Article
Endocrinology & Metabolism
Xin Wang, Ying Wang, Xiaolan Yong, Bojun Wu, Zilin Sun, Ning Lou, Qing Wen, Yufang Zhang, Shiyun Li, Jiarui Li, Yan He, Jinluo Cheng, Xiangdong Zhong, Jing Shen, Wenying Yang
Summary: The xanthine dipeptidyl peptidase-4 inhibitor, yogliptin, demonstrated effective hypoglycemic activity as a monotherapy in individuals with type 2 diabetes mellitus. It significantly reduced HbA1c levels and improved secondary efficacy outcomes, such as fasting plasma glucose levels, in Chinese T2DM patients. The safety profile of yogliptin was found to be favorable, supporting its use in phase III clinical studies.
JOURNAL OF DIABETES
(2022)
Article
Nutrition & Dietetics
Tzu-Fang Hsu, Zi-Rong Su, Yao-Hao Hsieh, Ming-Fu Wang, Mariko Oe, Ryosuke Matsuoka, Yasunobu Masuda
Summary: Oral intake of hyaluronan can improve skin condition by reducing wrinkles and increasing hydration, as demonstrated in a clinical trial.
Article
Medicine, General & Internal
Vanda Faria, Jana Dulheuer, Akshita Joshi, Hannes Wahl, Anna Klimova, Antje Haehner, Gudrun Gossrau
Summary: This study aims to investigate the impact of structured odour exposure on women with migraine. The study will recruit 54 women aged 18 to 55 with migraine with aura. The primary outcomes include mechanical and electrical pain thresholds, olfactory threshold, and number of headache days. The study will also assess neuroanatomical and neurofunctional changes associated with the 12-week olfactory training.
Article
Medicine, General & Internal
Vanda Faria, Jana Dulheuer, Akshita Joshi, Hannes Wahl, Anna Klimova, Antje Haehner, Gudrun Gossrau
Summary: This study aims to investigate the impact of structured odour exposure on women with migraine. Participants will be recruited and randomly assigned to receive odour training or odourless training, and various outcomes such as pain thresholds and number of headache days will be evaluated. The findings of this study will be disseminated through peer-reviewed journals and scientific conferences.
Article
Endocrinology & Metabolism
Ye Seul Yang, Kyung Wan Min, Seok-O Park, Kyung-Soo Kim, Jae Myung Yu, Eun-Gyoung Hong, Sung Rae Cho, Kyu Chang Won, Yong Hyun Kim, Seungjoon Oh, Sung Hee Choi, Gwanpyo Koh, Wan Huh, Su Young Kim, Kyong Soo Park
Summary: This study aimed to evaluate and compare the efficacy and safety of enavogliflozin, a newly developed sodium-glucose cotransporter 2 inhibitor, with placebo in Korean patients with type 2 diabetes mellitus. The results showed that once-daily enavogliflozin monotherapy for 12 weeks is an effective, safe, and well-tolerated treatment for Korean patients with type 2 diabetes mellitus.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Roy Eldor, Bruce H. H. Francis, Alexander Fleming, Joel Neutel, Kenneth Homer, Miriam Kidron, Julio Rosenstock
Summary: This study evaluated the safety and efficacy of oral insulin (ORMD-0801) in patients with type 2 diabetes. The results showed that ORMD-0801 effectively lowered HbA1c levels, was well tolerated during treatment, and did not cause weight gain or hypoglycemia.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Alexa B. Kimball, Gregor B. E. Jemec, Afsaneh Alavi, Ziad Reguiai, Alice B. Gottlieb, Falk G. Bechara, Carle Paul, Evangelos J. Giamarellos Bourboulis, Axel P. Villani, Andreas Schwinn, Franziska Rueff, Larisha Pillay Ramaya, Adam Reich, Ines Lobo, Rodney Sinclair, Thierry Passeron, Antonio Martorell, Pedro Mendes-Bastos, Georgios Kokolakis, Pierre-Andre Becherel, Magdalena B. Wozniak, Angela Llobet Martinez, Xiaoling Wei, Lorenz Uhlmann, Anna Passera, Deborah Keefe, Ruvie Martin, Clarice Field, Li Chen, Marc Vandemeulebroecke, Shoba Ravichandran, Elisa Muscianisi
Summary: Two randomized trials showed that secukinumab was clinically effective at rapidly improving signs and symptoms of moderate-to-severe hidradenitis suppurativa with a favorable safety profile and sustained response up to 52 weeks of treatment.
Article
Psychiatry
Richard A. Kanaan, Gina Oliver, Anita Dharan, Shahbaz Sendi, Alice Maier, Mohammadreza Mohebbi, Chee Ng, Sudie E. Back, Peter Kalivas, Michael Berk
Summary: This study investigated the efficacy of adjuvant N-acetylcysteine (NAC) treatment in patients with treatment-resistant PTSD. The results showed that there were no significant differences between NAC and placebo groups in CAPS-5 scores at 12 weeks, but significant differences were observed in craving duration and resistance at 64 weeks. Further research is needed to determine the efficacy of NAC for treatment-resistant PTSD.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Caitlin M. P. Jones, Richard O. Day, Bart W. Koes, Jane Latimer, Chris G. Maher, Andrew J. McLachlan, Laurent Billot, Sana Shan, Chung-Wei Christine Lin
Summary: This study investigated the efficacy and safety of opioid analgesics for acute low back pain and neck pain. The results showed no significant difference in pain severity compared with placebo, indicating that opioids should not be recommended for these conditions.
Article
Psychology, Developmental
Robert L. Findling, Melissa P. DelBello, Alessandro Zuddas, Graham J. Emslie, Anders Ettrup, Maria L. Petersen, Simon N. Schmidt, Monika Rosen
Summary: The study evaluated the efficacy and safety of vortioxetine in adolescents with MDD, and found no significant difference between vortioxetine at two doses and placebo.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Katharina Schmidt, Julian Kleine-Borgmann, Dagny Holle-Lee, Charly Gaul, Ulrike Bingel
Summary: This study aims to systematically investigate the impact of open-label placebo treatment on headache days in patients with migraine, analyzing various indicators such as pain intensity, quality of life, and brain connectivity to identify potential predictors of placebo responses.
Article
Clinical Neurology
Talieh Abedini, Reyhaneh Hosseyni, Farnaz Ghannadi, Hossein Sanjari Moghaddam, Mohammad-Reza Khodaei Ardakani, Ali Talaei, Shahin Akhondzadeh
Summary: This study suggests that palmitoylethanolamide can be an effective adjunctive medication in improving manic symptoms and clinical status in acute episodes of mania. However, further studies with larger sample sizes and longer follow-up therapy are needed to confirm these findings.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Nutrition & Dietetics
Sung-Ho Park, Eun Sil Lee, Sung Taek Park, Soo Young Jeong, Yeoul Yun, YongGyeong Kim, Yulah Jeong, Chang-Ho Kang, Hyun Jin Choi
Summary: Bacterial vaginosis (BV) is a common disease in women caused by abnormal microbiota growth in the vagina. This study evaluated the efficacy and safety of MED-01, a complex of five strains of probiotics, in improving vaginal health. The results showed that MED-01 significantly reduced the Nugent score and increased Lactobacillus plantarum while suppressing harmful bacteria after 12 weeks. No adverse events were observed. Therefore, MED-01 can be used as a probiotic for treating BV.
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Medicine, General & Internal
Mathias Ebbesen Jensen, Dea Siggaard Stenbaek, Tobias Sogaard Juul, Patrick MacDonald Fisher, Claus Thorn Ekstrom, Gitte Moos Knudsen, Anders Fink-Jensen
Summary: This study aims to investigate the efficacy of psilocybin-assisted therapy in treating alcohol use disorder and explore its potential neurobiological mechanisms. The results of this study may provide valuable insights into the use of psilocybin as a therapeutic option for alcohol addiction.