Review
Pharmacology & Pharmacy
Nicholas Dale
Summary: This review emphasizes the importance of real-time measurements of extracellular ATP and adenosine concentrations, provides additional mechanistic insights, and outlines current techniques available for spatially localized measurements. The examples of CO2 and nutrient sensing highlight the impact of direct real-time measurements, demonstrating the role of purinergic signaling in breathing control, weight regulation, and sleep-wake state. Additionally, the complex mechanisms of activity-dependent adenosine release in different brain regions are discussed, underscoring the potential of whole blood purine measurements in clinical practice.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alice McDouall, Kelly Q. Zhou, Laura Bennet, Colin R. Green, Alistair J. Gunn, Joanne O. Davidson
Summary: Perinatal brain injury, caused by hypoxia-ischemia and/or infection/inflammation, is a major cause of disability. Despite the effectiveness of therapeutic hypothermia, additional interventions are needed as nearly half of the infants still have adverse outcomes. Recent studies have shown that brain injury spreads over time from the initial site to previously unaffected regions, partly due to the opening of connexin hemichannels and pannexin channels. Blockade of these channels has demonstrated neuroprotective effects in animal models, suggesting their potential as targeted interventions in combination or separate from therapeutic hypothermia.
Article
Multidisciplinary Sciences
Ross Luu, Silvana Valdebenito, Eliana Scemes, Antonio Cibelli, David C. Spray, Maximiliano Rovegno, Juan Tichauer, Andrea Cottignies-Calamarte, Arielle Rosenberg, Calude Capron, Sandrine Belouzard, Jean Dubuisson, Djillali Annane, Geoffroy Lorin de la Grandmaison, Elisabeth Cramer-Borde, Morgane Bomsel, Eliseo Eugenin
Summary: The study found that SARS-CoV-2 induces a more significant and prolonged opening of Panx-1 channels compared to other viruses, leading to increased release of ATP, PGE(2), and IL-1 beta. Therefore, the Panx-1 channel is considered a critical factor in SARS-CoV-2 infection and could be a potential alternative therapy.
Article
Medicine, Research & Experimental
Carina Herman de Sousa, Maria Adelina Costa, Rafaela Pedro Silva, Fatima Ferreirinha, Severino Ribeiro, Paulo Correia-de-Sa
Summary: This study demonstrates for the first time the overexpression of Panx1 in HSCF induced by A(2A)R, indirectly implicating ATP release in the fibrogenic vicious cycle operated by adenosine accumulating in subcutaneous tissue fibrosis and myofascial pain associated with dermal inflammation.
Article
Neurosciences
Javier Gonzalez Sanabria, Maximiliano Hurtado Paso, Tamara Frontera, Adriana Losavio
Summary: ATP and adenosine modulate neurotransmitter release at the mouse neuromuscular junction by activating different types of receptors. Depending on the frequency and pattern of stimulation, endogenous purines can fine-tune neurosecretion in response to repetitive stimulation of the phrenic nerve.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Connor D. Courtney, Courtney Sobieski, Charu Ramakrishnan, Robbie J. Ingram, Natalia M. Wojnowski, R. Anthony DeFazio, Karl Deisseroth, Catherine A. Christian-Hinman
Summary: Astrocytes play a crucial role in modulating synaptic transmission and can respond to local synaptic activity. Researchers have used a viral vector called Opto alpha 1AR to selectively activate G protein signaling pathways in astrocytes. It was found that high-frequency light stimulation of Opto alpha 1AR can increase both inhibitory and excitatory synaptic currents, while low-frequency stimulation does not have the same effect. This study highlights the importance of temporal dynamics in manipulating astrocyte function using optical tools.
Article
Neurosciences
Lorenzo Di Cesare Mannelli, Laura Micheli, Chiara Cervetto, Alessandra Toti, Elena Lucarini, Carmen Parisio, Manuela Marcoli, Carla Ghelardini
Summary: The role of interleukin 1 alpha (IL-1 alpha) in the interaction between neurons and astrocytes has been studied, and it has been found to have a protective effect. Treatment with IL-1 alpha can reduce the mortality of neurons when co-cultured with astrocytes. In rat experiments, IL-1 alpha treatment can alleviate hypersensitivity and pain caused by neuropathy. IL-1 alpha can also decrease the release of endogenous glutamate induced by neurotoxicity by reducing extracellular ATP and increasing the release of transforming growth factor beta 1.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Hyun-Bum Kim, Jacqueline Morris, Kevin Miyashiro, Tonis Lehto, Ulo Langel, James Eberwine, Jai-Yoon Sul
Summary: The research found that astrocytes can generate a stronger calcium signal response after acute ethanol exposure, primarily influenced by neuronally-derived purinergic signaling. Astrocytes adapt to the effects of ethanol by modulating the activity of adenylyl cyclase and phospholipase C, highlighting their important role in shaping the overall physiological responsiveness to ethanol.
Review
Chemistry, Multidisciplinary
Ning-ning Zhang, Yi Zhang, Zhen-zhen Wang, Nai-hong Chen
Summary: This review summarizes the role of connexin 43 (Cx43) in the pathogenesis of depression. Studies have shown that dysfunction of Cx43 is associated with depression and regulating the expression of Cx43 can influence depressive behaviors. The review also discusses the effects of antidepressants on Cx43.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Neurosciences
Rachel Naomi Curry, Isamu Aiba, Jochen Meyer, Brittney Lozzi, Yeunjung Ko, Malcolm Ford McDonald, Anna Rosenbaum, Alexis Cervantes, Emmet Huang-Hobbs, Carolina Cocito, Jeffrey Peter Greenfield, Ali Jalali, Jay Gavvala, Carrie Mohila, Akdes Serin Harmanci, Jeffrey Noebels, Ganesh Rao, Benjamin Deneen
Summary: Seizures are a common feature of malignant glioma and recent studies have found that peritumoral synaptic dysregulation plays a role in brain hyperactivity and tumor progression. Through single-cell RNA sequencing and patient ECoG recordings, this study shows that seizure patients have enriched gene signatures related to synapse formation in their tumors. The gene IGSF3 is identified as a mediator of glioma progression and dysregulated neural circuitry, leading to spreading depolarization. Further investigation reveals that IGSF3 interacts with Kir4.1 to suppress potassium buffering and seizure patients have reduced expression of potassium handlers in proliferating tumor cells. In vivo imaging confirms that dysregulated synaptic activity originates from the tumor-neuron interface, validating findings in patients. This study highlights the importance of ion dyshomeostasis in tumor progression and seizures.
Article
Neurosciences
Daniela Madeira, Liliana Dias, Patricia Santos, Rodrigo A. Cunha, Paula M. Canas, Paula Agostinho
Summary: The study identifies a feed-forward loop involving astrocytic A(2A)R and Cx43 hemichannels, where A(2A)R increases Cx43 hemichannel activity leading to increased ATP release, which is converted into adenosine by CD73, sustaining the increased astrocytic A(2A)R activity in AD-like conditions.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sahel Motaghi, Hadi Moghaddam Dizaj Herik, Gholamreza Sepehri, Mehdi Abbasnejad, Saeed Esmaeli-Mahani
Summary: The study found that Salicylic acid has anxiolytic and hypnotic effects in animal models, partially exerting its anxiolytic effect through up-regulating GAD1 gene expression in the ventral part of the hippocampus.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Clinical Neurology
Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Cherie Amalie Waldorff Nielsen, Messoud Ashina
Summary: This study investigated the effect of the K-ATP channel blocker glibenclamide on levcromakalim-induced headache in healthy volunteers and found that glibenclamide did not attenuate levcromakalim-induced headache. Future studies should further explore the role of different isoforms of sulfonylurea receptor subunits of K-ATP channels in the pathogenesis of headache and migraine.
Article
Physiology
Simon Schemke, Cor de Wit
Summary: Functional hyperemia in skeletal muscle during exercise involves various mechanisms including adenosine, endothelial autacoids, and K-ATP channels. Muscular contractions and NO release are essential for arteriolar dilation induced by motor nerve stimulation, suggesting redundant mechanisms for coordinated response in the network.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cristian A. Hernandez, Eliseo A. Eugenin
Summary: This article describes the potential therapeutic role of Pannexin-1/purinergic approaches in preventing or reducing the devastating consequences of pathogens such as HIV and SARS-CoV-2.
CURRENT OPINION IN PHARMACOLOGY
(2023)
Article
Neurosciences
Gergely Farkas Turi, Wen-Ke Li, Spyridon Chavlis, Ioanna Pandi, Justin O'Hare, James Benjamin Priestley, Andres Daniel Grosmark, Zhenrui Liao, Max Ladow, Jeff Fang Zhang, Boris Valery Zemelman, Panayiota Poirazi, Attila Losonczy
Article
Cell Biology
Preeti Mehta, Lauren Kreeger, Dennis C. Wylie, Jagruti J. Pattadkal, Tara Lusignan, Matthew J. Davis, Gergely F. Turi, Wen-Ke Li, Matthew P. Whitmire, Yuzhi Chen, Bridget L. Kajs, Eyal Seidemann, Nicholas J. Priebe, Attila Losonczy, Boris V. Zemelman
Article
Cell Biology
Hai Yin Hu, Dennis L. H. Kruijssen, Catia P. Frias, Balazs Rozsa, Casper C. Hoogenraad, Corette J. Wierenga
Article
Spectroscopy
Attila Jancso, Ervin Kovacs, Levente Cseri, Balazs J. Rozsa, Gabor Galbacs, Imre G. Csizmadia, Zoltan Mucsi
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2019)
Article
Multidisciplinary Sciences
Gabor Orban, Domokos Meszena, Kinga Reka Tasnady, Balazs Rozsa, Istvan Ulbert, Gergely Marton
Article
Agricultural Engineering
Moritz Zurn, Gergo Toth, Marta Kraszni, Anna Solyomvary, Zoltan Mucsi, Ruth Deme, Balazs Rozsa, Blanka Fodor, Ibolya Molnar-Perl, Kata Horvati, Szilvia Bosze, Bernadett Palyi, Zoltan Kis, Szabolcs Beni, Bela Noszal, Imre Boldizsar
INDUSTRIAL CROPS AND PRODUCTS
(2019)
Article
Neurosciences
Tristan Geiller, Bert Vancura, Satoshi Terada, Eirini Troullinou, Spyridon Chavlis, Grigorios Tsagkatakis, Panagiotis Tsakalides, Katalin Ocsai, Panayiota Poirazi, Balazs J. Rozsa, Attila Losonczy
Article
Biology
Vanessa Lage-Rupprecht, Li Zhou, Gaia Bianchini, S. Sara Aghvami, Max Mueller, Balazs Rozsa, Marco Sassoe-Pognetto, Veronica Egger
Article
Multidisciplinary Sciences
Attila Kaszas, Gergely Szalay, Andrea Slezia, Alexandra Bojdan, Ivo Vanzetta, Balazs Hangya, Balazs Rozsa, Rodney O'Connor, David Moreau
Summary: Infrared neural stimulation is a promising tool for exciting the brain with high spatial precision without the need for exogenous agents. Studies have shown that this method can induce intracellular calcium signals in mouse cortex neurons, with the number of neurons responding and signal amplitude increasing with the energy density applied. Achieving reproducible stimulation mainly in the central part of the infrared beam path opens up possibilities for various applications in neuroscience and brain research.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Balazs Chiovini, Denes Palfi, Myrtill Majoros, Gabor Juhasz, Gergely Szalay, Gergely Katona, Milan Szori, Orsolya Frigyesi, Csilla Lukacsne Haveland, Gabor Szabo, Ferenc Erdelyi, Zoltan Mate, Zoltan Szadai, Miklos Madarasz, Miklos Dekany, Imre G. Csizmadia, Ervin Kovacs, Balazs Rozsa, Zoltan Mucsi
Summary: This paper introduces a new cage-GABA compound, iDMPO-DNI-GABA, which is currently the only photoreagent for GABA uncaging without experimental compromises. Through systematic theoretical design and synthesis, the best reagent exhibits high two-photon efficiency within the 700-760 nm range, demonstrating excellent pharmacological properties suitable for complex epileptic studies.
Article
Multidisciplinary Sciences
Tristan Geiller, Sadra Sadeh, Sebastian V. Rolotti, Heike Blockus, Bert Vancura, Adrian Negrean, Andrew J. Murray, Balazs Rozsa, Franck Polleux, Claudia Clopath, Attila Losonczy
Summary: Using in vivo electroporation and optogenetic manipulation, this study investigated the dynamic interaction between place cells in the hippocampus and their microcircuitry. It identified a local circuit mechanism in CA1 that allows spatial selectivity of individual place cells to propagate within functionally recurrent subnetworks, inducing inverse selectivity and recruiting functionally coupled place cells at specific locations. This local circuit plasticity amplifies spatial selectivity of single CA1 neurons, enabling effective multi-neuronal representations without degrading feedforward input structure.
Article
Biology
Zoltan Szadai, Hyun-Jae Pi, Quentin Chevy, Katalin Ocsai, Dinu F. Albeanu, Balazs Chiovini, Gergely Szalay, Gergely Katona, Adam Kepecs, Balazs Rozsa
Summary: This study identified a type of inhibitory neuron that is recruited by rewards and punishments and is activated throughout the cortex. The global response mode of these neurons may support a specific circuit mechanism that regulates reward and punishment information in local processing and plasticity.
Article
Computer Science, Artificial Intelligence
Eirini Troullinou, Grigorios Tsagkatakis, Spyridon Chavlis, Gergely F. Turi, Wenke Li, Attila Losonczy, Panagiotis Tsakalides, Panayiota Poirazi
Summary: Identification of neuronal cell types is crucial for understanding brain functions, but traditional methods face challenges. A novel approach using neuronal activity instead of molecular or cellular features achieved automated classification with unprecedented accuracy.
IEEE TRANSACTIONS ON EMERGING TOPICS IN COMPUTATIONAL INTELLIGENCE
(2021)
Article
Multidisciplinary Sciences
Erzsebet Farkas, Edina Varga, Balazs Kovacs, Anett Szilvasy-Szabo, Antonieta Cote-Velez, Zoltan Peterfi, Magdalini Matziari, Monika Toth, Dora Zelena, Zsolt Mezriczky, Andrea Kadar, Dora Kovari, Masahiko Watanabe, Masanobu Kano, Ken Mackie, Balazs Rozsa, Yvette Ruska, Blanka Toth, Zoltan Mate, Ferenc Erdelyi, Gabor Szabo, Balazs Gereben, Ronald M. Lechan, Jean-Louis Charli, Patricia Joseph-Bravo, Csaba Fekete
Article
Neurosciences
Mary J. Donahue, Attila Kaszas, Gergely F. Turi, Balazs Rozsa, Andrea Slezia, Ivo Vanzetta, Gergely Katona, Christophe Bernard, George G. Malliaras, Adam Williamson