Article
Chemistry, Medicinal
Nicola Gambacorta, Fulvio Ciriaco, Nicola Amoroso, Cosimo Damiano Altomare, Ju''rgen Bajorath, Orazio Nicolotti
Summary: In this study, a CIRCE compound prediction platform was developed based on explainable machine learning to support the design of selective CB1R and CB2R ligands. The platform achieved about 80% accuracy in test calculations and provided rationalized explanations for the predictions. CIRCE is freely available as a web-based prediction platform.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Cell Biology
Huixing Wang, Xiaodong Huo, Chenyang Han, Jiang Ning, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Quanbo Li, Yonghao Yu, Kemei Shi
Summary: The study in rats indicated that ferroptosis is involved in the development of neuropathic pain by blocking neuron and astrocyte activation in the spinal dorsal horn.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Behavioral Sciences
Guadalupe Garcia, Vladimir A. Martinez-Rojas, Janet Murbartian
Summary: TREK-1 channels play a crucial role in acute and persistent nociceptive hypersensitivity, with selective blockade or activation affecting pain behaviors. The activity of TREK-1 at peripheral and spinal sites can reduce neuronal excitability in a formalin-induced nociception model.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Anesthesiology
Tobias Schneider, Laura Zurbriggen, Markus Dieterle, Eckhard Mauermann, Priska Frei, Katja Mercer-Chalmers-Bender, Wilhelm Ruppen
Summary: This study assessed the effect of cannabidiol (CBD) on acute pain and found that oral administration of 800 mg CBD did not show a significant effect on pain intensity, hyperalgesia, and allodynia compared with placebo. The study suggests the need for further research on different dosing, routes of administration, and the use of CBD as part of multimodal treatment strategies.
Article
Anesthesiology
Markus Dieterle, Laura Zurbriggen, Eckhard Mauermann, Katja Mercer-Chalmers-Bender, Priska Frei, Wilhelm Ruppen, Tobias Schneider
Summary: This study suggests that a high single-oral dose of 1600 mg cannabidiol is not effective in reducing opioid-induced hyperalgesia (OIH).
Article
Pharmacology & Pharmacy
Myrna Deciga-Campos, Rodrigo Villafan-Gutierrez, Josue Vidal Espinosa-Juarez, Osmar Antonio Jaramillo-Morales, Francisco Javier Lopez-Munoz
Summary: The study found that specific combinations of gabapentin and haloperidol can synergistically reduce nerve injury-induced allodynia and hyperalgesia, demonstrating an antiallodynic and antihyperalgesic effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ozgur Gunduz, Zekiye Gulfem Yurtgezen, Ruhan Deniz Topuz, Melike Sapmaz-Metin, Oktay Kaya, Abdullah Erkan Orhan, Ahmet Ulugol
Summary: This study investigated the effect of RIPCs transfusion by different routes on neuropathic pain symptoms and found that intravenous administration of RIPCs remarkably improved neuropathic pain symptoms, thermal hyperalgesia, and mechanical allodynia.
Article
Dermatology
Sara Moradi Tuchayi, Ying Wang, Alla Khodorova, Isaac J. Pence, Conor L. Evans, R. Rox Anderson, Ethan A. Lerner, Clifford J. Woolf, Lilit Garibyan
Summary: We developed a neural selective and injectable cryoneurolysis method using ice slurry, which effectively reduces cutaneous pain caused by skin disease. This method shows comparable effects on nerve structure and function compared to an FDA-approved cryoneurolysis device. The decrease in mechanical pain from slurry injection, although less profound than that of the FDA-approved device, lasts longer without inducing dysesthesia.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Mohammad Mehdi Haghighat Lari, Hamid Reza Banafshe, Elahe Seyed Hosseini, Hamed Haddad Kashani
Summary: In this study, the chronic administration of risperidone was found to be effective in reducing heat hyperalgesia and allodynia in rats with neuropathic pain induced by the CCI model. However, acute administration of risperidone did not show any significant changes in behavioral tests. Gene expression analysis indicated an increase in IL-4 and IL-10 gene expression in the risperidone group compared to the sham group.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafael Tamborena Malheiros, Gabriela Escalante Brites, Elizandra Gomes Schmitt, Laura Smolski dos Santos, Genifer Erminda Schreiner, Silvia Muller de Moura Sarmento, Itamar Luis Goncalves, Morgana Duarte da Silva, Vanusa Manfredini
Summary: This study aimed to evaluate whether obesity associated with osteoarthritis (OA) may increase inflammation and pain. The results showed that obesity altered the nociceptive profile, increased systemic inflammatory cytokines, and reduced anti-inflammatory cytokines. When obesity occurred together with OA, the inflammatory progression was intensified, leading to increased pain scores.
Article
Multidisciplinary Sciences
Basak Donertas-Ayaz, Ariana C. Brice-Tutt, Wendi L. Malphurs, Darrice Montgomery, Richard H. Mills, John K. Neubert, Robert M. Caudle
Summary: This paper presents a protocol for assessing mechanical hypersensitivity following chronic constriction injury of the infraorbital nerves (CCI-ION) in rats using an orofacial operant pain system. The data showed that CCI-ION resulted in a significant decrease in the number of licks and the L/F ratio and an increase in the latency to the first lick, indicating mechanical hypersensitivity. These data support the use of operant-based pain assays to assess mechanical pain sensitivity in preclinical pain research.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Behavioral Sciences
Akshat D. Modi, Anavi Parekh, Yajan N. Pancholi
Summary: Globally, pain is a common post-operative side effect with over 300 million surgical procedures performed annually. Acute pain alerts individuals to remove harmful stimuli, while chronic pain without physiological cause hinders the recovery process. Rodent pain models provide an opportunity for pain studies, and various neurobehavioral tests are used to assess drug efficacy. This review article provides an overview of mechanical and thermal tests used in clinically relevant rodent pain models, discussing modifications, confounding variables, and advantages/disadvantages.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Plant Sciences
Donya Ziafatdoost Abed, Reyhaneh Sadeghian, Saeed Mohammadi, Muhammad Akram
Summary: The essential oil of Thymus persicus showed strong antinociceptive and anti-neuropathic effects in Swiss mice, involving various signaling pathways and receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Anesthesiology
Shanni Yamaki, Amanda Chau, Luigi Gonzales, David D. McKemy
Summary: Proper detection and response to painful cold temperatures are crucial for preventing tissue damage. TRPM8 and TRPA1 ion channels play important roles in sensing temperature, with recent evidence suggesting that TRPA1 channels work upstream of GFR alpha 3 and TRPM8 to produce cold hypersensitivity. The role of TRPA1 as a cold sensor remains controversial, while TRPM8 channels and afferents mediate the detection of pleasant and painful cold.
Review
Biochemistry & Molecular Biology
Andrea Bortolin, Estrela Neto, Meriem Lamghari
Summary: Calcium plays a crucial role in various physiological processes as a signalling mediator. It is involved in pathways that control fast responses like neuronal action potential firing and slow processes like gene transcriptional regulation. In pathological conditions, these mechanisms are also implicated in tumor cell reprogramming and pain regulation. Understanding the interactions between these mechanisms can lead to the identification of new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
