Review
Biochemistry & Molecular Biology
Adam W. Doelman, Femke Streijger, Steve J. A. Majerus, Margot S. Damaser, Brian K. Kwon
Summary: Neurogenic bladder dysfunction is a common condition after spinal cord injury, and animal models are crucial for studying its mechanisms and testing potential therapies. This review summarizes the use of animal models, particularly cystometry testing, in assessing SCI-related NLUTD. The advantages, disadvantages, and future research opportunities of different animal models are also discussed.
Review
Urology & Nephrology
Matthias Vanneste, Andrei Segal, Thomas Voets, Wouter Everaerts
Summary: Disruptions to sensory pathways in the lower urinary tract can lead to lower urinary tract symptoms (LUTS), and the molecular mechanisms underlying neuronal control of the bladder have been the focus of research. Transient receptor potential (TRP) channels play a key role in regulating bladder function by acting as molecular sensors in urothelial cells and afferent nerve fibres, and have the potential to be targeted for treating LUTS in functional disorders of the lower urinary tract.
NATURE REVIEWS UROLOGY
(2021)
Review
Environmental Sciences
Nelson T. Peterson, Chad M. Vezina
Summary: Lower urinary tract dysfunction (LUTD) is a common condition in men that imposes significant physical, mental, social, and financial burdens on society. However, research on the influence of environmental chemicals on LUTD is lacking. This review provides toxicologists with an overview of the disease process and the role of environmental chemicals in contributing to LUTD, using both men and male mice as research models.
Review
Urology & Nephrology
Nadine Binder, Holger Dette, Julia Franz, Daniela Zoeller, Rodrigo Suarez-Ibarrola, Christian Gratzke, Harald Binder, Arkadiusz Miernik
Summary: With the increasing number of treatment options, different combinations of treatment decisions lead to diverse treatment pathways. Lack of randomized controlled trial evidence necessitates the integration of evidence from routine clinical data. Statistical multi-state models offer a powerful framework for analyzing heterogeneous pathways.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Obstetrics & Gynecology
Iwona Gabriel, Allison F. Vitonis, Stacey A. Missmer, Ayotunde Fadayomi, Amy D. DiVasta, Kathryn L. Terry, Vatche A. Minassian
Summary: The objective of this study was to determine if women with endometriosis experience lower urinary tract symptoms (LUTSs) more often than those without. The study found that women with surgically confirmed endometriosis were more likely to report LUTS, including difficulty passing urine, still feeling full after urination, having to urinate again within minutes of urinating, dysuria, and pain when the bladder is full.
FERTILITY AND STERILITY
(2022)
Review
Urology & Nephrology
Stavros Gravas, Mauro Gacci, Christian Gratzke, Thomas R. W. Herrmann, Markos Karavitakis, Iason Kyriazis, Sachin Malde, Charalampos Mamoulakis, Malte Rieken, Vasileios I. Sakalis, Natasha Schouten, Mark J. Speakman, Kari A. O. Tikkinen, Jean-Nicolas Cornu
Summary: The 2023 version of the European Association of Urology guidelines presents evidence-based recommendations for the management of male lower urinary tract symptoms (LUTS). The guidelines emphasize the importance of comprehensive assessment and individualized treatment for patients. Treatment options include behavioral modification, medical therapy, and surgical management, with the choice depending on symptom type and patient expectations. These guidelines provide evidence-based guidance for the management of LUTS.
Review
Urology & Nephrology
Arjun K. Nambiar, Salvador Arlandis, Kari Bo, Hanny Cobussen-Boekhorst, Elisabetta Costantini, Monica de Heide, Fawzy Farag, Jan Groen, Markos Karavitakis, Marie Carmela Lapitan, Margarida Manso, Serenella Monagas Arteaga, Aisling Nic An Riogh, Eabhann O'Connor, Muhammad Imran Omar, Benoit Peyronnet, Veronique Phe, Vasileios Sakalis, Neha Sihra, Lazaros Tzelves, Mary-Lynne van Poelgeest-Pomfret, Tine W. L. van den Bos, Huub van der Vaart, Christopher K. Harding
Summary: This article summarizes the guidelines from the European Association of Urology on non-neurogenic female lower urinary tract symptoms and diseases. It provides recommendations for the diagnosis and management of female overactive bladder, stress urinary incontinence, and mixed urinary incontinence.
Review
Urology & Nephrology
Mauro Gacci, Vasileios Sakalis, Markos Karavitakis, Jean-Nicolas Cornu, Christian Gratzke, Thomas R. W. Herrmann, Iason Kyriazis, Sachin Malde, Charalampos Mamoulakis, Malte Rieken, Natasha Schouten, Emma J. Smith, Mark J. Speakman, Kari A. O. Tikkinen, Stavros Gravas
Summary: This 2022 European Association of Urology guideline summary provides updated information on the definition, pathophysiology, diagnosis, and treatment of male UI, and introduces treatment methods for different types of UI.
Review
Medicine, General & Internal
Seong Hyeon Yu, Seung Il Jung
Summary: Historically, urine was believed to be sterile, but recent studies have shown the presence of bacteria and microbial DNA in urine. This article focuses on the evidence of a microbial presence in urine and its association with lower urinary tract symptoms, particularly in men with benign prostate hyperplasia (BPH).
Article
Medicine, General & Internal
Yu-Chen Chen, Yin-Chi Liang, Shuo-Jung Ho, Hao-Wei Chen, Yung-Shun Juan, Wei-Chung Tsai, Shu-Pin Huang, Jung-Ting Lee, Yu-Peng Liu, Chung-Yao Kao, Yen-Ko Lin, Cheng-Yu Long, Meng-Ni Wu, Chao-Ju Chen, Wen-Jeng Wu
Summary: The study found that storage lower urinary tract symptoms may deteriorate after COVID-19 vaccination, with individuals pre-existing overactive bladder being more susceptible to worsening of storage LUTS post-vaccination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Jamison E. Montes de Oca, Michael P. Veve, Marcus J. Zervos, Rachel M. Kenney
Summary: This study compares the outcomes of Aminopenicillins (APs) and non-Aminopenicillins (NAPs) in treating enterococcal lower urinary tract infection (UTI). The results show that APs are non-inferior to NAPs and can be considered regardless of susceptibility results.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Obstetrics & Gynecology
Joseph T. Kowalski, Jonathan B. Wiseman, Abigail R. Smith, Margaret E. Helmuth, Anne Cameron, John O. L. DeLancey, Whitney K. Hendrickson, J. Eric Jelovsek, Anna Kirby, Karl Kreder, H. Henry Lai, Margaret Mueller, Nazema Siddiqui, Catherine S. Bradley
Summary: This study aimed to explore the association between pelvic organ prolapse and lower urinary tract symptoms, and to assess the changes in symptoms over 12 months. The results showed a positive association between prolapse and obstructive symptoms, and a negative association between overall lower urinary tract symptom severity and prolapse. Lower urinary tract symptom scores improved over 12 months regardless of prolapse status.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Urology & Nephrology
Hisae Nishii
Summary: As the elderly population with multiple comorbidities is increasing, the burden of LUTS will increase. Factors such as frailty and dementia should not be overlooked in the evaluation of elderly patients. Active case identification and multidisciplinary collaboration are recommended for better treatment and management.
INTERNATIONAL NEUROUROLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Anke K. Jaekel, Franziska I. Winterhagen, Federico L. Zeller, Anna-Lena Butscher, Franziska K. Knappe, Franziska Schmitz, Christopher Hauk, Johannes Stein, Ruth K. M. Kirschner-Hermanns, Stephanie C. Knuepfer
Summary: Neurogenic lower urinary tract dysfunction (NLUTD) is present in asymptomatic patients with multiple sclerosis (MS). Early diagnosis and treatment of NLUTD are recommended in MS patients. Bladder diary and urinary tract infections are correlated with NLUTD. Therefore, asymptomatic MS patients should be screened for NLUTD.
Review
Chemistry, Medicinal
Lukasz Dobrek
Summary: A potential complication of pharmacotherapy is the possibility of various drug side effects, which can cause diseases. Among the systemic side effects, there are also those involving the urinary tract. The use of certain drugs may increase the risk of urological disorders, such as urinary retention or incontinence, urinary tract infections, urolithiasis, erectile dysfunction, and retroperitoneal fibrosis.
Article
Urology & Nephrology
Gaetan Devos, Lorenzo Tosco, Marcella Baldewijns, Thomas Gevaert, Karolien Goffin, Valentin Petit, Cindy Mai, Annouschka Laenen, Yannic Raskin, Carl Van Haute, Lieven Goeman, Gert De Meerleer, Charlien Berghen, Wout Devlies, Frank Claessens, Hendrik Van Poppel, Wouter Everaerts, Steven Joniau
Summary: In this study, it was demonstrated that the combination of degarelix and apalutamide prior to radical prostatectomy significantly improved tumor response in high-risk prostate cancer patients compared to degarelix alone. These trial results provide a solid hypothesis-generating basis for neoadjuvant phase 3 trials to detect differences in long-term oncological outcomes.
Article
Urology & Nephrology
Henri Van Eecke, Gaetan Devos, Bram Vansevenant, Arthur Vander Stichele, Wout Devlies, Charlien Berghen, Wouter Everaerts, Gert De Meerleer, Steven Joniau
Summary: The study suggests that unilateral pelvic salvage lymph node dissection (sLND) may be sufficient in patients with unilateral pelvic lymph node recurrence on PET/CT imaging.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jose M. Abascal Junquera, Nina N. Harke, Jochen C. Walz, Boris Hadaschik, Jim Adshead, Wouter Everaerts, Karolien Goffin, Maarten R. Grootendorst, Francesca Oldfield, Kunal Vyas, Antoni Mestre Fusco, Nuria Juanpere, Sergi Vidal-Sicart, Lluis Fumado
Summary: This study evaluated the performance of a drop-in gamma probe for SLND in PCa patients. The probe successfully detected sentinel lymph nodes in all patients, outperforming the rigid laparoscopic gamma probe. No adverse events or false-negative cases were reported.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jan Daniluk, Thomas Voets
Summary: TRPV1 antagonists have pH-dependent effects on channel inhibition, but their modality selectivity is not strict. The antagonistic efficacy of TRPV1 antagonists is limited at acidic pH, which may restrict their analgesic efficacy in injured tissues.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Lena-Luise Becker, Denise Horn, Felix Boschann, Evelien Van Hoeymissen, Thomas Voets, Joris Vriens, Christine Prager, Angela M. Kaindl
Summary: DEE-SWAS is an age-dependent disease that causes cognitive decline. This study reports on two children with DEE-SWAS and developmental delay/regression, who had missense variants in the TRPM3 gene. Treatment with primidone improved their developmental regression, psychomotor development, and eliminated CSWS.
Article
Pharmacology & Pharmacy
Noemie Luyts, Jan Daniluk, Ana Cristina Nogueira Freitas, Bahar Bazeli, Annelies Janssens, Marie Mulier, Wouter Everaerts, Thomas Voets
Summary: In this study, the effect of Phenazopyridine (PAP) on pain-related Transient Receptor Potential (TRP) channels was investigated. The results showed that PAP can rapidly and reversibly inhibit the cold and menthol sensitivity of TRPM8 channels. This suggests that the inhibition of TRPM8 may be the mechanism underlying the analgesic activity of PAP.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Editorial Material
Urology & Nephrology
Thomas Van den Broeck, Steven Joniau, Wouter Everaerts
Review
Oncology
Alexander Giesen, Loic Baekelandt, Wout Devlies, Gaetan Devos, Herlinde Dumez, Wouter Everaerts, Frank Claessens, Steven Joniau
Summary: This review provides a comprehensive overview of the synergistic effect of maximal androgen receptor (AR) blockade through the combination of an AR signaling inhibitor (ARSI) and a poly-(ADP-ribose)-polymerase (PARP) inhibitor (PARPi) in both homologous recombination repair (HRR)-mutated and HRR-non-mutated prostate cancer (PCa) patients. The inhibition of PARP enhances the effect of ARSI by preventing the repair of single-strand DNA breaks and inducing the accumulation of DNA double-strand breaks. This leads to apoptosis in the HRR-deficient state induced by combining androgen deprivation therapy (ADT) with ARSI.
FRONTIERS IN ONCOLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Helene De Bruyn, Noemie Luyts, Thomas Voets, Wouter Everaerts
JOURNAL OF UROLOGY
(2022)
Meeting Abstract
Urology & Nephrology
Jose Maria Abascal Junquera, Nuria Juanpere, Marta Corcoy, Maria Yolanda Aguilar, Jochen Christoph Walz, Wouter Everaerts, Karolien Goffin, Maarten Ruben Grootendorst, Francesca Oldfield, Antoni Mestre Fusco, Sergi Vidal-Sicart, Lluis Fumado
JOURNAL OF UROLOGY
(2022)
Meeting Abstract
Urology & Nephrology
N. Luyts, H. De Bruyn, T. Voets, W. Everaerts
Meeting Abstract
Urology & Nephrology
P. Ost, S. Siva, R. Heikkila, P. Dirix, N. Liefhooghe, F-X Otte, A. Gomez-Iturriaga, W. Everaerts, M. Shelan, A. Conde-Moreno, F. Lopez Campos, A. Papachristofilou, M. Guckenberger, M. Scorsetti, A. Zapatero, A-E Villafranca Iturre, C. Eito, F. Counago, P. Muto, L. Van De Voorde, V Fonteyne, D. Reynders, T. Zilli
Meeting Abstract
Oncology
T. Zilli, S. Siva, R. Heikkila, P. Dirix, N. Liefhooghe, F. Otte, A. Gomez-Iturriaga, W. Everaerts, M. Shelan, A. Conde-Moreno, F. Lopez Campos, A. Papachristofilou, M. Guckenberger, M. Scorsetti, A. Zapatero, A. Villafranca Iturre, C. Eito, F. Counago, P. Muto, L. Van De Voorde, V. Fonteyne, D. Moon, K. Thon, C. Mercier, V. Achard, K. Stellamans, E. Goetghebeur, D. Reynders, P. Ost
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
C. Berghen, A. Laenen, R. De Roover, D. Dierickx, S. Joniau, K. Rans, W. Crijns, E. Baten, H. Dumez, W. Everaerts, G. De Meerleer
RADIOTHERAPY AND ONCOLOGY
(2022)