Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients

Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence

(2012) Yi Ling Teo et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeted Therapies for Renal Cell Carcinoma: Review of Adverse Event Management Strategies

(2012) T. Eisen et al.   JNCI-Journal of the National Cancer Institute

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Bioactivation of Glafenine by Human Liver Microsomes and Peroxidases: Identification of Electrophilic Iminoquinone Species and GSH Conjugates

(2011) B. Wen et al.   DRUG METABOLISM AND DISPOSITION

Investigation of Isomeric Transformations of Chlorogenic Acid in Buffers and Biological Matrixes by Ultraperformance Liquid Chromatography Coupled with Hybrid Quadrupole/Ion Mobility/Orthogonal Acceleration Time-of-Flight Mass Spectrometry

(2011) Cen Xie et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile

(2010) X. Li et al.   DRUG METABOLISM AND DISPOSITION

Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib

(2010) W. C. Teng et al.   MOLECULAR PHARMACOLOGY

Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Gefitinib: Implications for Pulmonary and Hepatic Toxicities

(2009) Xiaohai Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Characterization of Dasatinib and Its Structural Analogs as CYP3A4 Mechanism-Based Inactivators and the Proposed Bioactivation Pathways

(2009) X. Li et al.   DRUG METABOLISM AND DISPOSITION

Sorafenib and Sunitinib

(2009) A. Kim et al.   ONCOLOGIST

Bioactivation of Lumiracoxib by Peroxidases and Human Liver Microsomes: Identification of Multiple Quinone Imine Intermediates and GSH Adducts

(2008) Ping Kang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

Multicenter, Phase II Trial of Sunitinib in Previously Treated, Advanced Non–Small-Cell Lung Cancer

(2008) Mark A. Socinski et al.   JOURNAL OF CLINICAL ONCOLOGY

Dasatinib-induced acute hepatitis

(2008) A. Bonvin et al.   LEUKEMIA & LYMPHOMA

Sunitinib-Related Fulminant Hepatic Failure: Case Report and Review of the Literature

(2008) Eric W Mueller et al.   PHARMACOTHERAPY

Amodiaquine-induced oxidative stress in a hepatocyte inflammation model

(2008) Shahrzad Tafazoli et al.   TOXICOLOGY

Drug Insight: gastrointestinal and hepatic adverse effects of molecular-targeted agents in cancer therapy

(2008) Yohann Loriot et al.   Nature clinical practice. Oncology