Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Fang He, Xiaoyan Wu, Qingzhuo Zhang, Yikun Li, Yuyi Ye, Pan Li, Shuai Chen, Yuanyi Peng, Rudiger Hardeland, Yaoyao Xia
Summary: Melatonin exhibits antibacterial effects on various pathogenic bacteria in animals and plants, acting through multiple mechanisms such as direct actions at high concentrations, activation of hosts' defense mechanisms, attenuation of inflammation, and modulation of signaling pathways. Its protective functions involve inhibition of reactive oxygen and nitrogen species, detoxification, and protection against mitochondrial damage, suggesting melatonin as a potential effective approach against bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Zhuangwei Zhang, Shuoqi Jiang, Hengqun Tian, Yu Zeng, Kang He, Lin Lin, Fangmiao Yu
Summary: The study aimed to investigate the anti-inflammatory effects of Nymphaea hybrida ethanol extract and its polar fractions. The results showed that the ethyl acetate fraction of NHE exhibited significant inhibitory effects on inflammation by suppressing the activation of NF-kappa B and MAPK pathways in LPS-induced inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Hyun Ji Eo, Jun Hyuk Jang, Gwang Hun Park
Summary: Berchemia floribunda (BF), a plant from Rhamnaceae, known for its antioxidant and whitening effects, was studied for its anti-inflammatory properties in this research. The leaves extract (BR-L) showed strong anti-inflammatory activity by inhibiting NO production and suppressing pro-inflammatory mediators in LPS-induced cells. BR-L also demonstrated potential in inhibiting NF-kappa B activation and MAPKs phosphorylation. These findings suggest the potential of BR-L as a candidate for new anti-inflammatory drugs against acute and chronic inflammatory disorders.
Article
Plant Sciences
Ying Li, Jin-gang Hou, Zhi Liu, Xiao-jie Gong, Jun-nan Hu, Ying-ping Wang, Wen-cong Liu, Xiang-hui Lin, Zi Wang, Wei Li
Summary: In this study, treatment with 20(R)-Rg3 for 8 weeks in T2D mice not only decreased FBG and AGEs levels, but also improved insulin, blood lipids, oxidative stress, and renal function by regulating MAPKs and NF kappa B signal pathways, showing significant ameliorative effects on DN mice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Xinxin Zhang, Yating Qin, Weibin Ruan, Xiaoning Wan, Chao Lv, Lin He, Li Lu, Xiaomei Guo
Summary: Baicalein, a flavonoid phytochemical, demonstrates anti-inflammatory properties in macrophages, endothelial cells, and vascular smooth muscle cells by activating the AMPK/Mfn-2 axis and inhibiting MAPKs/NF-kappa B signaling transduction pathway. Baicalein effectively reduces proinflammatory cytokine levels, suggesting its potential role in atherosclerosis treatment. Further studies may be needed to fully understand the mechanisms of baicalein's anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sakawrat Janpaijit, Pattawika Lertpatipanpong, Chanin Sillapachaiyaporn, Seung Joon Baek, Somsri Charoenkiatkul, Tewin Tencomnao, Monruedee Sukprasansap
Summary: The seed extract of Cleistocalyx nervosum var. paniala (CNSE) has anti-neuroinflammatory effects and can inhibit LPS-induced inflammation through the MAPKs/NF-kappa B pathway.
Article
Cell Biology
Weibin Ruan, Xinyun Ji, Yating Qin, Xinxin Zhang, Xiaoning Wan, Chuanmeng Zhu, Chao Lv, Chongqing Hu, Juan Zhou, Li Lu, Xiaomei Guo
Summary: This study investigated the protective effects of harmine against sepsis-induced cardiomyopathy (SIC) and its underlying mechanisms. The results showed that harmine inhibited inflammation and apoptosis, alleviated cardiac dysfunction in mice, and suppressed M1 polarization and inflammatory responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huakang Zhou, Dilaware Khan, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad
Summary: Inflammaging is a potential risk factor for cardiovascular diseases, leading to the development of thrombosis and atherosclerosis. Ethanol can induce inflammation and senescence, which are both implicated in cardiovascular diseases. In this study, colchicine was used to mitigate the damaging effects of ethanol on endothelial cells. It prevented senescence, reduced oxidative stress, and inhibited the activation of NF-κB and MAPKs in ethanol-treated endothelial cells. Colchicine ameliorated the ethanol-induced molecular events, resulting in attenuated senescence and senescence-associated secretory phenotype in endothelial cells.
Article
Agriculture, Multidisciplinary
Xuefeng Wang, Baifei Hu, Haiming Hu, Shuhan Zhou, Mingzhu Yin, Xue Cheng, Zhigang Zhang, Hongtao Liu
Summary: In this study, tannic acid (TA) was found to effectively inhibit the replication of hepatitis B virus (HBV) by reducing the content of HBV DNA and viral antigens, decreasing the expression of HBV RNA, upregulating the expression of IL-8, TNF-a, IFN-a, and activating the NF-κB and MAPK pathways. Additionally, TA induced autophagy, which accelerated the elimination of HBV components. These findings elucidate the suppressive effect of TA on HBV replication and provide inspiration for its clinical application in HBV treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Hui Zhao, Lin Fu, Hui-Xian Xiang, Ying Xiang, Meng-Die Li, Bian-Bian Lv, Zhu-Xia Tan, Lan Gao, Cheng Zhang, De-Xiang Xu
Summary: The study found that Benzo[a]pyrene can cause acute lung injury and inflammation, while the antioxidant N-acetylcysteine (NAC) can alleviate the pulmonary inflammatory response induced by Benzo[a]pyrene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Changkai Zhou, Jing Gao, Hongyan Ji, Wenjing Li, Xiaomin Xing, Donghua Liu, Qie Guo, Lihua Zhou, Fanbo Jing
Summary: The study showed that BAC exhibits anti-inflammatory effects by inhibiting TLR-induced MAPK and NF-kappa B pathways, indicating its potential use in treating inflammatory diseases.
Article
Immunology
Luyao Yang, Hongqing Chen, Qiongying Hu, Lu Liu, Yun Yuan, Chuantao Zhang, Jianyuan Tang, Xiaofei Shen
Summary: This study found that eupalinolide B (EB) derived from Eupatorium lindleyanum effectively alleviated acute lung injury (ALI) in mice by inhibiting the activation of TAK1 and its downstream NF-κB and MAPKs pathways, leading to reduced inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yunbo Yan, Linqian Yu, Binyang Chen, Chang'an Cao, Hairong Zhao, Qiang Wang, De Xie, Yuemei Xi, Chenggui Zhang, Jidong Cheng
Summary: This study demonstrates that Mast-M has a significant inhibitory effect on LPS plus MSU-induced gouty arthritis. Mast-M can suppress the activation of NLRP3 inflammasomes by inhibiting the MAPK/NF-kappa B pathway and alleviating oxidative stress.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Plant Sciences
Bing-jie Ge, Peng Zhao, Hai-tao Li, Rui Sang, Meng Wang, Hong-yuan Zhou, Xue-mei Zhang
Summary: Taraxacum mongolicum shows protective effects against Staphylococcus aureus-infected mastitis by exerting anti-inflammatory role and inhibiting the TLR2-NF-kappa B/MAPKs pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Alessandro Pini, Roberta Verta, Cristina Grange, Maura Gurrieri, Arianna Carolina Rosa
Article
Biochemical Research Methods
Arianna Carolina Rosa, Elisa Benetti, Margherita Gallicchio, Valentina Boscaro, Luigi Cangemi, Chiara Dianzani, Gianluca Miglio
Review
Pharmacology & Pharmacy
Cristina Grange, Maura Gurrieri, Roberta Verta, Roberto Fantozzi, Alessandro Pini, Arianna Carolina Rosa
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Roberta Verta, Cristina Grange, Maura Gurrieri, Sara Borga, Patrizia Nardini, Monica Argenziano, Corrado Ghe, Roberta Cavalli, Elisa Benetti, Gianluca Miglio, Benedetta Bussolati, Alessandro Pini, Arianna Carolina Rosa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Marie Angele Cucci, Alessandra Compagnone, Martina Daga, Margherita Grattarola, Chiara Ullio, Antonella Roetto, Antonietta Palmieri, Arianna Carolina Rosa, Monica Argenziano, Roberta Cavalli, Maria Maddalena Simile, Rosa Maria Pascale, Chiara Dianzani, Giuseppina Barrera, Stefania Pizzimenti
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Elisa Benetti, Erica Liberto, Davide Bressanello, Valentina Bordano, Arianna C. Rosa, Gianluca Miglio, Jonida Haxhi, Giuseppe Pugliese, Stefano Balducci, Chiara Cordero
Review
Biochemistry & Molecular Biology
Arianna Carolina Rosa, Natascia Bruni, Giorgia Meineri, Daniele Corsi, Niccolo Cavi, Daniela Gastaldi, Franco Dosio
Summary: The review discusses the potential harms of overproduction of free radicals and the importance of SOD supplementation in reducing oxidative stress. It also explores various methods and strategies to improve the bioavailability of SOD in recent years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Alessandro Pini, Camilla Fazi, Patrizia Nardini, Maura Calvani, Sergio Fabbri, Alessandro Guerrini, Giulia Forni, Giancarlo La Marca, Arianna Carolina Rosa, Luca Filippi
Review
Biochemistry & Molecular Biology
Arianna Carolina Rosa, Daniele Corsi, Niccolo Cavi, Natascia Bruni, Franco Dosio
Summary: Superoxide dismutases (SODs) are metalloenzymes that play a crucial role in antioxidant defense against oxidative stress. While SOD supplementation may help neutralize free-radical excess, clinical evidence for its efficacy is currently lacking.
Article
Biochemistry & Molecular Biology
Gemma K. Kinsella, Stefania Cannito, Valentina Bordano, John C. Stephens, Arianna C. Rosa, Gianluca Miglio, Valeria Guaschino, Valeria Iannaccone, John B. C. Findlay, Elisa Benetti
Summary: GPR21 mediates negative effects on glucose uptake by liver cells, and its inhibition leads to activation of the insulin signaling pathway and increased glucose uptake. In addition, inhibition of GPR21 also reduces ERK activation in liver cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Roberta Verta, Maura Gurrieri, Sara Borga, Elisa Benetti, Paolo Pollicino, Roberta Cavalli, Robin L. Thurmond, Paul L. Chazot, Alessandro Pini, Arianna Carolina Rosa, Cristina Grange
Summary: The study compared the renal function and tubular protein expression between H4R-/- mice and wild-type mice, revealing differences in urine outflow and albumin-to-creatinine ratio (ACR). The results suggest a role of the histamine H-4 receptor in regulating renal reabsorption processes, particularly in albumin uptake.
Article
Biochemistry & Molecular Biology
Arianna Carolina Rosa, Patrizia Nardini, Silvia Sgambellone, Maura Gurrieri, Simona Federica Spampinato, Alfonso Dell'Accio, Paul L. Chazot, Ilona Obara, Wai L. Liu, Alessandro Pini
Summary: The study evaluated the effect of a histamine H-3 receptor antagonist on autonomic neuropathy of the intestinal tract associated with diabetes. The antagonist effectively prevented mucus overproduction and the decrease in inhibitory component of enteric motility caused by diabetes, suggesting its potential importance in preventing diabetes-induced gastrointestinal complications.
Article
Pharmacology & Pharmacy
Valentina Bordano, Gemma K. Kinsella, Stefania Cannito, Chiara Dianzani, Casimiro Luca Gigliotti, John C. Stephens, Chiara Monge, Claudia Bocca, Arianna C. Rosa, Gianluca Miglio, Umberto Dianzani, John B. C. Findlay, Elisa Benetti
Summary: This study evaluated the role of GPR21 in human macrophages, finding its involvement in cell migration and cytokine release, and the inhibition of its activity by the drug GRA2. GRA2 reduced the release of inflammatory cytokines from M1 macrophages and promoted the migration of M2 macrophages. Thus, pharmacological inhibition of GPR21 may be important in pathological conditions characterized by low-grade chronic inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Valentina Boscaro, Matteo Rivoira, Barbara Sgorbini, Valentina Bordano, Francesca Dadone, Margherita Gallicchio, Aline Pons, Elisa Benetti, Arianna Carolina Rosa
Summary: Data on diabetes prevalence ratios in urban and rural areas show lower rates in rural areas. Several bioactive compounds found in plants, particularly those in mountainous regions, have been identified to have anti-diabetic properties. This review evaluates the evidence from the past 10 years on the potential use of 9 plants traditionally used in the Piedmont Alps region of Italy for diabetes treatment. The findings suggest the possible use of these plants as preventive or add-on therapy, but further studies are needed for standardization and validation.
Article
Pharmacology & Pharmacy
Silvia Lucia Appleton, Maria Tannous, Monica Argenziano, Elisabetta Muntoni, Arianna Carolina Rosa, Davide Rossi, Fabrizio Caldera, Anna Scomparin, Francesco Trotta, Roberta Cavalli
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)