Article
Environmental Sciences
Eman A. Abdelfattah, David Renault
Summary: Research investigated the physiological effects of different concentrations of epinephrine on larvae of the flesh fly Sarcophaga dux, revealing significant differences among different body compartments and epinephrine concentrations. Epinephrine treatments did not increase reactive oxygen species production except for gut tissues.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Letter
Biochemistry & Molecular Biology
Sergio Verd, Mateo Verd
Summary: Individual resilience against COVID-19 is closely related to dietary quality and nutrient status, as well as the body's ability to handle ingested substances. The availability of building blocks essential for cell and organ protection, function, adjustment, and healing plays a crucial role in coping with competing demands and maintaining balance. Over-the-counter medications can also impact the balanced functioning of the reactive species interactome, highlighting the importance of dietary quality and nutrient status in determining human resilience.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biology
Cristian Adrian Marquez-Ramirez, Berenice Eridani Olmos-Orizaba, Claudia Isabel Garcia-Berumen, Elizabeth Calderon-Cortes, Rocio Montoya-Perez, Alfredo Saavedra-Molina, Alain Raimundo Rodriguez-Orozco, Christian Cortes-Rojo
Summary: This study investigated the effects of avocado oil on renal vascular responses, mitochondrial function, oxidative stress, and kidney damage in hypertensive rats. The results showed that avocado oil prevented hypertensive renal damage by improving mitochondrial function.
Article
Medicine, Research & Experimental
W. A. Saka, R. E. Akhigbe, A. O. Abidoye, O. S. Dare, A. O. Adekunle
Summary: The study showed that Dichlorvos induced hepatic and renal damage, accompanied by redox dyshomeostasis. L-arginine was found to reverse the damage and improve organ structure, suggesting a potential therapeutic role against Dichlorvos-induced toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Domenico Lapenna
Summary: Glutathione (GSH) is an important low-molecular weight thiol nucleophile and reductant with multiple functions, including antioxidant protection, detoxification, and cell signaling. It works in concert with GSH-dependent enzymes and its levels decline during aging, although elevated GSH levels in elderly individuals with good health suggest a potential link to increased healthspan and lifespan.
AGEING RESEARCH REVIEWS
(2023)
Article
Environmental Sciences
Pimchanok Nuchniyom, Ketsarin Intui, Jiraporn Laoung-on, Churdsak Jaikang, Ranida Quiggins, Kornravee Photichai, Paiwan Sudwan
Summary: This study aimed to determine the effects of Nelumbo nucifera extract on hepatotoxicity and oxidative stress induced by mancozeb. The results showed that the extract could suppress the toxicity of mancozeb, reduce liver injury, and regulate oxidative stress, making it a safe and effective natural antioxidant supplement.
Article
Biochemistry & Molecular Biology
Anke Schmidt, Melissa Muehl, Walison Augusto da Silva Brito, Debora Singer, Sander Bekeschus
Summary: Polystyrene nano- and micro-sized plastic particles (NMP) are common pollutants in the environment, water, and oceans. They can be absorbed by the body through various routes and have been shown to cause oxidative stress and affect cellular responses. In this study, we exposed murine lung cells to NMP of different sizes and observed significant correlations between cellular consequences and particle size. Our findings highlight the potential hazards of plastic contamination and uptake in lung cells.
Article
Engineering, Environmental
Mohammad Golam Mostofa, Md Mezanur Rahman, Kien Huu Nguyen, Weiqiang Li, Yasuko Watanabe, Cuong Duy Tran, Minghui Zhang, Misao Itouga, Masayuki Fujita, Lam-Son Phan Tran
Summary: The study revealed that strigolactones are involved in mitigating arsenic stress in rice roots by regulating arsenate uptake, glutathione biosynthesis, vacuolar sequestration of arsenic, and antioxidant defense responses.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Rohit Kumar Mishra, Gitanjali Mishra, Rachana Singh, Parul Parihar, Jitendra Kumar, Prabhat Kumar Srivastava, Sheo Mohan Prasad
Summary: The study aimed to reduce arsenic-induced toxicity in rice seedlings through phosphate supplementation, which significantly recovered diminished growth parameters and photosynthetic pigment contents. The activities of various enzymes in the AsA-GSH cycle were modulated to manage oxidative stress in rice seedlings caused by arsenic exposure. Supplementation of phosphate effectively increased the ratio of reduced to oxidized ascorbate and glutathione, contributing to the alleviation of arsenic toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Florence P. Varodayan, Reesha R. Patel, Alessandra Matzeu, Sarah A. Wolfe, Dallece E. Curley, Sophia Khom, Pauravi J. Gandhi, Larry Rodriguez, Michal Bajo, Shannon D'Ambrosio, Hui Sun, Tony M. Kerr, Rueben A. Gonzales, Lorenzo Leggio, Luis A. Natividad, Carolina L. Haass-Koffler, Remi Martin-Fardon, Marisa Roberto
Summary: This study sheds light on the crucial role of adrenergic receptors in the central amygdala (CeA) in alcohol use disorder (AUD) and uncovers the mechanisms underlying the association between specific adrenergic receptors and AUD. These findings are significant for the development of novel medications for the treatment of AUD.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Han-Mei Du, Chan Liu, Xin-Wu Jin, Cheng-Feng Du, Yan Yu, Shuai Luo, Wen-Zhu He, Su-Zhi Zhang
Summary: Aluminum (Al) toxicity is a major constraint for plant growth and cereal crop yield in acidic soils. This study identified a maize ALDH gene, ZmALDH, which is involved in protection against Al-induced oxidative stress. Overexpression of ZmALDH in Arabidopsis increased Al tolerance by promoting antioxidant mechanisms and reducing Al accumulation in roots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Henrique Soares Paiva, Idiberto Jose Zotarelli Filho, Carlos Filinto da Silva Cais
Summary: Several clinical studies have shown the significant role of prazosin in treating PTSD symptoms, especially in improving sleep symptoms. Prazosin is seen as an affordable and cost-effective pharmacological option compared to other drugs for PTSD treatment, but more randomized studies are needed for further evaluation.
PSYCHIATRY INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Tahmina Islam, M. K. Reddy
Summary: Non-essential toxic heavy metals like cadmium (Cd2+) have adverse effects on the growth and development of plants and can potentially harm human health. This study focused on the role of a peroxidase gene family member, PgGPx, in rice under Cd2+ stress. The overexpression of PgGPx enhanced Cd2+ tolerance in transgenic rice plants and improved oxidative stress response by increasing the activity of antioxidant enzymes. These findings provide insights for developing strategies to engineer Cd2+ stress tolerance in economically important crop plants.
Article
Multidisciplinary Sciences
Chinyere Aloke, Nwogo Ajuka Obasi, Chinedum Uche Emelike, Patience Nkemjika Ogbu, Godswill Odumero Ufebe, Onyebuchi Federick Orinya, Egwu Chinedu Ogbonnia, Anthony Chinwendu Onyekwere
Summary: This study investigated the protective efficacy of Copaifera salikounda seed pod ethanol extract (CSSPEE) against paracetamol-induced hepatorenal toxicity, showing that CSSPEE can reduce liver enzyme activities and oxidative stress markers, as well as improve tissue pathology.
Article
Plant Sciences
Sanjesh Tiwari, Anuradha Patel, Sheo Mohan Prasad
Summary: The study indicates that exogenous supplementation of plant growth regulators can alleviate the negative effects of high concentrations of chromium pollution on cyanobacteria, enhancing their ability to resist toxic metals.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Food Science & Technology
Jaber Alyami, Nidhi Ladd, Susan E. Pritchard, Caroline L. Hoad, Alyshah Abdul Sultan, Robin C. Spiller, Penny A. Gowland, Ian A. Macdonald, Guruprasad P. Aithal, Luca Marciani, Moira A. Taylor
FOOD RESEARCH INTERNATIONAL
(2019)
Editorial Material
Endocrinology & Metabolism
R. L. Atkinson, I. A. Macdonald
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Endocrinology & Metabolism
A. Madjd, M. A. Taylor, A. Delavari, R. Malekzadeh, I. A. Macdonald, H. R. Farshchi
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Nutrition & Dietetics
Nilanjana Tewari, Sherif Awad, Frantisek Duska, Julian P. Williams, Andrew Bennett, Ian A. Macdonald, Dileep N. Lobo
CLINICAL NUTRITION
(2019)
Article
Endocrinology & Metabolism
Joel T. Dunn, Pratik Choudhary, Ming Ming Teh, Ian Macdonald, Katharine F. Hunt, Paul K. Marsden, Stephanie A. Amiel
Article
Physiology
Jack A. Sargeant, Stephen Bawden, Guruprasad P. Aithal, Elizabeth J. Simpson, Ian A. Macdonald, Mark C. Turner, Jessica Cegielski, Kenneth Smith, James L. Dorling, Penny A. Gowland, Myra A. Nimmo, James A. King
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Review
Nutrition & Dietetics
A. E. Buyken, D. J. Mela, P. Dussort, I. T. Johnson, I. A. Macdonald, J. D. Stowell, F. J. P. H. Brouns
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2018)
Article
Endocrinology & Metabolism
Anna Wittekind, Kelly Higgins, Lauren McGale, Camille Schwartz, Nikoleta S. Stamataki, Gary K. Beauchamp, Angela Bonnema, Pierre Dussort, Sigrid Gibson, Cees de Graaf, Jason C. G. Halford, Cyril F. M. Marsaux, Richard D. Mattes, John McLaughlin, David J. Mela, Sophie Nicklaus, Peter J. Rogers, Ian A. Macdonald
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Article
Nutrition & Dietetics
Nilanjana Tewari, Sherif Awad, Ian A. Macdonald, Dileep N. Lobo
Article
Nutrition & Dietetics
Grith Moller, Jens Rikardt Andersen, Christian Ritz, Marta P. Silvestre, Santiago Navas-Carretero, Elli Jalo, Pia Christensen, Elizabeth Simpson, Moira Taylor, J. Alfredo Martinez, Ian Macdonald, Nils Swindell, Kelly A. Mackintosh, Gareth Stratton, Mikael Fogelholm, Thomas M. Larsen, Sally D. Poppitt, Lars O. Dragsted, Anne Raben
Article
Chemistry, Multidisciplinary
Alessio del Casino, Valentina Lukinovic, Rakesh Bhatt, Laura E. Randle, Michael J. Dascombe, Brian J. Fennell, Michael G. B. Drew, Angus Bell, Alistair J. Fielding, Fyaz M. D. Ismail
Article
Multidisciplinary Sciences
Ross A. Kelly, Joseph Leedale, Andy Harrell, Daniel A. Beard, Laura E. Randle, Amy E. Chadwick, Steven D. Webb
Article
Multidisciplinary Sciences
S. J. Chidlow, L. E. Randle, R. A. Kelly
Summary: Precision cut liver slices are a promising ex vivo method for studying liver disease and drug induced liver injury. However, their application is limited by the availability of healthy human tissue and experimental variability. This study uses mathematical modeling to predict the generation of a desired oxygen gradient in precision cut liver slices.
Article
Endocrinology & Metabolism
Elaine Chow, Alan Bernjak, Emma Walkinshaw, Alexandra Lubina-Solomon, Jenny Freeman, Ian A. Macdonald, Paul J. Sheridan, Simon R. Heller
Article
Endocrinology & Metabolism
Nils Swindell, Kelly Mackintosh, Melitta McNarry, Jeffrey W. Stephens, Diewertje Sluik, Mikael Fogelholm, Mathijs Drummen, Ian MacDonald, J. Alfredo Martinez, Teodora Handjieva-Darlenska, Sally D. Poppitt, Jennie Brand-Miller, Thomas M. Larsen, Anne Raben, Gareth Stratton