Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates

Docetaxel metabolism is not altered by imatinib: findings from an early phase study in metastatic breast cancer

(2011) Roisin M. Connolly et al.   BREAST CANCER RESEARCH AND TREATMENT

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prediction of time-dependent CYP3A4 drug–drug interactions by physiologically based pharmacokinetic modelling: Impact of inactivation parameters and enzyme turnover

(2011) K. Rowland Yeo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes

(2010) Noelia Nebot et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeted Cancer Therapies in the Twenty-First Century: Lessons From Imatinib

(2010) F Stegmeier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Managing imatinib resistance in chronic myeloid leukaemia

(2010) Michael Osborn et al.   CURRENT OPINION IN HEMATOLOGY

Seeking the causes and solutions to imatinib-resistance in chronic myeloid leukemia

(2010) D Bixby et al.   LEUKEMIA

Imatinib in the treatment of solid tumours

(2009) Florence Duffaud et al.   Targeted Oncology

In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1

(2008) Bertrand Rochat et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia

(2008) S. Dulucq et al.   BLOOD

Effects of imatinib (Glivec) on the pharmacokinetics of metoprolol, a CYP2D6 substrate, in Chinese patients with chronic myelogenous leukaemia

(2008) Yanfeng Wang et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Population Pharmacokinetics and Pharmacogenetics of Imatinib in Children and Adults

(2008) A. Petain et al.   CLINICAL CANCER RESEARCH

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

(2008) Jiansong Yang et al.   CURRENT DRUG METABOLISM

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

(2008) J. Houston et al.   CURRENT DRUG METABOLISM

Grapefruit Juice-Drug Interaction Studies as a Method to Assess the Extent of Intestinal Availability: Utility and Limitations

(2008) Michael Gertz et al.   CURRENT DRUG METABOLISM

Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods

(2008) Kenneth H. Grime et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES