Article
Virology
Agnieszka Lembas, Katarzyna Zawartko, Mariusz Sapula, Tomasz Mikula, Joanna Kozlowska, Alicja Wiercniska-Drapalo
Summary: This study found that long-term antiretroviral therapy was associated with lower VCAM-1 levels in HIV-infected patients, suggesting reduced endothelial activation and decreased risk of cardiovascular disease development. However, VCAM-1 alone may not be sufficient to assess this, as there are also many well-known cardiovascular adverse effects of antiretroviral therapy.
Article
Oncology
Chiang-Wen Lee, Yao-Chang Chiang, Pei-An Yu, Kuo-Ti Peng, Miao-Ching Chi, Ming-Hsueh Lee, Mei-Ling Fang, Kuan-Han Lee, Lee-Fen Hsu, Ju-Fang Liu
Summary: CXCL1 and CXCR2 play crucial roles in lung metastasis of osteosarcoma by promoting neutrophil infiltration into the tumor microenvironment, affecting cell migration and invasion activities. Additionally, CXCL1 activates the CXCR2/FAK/PI3K/Akt signaling pathway to promote the expression and nuclear translocation of VCAM-1, thus playing a critical role in osteosarcoma metastasis to the lung.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Chia-Chia Chao, Wei-Fang Lee, Wei-Hung Yang, Chih-Yang Lin, Chien-Kuo Han, Yuan-Li Huang, Yi-Chin Fong, Min-Huan Wu, I-Ta Lee, Yuan-Hsin Tsai, Chih-Hsin Tang, Ju-Fang Liu
Summary: IGFBP-3 levels were found to be significantly higher in osteosarcoma tissue compared to normal tissue, and IGFBP-3 promoted cell migration in osteosarcoma cells by upregulating VCAM-1 expression through PI3K/Akt and AP-1 signaling pathways, suggesting IGFBP-3 as a potential therapeutic target in metastatic osteosarcoma.
Article
Immunology
Hye Won Jun, Hong Kyung Lee, Ik Ho Na, Su Jeong Lee, Kihyeon Kim, Geuno Park, Hyung Sook Kim, Dong Ju Son, Youngsoo Kim, Jin Tae Hong, Sang-Bae Han
Summary: This study examined the role of endothelial cells in the homing of natural killer (NK) cells to solid tumors. It was found that TNF-α and IL-1β activated endothelial cells, which increased NK cell migration and adhesion to the endothelial cells through the production of CCL2 and CCL7, as well as the upregulation of ICAM-1 and VCAM-1 expression on the endothelial cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Seoung-Woo Lee, Su-Min Baek, Young-Jin Lee, Tae-Un Kim, Jae-Hyuk Yim, Jun-Hyeok Son, Hee-Yeon Kim, Kyung-Ku Kang, Jong Hun Kim, Man Hee Rhee, Sang-Joon Park, Seong-Kyoon Choi, Jin-Kyu Park
Summary: This study explored the therapeutic effects of Rg3-enriched red ginseng extract (Rg3-RGE) on the progression of NAFLD and found that Rg3-RGE treatment can ameliorate NAFLD progression by inhibiting chemotaxis activities in liver sinusoidal endothelial cells (LSECs).
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Medicine, Research & Experimental
Guoxun Li, Xiaohan Jiang, Xiaoyu Liang, Yue Hou, Jingnan Zang, Benzhi Zhu, Congcong Jia, Kunwei Niu, Xia Liu, Xiaoli Xu, Rui Jiang, Bing Wang
Summary: This study aimed to investigate the impact of B-cell receptor associated protein 31 (BAP31) in endothelial cells on the pathogenesis of acute lung injury (ALI) through regulating cell adhesion molecules (CAMs), as well as its possible mechanism. The results showed that BAP31 deficiency reduced neutrophil-endothelium adhesion, inhibited NF-KB activation and nuclear translocation. Therefore, BAP31 is a promising protein for regulating the pathogenesis process of ALI.
Article
Pharmacology & Pharmacy
Sara Pastorino, Sara Baldassari, Giorgia Ailuno, Guendalina Zuccari, Giuliana Drava, Andrea Petretto, Vanessa Cossu, Cecilia Marini, Silvana Alfei, Tullio Florio, Gianmario Sambuceti, Gabriele Caviglioli
Summary: Atherosclerosis is a chronic progressive disease involving VCAM-1 overexpression. New PET radiopharmaceuticals MacroP and NAMP, based on VCAM-1 binding peptide, show high radiochemical purity and potential for early atheroma detection. NAMP also demonstrates higher radioactive uptake in vitro and may have future applications in theranostics.
Review
Pharmacology & Pharmacy
Mayarling F. Troncoso, Magda C. Diaz-Vesga, Fernanda Sanhueza-Olivares, Jaime A. Riquelme, Marioly Muller, Luis Garrido, Luigi Gabrielli, Mario Chiong, Ramon Corbalan, Pablo F. Castro, Sergio Lavandero
Summary: This review discusses the potential targeting of VCAM-1 in atherosclerosis, diabetes, hypertension, and ischemia/reperfusion injury, and highlights that VCAM-1 may be a promising therapeutic target for vascular diseases.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Medicine, Research & Experimental
Xiaojie Chu, Wei Li, Margaret G. Hines, Ilya Lyakhov, John W. Mellors, Dimiter S. Dimitrov
Summary: The elevated expression of GPNMB and VCAM-1 has been associated with poor prognosis and increased cancer metastasis in various types of cancer. In this study, two high-affinity specific human VH domain antibody candidates, 87 (GPNMB) and 1B2 (VCAM-1), were isolated and converted to VH-Fc to increase avidity. Domain-based bispecific T-cell engagers (DbTE) based on these antibodies showed potent killing against GPNMB and VCAM-1-positive cancer cells. Therefore, these domain antibodies are promising therapeutic candidates for cancers expressing GPNMB or VCAM-1.
MOLECULAR PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Alessandra Iscaro, Christian Jones, Neil Forbes, Amina Mughal, Faith Nutter Howard, Haider Al Janabi, Secil Demiral, Yvonne Perrie, Magnus Essand, Aleksandra Weglarz, Luis J. Cruz, Claire E. Lewis, Munitta Muthana
Summary: This study demonstrates that encapsulating oncolytic adenovirus into CCL2-coated liposomes can effectively target tumors by recruiting circulating monocytes expressing CCR2. The nanomedicine approach significantly reduces tumor size and metastasis, providing a potential strategy for treating inaccessible tumors.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chiou-Mei Lee, Ming-Ling Chang, Ren-Hao Chen, Fan-Wen Chen, Jo-Chuan Liu, Shun-Li Kuo, Hsin-Hsin Peng
Summary: This study demonstrates that thrombin-activated platelets (TAPLT) can protect endothelial cells against tumor-related pro-inflammatory changes, inhibiting angiogenesis and metastasis. The protection is likely mediated by VCAM-1-mediated endothelial cell linkage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Teizo Yoshimura, Chunning Li, Yuze Wang, Akihiro Matsukawa
Summary: Breast cancer is a common cancer worldwide, and metastasis is the main cause of cancer-related death. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was identified as a chemotactic factor for monocytes, and its role in cancer development and progression was investigated. Studies showed positive correlations between MCP-1 production in tumors and TAM infiltration, as well as cancer progression. MCP-1 was found to promote breast cancer metastasis to the lung and brain, but not bone. The mechanisms of MCP-1 production in the breast cancer microenvironment were also reported.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenting Zhu, Hang Yu, Menglei Jia, Caiyan Lin, Zhongwen Yuan, Xiaoxiao Tan, Pengke Yan
Summary: Pancreatic cancer treatment is hindered by drug resistance and liver metastasis. A new strategy, combination therapy, was developed to address these challenges. By using ATF peptide-decorated liposomal co-loaded with cisplatin and rapamycin, the delivery of drugs to tumor cells was significantly improved, leading to enhanced therapeutic effects in vitro and in vivo. This multi-targeting nanomedicine may provide a new approach for treating metastatic pancreatic cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Eugenia Belcastro, Asad Ur Rehman, Lamia Remila, Sin-Hee Park, Dal Seong Gong, Nicolas Anton, Cyril Auger, Olivier Lefebvre, Jacky G. Goetz, Mayeul Collot, Andrey S. Klymchenko, Thierry F. Vandamme, Valerie B. Schini-Kerth
Summary: Endothelial senescence is identified as an early event in cardiovascular disease development. Theranostic nanocarriers decorated with VCAM-1 antibodies show potential in targeting senescent endothelial cells, and loading with omega 3 polyunsaturated fatty acids may effectively prevent senescence in endothelial cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jie Wang, Fengling Wang, Dandan Xie, Min Zhou, Jiaxing Liao, Hongliang Wu, Yue Dai, Jingbin Huang, Yu Zhao
Summary: The treatment of malignant tumors often leads to poor prognosis due to tumor cell metastasis. Inhibiting VCAM-1 expression, a key factor in tumor cell metastasis, shows promise in inhibiting tumor cell metastasis. This study developed dual drug-loaded PLGA nanoparticles (Co-NPs) that effectively delivered a VCAM-1 inhibitor (Suc) and a chemotherapeutic drug (Dox) to suppress primary melanoma and lung metastases. In vitro experiments demonstrated potent cytotoxicity and inhibition of VCAM-1 expression and migration of B16F10 cells by Co-NPs. In vivo experiments further showed efficient suppression of primary melanoma and lung metastases. These findings suggest that PLGA nanoparticles containing Suc and Dox provide a promising drug delivery strategy for treating metastatic malignant tumors.
Article
Oncology
Monika Ducka, Martina Kucerikova, Filip Trcka, Jakub Cervinka, Elisabetta Biglieri, Jan Smarda, Lubor Borsig, Petr Benes, Lucia Knopfova
Summary: c-Myb is involved in the activation of genes with protumorigenic function, and its interaction with IL1 alpha and NF-kappa B signaling axis in tumor cells plays a critical role in regulating metastasis and inflammatory genes in breast cancer. This pathway presents a potential target for therapeutic interventions to mimic the antimetastatic effect of c-Myb.
Article
Biochemistry & Molecular Biology
Mihaela Turtoi, Maria Anghelache, Sanda-Maria Bucatariu, Mariana Deleanu, Geanina Voicu, Florentina Safciuc, Ileana Manduteanu, Gheorghe Fundueanu, Maya Simionescu, Manuela Calin
Summary: The newly developed hyaluronic acid-based 3D model is suitable for chemotherapeutic drug testing on hepatocellular carcinoma, showing improved cellular functions and sensitivity compared to 2D cultures.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Sinziana Popescu, Mihai Bogdan Preda, Catalina Iolanda Marinescu, Maya Simionescu, Alexandrina Burlacu
Summary: The study showed that using a dual-cell approach with ECFC and MSC can enhance the therapeutic effects for infarcted hearts, improving heart function and angiogenic properties. In vitro experiments demonstrated that ECFC can enhance MSC effector properties, while MSC can help organize ECFC into vascular networks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Adriana Georgescu, Maya Simionescu
Summary: Cells communicate with each other via extracellular vesicles (EVs). These EVs carry various types of cargo and can have different effects on recipient cells. They play important roles in atherosclerosis and COVID-19-related thrombosis, and have potential as signaling mediators, biomarkers, and therapeutic agents. More research is needed to fully understand the mechanisms of EVs in normal and pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Maria Dorobantu, Maya Simionescu, Nicoleta-Monica Popa-Fotea
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Maria Anghelache, Mihaela Turtoi, Anca Roxana Petrovici, Adrian Fifere, Mariana Pinteala, Manuela Calin
Summary: This study developed dextran shell-iron oxide core nanoparticles loaded with protocatechuic acid (PCA) and evaluated their anti-inflammatory potential at non-cytotoxic and therapeutically relevant concentrations. The results showed that MNP-Dex/PCA reduced inflammatory molecules levels in activated endothelial cells and M1-type macrophages, along with decreased monocyte adhesion, through the modulation of ERK1/2, p38-alpha MAPKs, and NF-kB signaling pathways. These findings support the future development of dextran shell-magnetic core nanoparticles as theranostic tools for vascular inflammation therapy.
Article
Biochemistry & Molecular Biology
Geanina Voicu, Daniela Rebleanu, Cristina Ana Mocanu, Gabriela Tanko, Ionel Droc, Cristina Mariana Uritu, Mariana Pinteala, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Summary: This study designed and obtained targeted lipid-enveloped polyplexes (V-LPP/shRunx2) suitable for systemic administration and targeted delivery of shRunx2 to osteoblast-differentiated VIC cells. The lipopolyplexes were shown to be cyto- and hemo-compatible, and specifically taken up by osteoblast-differentiated VIC cells. They successfully downregulated the expression of osteogenic molecules and could be a potential nanomedicine approach for blocking the progression of CAVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Valentina Mele, Camilla Basso, Valeria Governa, Jesus F. Glaus Garzon, Manuele G. Muraro, Silvio Daester, Christian A. Nebiker, Robert Mechera, Martin Bolli, Alexander Schmidt, Roger Geiger, Giulio C. Spagnoli, Dimitri Christoforidis, Pietro E. Majno, Lubor Borsig, Giandomenica Iezzi
Summary: Non-transformed cells of the tumor microenvironment, such as cancer-associated fibroblasts (CAFs) or tumor-associated stromal cells (TASCs), play a role in the growth and prognosis of colon cancer. By comparing the proteome of TASCs derived from colon cancer tissue with that of healthy colon tissue, two novel markers highly associated with poor prognosis were identified.
Article
Pharmacology & Pharmacy
Gheorghe Fundueanu, Marieta Constantin, Mihaela Turtoi, Sanda-Maria Bucatariu, Bogdan Cosman, Maria Anghelache, Geanina Voicu, Manuela Calin
Summary: In this study, pH/temperature-responsive carriers were designed and characterized for the delivery of the anti-tumoral drug doxorubicin. The carriers disintegrated and released the drug under endosomal and lysosomal conditions. The results showed that the carriers were more effective in delivering the drug to hepatic carcinoma cells HepG2 compared to lung adenocarcinoma cells A549, resulting in increased cytotoxicity. Additionally, the carriers were found to be biocompatible and reduced the renal clearance of doxorubicin when administered in vivo. These findings suggest the potential importance of the newly developed carriers for the treatment of hepatic tumors.
Article
Biochemistry & Molecular Biology
Mihaela Turtoi, Maria Anghelache, Andrei A. Patrascu, Mariana Deleanu, Geanina Voicu, Mihai Raduca, Florentina Safciuc, Ileana Manduteanu, Manuela Calin, Delia-Laura Popescu
Summary: A new vanadium-based drug was developed and evaluated for its antitumor properties in a human hepatocarcinoma cell line. The compound exhibited high cytotoxicity, inducing cell death by altering the oxidative and mitochondrial status. It showed differences in cell cycle regulation compared to cisplatin, a traditional cytotoxic drug.
Article
Pharmacology & Pharmacy
Irina Florina Tudorache, Violeta Georgeta Bivol, Madalina Dumitrescu, Ioana Madalina Fenyo, Maya Simionescu, Anca Violeta Gafencu
Summary: The study found that fullerenol-based nanoparticles carrying apoE3 can limit the progression of atherosclerotic plaques by reducing plasma cholesterol levels and increasing the expression of major proteins involved in lipid metabolism.
PHARMACOLOGICAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Xiaobo Liu, Yuanyuan Wang, Alexander T. Bauer, Michael Kirschfink, Peipei Ding, Christoffer Gebhardt, Lubor Borsig, Thomas Tuting, Thomas Renne, Karsten Haffner, Weiguo Hu, Stefan W. Schneider, Christian Gorzelanny
Summary: The microenvironment of malignant melanomas plays a crucial role in the infiltration and vascular dissemination of immune and cancer cells. In this study, we found that the complement system is activated in melanoma patients and murine melanomas. Complement-derived C5a recruits neutrophils, and activated neutrophils release neutrophil extracellular traps (NETs), which open the endothelial barrier and facilitate the entrance of melanoma cells into circulation. Inhibition of neutrophil activation could prevent vascular intravasation of melanoma cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Mirela-Fernanda Zaltariov, Mihaela Turtoi, Dragos Peptanariu, Ana-Maria Macsim, Lilia Clima, Corneliu Cojocaru, Nicoleta Vornicu, Bianca-Iulia Ciubotaru, Alexandra Bargan, Manuela Calin, Maria Cazacu
Summary: In this study, a new compound SIL-BS was synthesized by coupling 1-(3-aminopropyl) silatrane and nitro group attached to salicylaldehyde through an azomethine moiety. The results showed that SIL-BS exhibited good hydrolytic stability and cytotoxicity in vitro, increased drug permeation and residence time in tumor location, as well as antimicrobial activity and potential application in combined therapy.
Article
Oncology
Merel van Gogh, Jesus F. Glaus Garzon, Dilara Sahin, Lucia Knopfova, Petr Benes, Onur Boyman, Igor Jurisica, Lubor Borsig
Summary: The authors demonstrate that c-Myb expression in tumor cells induces the expression of immune-related genes, leading to immunomodulation and inhibition of tumor growth.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Polymer Science
Irina Mihaela Pelin, Irina Popescu, Manuela Calin, Daniela Rebleanu, Geanina Voicu, Daniela Ionita, Marius-Mihai Zaharia, Marieta Constantin, Gheorghe Fundueanu
Summary: This study developed a porous biocompatible hydrogel scaffold with deposited apatite-like particles to support osteoblast proliferation. The results showed high concentration of apatite particles deposited on the pore walls of the hydrogel. The composition of the organic matrix also influenced the crystallization of calcium phosphates and the mechanical properties of the composite hydrogels.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)