期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 147, 期 -, 页码 S17-S26出版社
WILEY
DOI: 10.1038/sj.bjp.0706502
关键词
ion channel; single channel; receptor; acetylcholine; glycine receptor; history
This paper looks at ion channels as an example of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked at in this way, ion channels have been helpful because they are still the only system which is simple enough for quantitative investigation of transduction mechanisms. A short history is given of attempts to elucidate what happens between the time when agonist first binds, and the time when the channel opens.
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