Article
Chemistry, Multidisciplinary
Qingyu Zhou, Justin Doherty, Antonina Akk, Luke E. Springer, Ping Fan, Ivan Spasojevic, Ganesh V. Halade, Huanghe Yang, Christine T. N. Pham, Samuel A. Wickline, Hua Pan
Summary: In this study, the potential of rapamycin perfluorocarbon (PFC) nanoparticles to mitigate cisplatin-induced acute kidney injury was demonstrated with a single preventative dose. The pharmacokinetics and biodistribution of rapamycin were improved by the PFC nanoparticle delivery system. The safety of rapamycin PFC nanoparticles was also confirmed in both in vitro and in vivo experiments.
Review
Chemistry, Multidisciplinary
Hicheme Hadji, Kawthar Bouchemal
Summary: This article discusses the impact of the shape of micro- and nanoparticles (M&NPs) on their biological fate. The role of particle shape in cell capture, drug delivery, and cytotoxicity is highlighted, along with theoretical approaches to understanding the effect on cell membrane internalization. Recent advances in the behavior of M&NPs in the systemic circulation are also detailed, including interactions with blood proteins and biodistribution. The challenges and future directions for developing nonspherical M&NPs are underscored.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Zhongchao Zhao, Andrea Simms, Nicole F. Steinmetz
Summary: This study utilizes tobacco mosaic virus (TMV) protein nanotubes as drug carriers to deliver platinum therapies to ovarian tumors, increasing efficacy and maintaining safety. It demonstrates superior efficacy compared to free drugs in mouse models and may induce immune response against tumors.
Article
Chemistry, Medicinal
Samila Horst Peczek, Ana Paula Santos Tartari, Isabella Camargo Zittlau, Camila Diedrich, Christiane Schineider Machado, Rubiana Mara Mainardes
Summary: This study developed nanostructured lipid carriers (NLCs) loaded with perillyl alcohol (POH) to improve its distribution in the brain. The results showed significantly enhanced oral bioavailability of POH when encapsulated in the NLCs, with increased concentration in brain tissue. This provides a potential therapeutic strategy for brain tumor treatment.
Article
Pharmacology & Pharmacy
Yue Huang, Chenguang Yang, Jianlin Lv, Yu Zhang, Kun Wang, Lili Ma, Zhilin Liu, Haiyang Yu, Mingqiang Li, Zhaohui Tang
Summary: In this study, the effects of injection dose and active agent ratio on the in vivo efficacy of CB-NPs were investigated. CB-NPs 20, with a B/C weight ratio of 0.45/1 and total drug loading content of 20.7 wt%, showed the highest potential for clinical application.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Nikita Lomis, Ziyab K. Sarfaraz, Aiman Alruwaih, Susan Westfall, Dominique Shum-Tim, Satya Prakash
Summary: A novel protein nanoparticle formulation designed for heart-targeted delivery of milrinone demonstrated improved pharmacokinetics and cardiac function parameters compared to the non-targeted drug, effectively enhancing treatment for congestive heart failure.
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Biochemistry & Molecular Biology
Andrew Kerr, Erny Sagita, Edward D. H. Mansfield, Tri-Hung Nguyen, Orlagh M. Feeney, Colin W. Pouton, Christopher J. H. Porter, Joaquin Sanchis, Sebastien Perrier
Summary: In this study, the behavior of molecular bottle-brush and cyclic peptide self-assembled nanotubes was investigated in vitro and in vivo. The results showed that the molecular bottle-brush had the longest circulation time, while the cyclic peptide nanotubes were able to avoid organ accumulation.
Article
Biotechnology & Applied Microbiology
Alexey V. Yaremenko, Ivan V. Zelepukin, Ilya N. Ivanov, Roman O. Melikov, Nadezhda A. Pechnikova, Dzhuliia Sh. Dzhalilova, Aziz B. Mirkasymov, Vera A. Bragina, Maxim P. Nikitin, Sergey M. Deyev, Petr I. Nikitin
Summary: This study observed the complete lifecycle of 40-nm magnetic particles in vivo and analyzed their impact on the organism. The nanoparticles were eliminated from the bloodstream in 2 hours, but their initial biodistribution changed over time. After 1 week, a major part of the nanoparticles was transferred to the liver and spleen, where they degraded with a half-life of 21 days. MRI and a magnetic spectral approach revealed that the contrast in these organs was preserved for over 1 month. The degradation of the particles led to an increase in the number of red blood cells and blood hemoglobin level without causing toxicity in tissues.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Paula S. Ferreira, John A. Manthey, Marina S. Nery, Thais B. Cesar
Summary: The study demonstrated the metabolism and distribution of orally administered eriocitrin in rats for the first time, identifying multiple metabolites in rat urine and tissues, with homoeriodictyol and homoeriodictyol-7-O-glucuronide as the major metabolites. The half-lives of metabolites in plasma were approximately 3 to 3.2 hours, and the total bioavailability of eriocitrin was less than 1%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonniere, Xavier Pivot, Alexandre Detappe
Summary: Tumor-targeted antibody/fragment-conjugated nanoparticles show promise in improving local delivery of small molecules. A meta-analysis of 161 studies confirmed that targeted nanoparticles had significantly higher tumor uptake compared to naked nanoparticles. The study also found that the choice of nanoparticle type, size, and antibody moiety affected tumor uptake.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Qing Yu, Megan G. Roberts, Loujin Houdaihed, Yang Liu, Kuan Ho, Gilbert Walker, Christine Allen, Raymond M. Reilly, Ian Manners, Mitchell A. Winnik
Summary: The physicochemical properties of drug nanocarriers, such as size, shape, and surface chemistry, play a crucial role in their efficient penetration into tumor tissues. Rigid rod-like micelles with uniform width and varied lengths were found to exhibit significant cell uptake and penetration into multicellular tumor spheroids, with elongated micelles showing deeper penetration. However, the extent and depth of tumor penetration decreased with increasing aspect ratio of the rod-like micelles, indicating a shape-dependent effect on cellular uptake and penetration.
Article
Pharmacology & Pharmacy
Swati Korake, C. Bothiraja, Atmaram Pawar
Summary: PEG-decorated solid lipid nanoparticles were developed to enhance the biopharmaceutical properties of docetaxel, showing improved bioavailability and anticancer activity.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Fei Wang, Ling Sum Liu, Pan Li, Cia Hin Lau, Hoi Man Leung, Y. Rebecca Chin, Chung Tin, Pik Kwan Lo
Summary: Compared with siRNAs or other ASOs, TNA has the advantages of chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability, which make it a promising tool in biomedical applications. This study investigates the pharmacokinetics and biosafety of TNAs in living organisms, finding that they exhibit excellent stability, low cytotoxicity, and substantial uptake in living cells without transfection. TNAs also show the ability to efficiently penetrate multicellular spheroids and can be safely administered in mice without causing pathological changes in the kidneys.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Zhongyu Jiang, Xiangru Feng, Haoyang Zou, Weiguo Xu, Xiuli Zhuang
Summary: This study designed and prepared two kinds of PLG-CDDP nanoformulations with detachable PEG, utilizing pH(e) and MMP as trigger factors to prolong circulation time and enhance cell uptake. The smart nanoformulations showed higher antitumor efficacy in vivo, indicating promising prospects for future clinical applications.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yue Wang, Na Shen, Ying Wang, Yu Zhang, Zhaohui Tang, Xuesi Chen
Summary: This study developed a novel self-amplifying tumor-targeting strategy with a chain reaction mechanism, increasing the targeting efficiency of the drug in tumors and enhancing the antitumor effect.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Jiayu Zhao, Sheng Ma, Yudi Xu, Xinghui Si, Haochen Yao, Zichao Huang, Yu Zhang, Haiyang Yu, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: The study presented a method for in situ activation of the STING pathway using nanoparticles to deliver DNA-targeting chemo agents, demonstrating the potent ability of SN38 in stimulating interferon secretion and activating the STING pathway. The nanoparticle formulation effectively stimulated STING pathway activation, resulting in significant tumor suppression.
Article
Chemistry, Multidisciplinary
Yinan Wang, Na Shen, Shuchun Li, Haiyang Yu, Yue Wang, Zhilin Liu, Liying Han, Zhaohui Tang
Summary: In this study, cisplatin was used as a stabilizer and cooperator to enhance the efficacy of JQ1 in the treatment of cervical cancer. The nano system PGP-CDDP/JQ1 showed a strong cytotoxic synergistic effect, significantly higher tumor inhibition effect and improved plasma stability compared to free JQ1. The synergism of JQ1 with CDDP in PGP-CDDP/JQ1 was found to be through inhibiting the Plk1-mutant Trp53 axis, providing a potential method for improving the clinical application of JQ1 in cervical cancer.
Review
Pharmacology & Pharmacy
Zhilin Liu, Yu Zhang, Na Shen, Jiali Sun, Zhaohui Tang, Xuesi Chen
Summary: Nanomedicine improves the efficiency of delivering antitumor drugs into tumors, but insufficient tumor penetration hampers therapeutic efficacy. Vascular disrupting agent (VDA) nanomedicines selectively destroy immature tumor vessels, block the supply of oxygen and nutrients, and increase vascular permeability, reducing the dependence on enhanced permeability and retention effect. This review discusses the recent progress and application of VDA nanomedicines in cancer therapy, including mechanisms, delivery strategies, and combination therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jianlin Lv, Yajun Xu, Yue Huang, Haiyang Yu, Zhaohui Tang
Summary: The novel Plinabulin derivative HBP and noncovalent HBP nanoparticles (HBP NPs) demonstrated higher antitumor efficacy than Plinabulin in 4T1 tumor-bearing mice.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Haochen Yao, Na Shen, Guofeng Ji, Juanjuan Huang, Jiali Sun, Guoqing Wang, Zhaohui Tang, Xuesi Chen
Summary: The study demonstrates the strong antitumor immune response of cisplatin-based nanoparticles in a tumor-bearing mouse model. The sustained retention of nanoparticles leads to persistent tumor MHC-I overexpression, promoting the formation of pMHC-I and enhancing the interaction with T cell receptors. Additionally, the nanoparticles upregulate OX40 on intratumoral CD8+ T cells and synergize with an agonistic OX40 antibody to suppress tumor growth by 89.2%.
Article
Engineering, Biomedical
Yajun Xu, Jianlin Lv, Na Shen, Zhaohui Tang, Xuesi Chen
Summary: In this study, researchers constructed a self-activating nanoized plinabulin that can be selectively activated by intrinsic tumor hypoxia to disrupt tumor vessels and inhibit tumor growth. The nanoized plinabulin demonstrated selective distribution in tumors and showed stronger anti-tumor effects compared to traditional plinabulin.
Article
Engineering, Biomedical
Sijia Zhang, Yuanji Feng, Meng Meng, Zhen Li, Huixin Li, Lin Lin, Caina Xu, Jie Chen, Kai Hao, Zhaohui Tang, Huayu Tian, Xuesi Chen
Summary: As a representative of tumor immunotherapy, tumor vaccines can activate tumor-specific immune responses to inhibit tumor growth with the advantages of relatively low toxicity and high efficiency. This study developed a high-efficiency personalized nanovaccine by loading tumor-specific antigens with suitable carriers, which has a wide range of potential applications in tumor treatment.
Article
Polymer Science
Yajun Xu, Jianlin Lv, Chaoying Kong, Yanran Li, Kun Wang, Na Shen, Zhaohui Tang
Summary: In order to improve the therapeutic efficacy of Tirapazamine (TPZ) in cancer treatment, researchers synthesized a novel TPZ derivative and covalently conjugated it to poly (L-glutamic acid) to obtain TPZ nanoparticles (TPZH-NPs). TPZH-NPs showed advantages in prolonged blood circulation, enhanced tumor accumulation, and increased maximum tolerated dose compared to TPZH. Furthermore, TPZH-NPs exhibited significantly enhanced antitumor therapeutic efficiency against 4T1 breast tumors compared to free TPZH.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Jiali Sun, Zhilin Liu, Haochen Yao, Honglei Zhang, Mengfei Zheng, Na Shen, Jianjun Cheng, Zhaohui Tang, Xuesi Chen
Summary: A selective activatable prodrug R848-N-3 was developed, which reduced pro-inflammatory cytokines to 1/12 of R848 at the same dose by selectively activating in hypoxic tumors. By using CA4-NPs, the tumor selectivity of R848-N-3 was enhanced, resulting in a 21.45-fold increase in concentration of active R848 in the tumor compared to the heart. Therefore, the azide-masking strategy holds potential for developing tumor-selective prodrugs with reduced toxicity.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Fuxin Xue, Haochen Yao, Linjie Cui, Yue Huang, Changlu Shao, Na Shen, Junli Hu, Zhaohui Tang, Xuesi Chen
Summary: Multispecific antibodies (MsAbs) have the potential to redirect T cells to tumors and maintain the specificity of versatile antibodies. However, the complex production process and limitations such as low yield, inconsistent quality, and impurities pose challenges to their development.
Article
Chemistry, Multidisciplinary
Zhilin Liu, Honglei Zhang, Jiali Sun, Mengfei Zheng, Linjie Cui, Yu Zhang, Jianjun Cheng, Zhaohui Tang, Xuesi Chen
Summary: This study establishes an organic-solvent-free Lego-like modular construction platform for preparing Fab-nondestructive antibody-drug conjugates (ADCs) with ultrahigh drug-antibody ratio (DAR), which can be used for personalized anticancer therapy. Among them, aHER2-P-MMAE achieves tumor growth inhibition (TGI) of 99.7% for ovarian tumors, and aPDL1-P-MMAE achieves TGI of 98.5% for colon tumors.
ADVANCED MATERIALS
(2023)
Article
Otorhinolaryngology
Tianying Zhai, Pingping Ai, Zhaohui Tang, Chaoliang He, Xuesi Chen, Shiming Yang, Nan Wu
Summary: This article introduces the key techniques and latest progress in thermo-sensitive hydrogel nanodrug delivery system for safe and efficient drug administration in the inner ear.
JOURNAL OF OTOLOGY
(2023)
Article
Materials Science, Biomaterials
Zhenqian Zhang, Honglei Zhang, Linjie Cui, Xiaoshuang Wang, Di Wang, Zhilin Liu, Xuefei Zhang, Zhaohui Tang
Summary: We have developed a tumor-active-targeting nanomedicine, aPDL1-PLG-MMAE, which effectively targets tumors expressing high levels of PDL1 and delivers MMAE. This nanomedicine consists of an anti-PDL1 monoclonal antibody (aPDL1) and poly(l-glutamic acid) (PLG) grafted Fc-III-4C peptide/Val-Cit-PAB-MMAE (Fc-PLG-MMAE). It can be rapidly prepared and stored separately from the antibody portion for extended periods, allowing for easy transport. The aPDL1-PLG-MMAE demonstrated strong tumor recognition and targeting effects, leading to potent therapeutic efficacy without significant toxicities.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Ying Wang, Na Shen, Yue Wang, Mo Li, Wanze Zhang, Liwen Fan, Linlin Liu, Zhaohui Tang, Xuesi Chen
Summary: CDDP-NPs enhance the abscopal effect of radiation therapy by increasing the CD8(+) T cell population, promoting immunogenic cell death, and facilitating CD8(+) T cell infiltration. Additionally, CDDP-NPs induce chemokine secretion, leading to enhanced CD8(+) T cell infiltration in non-irradiated tumors. This study demonstrates the potential of CDDP-NPs in boosting immune activation and overcoming the efficiency limitation of the abscopal effect induced by radiation therapy combined with anti-PD1.
BIOMATERIALS SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)