Review
Psychiatry
Sujita Kumar Kar, Vikas Menon, S. M. Yasir Arafat, Amit Singh, Anamika Das, Akanksha Shankar, Pawan Sharma, Sayuri Perera
Summary: Although Dhat syndrome is commonly diagnosed in the South Asian population, research on Dhat syndrome is scarce and of poor quality. Most studies lack population representativeness, leading to poor generalizability of the findings.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Jennifer Allen, Selene S. Mak, Meron Begashaw, Jody Larkin, Isomi Miake-Lye, Jessica Beroes-Severin, Juli Olson, Paul G. Shekelle
Summary: Despite a large number of studies, systematic reviews of acupuncture for adult health conditions have only found a minority of conclusions to be of high or moderate-certainty evidence, with most conclusions comparing acupuncture to sham treatment or no benefit.
Review
Nutrition & Dietetics
Alvin Man Lung Chan, Angela Min Hwei Ng, Mohd Heikal Mohd Yunus, Ruszymah Bt Hj Idrus, Jia Xian Law, Muhammad Dain Yazid, Kok-Yong Chin, Sharen Aini Shamsuddin, Yogeswaran Lokanathan
Summary: Metabolic syndrome is a cluster of physiological features, with chronic illnesses including obesity, cardiovascular system, renal operation, hepatic function, oncology, and mortality; rodents have been ideal models for mammalian studies for centuries.
Review
Psychiatry
Noa Reuveni, Cole A. Carlson, Sarah Schwartz, Diana Meter, Tyson S. Barrett, Sara M. Freeman
Summary: This systematic review and meta-analysis of preclinical literature on the effects of cannabinoids in the chronic unpredictable stress model of depression found that cannabinoid administration moderately improved the negative effects of stress on depressive-like behavior, suggesting that cannabinoids may be a viable long-term treatment for stress-related psychopathologies such as depression.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Psychiatry
Mattia Marchi, Pietro Grenzi, Valentina Serafini, Francesco Capoccia, Federico Rossi, Patrizia Marrino, Luca Pingani, Gian Maria Galeazzi, Silvia Ferrari
Summary: People with persistent symptoms after 4 weeks of COVID-19 recovery may have Long-COVID syndrome (LC). This systematic review identified depression, anxiety, post-traumatic symptoms (PTS), cognitive impairment, and sleep disturbances as the main psychiatric manifestations of LC. The prevalence of these conditions varied, with sleep disturbances being the most commonly reported.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Krista Fisher, Zac E. Seidler, Kylie King, John L. Oliffe, Simon M. Rice
Summary: Anxiety disorders are commonly diagnosed among men, but research specifically focused on male anxiety is lacking. Men tend to rely on themselves rather than seeking formal help, and masculinity is related to anxiety in complex ways.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Ludovica Giani, Giovanni Michelini, Maria Nobile, Paola Francesca Ajmone, Paola Giovanna Vizziello, Simona Scaini
Summary: The social impairments in individuals with Cornelia de Lange Syndrome (CdLS) are mainly characterized by social anxiety, which differs from those observed in idiopathic autism. This systematic review examines the relationship between social anxiety and CdLS through cross-sectional comparisons, highlighting the importance of considering the nature of social demand and familiarity of the examiner in understanding social anxiety in CdLS individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Amelia Wright, Peter L. Fisher, Nita Baker, Louise O 'Rourke, Mary Gemma Cherry
Summary: The systematic review found a strong correlation between maladaptive perfectionism and depression in patients with CFS/ME, but more research is needed to understand the relationship between perfectionism and anxiety. Longitudinal, cross-cultural studies are necessary to confirm these associations.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Review
Neurosciences
Vasilios G. Masdrakis, Manolis Markianos, David S. Baldwin
Summary: Administration of antidepressant drugs, particularly SSRIs, may induce clinically significant 'apathy' which can affect treatment outcomes adversely. According to previous studies, antidepressant-induced apathy, or emotional blunting, can occur, resulting in a decrease in emotional responsiveness. The prevalence of antidepressant-induced apathy ranges from 5.8% to 50%, and for SSRIs, it ranges from 20% to 92%. The main treatment strategy is dose reduction, but other medications such as olanzapine, bupropion, agomelatine, amisulpride, or a combination of methylphenidate, modafinil, and olanzapine may also be effective.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Anesthesiology
Hyke Algera, Rutger van der Schrier, David Cavalla, Monique van Velzen, Margot Roozekrans, Alison McMorn, Michael Snape, Joseph P. Horrigan, Stuart Evans, Bernard Kiernan, Elise Sarton, Erik Olofsen, Marieke Niesters, Albert Dahan
Summary: This study found that both oral and intravenous tianeptine do not have a respiratory stimulant effect in humans. In fact, intravenous tianeptine may worsen respiratory depression induced by opioids.
Review
Clinical Neurology
Shaun Sweeney, Charlotte Wilson
Summary: Parental anxiety has an impact on their child's development, with the association being stronger in childhood and adolescence. The influence of both mothers and fathers has been found to negatively affect the functioning of offspring. However, the impact of maternal anxiety may be more significant in adolescence.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Shuang Ji, Yujiao Chen, Yuying Zhou, Yiting Cao, Xiao Li, Guoyong Ding, Fang Tang
Summary: Previous studies have shown a controversial association between anxiety and metabolic syndrome (MetS). This updated meta-analysis reanalyzed the association between anxiety and MetS. The results of cross-sectional studies indicated a significant association, but the results of cohort studies were inconsistent. More large-scale prospective studies are needed to further investigate the causal relationship.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Cecilie Bay-Richter, Gregers Wegener
Summary: In recent years, there has been significant focus on the neuroimmune mechanisms of depression. This article systematically reviews the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on depressive-like behavior in rodent models of depression. The results suggest that stress models are the best choice for examining the antidepressant effects of NSAIDs, and rat models show a more homogeneous response compared to mouse models.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Avelyn Aw, Mechteld C. de Jong, Shriya Varghese, James Lee, Roger Foo, Rajeev Parameswaran
Summary: This review assessed the features and outcomes of pheochromocytoma-induced takotsubo cardiomyopathy (PCC-TCM), comparing typical and atypical subtypes. It found that atypical subtype patients were younger and had more severe clinical presentations and lower pre-operative mortality rates. However, the study also highlighted the need for further research to draw more reliable conclusions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Clinical Neurology
S. E. Cohen, J. B. Zantvoord, B. N. Wezenberg, J. G. Daams, C. L. H. Bockting, D. Denys, G. A. van Wingen
Summary: This study assessed the accuracy of electroencephalography (EEG) in predicting treatment response in major depressive disorder. The results showed that EEG can accurately predict the response to antidepressant treatment, but further validation studies are needed to develop a clinical tool for guiding interventions in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Jeremiah Ayalde, Deborah Wearne, Sean Hood, Flavie Waters
Summary: This study aims to increase awareness among clinicians and researchers about distinguishing between visual hallucinations and trauma-related visual re-experiencing phenomena. Visual hallucinatory experiences may not be exclusive to psychiatric disorders, as similar experiences can occur in trauma patients and potentially affect diagnosis. Further research is needed to characterize the differences between visual hallucinations in psychosis and trauma-associated visual phenomena.
AUSTRALASIAN PSYCHIATRY
(2022)
Article
Neurosciences
Hugo A. E. Morandini, Pradeep Rao, Sean D. Hood, Kristi Griffiths, Timothy J. Silk, Florian D. Zepf
Summary: The study did not find a significant relationship between dietary omega-3 intake and resting-state functional connectivity or vigilant attention performance.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Davinder Hans, Anthony Rengel, Jaspreet Hans, Darryl Bassett, Sean Hood
Summary: Objective N-acetylcysteine has shown potential as a rapidly acting adjunctive treatment in reducing suicidality and depressive symptoms in intentional medication overdose patients.
Article
Biochemistry & Molecular Biology
Richard E. Daws, Christopher Timmermann, Bruna Giribaldi, James D. Sexton, Matthew B. Wall, David Erritzoe, Leor Roseman, David Nutt, Robin Carhart-Harris
Summary: Psilocybin therapy has the potential to treat depression by increasing brain network integration, according to two clinical trials. The antidepressant response to psilocybin was rapid and sustained, while escitalopram had milder effects on brain network organization.
Article
Public, Environmental & Occupational Health
Simon J. C. Davies, Blanca Bolea-Alamanac, Kaori Endo, Yu Yamamoto, Syudo Yamasaki, Alex Malins, Jonathan Evans, Sarah Sullivan, Shuntaro Ando, Atsushi Nishida, Kiyoto Kasai
Summary: This study found that the distance between home and railway stations is associated with mental health symptoms in children, specifically hyperactivity/inattention. The farther the distance, the higher the likelihood of these symptoms, particularly in boys. This suggests that access to high-frequency rail transit in urban environments may have a positive impact on children's mental health.
JOURNAL OF TRANSPORT & HEALTH
(2023)
Article
Medicine, Research & Experimental
Venkata K. K. Yellepeddi, Marco Battaglia, Simon J. C. Davies, Jeremiah Alt, Shaelene Ashby, Paige Shipman, David J. J. Anderson, Joseph E. Rower, Christopher Reilly, Michael Voight, Sabiha Rahman Mim
Summary: Anxiety and panic disorders are common mental illnesses with limited treatment options in the United States. Acid-sensing ion channels (ASICs) in the brain play a role in fear conditioning and anxiety responses, making them potential targets for treating panic disorder. Amiloride, an ASICs inhibitor, has shown promise in reducing panic symptoms in animal models. This study evaluated the pharmacokinetics and safety of intranasal amiloride in healthy human volunteers, demonstrating its rapid absorption and safety at various doses.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Christine A. A. Parker, David J. J. Nutt, Robin J. J. Tyacke
Summary: Targeting neuroinflammation, specifically microglial activation and astrocytosis, is a current focus in the development of new treatment interventions for various neurodegenerative disorders. This review focuses on the recent advancements in the development of I2BS PET tracers that target astrocytes and could serve as clinical imaging tools for neurodegenerative diseases. The review discusses five PET tracers for I2BS, with C-11-BU99008 currently being validated for clinical use and showing potential in revealing early astrogliosis involvement in neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Neurosciences
David J. Nutt
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Pharmacology & Pharmacy
Balazs Szigeti, Lawrence D. D. Phillips, David Nutt
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matthew B. Wall, Rebecca Harding, Rayyan Zafar, Eugenii A. Rabiner, David J. Nutt, David Erritzoe
Summary: Psychedelic therapy shows potential for treating psychiatric disorders, but there are still gaps in knowledge regarding the relationship between acute drug effects and long-term outcomes, as well as the impact of these drugs on neuroplasticity. The use of neuroimaging methods can help address these questions and provide a foundation for the development of psychedelic therapy.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Otto Simonsson, Per Carlbring, Robin Carhart-Harris, Alan K. Davis, David J. Nutt, Roland R. Griffiths, David Erritzoe, Simon B. Goldberg
Summary: In this meta-analysis of three psilocybin trials for depression, clinically significant symptom worsening occurred for a minority of participants in the psilocybin and escitalopram conditions (similar to 10%) and for a majority of participants in the waitlist condition (63.6%). The psilocybin arm showed a lower likelihood of symptom worsening versus waitlist, and no difference in the likelihood of symptom worsening versus escitalopram based on the two trials with control arms. Future studies should address the limitation of a relatively small sample size.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Emily Eyles, Ruta Margelyte, Hannah B. Edwards, Paul A. Moran, David S. Kessler, Simon J. C. Davies, Blanca Bolea-Alamanac, Maria Theresa Redaniel, Sarah A. Sullivan
Summary: This study investigated the association between combined use of two antipsychotic drugs and the risk of developing diabetes, hypertension, or hyperlipidemia in adults with schizophrenia. The results showed that compared to monotherapy, polypharmacy increased the risk of hypertension in patients.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Pharmacology & Pharmacy
Alexander T. Gallo, Stephen Addis, Vlad Martyn, Hishani Ramanathan, Grace K. Wilkerson, Kellie S. Bennett, Sean D. Hood, Hans Stampfer, Gary K. Hulse
Summary: This open-label pilot study aimed to assess the efficacy and safety of low-dose flumazenil (FMZ) for generalized anxiety disorder (GAD). The results showed that continuous low-dose FMZ infusion can reduce anxiety and stress, and improve sleep quality without serious adverse events in GAD patients. Therefore, this study suggests that low-dose continuous FMZ infusion is a safe, well-tolerated, and feasible treatment option for GAD.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Bradley Roberts, Zahra Cooper, Stephanie Lu, Susanne Stanley, Bernadette T. Majda, Khan R. L. Collins, Lucy Gilkes, Jennifer Rodger, P. Anthony Akkari, Sean D. Hood
Summary: Pharmacogenetics (PGx) studies how individual genetic differences can affect drug responses. PGx testing can individualize primary care and provide a safer drug prescription model. It has shown promising evidence in improving drug efficacy and reducing toxicity in psychiatry. However, there are barriers hindering its implementation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Faiz M. Kassim, Sophie Tod, Jennifer Rodger, Sean D. Hood, Joseph W. Y. Lee, Matthew A. Albrecht, Mathew T. Martin-Iverson
Summary: This study found that low doses of synthetic cannabinoids have an impact on spatial working memory and verbal working memory. Schizotypy scores were negatively correlated with deficits in working memory.
CANNABIS AND CANNABINOID RESEARCH
(2022)