期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 157, 期 2, 页码 179-194出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1476-5381.2009.00148.x
关键词
antisense oligonucleotides; siRNA; pharmacokinetics; cell penetration; nanoparticles; microparticles; controlled release
Antisense oligonucleotides and small interfering RNA have enormous potential for the treatment of a number of diseases, including cancer. However, several impediments to their widespread use as drugs still have to be overcome: in particular their lack of stability in physiological fluids and their poor penetration into cells. Association with or encapsulation within nano- and microsized drug delivery systems could help to solve these problems. In this review, we describe the progress that has been made using delivery systems composed of natural or synthetic polymers in the form of complexes, nanoparticles or microparticles.
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