Article
Cell Biology
Maurizio Mazzoni, Filippo Caremoli, Luis Cabanillas, Janira de los Santos, Mulugeta Million, Muriel Larauche, Paolo Clavenzani, Roberto De Giorgio, Catia Sternini
Summary: The distribution and density of enteric neurons in the pig colon varies in different regions, indicating that different parts may play different roles in gastrointestinal function. This provides important insights for investigating the mechanisms underlying human colonic diseases.
CELL AND TISSUE RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Sarah A. Najjar, Brian S. Edwards, Kathryn M. Albers, Brian M. Davis, Kristen M. Smith-Edwards
Summary: This study demonstrates that colon epithelial cells likely use purinergic and serotonergic signaling to initiate activity in myenteric neurons, leading to local contractions and facilitating large-scale coordination of ENS activity responsible for whole colon motility patterns.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Marcello Costa, Lauren J. Keightley, Timothy J. Hibberd, Lukasz Wiklendt, David J. Smolilo, Phil G. Dinning, Simon J. Brookes, Nick J. Spencer
Summary: Two distinct types of colonic motor complexes (CMCs) were identified in isolated mouse colon, complete and incomplete CMCs, with differences in the duration of smooth muscle action potentials, propagation speed, and frequency. Recognizing these different patterns of motility will be important for future interpretation of murine colonic motility recordings. Alternating patterns of motor activity in the proximal colon, but not in the distal colon, may reflect specific neural mechanisms for fecal pellet formation.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Neurosciences
Erika Coletto, Iain R. Tough, Sara Pritchard, Atsuko Hikima, Michael J. Jackson, Peter Jenner, K. Ray Chaudhuri, Helen M. Cox, Mahmoud M. Iravani, Sarah Rose
Summary: The study indicates that long-term alterations in colonic mucosal function associated with amplified muscarinic mucosal activity but decreased cholinergic innervation in myenteric plexi and increased nitrergic enteric neurotransmission may lead to gastrointestinal dysfunction.
NPJ PARKINSONS DISEASE
(2021)
Article
Multidisciplinary Sciences
Yushan Wang, Po-Min Wang, Muriel Larauche, Million Mulugeta, Wentai Liu
Summary: This study investigates the use of bio-impedance characterization to monitor colonic motor activity. The results show a significant decrease in bio-impedance during strong colonic contractions in response to electrical stimulation. The dominant frequencies of colonic contractions also increase after the stimulation, and positive correlations are found between bio-impedance and manometry. The bio-impedance-based method offers high spatial and temporal resolution for monitoring colonic motor pattern.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Lori B. Dershowitz, Li Li, Anca M. Pasca, Julia A. Kaltschmidt
Summary: The study reveals that the human enteric nervous system starts to develop during the second trimester and follows a similar pattern to embryonic mice in terms of gastrointestinal motility. These findings are crucial for comparing with animal models, which can improve disease investigations and drug testing.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Ryo Hotta, Ahmed Rahman, Sukhada Bhave, Rhian Stavely, Weikang Pan, Shriya Srinivasan, Geoffrey de Couto, Luis Rodriguez-Borlado, Richard Myers, Alan J. Burns, Allan M. Goldstein
Summary: This study demonstrates that transplanted enteric neuronal stem cells (ENSCs) can form effective neuromuscular connections and improve colonic motor function in a model of colonic dysmotility. Multiple injections of ENSCs led to an improved response, paving the way for optimized clinical trial design.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Li-zhe-xiong Song, Yuan Li, Xu Qian, Na Xu, Zhi Yu, Jing-wen Dai, Bin Xu, Xuan-ming Hu
Summary: This study found that electroacupuncture (EA) can improve constipation symptoms in Parkinson's disease (PD) by regulating the Enteric Nervous System (ENS) structure and function. By observing constipation symptoms, colonic motility, and tissue pathology, it was found that EA promotes ENS restoration and regulates the ratio of inhibitory and excitatory neurotransmitters.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rachel L. Wolfson, Amira Abdelaziz, Genelle Rankin, Sarah Kushner, Lijun Qi, Ofer Mazor, Seungwon Choi, Nikhil Sharma, David D. Ginty
Summary: The properties of neurons that innervate the distal colon are not well defined. This study identified distinct subsets of colon-innervating neurons with different morphologic and physiologic characteristics. These neurons exhibit diverse force thresholds to colon distension, and a specific subset mediates behavioral responses to high levels of distension and inflammation. This finding provides a potential target for therapeutic intervention in gastrointestinal diseases.
Article
Gastroenterology & Hepatology
Andrea Nestor-Kalinoski, Kristen M. Smith-Edwards, Kimberly Meerschaert, Joseph F. Margiotta, Bartek Rajwa, Brian M. Davis, Marthe J. Howard
Summary: This study describes the structural architecture of the mouse enteric nervous system and shows regional underpinnings of different motor patterns. The findings provide direct evidence of neural circuit structural and functional regional differences, advancing our understanding of neurogenic control of patterned motor function in the mouse colon. The study also highlights the usefulness and relevance of the mouse system for translating to the human colon.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiao-Li Zhang, Qi Sun, Zhu-Sheng Quan, Liang Wu, Zi-Ming Liu, Yan-Qi Xia, Qian-Yi Wang, Yue Zhang, Jin-Xia Zhu
Summary: This study found that dopamine promotes the secretion of colonic glial cell-derived neurotrophic factor (GDNF) via D1 receptors on cholinergic neurons, while high concentrations of dopamine inhibit GDNF secretion via D2 receptors on enteric glial cells (EGCs) and/or cholinergic neurons.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Physiology
Timothy J. Hibberd, Stewart Ramsay, Phaedra Spencer-Merris, Phil G. Dinning, Vladimir P. Zagorodnyuk, Nick J. Spencer
Summary: This review discusses the role of peripheral clocks in regulating major colonic functions, including colonic motility, absorption, hormone secretion, permeability, and pain signalling. It also describes the interactions between pathophysiological states such as irritable bowel syndrome and ulcerative colitis and circadian rhythmicity.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Georgina Navoly, Conor J. McCann
Summary: Through ex vivo organotypic culture experiments, it was found that donor cells derived from ENSC can dynamically integrate into recipient intestinal tissues in a longitudinal migration and medial invasion manner. Organotypic culture allowed for sustained integration of donor cells post-transplantation and led to remodeling of intestinal mucosa and muscle layers.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Jackson L. K. Yip, Gayathri K. Balasuriya, Sarah J. Spencer, Elisa L. Hill-Yardin
Summary: Mice and rats have fundamental differences in colon motility and response to inhibition of nitric oxide neurotransmitter, making them important animal models for different questions in gastrointestinal research.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Theresa B. Legan, Brigitte Lavoie, Emilia Norberg, Isabella C. Ley, Stephanie Tack, Thomas A. Tompkins, Matthew J. Wargo, Gary M. Mawe
Summary: This study discovered a method to promote intestinal motility by using bacteria that produce tryptophan, possibly through increased 5-HT signaling and/or actions of tryptophan metabolites, and involvement of the 5-HT4 receptor.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Letter
Surgery
Francisco Espin, Maria Isabel Garcia-Domingo, Manel Cremades, Esteban Cugat
Article
Surgery
Eric Herrero Fonollosa, Maria Galofre Recasens, Alba Zarate Pinedo, Maria Isabel Garcia Domingo, Judith Camps Lasa, Fernando Pardo Aranda, Francisco Espin Alvarez, Esteban Cugat Andorra
Summary: The liver-first approach (LFA) is an effective strategy for treating advanced synchronous liver metastases (ASLM) from colorectal cancer (CRC). This study retrospectively analyzed a database of hepatectomies from CRC liver metastases in two centers. The LFA allowed control of liver disease and assessment of tumor response to neoadjuvant chemotherapy, optimizing the chance of curative liver resection and influencing long-term survival.
Review
Gastroenterology & Hepatology
Maura Corsetti, Sylvie Forestier, Marcel Jimenez
Summary: This review aims to provide an updated overview of the mechanisms of action of HBB and its clinical efficacy to guide clinical practice and future research.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Biochemistry & Molecular Biology
Noemi Tomsen, Omar Ortega, Daniel Alvarez-Berdugo, Laia Rofes, Pere Clave
Summary: This study compared the effects of increasing bolus viscosity and using TRPV1, TRPA1, or TRPM8 agonists on the swallow response in patients with oropharyngeal dysphagia (OD). The results showed that fluid thickening and substances like capsaicin and piperine significantly improved swallow safety and speed, providing potential candidates for the development of new pharmacological strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Paula Vinas, Alberto Martin-Martinez, Claudia Alarcon, Stephanie A. Riera, Jaume Miro, Cristina Amado, Pere Clave, Omar Ortega
Summary: The prevalence of oropharyngeal dysphagia (OD), malnutrition (MN), and mortality among COVID-19 patients was found to be very high. OD was independently associated with MN and mortality. Early and proactive multimodal nutritional intervention can improve the nutritional status of patients.
Article
Gastroenterology & Hepatology
Fernando Pardo Aranda, Clara Gene Skrabec, Jaime Lopez-Sanchez, Alba Zarate Pinedo, Francisco Espin Alvarez, Manel Cremades Perez, Jordi Navines Lopez, Christian Herrero Vicente, Laura Vidal Pineiro, Esteban Cugat Andorra
Summary: This study aimed to analyze and simplify the optimal dose and time of intravenous indocyanine green (ICG) administration for identifying the cystic duct and the common bile duct (CBD). A consecutive series of 146 patients were prospectively analyzed and divided into three groups based on the timing of ICG administration and two groups based on the dose of ICG. The results showed that the CBD was better visualized when ICG was administered at the induction of anesthesia or 2-6 hours before surgery, and when a dose of 1cc was used. Therefore, the optimal choice is to administer 2.5mg of ICG 2-6 hours before surgery, but administering ICG 30 minutes before surgery is sufficient for adequate visualization of biliary structures.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Clinical Neurology
Laura Diaz-Marugan, Mattia Gallizioli, Leonardo Marquez-Kisinousky, Silvia Arboleya, Annalaura Mastrangelo, Francisca Ruiz-Jaen, Jordi Pedragosa, Climent Casals, Francisco Javier Morales, Sara Ramos-Romero, Sara Traserra, Carles Justicia, Miguel Gueimonde, Marcel Jimenez, Josep Lluis Torres, Xabier Urra, Angel Chamorro, David Sancho, Clara G. de los Reyes-Gavilan, Francesc Miro-Mur, Anna M. Planas
Summary: Severe stroke patients often experience respiratory and urinary tract infections. This is mainly due to opportunistic commensal bacteria translocating from the gut. This study investigated the mechanisms behind gut dysbiosis and poststroke infection.
Review
Nutrition & Dietetics
Sergio Marin, Omar Ortega, Mateu Serra-Prat, Ester Valls, Laia Perez-Cordon, Pere Clave
Summary: This study aimed to assess the efficiency of healthcare interventions in post-stroke oropharyngeal dysphagia (PS-OD) management. The findings suggest that screening and diagnosis of PS-OD can adjust and reduce hospitalization costs, while OD management after thrombolysis may not significantly reduce hospitalization costs. Videofluoroscopy is found to be the most cost-effective screening method. Rehabilitation programs and home enteral nutrition are also shown to be cost-effective. However, further evaluation and research on novel strategies are still needed.
Article
Medicine, General & Internal
Jaime Lopez-Sanchez, Sonsoles Garrosa-Munoz, Fernando Pardo Aranda, Clara Gene Skrabec, Ricardo Lopez Perez, Patricia Rodriguez-Fortunez, Jose Manuel Sanchez Santos, Luis Munoz-Bellvis
Summary: This study aims to analyze the differences in dose and administration ICG intervals to obtain good-quality NIRFC during LC. The primary outcome is the degree of identification of critical biliary structures during LC. The results of the study will be disseminated to the scientific community through publications, conferences, or other means.
Article
Physiology
Sara Traserra, Sergi Casabella-Ramon, Patri Vergara, Marcel Jimenez
Summary: This study aimed to assess the relationship between the integrity of the colonic barrier and the activation of enteric neural pathways associated with secretion and motility, induced by enterotoxigenic Escherichia coli (ETEC) challenge. The study used 50 Danbred male piglets, with 16 of them challenged with an oral dose of ETEC strain F4+ 1.5 x 10(9) colony-forming unit. The results showed that ETEC increased colonic permeability and induced an increase in mast cells, but did not alter neuromuscular function.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Surgery
Francisco Espin Alvarez, Maria Isabel Garcia-Domingo, Manel Cremades Perez, Fernando Pardo Aranda, Laura Vidal Pineiro, Eric Herrero Fonollosa, Jordi Navines Lopez, Alba Zarate Pinedo, Judith Camps-Lasa, Esteban Cugat Andorra
Summary: This study retrospectively reviewed 83 cases of distal pancreatectomy and found that minimally invasive surgery is a safe and feasible treatment option. The robotic-assisted approach is not inferior to laparoscopic surgery in distal pancreatectomy.
Editorial Material
Surgery
Maria Galofre-Recasens, Francisco Espin Alvarez, Fernando Pardo Aranda, Esteban Cugat Andorra
Article
Nutrition & Dietetics
Mireia Bolivar-Prados, Yuki Hayakawa, Noemi Tomsen, Viridiana Arreola, Weslania Nascimento, Stephanie Riera, Satomi Kawakami, Kazuhiro Miyaji, Yasuhiro Takeda, Jun Kayashita, Pere Clave
Summary: The study aimed to determine the therapeutic effect of the xanthan-gum-based thickener Tsururinko Quickly (TQ) in older patients with severe oropharyngeal dysphagia (OD). The results showed that TQ greatly improved the safety of swallowing and reduced the occurrences of penetration and aspiration in a shear-viscosity-dependent manner. The therapeutic range for TQ was found to be 100-800 mPa·s, with 200 and 800 mPa·s being the optimal doses for older patients with OD.
Article
Nutrition & Dietetics
Noemi Tomsen, Mireia Bolivar-Prados, Omar Ortega, Pere Clave
Summary: ThickenUp (R) Gel Express (TUGE) is a new liquid thickening product based on xanthan and acacia gum, which can improve swallowing difficulties in older adults without negative effects on oral and pharyngeal residues. During a 14-day treatment with TUGE-thickened fluids, older adults experienced increased fluid intake, improved hydration status, and good tolerance.