellm, Klaus Lieb, Erik Simonsen
Summary: A recent study confirms the efficacy of psychotherapy for borderline personality disorder (BPD). The study evaluated both standalone and add-on psychotherapeutic treatments and found that dialectical behaviour therapy and mentalisation-based treatment had significant effects in standalone treatments, while DBT skills training and other interventions showed beneficial effects in add-on interventions.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Nicole Ruebsamen, Stephanie Pape, Stefan Konigorski, Antonia Zapf, Gerta Ruecker, Andre Karch
Summary: This study conducted a network meta-analysis to compare the diagnostic accuracies of cerebrospinal fluid and blood biomarkers for sporadic Creutzfeldt-Jakob disease (sCJD) in specialized care settings. The results showed that RT-QuIC and NfL were the most sensitive biomarkers, and RT-QuIC was the most specific biomarker. However, there was high heterogeneity in accuracy estimates between studies.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Health Care Sciences & Services
Areti Angeliki Veroniki, Sofia Tsokani, Ridhi Agarwal, Eirini Pagkalidou, Gerta Ruecker, Dimitris Mavridis, Yemisi Takwoingi
Summary: This article aims to evaluate the characteristics and applications of diagnostic test accuracy network meta-analysis (DTA-NMA) and hierarchical meta-regression methods. The results show an increasing number of DTA-NMA publications over the years, and the two methods yield different results. The choice of method can have an impact on the NMA results, especially in terms of specificity.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Psychiatry
Jack Tomlin, Peggy Walde, Birgit Voellm
Summary: In Germany, section 63 of the Penal Code is frequently used to order forensic mental health treatment. However, there is a lack of epidemiological data on this patient group. This study aims to fill this gap by conducting an annual survey of eligible hospitals to develop a comprehensive database.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Maria Petropoulou, Gerta Ruecker, Stephanie Weibel, Peter Kranke, Guido Schwarzer
Summary: Network meta-analysis (NMA) is a useful tool for estimating and ranking the effects of multiple interventions. Component network meta-analysis (CNMA) is an extension of NMA that considers the individual components of interventions. CNMA can reconnect disconnected networks using common components. An additive assumption in CNMA can be relaxed by including interaction terms.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Review
Psychiatry
Daniel Brenig, Pauline Gade, Birgit Voellm
Summary: The effectiveness of staff training in de-escalation techniques in forensic psychiatric settings is limited, with no significant reduction in violent incidents. However, staff felt safer following the training.
Article
Medicine, General & Internal
Alexander Seipp, Andreas Klausen, Antje Timmer, Teresa Grimm, Martin Gross, Oliver Summ, Fabian Otto-Sobotka
Summary: This study aims to investigate the effect of mechanical insufflation-exsufflation (MI-E) intervention on the duration of mechanical ventilation and other outcomes. One hundred adult patients with neurological or neurosurgical disease will be recruited in a randomized controlled trial, with half receiving MI-E and half receiving best standard care. The primary endpoint is the duration of mechanical ventilation until successful weaning. The findings of this study will be disseminated in a peer-reviewed journal.
Article
Psychiatry
Jack Tomlin, Kate Walker, Jen Yates, Tom Dening, Kris Goethals, Birgit Vollm, Chris Griffiths
Summary: This article investigates the needs, experiences, and outcomes of older forensic mental health inpatients and provides recommendations to meet the unique needs of this group. The authors conducted a scoping review of service provision and age-responsive interventions, along with qualitative studies on staff and patient views on age-responsive inpatient care. The guidance emphasizes the importance of involving older patients in treatment decisions, adapting interventions to their specific needs, and training staff to recognize their vulnerabilities and cognitive decline.
EUROPEAN PSYCHIATRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Sara Balduzzi, Gerta Ruecker, Adriani Nikolakopoulou, Theodoros Papakonstantinou, Georgia Salanti, Orestis Efthimiou, Guido Schwarzer
Summary: Network meta-analysis is an important research topic for methodologists, which compares different interventions for the same condition by combining direct and indirect evidence. This article introduces the R package netmeta, which uses frequentist methods to fit network meta-analysis models. It provides a roadmap and examples for researchers to conduct network meta-analysis with netmeta, considering different outcome types and data formats.
JOURNAL OF STATISTICAL SOFTWARE
(2023)
Article
Public, Environmental & Occupational Health
Kate Walker, Jen Yates, Tom Dening, Birgit Voellm, Jack Tomlin, Chris Griffiths
Summary: The purpose of this research is to increase knowledge about the quality of life, wellbeing, recovery, and progress of older forensic mental health patients, and to make recommendations for enhancing these factors. Through in-depth interviews with patients and staff, environmental, relational, and individual factors were identified as facilitators or obstacles to wellbeing, recovery, progress, and quality of life. The results suggest the need to adapt the physical and psychological environment of services, encourage therapeutic relationships with staff, and foster positive social relationships with peers, friends, and family.
INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING
(2023)
Meeting Abstract
Psychiatry
B. Voellm
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
P. Wald, C. Benz, J. Hadala, B. Voellm
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
P. Walde, B. Voellm
EUROPEAN PSYCHIATRY
(2022)