Article
Psychiatry
Jinmin Liao, Lijun Liu, Xiaoyu Fu, Yingying Feng, Wei Liu, Weihua Yue, Jun Yan
Summary: The study revealed that the negative impact of COVID-19 on OCD patients persisted one year later, with female gender, concern about COVID-19, and baseline symptom severity being risk factors for exacerbation of symptoms. Optimism and resilience were found to be protective factors against symptom exacerbation both during the early stages of COVID-19 and at the one-year follow-up.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Maria E. Moreira-de-Oliveira, Gabriela B. de Menezes, Carla D. Loureiro, Luana D. Laurito, Lucy Albertella, Leonardo F. Fontenelle
Summary: The study investigated the impact of the COVID-19 pandemic on symptom changes in a sample of Brazilian OCD patients. The results showed that treated patients did not experience significant symptom deterioration during the pandemic, and individual variations in symptom severity did not seem to be related to experiences linked to the coronavirus.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Gina M. Belli, Clara Law, Maria Mancebo, Jane Eisen, Steven Rasmussen, Christina L. Boisseau
Summary: This study aims to investigate the impact of OCD symptoms on depression symptoms, and vice versa. The results show that the severity of OCD symptoms predicts the severity of depression symptoms in the following year, but depression symptoms do not predict the severity of OCD symptoms in the following year. Therefore, prioritizing the treatment of OCD over depression is suggested.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Mu-Hong Chen, Shih-Jen Tsai, Chih-Sung Liang, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Ya-Mei Bai
Summary: Evidence suggests a continuity between obsessive-compulsive disorder (OCD) and schizophrenia, but the factors that may predict diagnostic progression from OCD to schizophrenia remain unclear. The study found that male sex, obesity, autism spectrum disorder, bipolar disorder, posttraumatic stress disorder, cluster A personality disorder, and a family history of schizophrenia were associated with a higher likelihood of subsequent progression to schizophrenia in patients with OCD. Further research is needed to elucidate the exact pathomechanisms underlying diagnostic progression to schizophrenia in patients with OCD.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychology, Clinical
K. Jean Forney, Ross D. Crosby, Tiffany A. Brown, Kelly M. Klein, Pamela K. Keel
Summary: The study revealed that 58% of patients with PD still met criteria for an eating disorder at follow-up, with only 30% achieving full recovery. While there was improvement in eating pathology, mental health and quality of life were still affected.
PSYCHOLOGICAL MEDICINE
(2021)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Psychiatry
Tianran Zhang, Lu Lu, Fabrizio Didonna, Zhen Wang, Haiyin Zhang, Qing Fan
Summary: The study found that MBCT is effective for unmedicated OCD patients with mild to moderate symptoms, comparable to SSRIs, and can maintain treatment outcomes during follow-up. No adverse events were recorded in the MBCT treatment group, indicating good clinical compliance.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Lotta Winter, Assel Saryyeva, Kerstin Schwabe, Hans E. Heissler, Joachim Runge, Mesbah Alam, Ivo Heitland, Kai G. Kahl, Joachim K. Krauss
Summary: Chronic DBS of ALIC provides long-term benefits for trOCD patients, with four out of six patients showing sustained improvement over four to eight years. Quality of life significantly improved in responders and complete remitters, with no observed peri-interventional side effects or adverse effects of chronic stimulation. Targeting the BNST did not appear to be particularly relevant in this study.
Article
Medicine, General & Internal
Lilach Rachamim, Hila Mualem-Taylor, Osnat Rachamim, Michael Rotstein, Sharon Zimmerman-Brenner
Summary: This study found that in children and adolescents with tic disorders, both the presence of ADHD and the absence of comorbid ADHD were associated with similar reductions in tic symptoms after internet-delivered, self-help comprehensive behavioral intervention for tics (ICBIT). However, the presence of OCD comorbidity was associated with a lesser response to intervention. Furthermore, the intervention also led to significant reductions in parental reports of inattention, hyperactivity, and impulsivity. Larger studies are needed to further optimize the application of ICBIT in children and teens with both tic disorders and comorbid ADHD and OCD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Bernhard Weidle, Gudmundur Skarphedinsson, David R. M. A. Hojgaard, Per Hove Thomsen, Nor Christian Torp, Karin Melin, Tord Ivarsson
Summary: This study investigated the prevalence of sexual obsessions in children and compared the treatment outcomes to those without sexual obsessions. The results showed that sexual obsessions did not affect the treatment outcomes, suggesting that cognitive-behavioral therapy (CBT) is equally effective for sexual obsessions as for other obsessions.
JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS
(2022)
Article
Medicine, General & Internal
Francesco Demaria, Paolo Alfieri, Maria Cristina Digilio, Maria Pontillo, Cristina Di Vincenzo, Federica Alice Maria Montanaro, Valentina Ciullo, Giuseppe Zampino, Stefano Vicari
Summary: KBG syndrome is a rare disease characterized by short stature, facial dysmorphism, and other symptoms. This study found that a subset of patients with KBGS exhibited peculiar behaviors related to paper handling, reminiscent of symptoms seen in obsessive compulsive disorder.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Francesco Perris, Gaia Sampogna, Vincenzo Giallonardo, Salvatore Agnese, Carmela Palummo, Mario Luciano, Michele Fabrazzo, Andrea Fiorillo, Francesco Catapano
Summary: The duration of untreated illness (DUI) in obsessive-compulsive disorder (OCD) is associated with poorer response to treatments, indicating the importance of early diagnosis and treatment in improving long-term clinical outcomes for patients.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Maria Eduarda Moreira-de-Oliveira, Gabriela B. de Menezes, Andrea Pozza, Lucia Massa, Lucy Albertella, Davide Prestia, Martina Olcese, Leonardo F. Fontenelle, Donatella Marazziti
Summary: This study investigated the impact of the pandemic on symptom changes in OCD patients from Brazil and Italy. The results suggest that more stressful pandemic-related events were associated with decreased severity of OCD symptoms, but older patients and those with more severe symptoms were prone to exhibit increased OCD severity at follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Beatrice Benatti, Giulia Lucca, Riccardo Zanello, Fabio Fesce, Alberto Priori, Nicola Poloni, Camilla Callegari, Leonardo F. Fontenelle, Bernardo Dell'Osso
Summary: This study is the first to apply a staging model to OCD patients and found that staging changed during the follow-up period. The study found that patients with worsened stage had poorer comorbidity rates and employment characteristics, while patients with improved stage had higher rates of magical thinking and violence/harm obsessions.
Article
Psychiatry
Yan-Rong Wang, Shao-hua Chang, Xiao-Min Ma, Ji-Ying Li, Rui-Xia Zhang, Jian-Qun Fang
Summary: The study found that male OCD patients have a thinner lower lip and female OCD patients have a smaller nasolabial angle. The facial features of adolescents with OCD were positively correlated with lower lip redness and neutralizing symptoms.
Article
Psychology, Developmental
A. D. Jassi, P. Vidal-Ribas, G. Krebs, D. Mataix-Cols, B. Monzani
Summary: Despite the high comorbidity, there is limited knowledge about the clinical features and treatment outcomes for youth with Obsessive-Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD). This study compared young people with OCD and ASD to those with OCD alone, and found that those with OCD + ASD had poorer insight into their OCD, greater impairment in functioning, higher levels of concurrent psychopathology, more family accommodation, and higher medication usage. Treatment outcomes were also poorer for the OCD + ASD group, with greater functional impairment and medication usage mediating the difference in outcomes. Further research and treatment improvements are needed to enhance outcomes for youth with OCD + ASD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Tianyang Zhang, Angla Mantel, Bo Runeson, Anna Sidorchuk, Christian Ruck, Olof Stephansson, Henrik Larsson, Zheng Chang, David Mataix-Cols, Lorena Fernandez de la Cruz
Summary: Cesarean delivery (CD) is associated with an increased risk of suicide attempts during the first postpartum year, but is not associated with deaths by suicide. A study in Sweden showed that CD slightly increased the risk of suicide attempts, compared to vaginal delivery. Understanding the association between CD and maternal suicidal behaviors can help improve maternal mental well-being and reduce the risk of suicide.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Fabian Lenhard, Kristina Aspvall, Erik Andersson, Johan Ahlen, Eva Serlachius, Malin Lavner, Anna Brodin, David Mataix-Cols
Summary: This study compares the economic costs of pediatric OCD with a control group and finds that pediatric OCD is associated with higher healthcare costs, parental absence from work, and school productivity loss. The total societal burden of pediatric OCD in Sweden is estimated to be 94.3 million euros per year.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Psychology, Developmental
Charlotte L. Hall, Louise Marston, Kareem Khan, Beverley J. Brown, Charlotte Sanderson, Per Andren, Sophie Bennett, Isobel Heyman, David Mataix-Cols, Eva Serlachius, Chris Hollis, Tara Murphy
Summary: A study on children and young people with tic disorders found that the COVID-19 pandemic did not significantly impact existing tic symptoms, regardless of age, gender, symptoms of anxiety, or autism spectrum disorder.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Neurosciences
Tianyang Zhang, Gustaf Brander, Josef Isung, Kayoko Isomura, Anna Sidorchuk, Henrik Larsson, Zheng Chang, David Mataix-Cols, Lorena Fernandez de la Cruz
Summary: This study aimed to investigate the association between prenatal and early childhood infections and the risk of OCD and TS/CTD. The results showed a positive correlation between prenatal and early childhood infections and the risk of OCD and TS/CTD at the population level. However, these associations were no longer significant in sibling analyses.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Benedetta Monzani, Deanna Fallah, Daniel Rautio, Martina Gumpert, Amita Jassi, Lorena Fernandez de la Cruz, David Mataix-Cols, Georgina Krebs
Summary: The study provides empirical support for the use of the BDD-YBOCS-A in children and adolescents with BDD, showing good internal consistency, reliability, and sensitivity to change in 251 patients.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Review
Psychology, Clinical
Michelle Laving, Francesco Foroni, Madeleine Ferrari, Cynthia Turner, Keong Yap
Summary: This review systematically examines the association between shame and obsessive-compulsive disorder (OCD) and unacceptable thoughts. The meta-analyses find a significant, moderate, and positive correlation between total OCD and shame scores. In addition, there are significant, weak, and positive relationships between shame and three OCD symptom dimensions: unacceptable thoughts, harm obsessions, and symmetry concerns. However, it is important to note that the shame measures used in the reviewed studies are not specific to OCD, and there is significant between-study variance in the analysis of unacceptable thoughts.
BRITISH JOURNAL OF CLINICAL PSYCHOLOGY
(2023)
Article
Psychiatry
Josef Isung, Kayoko Isomura, Kyle Williams, Tianyang Zhang, Paul Lichtenstein, Lorena Fernandez de la Cruz, Anna Sidorchuk, David Mataix-Cols
Summary: This cohort study found that maternal primary antibody immunodeficiencies (PIDs) were associated with an increased risk of psychiatric disorders and suicidal behavior in offspring, while paternal PIDs were not. Furthermore, the risk was highest when PIDs co-occurred with autoimmune diseases.
Article
Psychology, Clinical
Johan Ahlen, Johan Bjureberg, Fabian Lenhard, Tove Wahlund, Johanna Linde, David Mataix-Cols
Summary: This study found that there is a group of individuals who experience impairing levels of obsessional jealousy and perceive a need for help with their difficulties. Further research is needed to explore the prevalence and clinical characteristics of these individuals. The development of jealousy-specific psychological models and treatments is recommended.
BRITISH JOURNAL OF CLINICAL PSYCHOLOGY
(2023)
Article
Psychiatry
David Mataix-Cols, Lorena Fernandez de la Cruz, Elles De Schipper, Ralf Kuja-Halkola, Cynthia M. Bulik, James J. Crowley, Janina Neufeld, Christian Rueck, Kristiina Tammimies, Paul Lichtenstein, Sven Boelte, Jan C. Beucke
Summary: This study aims to investigate environmental risk factors for OCD by studying Swedish identical twins, collecting biological specimens, conducting clinical assessments, and performing multimodal brain imaging. So far, 43 pairs of twins have been recruited for the study, including 21 discordant for OCD.
Article
Psychology, Clinical
Lina Lundstrom, Oskar Flygare, Ekaterina Ivanova, David Mataix-Cols, Jesper Enander, Diana Pascal, Long -Long Chen, Erik Andersson, Christian Ruck
Summary: This study evaluated the implementation of therapist-guided internet-delivered cognitive behaviour therapy (ICBT) for obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) in the Swedish public health system. The results showed that ICBT was efficacious in reducing symptoms and could be reproduced in a clinical setting. The implementation of OCD-NET and BDD-NET in the Swedish public health service was deemed suitable.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2023)
Article
Psychology, Clinical
Klara Olofsdotter Lauri, Erik Andersson, David Mataix-Cols, Lisa Norlin, Viktor Eriksson, Karin Melin, Fabian Lenhard, Eva Serlachius, Kristina Aspvall
Summary: This study presents two-year follow-up data from a non-inferiority trial comparing stepped-care and in-person CBT for pediatric obsessive-compulsive disorder. Both treatment approaches demonstrated similar long-term effects, with the majority of participants showing positive responses two years after treatment.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2023)
Article
Behavioral Sciences
Klara Olofsdotter Lauri, Kristina Aspvall, David Mataix-Cols, Eva Serlachius, Christian Rueck, Erik Andersson
Summary: This study evaluated the initial efficacy, feasibility, and acceptability of an online self-guided cognitive intervention for new parents with distressing unwanted intrusive thoughts (UITs). The intervention significantly reduced distress and impairment associated with UITs post-intervention and at the 1-month follow-up. The intervention was deemed feasible and acceptable by participants. Change in negative appraisals mediated the reduction in UITs. Large-scale trials are needed to further validate these findings.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Letter
Psychiatry
Johan Ahlen, Paulina Ghaderi, Rebecka Boyaci, David Mataix-Cols
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Oskar Flygare, John Wallert, Long-Long Chen, Lorena Fernandez de la Cruz, Lina Lundstroem, David Mataix-Cols, Christian Rack, Erik Andersson
Summary: This study evaluated cutoffs for treatment response and remission in OCD using the self-rated Obsessive-Compulsive Inventory-Revised (OCI-R). The results showed that OCI-R is a simple and time-efficient way to determine treatment response and remission in OCD.