Review
Cardiac & Cardiovascular Systems
Ahmed Elsanhoury, Carsten Tschoepe, Sophie Van Linthout
Summary: Myocarditis is a multifactorial disorder with inflammatory reaction triggered by infectious agents, and the treatment aims to eliminate chronic inflammation and preserve cardiac function. The use of systemic immunosuppressants may lead to harmful side effects.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Immunology
Michelle F. Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A. Chung, E. William St Clair, Gerald T. Nepom, Dawn E. Smilek
Summary: The article reviews concepts evolved from the clinical trial experience of the Immune Tolerance Network, focusing on lessons learned from innovative mechanistic studies and new strategies for tolerance induction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Vipula R. Bataduwaarachchi, S. M. N. Hansanie, Neesha Rockwood, Leon Gerard D'Cruz
Summary: Epidemiological studies have shown a high prevalence of tuberculosis among chronic opioid users. Opioids have immunomodulatory properties that could contribute to immunosuppression and the development or reactivation of tuberculosis. Blocking specific immune pathways may play a critical role in causing tuberculosis among chronic morphine users.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
A. S. M. Ali Reza, Samima Nasrin, Amjad Hossen, Atiar Rahman, Ibrahim Jantan, Md Areeful Haque, Eduardo Sobarzo-Sanchez
Summary: Medicinally important plant-foods offer a balanced immune function and can protect the body from antigenic invasion. Plant-based secondary metabolites have emerged as high potential immunomodulators for immune defense and cellular immunoresponsiveness. Phytochemicals such as alkaloids and flavonoids are responsible for the immunomodulatory effects of medicinal plants.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Engineering, Environmental
Mario Alberto Burgos-Aceves, Haitham G. Abo-Al-Ela, Caterina Faggio
Summary: Humans and wildlife are exposed to a variety of compounds, including plasticizers, which can disrupt endocrine and immune function. The presence of plastic debris in the environment is a growing concern. Studies have shown that plasticizers can cause mitochondrial dysfunction and immunosuppression, highlighting the need for further research on their impact on immune responses.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Qinmei Sun, Zhonghao Li, Zijing Wang, Qisheng Wang, Fenfen Qin, Haotian Pan, Weixin Lin, Xinru Mu, Yuxuan Wang, Yongwei Jiang, Jianjian Ji, Zhigang Lu
Summary: Opioids are effective analgesics for pain treatment, but they have immunosuppressive side effects that are often overlooked. Long-term opioid use can increase the risk of opportunistic infections. Understanding the molecular mechanism of opioids in immunosuppression can lead to effective therapeutic interventions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Adam E. Lynch, Leslie R. Noble, Catherine S. Jones, Edwin J. Routledge
Summary: This study developed an in vitro toolkit to investigate the impacts of common aquatic pollutants on the immune responses of B. glabrata, a freshwater mollusc. The results suggest that pollutants may alter innate immune responses in B. glabrata and potentially impact the dynamics of parasite transmission between molluscs and humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Sotaro Fujisawa, Shiro Murata, Masayoshi Isezaki, Shwe Yee Win, Takumi Sato, Eiji Oishi, Akira Taneno, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi
Summary: The poultry red mite is a serious threat to poultry farms and can cause various health problems in chickens, leading to a reduction in productivity. Infestation with these mites induces inflammatory and hemostatic reactions in the host, while the mites secrete immunosuppressants to suppress the host immune response. This study found that PRM infestation increases the expression of anti-inflammatory cytokines and immune checkpoint molecules, thus suppressing the host's immune response.
Review
Immunology
Hildegund C. J. Ertl
Summary: Adeno-associated virus (AAV)-mediated gene transfer has shown benefits in treating patients with inherited diseases like hemophilia B, but challenges remain due to potential rejection of AAV-transduced cells. Immunosuppression may prevent rejection in some patients. CD8(+) T cells induced by AAV infections may recognize AAV vector's capsids and eliminate cells expressing degraded capsid antigens, or AAV vectors themselves may induce de novo T cell responses, particularly at high doses. This chapter discusses strategies to prevent activation of CD8(+) T cell responses to AAV infections and gene transfer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Qin Zhao, Miusi Shi, Chengcheng Yin, Zifan Zhao, Jinglun Zhang, Jinyang Wang, Kailun Shen, Lingling Zhang, Hua Tang, Yin Xiao, Yufeng Zhang
Summary: The study reveals that biomaterials, such as biphasic calcium phosphate scaffolds, can promote osteogenesis by modulating the immune responses of macrophages and dendritic cells. This demonstrates that specific regulatory capacities for immune cells in biomaterials can control early inflammatory responses of implanted materials and induce bone formation.
NANO-MICRO LETTERS
(2021)
Article
Immunology
Daniel Mrak, Felix Kartnig, Daniela Sieghart, Elisabeth Simader, Helga Radner, Peter Mandl, Lisa Goeschl, Philipp Hofer, Thomas Deimel, Irina Gessl, Renate Kain, Stefan Winkler, Josef S. Smolen, Thomas Perkmann, Helmuth Haslacher, Daniel Aletaha, Leonhard X. Heinz, Michael Bonelli
Summary: A study found that patients under immunosuppression experienced a rapid decline in antibodies after the third COVID-19 vaccine dose, and it remains unclear whether immunosuppressive therapy affects immune responses. Monitoring the immune response and adverse events in 50 immunosuppressed patients and 42 healthy controls, it was observed that immunosuppressed patients had significantly lower antibody levels, suggesting the need for an early fourth vaccination.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Food Science & Technology
Chia-Chien Hsieh, Yen-Fang Wang, Pin-Yu Lin, Shih-Han Peng, Mei-Jia Chou
Summary: The study revealed that lunasin can reduce inflammation levels in obese mice, decrease macrophage infiltration in adipose tissue, and regulate spleen size and cell numbers. Additionally, lunasin promotes the production of interferon gamma and interleukin-2 in splenocytes, thus modulating immune responses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Immunology
Jialing Peng, Jingrui Pan, Hongxuan Wang, Jingjing Mo, Lihuan Lan, Ying Peng
Summary: This study reveals that morphine activates insufficient mitophagy in microglia, regulated by NLRX1, ultimately leading to host immunosuppression and susceptibility in the brain.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Oncology
Bilal A. Siddiqui, Brian F. Chapin, Sonali Jindal, Fei Duan, Sreyashi Basu, Shalini S. Yadav, Ai-Di Gu, Alexsandra B. Espejo, Michelle Kinder, Curtis A. Pettaway, John F. Ward, Rebecca S. S. Tidwell, Patricia Troncoso, Paul G. Corn, Christopher J. Logothetis, Roland Knoblauch, Natalie Hutnick, Marco Gottardis, Charles G. Drake, Padmanee Sharma, Sumit K. Subudhi
Summary: This study aimed to explore the safety and efficacy of Daratumumab and edicotinib in the treatment of localized prostate cancer. The results showed that these two drugs were safe to use and did not induce complete remission. However, Daratumumab treatment led to a decreased frequency of CD38(+) immune cells in prostate tumors, bone marrow, and peripheral blood mononuclear cells (PBMCs), while edicotinib did not consistently affect CSF-1R(+) immune cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Inderjeet Kalia, Rajesh Anand, Afshana Quadiri, Shreya Bhattacharya, Bijayalaxmi Sahoo, Agam Prasad Singh
Summary: By manipulating macrophages, the Plasmodium parasite evades host immune responses, utilizing the PbTIP protein released in the host bloodstream to suppress inflammation and upregulate anti-inflammatory cytokines, ultimately leading to successful infection in the host.
FRONTIERS IN IMMUNOLOGY
(2021)