Article
Multidisciplinary Sciences
Yuan Wen, Davis A. Englund, Bailey D. Peck, Kevin A. Murach, John J. McCarthy, Charlotte A. Peterson
Summary: The study revealed that satellite cells in muscle are activated during acute exercise, but show limited lineage progression during muscle adaptation. Nuclei without satellite cells demonstrate divergent transcriptional dynamics compared to muscles with sufficient satellite cells.
Article
Clinical Neurology
Hong Li, Lingzhi Hou, Dong Wang, Qijin Wu, Haijin Li, Wen He, Sheng Li, Jianyue Pang, Yanyan Zhang, Quangang Ma, Cai Li, Jun Cheng
Summary: This study found that the combination of antidepressants and electroconvulsive therapy (ECT) is highly effective and safe for treating depression in both adolescents and adults. Depressed adolescents expressed stronger suicidal intent, which was alleviated by ECT. There were no significant differences in depression symptoms and treatment outcomes between adolescents and adults, and the side effects were similar.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Karen M. Ryan, Declan M. McLoughlin
Summary: The inflammatory response and its effect on depression and antidepressant treatment, including electroconvulsive therapy (ECT), were examined. The study found elevated levels of certain inflammatory markers in depressed patients compared to healthy controls, but these markers did not show a significant relationship with mood or neurocognitive outcomes. ECT did not alter the concentrations of these inflammatory mediators. The findings suggest that these specific inflammatory markers may not play a major role in clinical outcomes following ECT.
PSYCHIATRY RESEARCH
(2022)
Article
Oncology
Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphael Frederick, Etienne De Plaen, Christine Sers, Christiane A. Opitz, Benoit J. van den Eynde, Jingjing Zhu
Summary: This study aimed to clarify the link between IDO1/TDO expression, AHR pathway activation, and immune suppression. The results showed that tryptophan deprivation sensitizes the AHR pathway, leading to increased Treg differentiation and immune suppression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Medicine, General & Internal
Katarzyna Popiolek, Susanne Bejerot, Mikael Landen, Axel Nordenskjold
Summary: This study found that electroconvulsive therapy (ECT) was effective in improving manic episodes in clinical settings, with particularly high response rates in patients with severe illness and those without comorbid anxiety or obsessive-compulsive disorder (OCD).
Article
Green & Sustainable Science & Technology
Ragad M. Tawafak, Waleed Mugahed Al-Rahmi, Abeer S. Almogren, Muhammad Noor Al Adwan, Amjad Safori, Razaz Waheeb Attar, Mohammed Habes
Summary: This study examined the acceptance and use of e-learning systems by students in Omani higher education institutions, by combining the factors of the TAM and ECT. A survey was conducted with 220 students from Al-Buraimi University College, collecting data on perceived usefulness, perceived ease of use, behavioral intention, and e-learning system use. The results showed that perceived usefulness and ease of use were significant predictors of students' intention to use e-learning systems, and behavioral intention had a direct effect on the actual use of e-learning systems. These findings provide insights for e-learning system designers, developers, and educators in Oman and similar contexts.
Article
Neurosciences
Nils Opel, Katherine L. Narr, Christopher Abbott, Miklos Argyelan, Randall Espinoza, Louise Emsell, Filip Bouckaert, Pascal Sienaert, Mathieu Vandenbulcke, Pia Nordanskog, Jonathan Repple, Erhan Kavakbasi, Martin B. Jorgensen, Olaf B. Paulson, Lars G. Hanson, Annemieke Dols, Eric van Exel, Mardien L. Oudega, Akihiro Takamiya, Taishiro Kishimoto, Olga Therese Ousdal, Jan Haavik, Asa Hammar, Ketil Joachim Oedegaard, Ute Kessler, Hauke Bartsch, Anders M. Dale, Bernhard T. Baune, Udo Dannlowski, Leif Oltedal, Ronny Redlich
Summary: This study showed that higher body mass index (BMI) was associated with a lower increase in subcortical grey matter volume following ECT. It also found significant negative associations between BMI and change in subcortical grey matter volume, with pronounced effects in specific brain regions. Additionally, BMI moderated the association between subcortical grey matter volume change and clinical response to ECT.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Review
Psychiatry
Louis Simon, Martin Blay, Filipe Galvao, Jerome Brunelin
Summary: This study aimed to investigate the predictive value of baseline EEG settings on future clinical response to ECT in patients with depressive disorder. Results showed a correlation between P300 amplitude, coherence, and connectivity measures with remission, while sleep EEG recordings did not seem to be correlated with remission after ECT. Further large-scale prospective studies are needed to identify optimal EEG parameters associated with clinical response to ECT in depressive disorder.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Karen M. Ryan, Declan M. McLoughlin
Summary: This study found that PARP1 levels were reduced in patients with depression compared to controls, while there was no difference in OGG1 levels. Electroconvulsive therapy (ECT) had no effect on PARP1 or OGG1. Baseline PARP1 levels weakly correlated with greater mood improvement post ECT, and positively correlated with SIRT1. There were also positive correlations between change in PARP1 and change in OGG1 with change in tumor necrosis factor alpha post ECT.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Physiology
William Joyce, Yihang K. Pan, Kayla Garvey, Vishal Saxena, Steve F. Perry
Summary: This study aimed to clarify the role of the beta 1-adrenergic receptor (AR) in heart rate regulation in zebrafish. By using CRISPR-Cas9 technology, a stable adrb1(-/-) line was generated, showing a lower resting heart rate compared to wild-types. However, adrb1(-/-) zebrafish still exhibited positive chronotropic responses to adrenergic stimulation, likely due to the upregulation of other beta-AR subtypes.
Article
Agriculture, Dairy & Animal Science
Ingryd Palloma Teodosio da Nobrega, Matheus de Paula Reis, Rony Riveros Lizana, Thaila Fernanda de Moura, Guilherme Ferreira da Silva Teofilo, Leticia Cardoso Bittencourt, Nilva Kazue Sakomura
Summary: This study evaluated the response of laying hens to different levels of balanced protein in their diets. The results showed that laying hens were able to recover in performance after being given sufficient protein, but it took time. The nutritional value of the feed had an impact on the composition of the eggs.
Article
Psychiatry
Shih Ee Goh, Phern-Chern Tor
Summary: Limited literature exists on risk factors for prolonged seizures during electroconvulsive therapy, but adjusting to right unilateral ECT with a higher suprathreshold dose can allow for safe and effective continuation of treatment with reduced cognitive side effects.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Nanoscience & Nanotechnology
Xiao Zheng, Ying Liu, Yiqiong Liu, Tingting Zhang, Yuge Zhao, Jie Zang, Yan Yang, Ruiqing He, Gaowei Chong, Shuangrong Ruan, Dailin Xu, Yongyong Li, Haiqing Dong
Summary: In this study, a dual closed-loop strategy was developed using a rational material design to enhance the efficacy of cancer immunotherapy by catalyzing lactate depletion and immune response. This strategy effectively inhibited tumor growth, providing a promising treatment modality for cancer immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Behavioral Sciences
Piyush Pathak, Aseem Mehra, Sant Ram, Arnab Pal, Sandeep Grover
Summary: This study aimed to determine the association of Val66Met polymorphism in the BDNF gene and serum BDNF level with treatment response in MDD patients. The results showed that the presence of the Met allele was associated with a better response to antidepressant medications; serum BDNF level was significantly higher in MDD patients; lower serum BDNF level was associated with better outcomes in patients treated with ECT.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Microbiology
Nian Wei, Lirong Song, Nanqin Gan
Summary: This study used iTRAQ-based proteomics to investigate the effects of phosphorus depletion on Microcystis aeruginosa, showing that phosphorus depletion inhibits cell growth and primary metabolic processes while maintaining photosystem integrity, and influences the balance of carbon, nitrogen, and phosphorus in the cells.
Article
Behavioral Sciences
Katherine W. Scangos, Richard D. Weiner, Edward C. Coffey, Andrew D. Krystal
Letter
Biotechnology & Applied Microbiology
Andrew D. Krystal, Diego A. Pizzagalli, Sanjay J. Mathew, Gerard Sanacora, Richard Keefe, Allen Song, Joseph Calabrese, Andrew Goddard, Wayne Goodman, Sarah H. Lisanby, Moria Smoski, Richard Weiner, Dan Iosifescu, John Nurnberger, Steven Szabo, James Murrough, Anantha Shekhar, William Potter
NATURE REVIEWS DRUG DISCOVERY
(2019)
Article
Geriatrics & Gerontology
Sarah H. Lisanby, Shawn M. McClintock, George Alexopoulos, Samuel H. Bailine, Elisabeth Bernhardt, Mimi C. Briggs, C. Munro Cullum, Zhi-De Deng, Mary Dooley, Emma T. Geduldig, Robert M. Greenberg, Mustafa M. Husain, Styliani Kaliora, Rebecca G. Knapp, Vassilios Latoussakis, Lauren S. Liebman, William V. McCall, Martina Mueller, Georgios Petrides, Joan Prudic, Peter B. Rosenquist, Matthew V. Rudorfer, Shirlene Sampson, Abeba A. Teklehaimanot, Kristen G. Tobias, Richard D. Weiner, Robert C. Young, Charles H. Kellner
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2020)
Article
Clinical Neurology
Adriana P. Hermida, Felicia C. Goldstein, David W. Loring, Shawn M. McClintock, Richard D. Weiner, Irving M. Reti, A. Umair Janjua, Zixun Ye, Limin Peng, Yi-lang Tang, Gail C. Galendez, Mustafa M. Husain, Daniel F. Maixner, Patricio Riva-Posse, William M. McDonald
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Article
Psychiatry
Delin Sun, Andrea L. Gold, Chelsea A. Swanson, Courtney C. Haswell, Vanessa M. Brown, Daniel Stjepanovic, Kevin S. LaBar, Rajendra A. Morey, Jean C. Beckham, Mira Brancu, Patrick S. Calhoun, Eric Dedert, Eric B. Elbogen, Kimberly T. Green, Nathan Kimbrel, Angela Kirby, Gregory McCarthy, Scott D. Moore, Jennifer J. Runnals, Cindy Swinkels, Larry A. Tupler, Elizabeth E. Van Voorhees, Richard D. Weiner
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Andrew D. Krystal, Diego A. Pizzagalli, Moria Smoski, Sanjay J. Mathew, John Nurnberger, Sarah H. Lisanby, Dan Iosifescu, James W. Murrough, Hongqiu Yang, Richard D. Weiner, Joseph R. Calabrese, Gerard Sanacora, Gretchen Hermes, Richard S. E. Keefe, Allen Song, Wayne Goodman, Steven T. Szabo, Alexis E. Whitton, Keming Gao, William Z. Potter
Article
Neurosciences
Diego A. Pizzagalli, Moria Smoski, Yuen-Siang Ang, Alexis E. Whitton, Gerard Sanacora, Sanjay J. Mathew, John Nurnberger, Sarah H. Lisanby, Dan Iosifescu, James W. Murrough, Hongqiu Yang, Richard D. Weiner, Joseph R. Calabrese, Wayne Goodman, William Z. Potter, Andrew D. Krystal
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Geriatrics & Gerontology
Sarah H. Lisanby, Shawn M. McClintock, William McCall, Rebecca G. Knapp, C. Munro Cullum, Martina Mueller, Zhi-De Deng, Abeba A. Teklehaimanot, Matthew Rudorfer, Elisabeth Bernhardt, George Alexopoulos, Samuel H. Bailine, Mimi C. Briggs, Emma T. Geduldig, Robert M. Greenberg, Mustafa M. Husain, Styliani Kaliora, Vassilios Latoussakis, Lauren S. Liebman, Georgios Petrides, Joan Prudic, Peter B. Rosenquist, Shirlene Sampson, Kristen G. Tobias, Richard D. Weiner, Robert C. Young, Charles H. Kellner
Summary: After a 6-month course of RUL-UB ECT in older adults with major depressive disorder, there were no significant differences in neurocognitive outcomes between the STABLE plus pharmacotherapy group and the pharmacotherapy-only group. These findings support the safety of combining RUL-UB ECT with pharmacotherapy in prolonging remission in late-life depression.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Correction
Neurosciences
Diego A. Pizzagalli, Moria Smoski, Yuen-Siang Ang, Alexis E. Whitton, Gerard Sanacora, Sanjay J. Mathew, John Nurnberger, Sarah H. Lisanby, Dan V. Iosifescu, James W. Murrough, Hongqiu Yang, Richard D. Weiner, Joseph R. Calabrese, Wayne Goodman, William Z. Potter, Andrew D. Krystal
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Peter P. Zandi, Michael Morreale, Irving M. Reti, Daniel F. Maixner, William M. McDonald, Paresh D. Patel, Eric Achtyes, Mahendra T. Bhati, Brent R. Carr, Susan K. Conroy, Mario Cristancho, Marc J. Dubin, Andrew Francis, Kara Glazer, Wendy Ingram, Khurshid Khurshid, Shawn M. McClintock, Omar F. Pinjari, Kevin Reeves, Nelson F. Rodriguez, Shirlene Sampson, Stephen J. Seiner, Salih Selek, Yvette Sheline, Roy W. Smetana, Takahiro Soda, Nicholas T. Trapp, Jesse H. Wright, Mustafa Husain, Richard D. Weiner
Summary: Electroconvulsive therapy (ECT) is a highly effective treatment for severe depression, but there are challenges in standardizing its delivery and documentation. A task group from the National Network of Depression Centers was formed to promote best clinical practices for ECT and facilitate quality improvement and research efforts. This article focuses on harmonizing the clinical documentation of ECT and its implications for nationwide collaboration and research.
Article
Psychiatry
Nicholas A. Mischel, GenaLynne C. Mooneyham, Cecilia Lau, Heather Van Mater, Richard D. Weiner
Letter
Behavioral Sciences
Gopalkumar Rakesh, Nicholas A. Mischel, Grace Gunderson-Falcone, Amanda Anderson, Denna Copeland, Steven T. Szabo, Richard D. Weiner
Article
Psychology, Clinical
Robert D. Shura, Sarra Nazem, Holly M. Miskey, Trisha A. Hostetter, Jared A. Rowland, Lisa A. Brenner, Katherine H. Taber, Mira Brancu, Jean C. Beckham, Patrick S. Calhoun, Eric Dedert, Eric B. Elbogen, John A. Fairbank, Kimberly T. Green, Robin A. Hurley, Jason D. Kilts, Nathan A. Kimbrel, Angela Kirby, Christine E. Marx, Gregory McCarthy, Scott D. McDonald, Scott D. Moore, Rajendra A. Morey, Jennifer C. Naylor, Treven C. Pickett, Jennifer J. Runnals, Cindy Swinkels, Steven T. Szabo, Larry A. Tupler, Elizabeth E. Van Voorhees, H. Ryan Wagner, Richard D. Weiner, Ruth E. Yoash-Gantz
PSYCHOLOGICAL SERVICES
(2019)
Article
Health Policy & Services
Jeffrey Swanson, Michele Easter, Mira Brancu, John A. Fairbank
ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES RESEARCH
(2018)
Article
Psychology, Clinical
Eric B. Elbogen, H. Ryan Wagner, Nathan A. Kimbrel, Mira Brancu, Jennifer Naylor, Robert Graziano, Eric Crawford
PSYCHOLOGICAL ASSESSMENT
(2018)
