Article
Biochemistry & Molecular Biology
Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang, Zhe Chen, Xuan Lv, Zan Huang, Yuanlong Xie, Lin Cai
Summary: This study elucidates the importance of the Bhlhe40 gene in osteoclast differentiation and osteoporosis, and identifies the Bhlhe40/c-Fos/Nfatc1 axis as a mechanism involved in regulating osteoclastogenesis. Modulating Bhlhe40 may rescue osteoporosis caused by estrogen deficiency and aging, potentially providing a new therapeutic strategy for the treatment of osteoporosis.
CELL AND BIOSCIENCE
(2022)
Article
Immunology
Mei-Tzu Su, Karin Ono, Dai Kezuka, Shotaro Miyamoto, Yu Mori, Toshiyuki Takai
Summary: The interaction between LILRB4/gp49B and Fibronectin plays a crucial role in osteoclastogenesis, negatively regulating the signaling pathway induced by RANKL and inhibiting osteoclast formation.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhihao Chen, Mina Ding, Eunjin Cho, Jihyoun Seong, Sunwoo Lee, Tae-Hoon Lee
Summary: 2-NPPA has a strong inhibitory effect on osteoclastogenesis, reducing bone resorption activity and preventing the occurrence of bone diseases. It significantly inhibits the phosphorylation of NF-kappa B and c-fos in cell signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fujun Jin, Yexuan Zhu, Meijing Liu, Rongze Wang, Yi Cui, Yanting Wu, Gang Liu, Yifei Wang, Xiaogang Wang, Zhe Ren
Summary: In this study, Babam2 was identified as an essential negative regulator of osteoclast formation and bone resorption. It interacts with Hey1 to inhibit Nfatc1 transcription, thus negatively regulating osteoclastogenesis. Targeting Babam2 may be a novel therapeutic approach for osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Ziang Xie, Yizheng Wu, Yang Shen, Jiandong Guo, Putao Yuan, Qingliang Ma, Shiyu Wang, Zhiwei Jie, Hongyi Zhou, Shunwu Fan, Shuai Chen
Summary: This study reveals that USP7 functions as a negative regulator of osteoclast formation by inhibiting TRAF6 ubiquitination and suppressing NF-kappa B and MAPKs activation. USP7 also protects STING from degradation, inducing IFN-beta expression and inhibiting osteoclastogenesis cooperatively with the classical TRAF6 pathway. USP7 inhibition accelerates bone resorption, while its overexpression impairs osteoclast differentiation.
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Virology
Constanza E. Espada, Corine St Gelais, Serena Bonifati, Victoria V. Maksimova, Michael P. Cahill, Sun Hee Kim, Li Wu
Summary: SAMHD1 restricts HIV-1 replication by limiting the intracellular dNTP pool and suppresses NF-kappa B activation. This suppression is modulated by TRAF6 and TAK1, which play key roles in mediating the negative regulation of the NF-kappa B pathway by SAMHD1.
JOURNAL OF VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Linjie Ju, Peipei Hu, Ping Chen, Jiejie Wu, Zhuoqun Li, Zhixia Qiu, Jun Cheng, Fang Huang
Summary: The study showed that CSBTA can alleviate cancer-induced bone pain and inhibit osteoclastogenesis, possibly through suppressing RANKL-induced NF-kappa B and c-Fos/NFATc1 pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Mihyang Kim, Mihwa Park
Summary: This study investigated the effects of I. sinicola extract (ISE) on estrogen deficiency-induced bone loss and osteoclastogenesis. The results showed that ISE improved bone density, trabecular bone structure, and bone biomechanical properties. Moreover, ISE exhibited inhibitory effects on osteoclast formation.
Article
Biochemistry & Molecular Biology
Xinying Zhou, Zelin Zhang, Hui Xu, Bo Zhu, Lijie Zhang, Linmiao Lie, Yingqi Huang, Xialin Du, Honglin Liu, Yanfen Li, Yulan Huang, Shengfeng Hu, Chaoying Zhou, Qian Wen, Mailkel P. Pepplenbosch, Li Ma
Summary: Viperin protein is increased in abundance in patients with lymphatic and pulmonary tuberculosis (TB), and its deficiency reduces mycobacterium tuberculosis bacterial loads and enhances macrophage responses. Viperin promotes Mtb infection by inhibiting host innate immune responses in macrophages.
Article
Biochemistry & Molecular Biology
Seong-Sik Kim, Soon-Pill Jeong, Bong-Soo Park, In-Ryoung Kim
Summary: Melatonin inhibits osteoclast differentiation and cell fusion by inhibiting the expression of Atp6v0d2 through the inactivation of MAPK and NFATc1 signaling in RANKL-stimulated RAW264.7 macrophages, suggesting its potential role in bone health.
Article
Neurosciences
Michael Ohene-Nyako, Amanda L. Persons, T. Celeste Napier
Summary: Combined antiretroviral therapy for HIV infection can reduce plasma viral load and prolong life, but the brain remains a viral reservoir with pathologies such as cognitive decline and blood-brain barrier disruption. Methamphetamine abuse is common among HIV-infected individuals and both methamphetamine and HIV toxic proteins can disrupt the blood-brain barrier, potentially involving common pathways such as NF-kappa B/MMP-9 in inducing barrier damage.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sung-Hoon Lee, Shin-Young Park, Jung Ha Kim, Nacksung Kim, Junwon Lee
Summary: Ginsenoside Rg2 inhibits RANKL-induced osteoclast differentiation and suppresses the expression of osteoclast markers through the regulation of MAPK signaling. Therefore, it could be developed as a therapeutic drug for osteoporosis.
Article
Oncology
Chang-Young Cho, Se Hwang Kang, Byung-Chan Kim, Tae-Kyu Kim, Jae-Hyun Kim, Minsun Kim, Youngjoo Sohn, Hyuk-Sang Jung
Summary: Medical and economic developments have led to a longer human lifespan, resulting in a global increase in the elderly population. Osteoporosis, a common geriatric disease, can cause fractures and seriously impact the quality of life. Current treatments for osteoporosis have severe side effects, necessitating the development of therapeutic agents with fewer side effects.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Chen-Yi Tang, He Wang, Yan Zhang, Zhongliang Wang, Guochun Zhu, Abigail McVicar, Yi-Ping Li, Wei Chen
Summary: The GPCR125 gene is highly expressed in osteoclasts and positively regulates osteoclast formation and function through RANKL-stimulated MAPK and AKT-NF-kappa B signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)