Animal models of schizophrenia

Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment

(2011) David J. G. Watson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Influence of social isolation in the rat on serotonergic function and memory – Relevance to models of schizophrenia and the role  of 5-HT6 receptors

(2011) Charles A. Marsden et al.   NEUROPHARMACOLOGY

A Primate Model of Schizophrenia Using Chronic PCP Treatment

(2011) C.V. Mao et al.   REVIEWS IN THE NEUROSCIENCES

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

(2010) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning

(2010) Andrew W. Cassidy et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat

(2010) Samantha L. McLean et al.   BEHAVIOURAL BRAIN RESEARCH

Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABAA receptor binding

(2010) Richard J. Beninger et al.   BEHAVIOURAL PHARMACOLOGY

Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology

(2010) Bagrat Abazyan et al.   BIOLOGICAL PSYCHIATRY

The “Anhedonia Paradox” in Schizophrenia: Insights from Affective Neuroscience

(2010) Diego A. Pizzagalli   BIOLOGICAL PSYCHIATRY

Reduced Dysbindin Expression Mediates N-Methyl-D-Aspartate Receptor Hypofunction and Impaired Working Memory Performance

(2010) Katherine H. Karlsgodt et al.   BIOLOGICAL PSYCHIATRY

Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring

(2010) Hiroshi T. Ito et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of prenatal infection on brain development and behavior: A review of findings from animal models

(2010) Patricia Boksa   BRAIN BEHAVIOR AND IMMUNITY

Neonatal exposure to MK-801, an N-methyl-d-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats

(2010) Takashi Uehara et al.   BRAIN RESEARCH

Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia

(2010) F. Liu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Cognitive impairment following prenatal immune challenge in mice correlates with prefrontal cortical AKT1 deficiency

(2010) Byron K. Y. Bitanihirwe et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Phencyclidine withdrawal disrupts episodic-like memory in rats: reversal by donepezil but not clozapine

(2010) Romain Le Cozannet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The environment and schizophrenia

(2010) Jim van Os et al.   NATURE

Selective deficits in spatial working memory in the neonatal ventral hippocampal lesion rat model of schizophrenia

(2010) Anne Marie Brady et al.   NEUROPHARMACOLOGY

Late Prenatal Immune Activation in Mice Leads to Behavioral and Neurochemical Abnormalities Relevant to the Negative Symptoms of Schizophrenia

(2010) Byron KY Bitanihirwe et al.   NEUROPSYCHOPHARMACOLOGY

Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats

(2010) M.N. Quan et al.   NEUROSCIENCE

Increased dopaminergic activity in socially isolated rats: An electrophysiological study

(2010) Katrine Fabricius et al.   NEUROSCIENCE LETTERS

Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat

(2010) Trisha A. Jenkins et al.   NEUROSCIENCE LETTERS

Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

(2010) Joanna C. Neill et al.   PHARMACOLOGY & THERAPEUTICS

Neuropathological and Reelin Deficiencies in the Hippocampal Formation of Rats Exposed to MAM; Differences and Similarities with Schizophrenia

(2010) Julien Matricon et al.   PLoS One

Phenotypic Characterization of Transgenic Mice Overexpressing Neuregulin-1

(2010) Taisuke Kato et al.   PLoS One

The environment and susceptibility to schizophrenia

(2010) Alan S. Brown   PROGRESS IN NEUROBIOLOGY

The mGluR2/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat

(2010) Caitlin A. Jones et al.   PSYCHOPHARMACOLOGY

Mutant Mouse Models: Phenotypic Relationships to Domains of Psychopathology and Pathobiology in Schizophrenia

(2010) C. M. P. O'Tuathaigh et al.   SCHIZOPHRENIA BULLETIN

MATERNAL LIPOPOLYSACCHARIDE ADMINISTRATION LEADS TO DEVELOPMENTAL ALTERATIONS IN HIPPOCAMPAL NEURONAL DENSITY AND EXPRESSION OF CORTICAL DOPAMINERGIC RECEPTORS IN RAT OFFSPRING

(2010) Moogeh Baharnoori et al.   SCHIZOPHRENIA RESEARCH

Ultrasonic vocalisations explain unexpected effects on pre-pulse inhibition responses in rats chronically pre-treated with phencyclidine

(2009) Beth Tunstall et al.   BEHAVIOURAL BRAIN RESEARCH

Neonatal ventral hippocampal lesions in male and female rats: Effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood

(2009) Richard J. Beninger et al.   BEHAVIOURAL BRAIN RESEARCH

Evaluation of NMDA receptor models of schizophrenia: Divergences in the behavioral effects of sub-chronic PCP and MK-801

(2009) Alexandre Seillier et al.   BEHAVIOURAL BRAIN RESEARCH

Gestational methylazoxymethanol acetate administration: A developmental disruption model of schizophrenia

(2009) Daniel J. Lodge et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat

(2009) Claire E. McKibben et al.   BEHAVIOURAL BRAIN RESEARCH

Mutant models for genes associated with schizophrenia

(2009) Lieve Desbonnet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Neonatal Phencyclidine Treatment in Mice Induces Behavioral, Histological and Neurochemical Abnormalities in Adulthood

(2009) Akiko Nakatani-Pawlak et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions

(2009) Richard S. Ehrlichman et al.   BRAIN RESEARCH

Effects of quetiapine on phencyclidine-induced cognitive deficits in mice: A possible role of α1-adrenoceptors

(2009) Yuko Tanibuchi et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats

(2009) Maria Sabrina Spano et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Potential application as screening and drug designing tools of cytoarchitectural deficiencies present in three animal models of schizophrenia

(2009) Alfredo Bellon et al.   Expert Opinion on Drug Discovery

Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background

(2009) M. M. Cox et al.   GENES BRAIN AND BEHAVIOR

Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation

(2009) Maarten van den Buuse et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Subchronic Effects of Phencyclidine on Dopamine and Serotonin Receptors: Implications for Schizophrenia

(2009) Yong Kee Choi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Activation of dopamine D1 receptors blocks phencyclidine-induced neurotoxicity by enhancingN-methyl-D-aspartate receptor-mediated synaptic strength

(2009) Gang Lei et al.   JOURNAL OF NEUROCHEMISTRY

A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia

(2009) D. J. Lodge et al.   JOURNAL OF NEUROSCIENCE

Chronic infusion of PCP via osmotic mini-pumps: A new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance

(2009) Christian Spang Pedersen et al.   JOURNAL OF NEUROSCIENCE METHODS

Attenuation of Phencyclidine-Induced Object Recognition Deficits by the Combination of Atypical Antipsychotic Drugs and Pimavanserin (ACP 103), a 5-Hydroxytryptamine2A Receptor Inverse Agonist

(2009) S. Snigdha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field

(2009) SL McLean et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine

(2009) W. Michael Bullock et al.   NEUROCHEMISTRY INTERNATIONAL

The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-d-aspartate and D1 receptor binding in rats

(2009) C. Toua et al.   NEUROSCIENCE

Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation

(2009) A.W. Cassidy et al.   NEUROSCIENCE

In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders

(2009) Urs Meyer et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Oral administration of l-serine reduces the locomotor activity of socially isolated rats

(2009) Kazutaka Shigemi et al.   NEUROSCIENCE LETTERS

Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia

(2009) Daniel J. Lodge et al.   NEUROTOXICITY RESEARCH

Behavioral Perturbations After Prenatal Neurogenesis Disturbance in Female Rat

(2009) Franck Hazane et al.   NEUROTOXICITY RESEARCH

Altered adult locomotor activity in rats from phencyclidine treatment on postnatal days 7, 9 and 11, but not repeated ketamine treatment on postnatal day 7

(2009) Sherin Y. Boctor et al.   NEUROTOXICOLOGY

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

(2009) Jared W. Young et al.   PHARMACOLOGY & THERAPEUTICS

Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats

(2009) Xiaohong Zhao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Epidemiology-driven neurodevelopmental animal models of schizophrenia

(2009) Urs Meyer et al.   PROGRESS IN NEUROBIOLOGY

Long-term effects of neonatal MK-801 treatment on prepulse inhibition in young adult rats

(2009) Takashi Uehara et al.   PSYCHOPHARMACOLOGY

Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting

(2009) Brian Villumsen Broberg et al.   PSYCHOPHARMACOLOGY

Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT6 and 5-HT2A receptor mechanisms

(2009) Nagi Idris et al.   PSYCHOPHARMACOLOGY

Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models With Patients and Nongenetic Models

(2009) Hanna Jaaro-Peled et al.   SCHIZOPHRENIA BULLETIN

Cognition in Mouse Models of Schizophrenia Susceptibility Genes

(2009) P. A. Arguello et al.   SCHIZOPHRENIA BULLETIN

Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia

(2009) C. M. P. O'Tuathaigh et al.   SCHIZOPHRENIA BULLETIN

Modeling the Positive Symptoms of Schizophrenia in Genetically Modified Mice: Pharmacology and Methodology Aspects

(2009) M. van den Buuse   SCHIZOPHRENIA BULLETIN

Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation

(2009) Julia J. Turnock-Jones et al.   SYNAPSE

Increased dopamine D2Highreceptors in rats reared in social isolation

(2009) Madeleine V. King et al.   SYNAPSE

Effects of subchronic phencyclidine (PCP) treatment on social behaviors and operant discrimination and reversal learning in C57BL/6J mice

(2009) Jonathan L. Brigman   Frontiers in Behavioral Neuroscience

Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1.

(2008) Liesl Duffy et al.   BEHAVIORAL NEUROSCIENCE

Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat

(2008) Trisha A. Jenkins et al.   BEHAVIOURAL BRAIN RESEARCH

A sensitizing regimen of amphetamine that disrupts attentional set-shifting does not disrupt working or long-term memory

(2008) Robert E. Featherstone et al.   BEHAVIOURAL BRAIN RESEARCH

Behavioral characterization of dysbindin-1 deficient sandy mice

(2008) Sanjeev K. Bhardwaj et al.   BEHAVIOURAL BRAIN RESEARCH

The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia

(2008) Kuei Y. Tseng et al.   BEHAVIOURAL BRAIN RESEARCH

Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins

(2008) Alasdair M. Barr et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Repeated low dose of phencyclidine administration impairs spatial learning in mice: Blockade by clozapine but not by haloperidol

(2008) Simret Beraki et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Schizophrenia: From developmental deviance to dopamine dysregulation

(2008) Robin M. Murray et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

GLT-1 expression and Glu uptake in rat cerebral cortex are increased by phencyclidine

(2008) Giorgia Fattorini et al.   GLIA

DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release

(2008) Xiao-Wei Chen et al.   JOURNAL OF CELL BIOLOGY

Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice

(2008) Daisuke Ibi et al.   JOURNAL OF NEUROCHEMISTRY

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

(2008) S. Shen et al.   JOURNAL OF NEUROSCIENCE

Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats

(2008) SL McLean et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

(2008) Nicole C Allen et al.   NATURE GENETICS

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

Neonatal ventral hippocampus lesions disrupt extra-dimensional shift and alter dendritic spine density in the medial prefrontal cortex of juvenile rats

(2008) Jean-Philippe Marquis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Effects of neonatal repeated MK-801 treatment on delayed nonmatching-to-position responses in rats

(2008) Kouichi Kawabe et al.   NEUROREPORT

Effects of social isolation rearing on the limbic brain: A combined behavioral and magnetic resonance imaging volumetry study in rats

(2008) M.I. Schubert et al.   NEUROSCIENCE

Interaction between N-methyl-d-aspartic acid receptors and D1 dopamine receptors: An important mechanism for brain plasticity

(2008) L. Scott et al.   NEUROSCIENCE

Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval

(2008) Boyer D. Winters et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

(2008) Kevin C.F. Fone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neonatal NMDA receptor antagonist treatments have no effects on prepulse inhibition of postnatal day 25 Sprague–Dawley rats

(2008) Sherin Y. Boctor et al.   NEUROTOXICOLOGY

Atypical anti-schizophrenic drugs prevent changes in cortical N-methyl-d-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups

(2008) N ANASTASIO et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment

(2008) Nurith Amitai et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

(2008) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice

(2008) Elisa Ognibene et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats

(2008) Alice Egerton et al.   PSYCHOPHARMACOLOGY

A neurocognitive animal model dissociating between acute illness and remission periods of schizophrenia

(2008) Martin Sarter et al.   PSYCHOPHARMACOLOGY

Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study

(2008) Pascal Goetghebeur et al.   PSYCHOPHARMACOLOGY

Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration

(2008) Nurith Amitai et al.   PSYCHOPHARMACOLOGY

Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors

(2008) Taku Nagai et al.   PSYCHOPHARMACOLOGY

Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia

(2008) Y FENG et al.   SCHIZOPHRENIA RESEARCH

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

(2008) T. Walsh et al.   SCIENCE

Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats

(2008) Claire Bloomfield et al.   SYNAPSE

Cognitive Impairment in Schizophrenia: a Review of Developmental and Genetic Models, and Pro-cognitive Profile of the Optimised D3 > D2 Antagonist, S33138

(2008) Mark J. Millan et al.   THERAPIE

Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

(2008) Keizo Takao et al.   Molecular Brain

Postweaning social isolation enhances morphological changes in the neonatal ventral hippocampal lesion rat model of psychosis

(2007) Glenda Alquicer et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Differential regulation of the NMDA receptor by acute and sub-chronic phencyclidine administration in the developing rat

(2007) Noelle C. Anastasio et al.   JOURNAL OF NEUROCHEMISTRY

Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats

(2007) D.T. Malone et al.   NEUROSCIENCE

Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague–Dawley rats: A locomotor activity and gene induction study

(2007) Mikhail Kalinichev et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients

(2007) Cynthia Shannon Weickert et al.   SCHIZOPHRENIA RESEARCH