Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zaipul I. Md Dom, Caterina Pipino, Bozena Krolewski, Kristina O'Neil, Eiichiro Satake, Andrzej S. Krolewski
Summary: The study identified a kidney risk inflammatory signature (KRIS) consisting of 6 TNF receptors and 11 inflammatory proteins, which were found to be strongly associated with end-stage kidney disease (ESKD). In vitro experiments showed that TNF alpha stimulation affected the expression of KRIS proteins in human umbilical vein endothelial cells (HUVECs), while exposure to a hyperglycemic and inflammatory environment led to up-regulation of a distinct set of proteins.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Ryan Ha, Yoav Keynan, Zulma Vanessa Rueda
Summary: Immunomodulators like TNF inhibitors are used to treat autoimmune conditions but increase the risk of infections. Different types of TNF inhibitors have varying immunosuppressive effects and infection risks. Mycobacterium tuberculosis, Legionella pneumophila, and Pneumocystis jirovecii are common pathogens associated with TNF inhibitor-associated infections. Other immunomodulators and host-directed treatments can influence these infections and mitigate their severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Serena Patel, Meenu Wadhwa
Summary: The global outbreak of COVID-19 has caused significant devastation, with uncertainties around vaccine development highlighting the need for effective therapeutic agents. Research has shown promise in repurposing tumor necrosis factor blocker therapy, typically used in rheumatoid arthritis and inflammatory bowel disease, for reducing inflammation in COVID-19 patients and potentially preventing disease progression. Randomized controlled trials are ongoing to assess the benefit-risk profile of such interventions in COVID-19 therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Peripheral Vascular Disease
Abdoulaye Issotina Zibrila, Zheng Wang, Md Ahasan Ali, James Ampofo Osei, Yuyao Sun, Salman Zafar, Kaili Liu, Chunfang Li, Yuming Kang, Jinjun Liu
Summary: The study showed that PYR alleviated hypertension and other symptoms of preeclampsia in rat models by inhibiting TNF-α synthesis and directly counteracting its detrimental effects. This suggests that PYR may be a potential agent for preeclampsia management and warrants further investigation.
JOURNAL OF HYPERTENSION
(2021)
Article
Biotechnology & Applied Microbiology
Mustafa Ozkan, Nurullah Gunay, Elif Funda Sener, Ozgur Karcioglu, Reyhan Tahtasakal, Fatma Dal, Nahide Ekici Gunay, Abdullah Tuncay Demiryurek
Summary: The study revealed significant associations between TNF gene (-308G/A, rs1800629) and NOS3 gene -786T/C (rs2070744) polymorphisms with susceptibility to sepsis in the Turkish population. No significant associations were found with other polymorphisms studied in this research.
JOURNAL OF GENE MEDICINE
(2021)
Article
Oncology
Emma Newport, Ana Rita Pedrosa, Delphine Lees, Matthew Dukinfield, Edward Carter, Jesus Gomez-Escudero, Pedro Casado, Vinothini Rajeeve, Louise E. Reynolds, Pedro R. Cutillas, Stephen W. Duffy, Beatriz De Luxan Delgado, Kairbaan Hodivala-Dilke
Summary: The study identified the impact of EC FAK kinase activity on tumor cell sensitivity to DNA-damaging therapies, suggesting a modulation of tumor growth and chemotherapy response.
JOURNAL OF PATHOLOGY
(2022)
Article
Immunology
Xin Ma, Wenyang Xia, Yang Zong, Chaolai Jiang, Haojie Shan, Yiwei Lin, Fuli Yin, Nan Wang, Lihui Zhou, Gen Wen, Zubin Zhou
Summary: In S. aureus infection and osteomyelitis patients, TNF-a and miR-129-5p are upregulated while eNOS is downregulated, with miR-129-5p targeting eNOS. The signaling cascade of TNF-a/miR-129-5p/eNOS may play a crucial role in the pathogenesis of osteomyelitis.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Medicine, Research & Experimental
Daan C. H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A. H. Jan Danser, Ron H. J. Mathijssen, Jorie Versmissen
Summary: In the past two decades, novel anti-cancer therapies such as VEGFIs and ICIs have significantly improved treatment outcomes for a wide range of malignancies, but they are also associated with specific cardiovascular toxicities. Combining these two therapies may become an important direction for future treatment strategies, but it also poses an increased risk of cardiovascular toxicity, requiring close monitoring and evaluation by specialized teams.
Article
Pharmacology & Pharmacy
Tzu-Ling Tseng, Wen-Yueh Ho, Po-Jui Huang, Jin-Zhi Liao, Kuan-Han Lee
Summary: The study successfully synthesized OroA from baicalin using a one-pot reaction and demonstrated the positive effects of OroA and OroA-OET on vascular function, promoting vasorelaxation responses.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jose A. Adams, Jose R. Lopez, Arkady Uryash, Marvin A. Sackner
Summary: The study demonstrates that pGz can improve sepsis-induced cardiomyocyte dysfunction and reduce pro-inflammatory response. This could potentially benefit outcomes in patients with sepsis.
Article
Physiology
N. O. El-Shaer, W. B. El Gazzar, M. M. Allam, H. M. Anwer
Summary: The study found that ghrelin exerts cardioprotective effects through promoting the eNOS/Nrf2/HO-1 pathway, significantly improving oxidative stress injury and inflammation, preserving cardiac muscle tissue morphology, and ameliorating ECG changes.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Louis M. Chu, Shazhad Shaefi, James D. Byrne, Rodrigo W. Alves de Souza, Leo E. Otterbein
Summary: The relationship between carbon monoxide and the heart has been extensively studied, with the FDA focusing on potential negative effects. However, data from clinical trials suggest that CO is safe for use and may have cardioprotective benefits. As a result, CO is now being tested in multiple clinical trials and may be approved as a therapeutic option in the future.
Article
Multidisciplinary Sciences
Sara E. Mascone, Katherine I. Kim, William S. Evans, Steven J. Prior, Marc D. Cook, Sushant M. Ranadive
Summary: Black individuals and men are more susceptible to hypertension, but there is no significant difference in reactive oxygen species (ROS) production and superoxide dismutase (SOD) activity between Black and White individuals and between females and males in induced inflammation. Only female HUVECs show a significant increase in SOD activity with increased exposure time to induced inflammation. In contrast, male HUVECs from White individuals exhibit a pro-inflammatory state.
Article
Physiology
Nina Pavlovna Aleksandrova, Anna Andreevna Klinnikova, Galina Anatolevna Danilova
Summary: TNF-alpha, a key inflammatory cytokine, may affect lung ventilation and modulate hypoxic ventilatory response through COX and NOS pathways. The study found that TNF-alpha increased lung ventilation in normoxia but decreased ventilatory response to hypoxia, and pretreatment with COX and NOS inhibitors reduced the respiratory effects of TNF-alpha. Activation of COX and NOS-related pathways and their cross-talk may mediate TNF-alpha respiratory effects and inflammation's impact on respiratory function.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Hossam M. Abdallah, Hany M. El-Bassossy, Gamal A. Mohamed, Ali M. El-Halawany, Khalid Z. Alshali, Zainy M. Banjar
JOURNAL OF NATURAL MEDICINES
(2017)
Article
Integrative & Complementary Medicine
Basma G. Eid, Hala Mosli, Atif Hasan, Hany M. El-Bassossy
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Hany M. El-Bassossy, Thikryat Neamatallah, Khadijah S. Balamash, Amani T. Abushareb, Malcolm L. Watson
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Hany M. El-Bassossy, Basma G. Eid
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Medicine, Research & Experimental
Hany M. El-Bassossy, Mona F. Mahmoud, Basma G. Eid
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Plant Sciences
Noura A. Hassan, Hany M. El Bassossy, Ahmed Fahmy, Mona F. Mahmoud
Meeting Abstract
Oncology
Ohoud Y. Alshehri, Fahad A. Alabbasi, Islam F. Mahmoud, Alaa T. Abu-Sharib, Hany M. El-Bassossy, Hossam A. Abdallah, Ahmed M. Al-Abd
Article
Biochemistry & Molecular Biology
Basma G. Eid, Alaa T. Abu-Sharib, Hany M. El-Bassossy, Khadijah Balamash, Sergey Smirnov
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Ahmad S. Azhar, Hany M. El-Bassossy, Hossam M. Abdallah
JOURNAL OF FOOD BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Mayada Mohammed Tarkhan, Khadijah Saeed Balamsh, Hany Mohammed El-Bassossy
JOURNAL OF FOOD BIOCHEMISTRY
(2019)
Article
Plant Sciences
Hossam M. Abdallah, Ali M. El-Halawany, Hany M. El-Bassossy
PHYTOCHEMISTRY LETTERS
(2019)
Article
Microbiology
Yuan Ji, Albert Bolhuis, Malcolm L. Watson
JOURNAL OF MEDICAL MICROBIOLOGY
(2019)
Article
Oncology
Soad Al-Jaouni, Seham Abdul-Hady, Hany El-Bassossy, Numan Salah, Magda Hagras
INTEGRATIVE CANCER THERAPIES
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Mahmoud El-Mas, Hany El-Bassossy, Zuheir Awan