Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using anin vitrospinal cord injury model

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

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Effects of combining methylprednisolone with rolipram on functional recovery in adult rats following spinal cord injury

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Rolipram promotes remyelination possibly via MEK-ERK signal pathway in cuprizone-induced demyelination mouse

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The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant following Spinal Cord Injury

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The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination

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Elucidation of a Structural Basis for the Inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4)

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Functional Duality of Astrocytes in Myelination

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A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury

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Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs

(2010) Therese Keravis et al.   CURRENT PHARMACEUTICAL DESIGN

Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats

(2010) Yvette S. Nout et al.   EXPERIMENTAL NEUROLOGY

A model for ex vivo spinal cord segment culture—A tool for analysis of injury repair strategies

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Putting the lid on phosphodiesterase 4

(2010) Miles D Houslay et al.   NATURE BIOTECHNOLOGY

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

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Effects of rolipram on adult rat oligodendrocytes and functional recovery after contusive cervical spinal cord injury

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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

PDE4 inhibitors: current status

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Myelinated, synapsing cultures of murine spinal cord - validation as anin vitromodel of the central nervous system

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Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axonsin vitro

(2008) Annette Sorensen et al.   GLIA

Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration

(2008) Andrew J. Murray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury

(2008) Christopher M. Whitaker et al.   NEUROSCIENCE LETTERS

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

(2008) E. Huston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury

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