期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 157, 期 1, 页码 4-13出版社
WILEY
DOI: 10.1111/j.1476-5381.2009.00219.x
关键词
histamine; histidine decarboxylase; QM; MM; virtual screening; homology modelling; molecular dynamics
资金
- Ministerio de Ciencia e Innovacion [SAF2008-02522]
- Comunidad de Madrid [SBIO-0214-2006]
For a long time the structural and molecular features of mammalian histidine decarboxylase (EC 4.1.1.22), the enzyme that produces histamine, have evaded characterization. We overcome the experimental problems for the study of this enzyme by using a computer-based modelling and simulation approach, and have now the conditions to use histidine decarboxylase as a target in histamine pharmacology. In this review, we present the recent (last 5 years) advances in the structure-function relationship of histidine decarboxylase and the strategy for the discovery of new drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据