Allosteric interactions at adenosine A1and A3receptors: new insights into the role of small molecules and receptor dimerization

A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin

(2015) Stefania Merighi et al.   NEOPLASIA

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling

(2013) P. Charukeshi Chandrasekera et al.   CELLULAR SIGNALLING

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

(2013) Ross Corriden et al.   EMBO REPORTS

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

(2013) Sofia Cristóvão-Ferreira et al.   Purinergic Signalling

The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation

(2012) M.C. Peeters et al.   BIOCHEMICAL PHARMACOLOGY

The new oral adenosine A1 receptor agonist capadenoson in male patients with stable angina

(2012) Michal Tendera et al.   Clinical Research in Cardiology

Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A1receptors in naive and chronic epileptic rats

(2012) Zin-Juan Klaft et al.   EPILEPSIA

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

(2012) Eduard Gracia et al.   FASEB JOURNAL

Recombinant Ecto-5′-Nucleotidase (CD73) Has Long Lasting Antinociceptive Effects That are Dependent on Adenosine A1 Receptor Activation

(2012) Nathaniel A Sowa et al.   Molecular Pain

Studies of a ubiquitous receptor family

(2012) Bryan L. Roth et al.   NATURE

Functional selectivity of adenosine A1 receptor ligands?

(2012) Ellen V. Langemeijer et al.   Purinergic Signalling

New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors

(2012) Ross Corriden et al.   Purinergic Signalling

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

Functionally biased modulation of A3 adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers

(2011) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Biased signalling and allosteric machines: new vistas and challenges for drug discovery

(2011) Terry P Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics

(2011) Lauren T. May et al.   FASEB JOURNAL

Structural aspects of M3 muscarinic acetylcholine receptor dimer formation and activation

(2011) Jianxin Hu et al.   FASEB JOURNAL

Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H1Receptor

(2011) Chris de Graaf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

(2011) Eneko Urizar et al.   Nature Chemical Biology

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Partial adenosine A1 receptor agonists for cardiovascular therapies

(2011) Barbara E. Albrecht-Küpper et al.   Purinergic Signalling

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Allosteric modulation of adenosine receptors

(2010) Anikó Göblyös et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Recent developments in adenosine receptor ligands and their potential as novel drugs

(2010) Christa E. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Oligomeric Size of the M2Muscarinic Receptor in Live Cells as Determined by Quantitative Fluorescence Resonance Energy Transfer

(2010) Luca F. Pisterzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

(2010) S. Cohen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anticonvulsant action of 2-chloroadenosine against pentetrazol-induced seizures in immature rats is due to activation of A1 adenosine receptors

(2010) P. Mareš   JOURNAL OF NEURAL TRANSMISSION

Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators

(2010) C. Valant et al.   MOLECULAR PHARMACOLOGY

Antagonist Selective Modulation of Adenosine A1 and A3 Receptor Pharmacology by the Food Dye Brilliant Black BN: Evidence for Allosteric Interactions

(2010) L. T. May et al.   MOLECULAR PHARMACOLOGY

The Effect of Allosteric Modulators on the Kinetics of Agonist-G Protein-Coupled Receptor Interactions in Single Living Cells

(2010) L. T. May et al.   MOLECULAR PHARMACOLOGY

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

(2010) Nanna Goldman et al.   NATURE NEUROSCIENCE

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons

(2010) Sarah E Street et al.   NEUROPSYCHOPHARMACOLOGY

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

(2010) J. A. Hern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Pirenzepine Promotes the Dimerization of Muscarinic M1 Receptors through a Three-step Binding Process

(2009) Brigitte Ilien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors

(2009) Adam J. Kuszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Series of 2,4-Disubstituted Quinolines as a New Class of Allosteric Enhancers of the Adenosine A3Receptor

(2009) Laura H. Heitman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Modulators of the Adenosine A1Receptor: Synthesis and Pharmacological Evaluation of 4-Substituted 2-Amino-3-benzoylthiophenes

(2009) Luigi Aurelio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins

(2009) Terry P. Kenakin   TRENDS IN PHARMACOLOGICAL SCIENCES

Plasma membrane diffusion of g protein-coupled receptor oligomers

(2008) Stephen J. Briddon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

cAMP: fuel for extracellular adenosine formation?

(2008) A Gödecke   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1Adenosine Receptor

(2008) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human adenosine deaminase as an allosteric modulator of human A1adenosine receptor: abolishment of negative cooperativity for [3H](R)-pia binding to the caudate nucleus

(2008) Eduard Gracia et al.   JOURNAL OF NEUROCHEMISTRY

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers

(2007) Luigi Aurelio et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Skeletal muscle expresses the extracellular cyclic AMP-adenosine pathway

(2007) T Chiavegatti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor

(2006) Mark R Dowling et al.   BRITISH JOURNAL OF PHARMACOLOGY