Article
Neurosciences
Iven-Alex von Mucke-Heim, Jan M. Deussing
Summary: Psychiatric disorders are highly burdensome worldwide, with many patients experiencing treatment resistance. Recent research has revealed the importance of neuroimmune systems in mood disorder biology, specifically the dysregulation in neuroimmune cross-talk driven by genetic risk factors and environmental influences. One emerging immune target is purinergic signalling via the P2X7 receptor (P2X7R). However, no clinically meaningful applications have been identified so far, highlighting the need for further research and translation of findings from bench to bedside.
Article
Psychiatry
Ellen Martin, Tabea Schoeler, Jean-Baptiste Pingault, Wikus Barkhuizen
Summary: Loneliness is associated with adverse outcomes, including substance use problems and psychiatric disorders. This study used Genomic Structural Equation Modeling to investigate the genetic architecture between loneliness and psychiatric-behavioral traits. The results suggest a bidirectional causal relationship between a genetic predisposition to loneliness and neurodevelopmental/mood conditions. These findings emphasize the importance of addressing loneliness in mental health prevention and policy.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Paulo Ruiz-Grosso, Christian Loret de Mola, Larissa Otero, Cesar Ugarte-Gil
Summary: The objective of this study was to identify trajectories of depressive symptoms (DSs) during the first half of drug-sensitive pulmonary tuberculosis (PTB) treatment and examine their association with loss to follow-up (LTFU) in the second half. The study found that an increasing trajectory of DSs during the first half of PTB treatment is associated with a higher risk of LTFU during the second half.
Review
Behavioral Sciences
Joana Martins-Macedo, Antonio J. Salgado, Eduardo D. Gomes, Luisa Pinto
Summary: Psychiatric disorders have a significant impact on patients' lives, with common symptoms including motivational, cognitive and emotional deficits. Current treatments are often ineffective due to adverse side effects or low efficacy rates. Understanding neuro-and gliogenesis mechanisms is crucial for defining effective treatments, as they play a key role in cognitive and emotional behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Tamsyn E. Van Rheenen, Elysha Ringin, James A. Karantonis, Lisa Furlong, Kiymet Bozaoglu, Susan L. Rossell, Michael Berk, Vicent Balanza-Martinez
Summary: This study examined the role of vitamin D in bipolar disorder (BD) patients and found no significant differences in vitamin D levels or deficiency status between BD patients and healthy controls. The study also found no association between vitamin D and clinical symptoms or global cognition in BD.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Wenwen Chen, Yu Zeng, Chen Suo, Huazhen Yang, Yilong Chen, Can Hou, Yao Hu, Zhiye Ying, Yajing Sun, Yuanyuan Qu, Donghao Lu, Fang Fang, Unnur A. Valdimarsdottir, Huan Song
Summary: This study found a potential role of genetic factors in the association between psychiatric disorders and COVID-19, suggesting a need for increased medical surveillance for this vulnerable population.
Review
Clinical Neurology
Karren Xiao, Emily S. Gillissie, Leanna M. W. Lui, Felicia Ceban, Kayla M. Teopiz, Hartej Gill, Bing Cao, Roger Ho, Joshua D. Rosenblat, Roger S. McIntyre
Summary: The immune response following vaccination in individuals with mental disorders remains inconclusive, with some studies suggesting attenuated immune response in individuals with major depressive disorder and schizophrenia, while individuals with anorexia nervosa, post-traumatic stress disorder, and obstructive sleep apnea showed no attenuated immune response.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Melanie Bales, Elodie Pambrun, Charlotte Maguet, Judith van der Waerden, Nine Glangeaud-Freudenthal, Marie-Aline Charles, Corinne Bois, Maria Melchior, Jeannette Milgrom, Bruno Falissard, Helene Verdoux, Anne-Laure Sutter-Dallay
Summary: This study explored the pathways between maternal, infant, and parenthood vulnerabilities or risk/protective factors and postnatal depressive symptoms (PNDS) at 2 months postpartum (PP). The results showed that factors such as prenatal psychological distress, difficult pregnancy experience, family financial difficulties, and consultation with a mental health specialist before pregnancy were directly associated with the severity of maternal PNDS. Lack of perceived postnatal support and infant characteristics like self-regulation difficulties and maternal difficulty in understanding infant crying were also related to PNDS severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pediatrics
Tiffany L. Huang, Stacy L. Pineles
Summary: This literature review explores the potential correlation between strabismus and mental illness among children. A thorough search was conducted in PubMed and Google Scholar databases using various search terms related to strabismus, mental disorders, psychiatric illness, childhood, and adolescence. The review includes eleven published studies, which suggest an association between strabismus and mental illness, along with negative attitudes and social bias towards children with strabismus. These findings highlight the importance of healthcare providers counseling children and their caregivers about the risk of mood disorders in children with strabismus, as well as considering mental health screening and referral when necessary.
Article
Psychiatry
Peter B. Barr, Travis T. Mallard, Sandra Sanchez-Roige, Holly E. Poore, Richard Karlsson Linner, Irwin D. Waldman, Abraham A. Palmer, K. Paige Harden, Danielle M. Dick
Summary: In this study, multivariate GWAS was used to identify genetic variants associated with problematic alcohol use. These variants were found to be related to either shared risk factors for externalizing or specific risk factors for alcohol use disorders. SNPs associated with specific risk factors were primarily related to alcohol metabolism.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Cornelia Weise, Freyja Grupp, Jens-Peter Reese, Carmen Schade-Brittinger, Thomas Ehring, Nexhmedin Morina, Ulrich Stangier, Regina Steil, Johannes Johow, Ricarda Mewes
Summary: This study aims to investigate the effectiveness of brief culturally sensitive and transdiagnostic psychoeducation in increasing mental health literacy among asylum seekers in Western host countries. The research will be conducted as a parallel two-group randomized controlled trial at four study sites in Germany, involving 166 adult asylum seekers reporting at least mild mental distress. The primary outcome will focus on the percentage of participants achieving an increase in knowledge concerning symptoms of mental disorders, individual resources, and mental healthcare.
Article
Pharmacology & Pharmacy
Trang T. T. Truong, Chiara C. Bortolasci, Briana Spolding, Bruna Panizzutti, Zoe S. J. Liu, Srisaiyini Kidnapillai, Mark Richardson, Laura Gray, Craig M. Smith, Olivia M. Dean, Jee Hyun Kim, Michael Berk, Ken Walder
Summary: This study investigates the role of long non-coding RNAs (lncRNAs) in the mechanism of action of bipolar disorder (BD) medications. The findings suggest that certain lncRNAs may serve as major regulators of medication effects and have the potential to be developed as novel drug targets for treating BD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Joanne B. Newbury, Robert Stewart, Helen L. Fisher, Sean Beevers, David Dajnak, Matthew Broadbent, Megan Pritchard, Narushige Shiode, Margaret Heslin, Ryan Hammoud, Matthew Hotopf, Stephani L. Hatch, Ian S. Mudway, Ioannis Bakolis
Summary: Research indicates that residential air pollution exposure is associated with increased mental health service use among individuals recently diagnosed with psychotic and mood disorders, suggesting the potential impact of air pollution on illness severity and relapse.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Oncology
Katja Kloth, Denise Obrecht, Dominik Sturm, Torsten Pietsch, Monika Warmuth-Metz, Brigitte Bison, Martin Mynarek, Stefan Rutkowski
Summary: This study analyzed 16 patients with Gorlin syndrome, finding that common tumor types included desmoplastic medulloblastomas, medulloblastomas with extensive nodularity, and classic medulloblastomas, with most tumors showing SHH activation. There was no significant difference in survival rates between patients with PTCH1 and SUFU gene mutations in genetic analysis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Yiwen Zhu, Min-Jung Wang, Katherine M. Crawford, Juan Carlos Ramirez-Tapia, Alexandre A. Lussier, Kathryn A. Davis, Christiaan de Leeuw, Anne E. Takesian, Takao K. Hensch, Jordan W. Smoller, Erin C. Dunn
Summary: The study found that genes regulating sensitive periods are associated with increased depression risk, with a gene set opening sensitive periods particularly linked to vulnerability. There was also a statistical interaction identified between caregiver abuse during ages 1-5 and genetic risk for depression. These findings highlight the importance of gene-by-development interplay in understanding the complexity of depression etiology.
NEUROPSYCHOPHARMACOLOGY
(2022)
