期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 153, 期 -, 页码 S35-S43出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjp.0707525
关键词
membrane trafficking; synaptic plasticity; cytoskeleton; PDZ protein; endosomes; exocytosis; spine; hippocampus
资金
- NIMH NIH HHS [MH070417, R01 MH070417, MH070205, F31 MH070205] Funding Source: Medline
AMPA-type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors reach their synaptic targets after a complicated journey involving multiple transport steps through different membrane compartments. This review summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity.
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