Article
Food Science & Technology
Ji-Eun Lee, Jae Hoon Lee, Byungrok Min, Kee-Tae Kim, Dong Uk Ahn, Hyun- Dong Paik
Summary: This study found that phosphovitins phosphopeptides (PPPs) have immunostimulatory effects on RAW 264.7 macrophages by activating the TLR2-mediated MAPK signaling pathway, increasing nitric oxide (NO) production, and enhancing the expression and secretion of pro-inflammatory cytokines (TNF-α and IL-6).
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Chiara De Stefani, Marzia Vasarri, Maria Cristina Salvatici, Lucia Grifoni, Jose Carlos Quintela, Anna Rita Bilia, Donatella Degl'Innocenti, Maria Camilla Bergonzi
Summary: The study formulated oleanolic acid (OA) into two different microemulsions (ME-1 and ME-2) to enhance its solubility and intestinal permeability, leading to a significant increase in bioavailability. Both MEs showed enhanced intestinal permeability compared to free OA according to PAMPA assay results. The study suggests that MEs could be a promising formulation to improve the oral bioavailability of OA with potential clinical applications.
Article
Biochemistry & Molecular Biology
Hyun-Ju Han, Chang-Gu Hyun
Summary: The anticoagulant drug acenocoumarol has the potential as a repurposed medication for the treatment of chronic inflammatory diseases. It can decrease the production of inflammatory mediators and cytokines by inhibiting the NF-kappa B and MAPK signaling pathways, leading to attenuated macrophage activation and reduced inflammation.
Article
Biotechnology & Applied Microbiology
Won-Ju Kim, Hyung-Seok Yu, Na-Kyoung Lee, Hyun-Dong Paik
Summary: Levilactobacillus brevis KU15151 has anti-inflammatory potential by inhibiting aLTA-induced inflammation. By suppressing related signaling pathways and reducing the generation of reactive oxygen species, this strain may help prevent inflammatory disorders.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Chemistry, Medicinal
Yukino Tsunekage, Masatoshi Takeiri, Yuri Yoshioka, Shinichi Matsumura, Yoshihide Kimura, Kohsuke Kataoka
Summary: Extract from watercress suppresses osteoclast differentiation and function through inhibition of key signaling pathways and gene expression, showing potential anti-osteoporosis effects.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Chang-Ho Kang, Jin-Seong Kim, Hyemin Kim, Hye Min Park, Nam-Soo Paek
Summary: The study found that heat-killed lactic acid bacteria have immunomodulatory functions and antioxidant activity, making them suitable for use as probiotics. Heat treatment of strains can prolong the shelf-life of probiotic foods and significantly inhibit the expression of nitric oxide synthase and cyclooxygenase-2.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Chemistry, Medicinal
Aysegul Alyamac, Cansu Ozel-Tasci, Sukru Gulec
Summary: Ankaferd Blood Stopper (ABS) is a medicinal plant extract with anti-inflammatory properties. The study showed that ABS can suppress COX-2 mRNA expression in Caco-2 cells, indicating a potential protective and therapeutic effect for colonic inflammation.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Chemistry, Medicinal
Arachchige Maheshika Kumari Jayasinghe, Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Kil-Nam Kim, Jae-Young Oh, Ginnae Ahn
Summary: This study demonstrates the protective effect of low molecular weight fucoidan (FSSQ) isolated from Sargassum siliquastrum on lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW 264.7 macrophages. FSSQ increases cell viability while reducing reactive oxygen species production, iNOS and COX-2 expression, as well as NO and prostaglandin E-2 production. FSSQ also downregulates L-1 beta, IL-6, and TNF-alpha expression via modulation of MAPK and NF-kappa B signaling.
Article
Biochemistry & Molecular Biology
Mengshan Liu, Zhen Zhang, Qianqian He, Shizhou Qi, Kunlai Sun, Shuang Miao, Yan Wu, Kaikai Gong
Summary: Two new naphthyridine compounds, 4-methoxycarbonyl-5-oxo-1,6-naphthyridine (1) and 5-methoxycarbonyl-4-oxo-1,6-naphthyridine (2), were isolated from the MeOH extracts of sponge Aaptos suberitoides. Their structures were determined by spectroscopic methods, and compound 1 was further confirmed by X-ray diffraction analysis. Compound 1 showed inhibitory effects on NO production and reduced the expression of pro-inflammatory mediators in LPS-induced macrophages through the MAPK and Nrf2/HO-1 signaling pathways.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Pharmacology & Pharmacy
Abayomi M. Ajayi, Benneth Ben-Azu, Sikiru O. Balogun, Ruberlei Godinho de Oliveira, Solomon Umukoro, Domingos Tabajara de Oliveira, Olusegun G. Ademowo
Summary: This study demonstrated the potential anti-inflammatory effects of Ocimum gratissimum L. The extract induced apoptosis in activated macrophages and reduced inflammatory responses provoked by LPS in rats, suggesting its therapeutic value in treating inflammation.
ADVANCES IN TRADITIONAL MEDICINE
(2022)
Article
Plant Sciences
Jia-Ying Wu, Jian-Hua Xie, Ying-Jie Chen, Xiu-Qiong Fu, Rui-Jun Wang, Yu-Yi Deng, Shuo Wang, Hai-Xia Yu, Chun Liang, Zhi-Ling Yu
Summary: The study investigates the anti-inflammatory effects of an ethanolic extract of Vernonia amygdalina (VA) leaves, demonstrating that the extract ameliorates TPA-induced mouse ear edema by suppressing ERK/STAT3 (Ser727) signaling and reducing inflammatory protein expression.
Article
Plant Sciences
Jose-Luis Rios, Rosa M. Giner, Marta Marin, M. Carmen Recio
Article
Plant Sciences
Isabel Andujar, Alberto Marti-Rodrigo, Rosa Maria Giner, Jose Luis Rios, Maria Carmen Recio
Article
Microbiology
Javier Roig, Maria L. Saiz, Alicia Galiano, Maria Trelis, Fernando Cantalapiedra, Carlos Monteagudo, Elisa Giner, Rosa M. Giner, M. C. Recio, Dolores Bernal, Francisco Sanchez-Madrid, Antonio Marcilla
FRONTIERS IN MICROBIOLOGY
(2018)
Review
Plant Sciences
Jose-Luis Rios, Isabel Andujar, Guillermo R. Schinella, Flavio Francini
Article
Food Science & Technology
Gabriel Lopez-Garcia, Antonio Cilla, Reyes Barbera, Amparo Alegria, Maria C. Recio
Article
Chemistry, Multidisciplinary
E. Goya-Jorge, T. Q. Doan, M. L. Scippo, M. Muller, R. M. Giner, S. J. Barigye, R. Gozalbes
SAR AND QSAR IN ENVIRONMENTAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Elizabeth Goya-Jorge, Fatma Abdmouleh, Laureano E. Carpio, Rosa M. Giner, Maite Sylla-Iyarreta Veitia
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Letter
Dermatology
Patricia Garcia-Martinez, Victor Collado-Diaz, Almudena Mateu-Puchades, Carlos Villarroel-Vicente, Susana Rovira-Llopis, Ana Blas-Garcia, Angeles Alvaez, Juan Vicente Esplugues, Isabel Andujar
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Elizabeth Goya-Jorge, Maria Elisa Jorge Rodriguez, Maite Sylla-Iyarreta Veitia, Rosa M. Giner
Summary: The aryl hydrocarbon receptor (AhR) is a crucial transcription factor in health and disease, particularly in cancer, immunology, inflammatory conditions, and aging. Flavonoids, the largest group of natural AhR ligands in the human diet, have complex modulatory effects on AhR that need further investigation to understand their potentially harmful and beneficial effects. Flavonoids exhibit tissue, organ, and species-specific activities on AhR, suggesting potential benefits in pharmacotherapy.
Article
Nutrition & Dietetics
Montana Camara, Rosa Maria Giner, Elena Gonzalez-Fandos, Esther Lopez-Garcia, Jordi Manes, Maria P. Portillo, Magdalena Rafecas, Laura Dominguez, Jose Alfredo Martinez
Summary: Food-Based Dietary Guidelines (FBDG) from different countries around the world share common principles but show significant differences in recommended amounts, reflecting diverse cultural and dietary preferences among nations.
Review
Chemistry, Medicinal
Isabel Andujar, Juan Esplugues, Patricia Garcia-Martinez
Summary: Psoriasis is associated with a higher incidence of cardiovascular disease, especially in moderate to severe cases. Severe psoriasis confers a 25% increase in relative risk of cardiovascular disease, regardless of traditional risk factors. The exact mechanism linking psoriasis to increased cardiovascular risk is unclear, but atherosclerosis is emerging as a possible link between skin and vascular affection.
Article
Nutrition & Dietetics
Carmen Rubio, Montana Camara, Rosa Maria Giner, Maria Jose Gonzalez-Munoz, Esther Lopez-Garcia, Francisco J. Morales, M. Victoria Moreno-Arribas, Maria P. Portillo, Elena Bethencourt
Summary: The consumption of energy drinks worldwide is increasing, along with concerns about potential health risks. This study assesses the exposure to caffeine, taurine, and D-glucuronolactone in energy drinks in different scenarios and consumer profiles, and characterizes the risks through the evaluation of intake levels and safety margins. The findings suggest the need for managing these risks and establishing consumption recommendations and restrictions.
Meeting Abstract
Pharmacology & Pharmacy
R. M. Giner, E. Giner-Ventura, R. Zanni, S. Manez, J. L. Rios, M. Carmen Recio
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2018)
Meeting Abstract
Pharmacology & Pharmacy
I Andujar, P. Garcia-Martinez, V Collado-Diaz, A. Mateu-Puchades, N. Alcon, E. Lopez-Fernandez, A. Blas-Garcia, A. Alvarez, J. Esplugues
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2018)