Article
Chemistry, Medicinal
Mehreen Arif, Khalid Rauf, Naeem Ur Rehman, Ahmed Tokhi, Muhammad Ikram, Robert Sewell
Summary: This study found that 6-MOF and donepezil have neuroprotective effects in chronic ethanol-induced cognitive impairment, improving cognitive performance and neurochemical markers in animals.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Neurosciences
Michael Longley, John Ballard, Maria Andres-Alonso, Rebecca Constance Varatharajah, Hadleigh Cuthbert, Christopher H. Yeo
Summary: The geometry of glutamatergic mossy-parallel fibre and climbing fibre inputs to cerebellar cortical Purkinje cells plays a significant role in understanding cerebellar functions. Serotonergic and noradrenergic afferent systems show anisotropy in the molecular layer of the rat cerebellar cortex, influencing multiple zones and microzones with different trajectories. These monoaminergic systems may not supply a global signal to all targets in the cerebellum, suggesting specific information processing mechanisms within the cerebellar cortex.
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima
Summary: This study found that Disulfiram produces anxiolytic-like effects in rodents by inhibiting the presynaptic inhibitory effects on glutaminergic neurons. Unlike diazepam, Disulfiram does not have adverse effects and may be an effective novel anxiolytic drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Nazzareno Cannella, Anna Maria Borruto, Michele Petrella, Maria Vittoria Micioni Di Bonaventura, Laura Soverchia, Carlo Cifani, Sara De Carlo, Esi Domi, Massimo Ubaldi
Summary: The neuropeptide S (NPS) and its receptor (NPSR) play an important role in the processing of emotional and affective behavior. NPS has both anxiolytic and arousal-promoting effects. It reduces alcohol consumption in alcohol-preferring rats and increases the anxiolytic effects in rodents with a history of alcohol dependence. These findings suggest that the NPS/NPSR system could be a potential target for treating alcohol and cocaine abuse.
Article
Biochemistry & Molecular Biology
Joyce Dos Reis Lima, Maria Kueirislene Amancio Ferreira, Ketelly Vanessa Barros Sales, Antonio Wlisses da Silva, Emanuelle Machado Marinho, Francisco Ernani Alves Magalhaes, Emmanuel Silva Marinho, Marcia Machado Marinho, Matheus Nunes da Rocha, Paulo Nogueira Bandeira, Alexandre Magno Rodrigues Teixeira, Jane Eire Silva Alencar de Menezes, Helcio Silva dos Santos
Summary: This study evaluated the anxiolytic potential of the clerodine-type diterpene CBWS isolated from Croton blanchetianus in adult zebrafish. The results indicated that CBWS has anxiolytic effects mediated by serotonergic and anti-acetylcholinesterase actions. The study also suggested the involvement of 5-HTR1 and 5-HTR2A/2C receptors in the low anticonvulsant effect of CBWS.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Psychiatry
Parth Dutta, Mohan Dhyani, Shobit Garg, Sai Krishna Tikka, Sumit Khattri, Sumit Mehta, Jyoti Mishra
Summary: Studies on intensive OFC cTBS treatment in OCD patients showed significant clinical improvements in anxiety symptoms and global severity.
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
Dhamyaa Abed Najm Al-Halboosi, Olena Savchenko, Lora K. Heisler, Sergiy Sylantyev
Summary: Obesity is a global health challenge caused by excessive calorie intake. The brain plays a crucial role in controlling food intake, and NAG neurons, which co-express NPY, AgRP, and GABA, are identified as hunger and food intake stimulators. Activation of 5-HT1BR leads to a decrease in food intake by suppressing NAG neuron activity and neurotransmitter release.
Article
Pharmacology & Pharmacy
Aitziber Mendiguren, Erik Aostri, Irati Rodilla, Iker Pujana, Ekaterina Noskova, Joseba Pineda
Summary: The pharmacological profile of cannabigerol (CBG), particularly its effect on alpha(2)-adrenoceptor and 5-HT1A receptor, is poorly understood. In this study, male Sprague-Dawley rat brain slices were used to investigate the impact of CBG on firing rate of LC NA cells and DRN 5-HT cells, as well as its interaction with alpha(2)-adrenergic and 5-HT1A autoreceptors. CBG was also evaluated for its anxiolytic-like effects using behavior tests. The findings indicate that CBG inhibits the suppressive effects of alpha(2)-adrenoceptor and 5-HT1A receptor agonists on NA-LC and 5-HT-DRN neurons, and produces anxiolytic-like effects through the 5-HT1A receptor.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Shuping Zhao, Tianyuan Yang, Xiaoyu Hou, Haiyang Zhang, Yuan Zhao, Hui Wang, Ning Sun, Haoyang Tan, Jiuyan Zhang, Honggang Fan
Summary: The study found that CGA could alleviate depression-like behaviors and PFC damage induced by restraint stress by reducing corticosterone levels and increasing 5-HT content. Particularly, 100 mg/kg of CGA showed significant protective effects on depression-like behaviors in rats, indicating the potential for further investigation into its mechanism of regulating 5-HT.
Article
Behavioral Sciences
Sergio M. Pellis, Vivien C. Pellis, Jackson R. Ham, Rachel A. Stark
Summary: The benefits of play fighting for young animals have been speculated for over a hundred years. Understanding the behavioral development and neurobiology of laboratory rats has provided a coherent model that explains this phenomenon. Depriving rats of peer-peer play experience during their juvenile period leads to adult rats with socio-cognitive deficiencies and changes in the neurons of the prefrontal cortex. Analysis of juvenile peer play shows that the ability to engage in reciprocal play fighting is crucial for obtaining these benefits, improving a skill set that can be applied in different social contexts.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Behavioral Sciences
R. Depoortere, A. L. Auclair, A. Newman-Tancredi
Summary: NLX-101 activates 5-HT1A receptors in the prefrontal cortex of rats, producing robust antidepressant-like effects with a distinctive bimodal dose-response pattern. These data suggest NLX-101 may target specific subpopulations of 5-HT1A receptors in the PFC, likely located on GABAergic and/or glutamatergic neurons.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Maria Smialowska, Barbara Zieba, Helena Domin
Summary: CRF is a neuropeptide that plays various roles in the brain, including activating stress and anxiety, but its specific role in the cortex remains unclear. Studies have shown that high doses of CRF injected into the Fr2 area can have an anxiolytic-like effect, primarily through activation of CRF1 receptors. The involvement of alpha1 and alpha2 adrenergic receptors in the noradrenergic system seems to play a key role in these anxiolytic effects, while beta receptors do not appear to have a significant impact.
Article
Food Science & Technology
Xiping Zhu, Dongxiao Sun-Waterhouse, Chun Cui
Summary: The study demonstrated that the RPFE formula could reverse behavioral dysfunctions and body weight gain induced by chronic stress, normalize inflammatory cytokines and oxidative stress markers, as well as relieve hippocampal neuronal injury. The enhanced serotonin levels in the hippocampus may be attributed to serotonergic activation mediated by anti-inflammatory and antioxidant actions.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Review
Psychiatry
Daniel S. Pine, Steven P. Wise, Elisabeth A. Murray
Summary: Human brain evolution includes the expansion of homotypical association areas and the hippocampus, which are particularly relevant to emotional disorders. Unique cognitive capacities allow humans to relive past events in the present and imagine future events without temporal limitations, contributing to both advantages and emotional problems.
AMERICAN JOURNAL OF PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Remo Guerrini, Erika Marzola, Claudio Trapella, Salvatore Pacifico, Maria Camilla Cerlesi, Davide Malfacini, Federica Ferrari, Mark Francis Bird, David George Lambert, Severo Salvadori, Girolamo Calo
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Anesthesiology
M. F. Bird, R. S. Vardanyan, V. J. Hruby, G. Calo, R. Guerrini, S. Salvadori, C. Trapella, J. McDonald, D. J. Rowbotham, D. G. Lambert
BRITISH JOURNAL OF ANAESTHESIA
(2015)
Article
Pharmacology & Pharmacy
F. Guida, R. Lattanzi, S. Boccella, D. Maftei, R. Romano, V. Marconi, G. Balboni, S. Salvadori, M. A. Scafuro, V. de Novellis, L. Negri, S. Maione, L. Luongo
PHARMACOLOGICAL RESEARCH
(2015)
Article
Biotechnology & Applied Microbiology
Roberta Lattanzi, Daniela Maftei, Veronica Marconi, Fulvio Florenzano, Silvia Franchi, Elisa Borsani, Luigi Fabrizio Rodella, Gianfranco Balboni, Severo Salvadori, Paola Sacerdote, Lucia Negri
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Biochemistry & Molecular Biology
Remo Guerrini, Erika Marzola, Claudio Trapella, Michela Pela', Stefano Molinari, Maria Camilla Cerlesi, Davide Malfacini, Anna Rizzi, Severo Salvadori, Girolamo Calo'
BIOORGANIC & MEDICINAL CHEMISTRY
(2014)
Article
Pharmacology & Pharmacy
A. Rizzi, D. Malfacini, M. C. Cerlesi, C. Ruzza, E. Marzola, M. F. Bird, D. J. Rowbotham, S. Salvadori, R. Guerrini, D. G. Lambert, G. Calo
BRITISH JOURNAL OF PHARMACOLOGY
(2014)
Article
Chemistry, Medicinal
Cenzo Congiu, Valentina Onnis, Alessandro Deplano, Severo Salvadori, Veronica Marconi, Daniela Maftei, Lucia Negri, Roberta Lattanzi, Gianfranco Balboni
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Maria Chiara Zatelli, Teresa Gagliano, Michela Pela, Sara Bianco, Valerio Bertolasi, Federico Tagliati, Remo Guerrini, Ettore degli Uberti, Severo Salvadori, Claudio Trapella
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Michela Pela, Puneet Saxena, Rosaria Luciani, Matteo Santucci, Stefania Ferrari, Gaetano Marverti, Chiara Marraccini, Andrea Martello, Silvia Pirondi, Filippo Genovese, Severo Salvadori, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi, Remo Guerrini
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Medicinal
C. Ruzza, L. del Zoppo, D. Malfacini, M. Pela', C. Trapella, P. Grieco, S. Salvadori, G. Calo', R. Guerrini
MEDICINAL CHEMISTRY RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Giordano Lesma, Severo Salvadori, Francesco Airaghi, Engin Bojnik, Anna Borsodi, Teresa Recca, Alessandro Sacchetti, Gianfranco Balboni, Alessandra Silvani
MOLECULAR DIVERSITY
(2013)
Article
Multidisciplinary Sciences
Xiaozhou He, Yilin Yang, Feng Zhi, Meredith L. Moore, Xuezhi Kang, Dongman Chao, Rong Wang, Gianfranco Balboni, Severo Salvadori, Dong H. Kim, Ying Xia
Article
Chemistry, Medicinal
Giordano Lesma, Severo Salvadori, Francesco Airaghi, Thomas F. Murray, Teresa Recca, Alessandro Sacchetti, Gianfranco Balboni, Alessandra Silvani
ACS MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Pharmacology & Pharmacy
Renzo Lazzarini, Severo Salvadori, Claudio Trapella, Remo Guerrini, Erica Marzola, Giada Pasini, Alessandro Dalpiaz
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2015)
Article
Chemistry, Medicinal
M. Pela, L. Del Zoppo, L. Allegri, E. Marzola, C. Trapella, C. Ruzza, G. Calo, E. Perissutti, F. Frecentese, S. Salvadori, R. Guerrini