期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 171, 期 4, 页码 811-813出版社
WILEY-BLACKWELL
DOI: 10.1111/bph.12571
关键词
bone remodeling; cancer; cardiovascular diseases; inflammatory diseases; immune system; midkine; neural diseases; neurogenesis; oocyte maturation; renal diseases
资金
- Grants-in-Aid for Scientific Research [23390078] Funding Source: KAKEN
Midkine is a multifunctional factor and has anti-apoptotic, migration-promoting, angiogenic, anti-microbial and other activities. Midkine ameliorates ischemic injury in the heart and brain, enhances oocyte maturation, and is involved in neurogenesis. On the other hand, midkine is an important factor in the etiology of various diseases, especially those with inflammatory backgrounds. Furthermore, midkine is overexpressed in most malignant tumors and plays roles in their invasive phenotypes as well as in their resistance to chemotherapeutics. Therefore, midkine itself is expected to be useful for the treatment of brain and heart diseases, while midkine inhibitors are promising for the treatment of malignant tumors, multiple sclerosis, restenosis, renal diseases, hypertension and osteoporosis. Blood levels of midkine are also expected to be helpful as disease markers, especially as cancer markers. Linked ArticlesThis article is part of a themed section on Midkine. To view the other articles in this section visit
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据