期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 147, 期 6, 页码 583-586出版社
WILEY
DOI: 10.1038/sj.bjp.0706670
关键词
skeletal muscle; muscle wasting; human heart; arrhythmias; beta(2)-adrenoceptor; formoterol; salmeterol
There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that beta(2)-adrenoceptor agonists cause hypertrophy of skeletal muscle. Their use in clinical practice will also need an understanding of possible effects of activation of human heart beta(2)-adrenoceptors. Consequences could include an increased probability of arrhythmias in susceptible patients.
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