Review
Chemistry, Multidisciplinary
Kaavian Shariati, Andrea Shin Ling, Stephanie Fuchs, Benjamin Dillenburger, Wanjun Liu, Minglin Ma
Summary: Recent advances in novel techniques in biology and material science have led to the creation of living materials and bioarchitectures imbued with engineered living behaviors, capable of performing programmable and time- or stimuli-dependent activities, namely 4D behaviors. The focus of the research is on enhancing the functional capacity of constructs through 4D activities driven by cellular events or processes, as well as discussing the fabrication strategies and future directions of living materials.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Polymer Science
Koji Nagahama, Seika Aoyama, Natsumi Ueda, Yuka Kimura, Tokitaka Katayama, Kimika Ono
Summary: This study introduces an approach inspired by biological tissues, where azide-modified living cells are covalently cross-linked with alkyne-modified alginate polymers via bioorthogonal reactions to create self-healing hydrogels. The unique self-healing capabilities of these hydrogels come from cadherin-mediated adhesion between cells within the gel. This research showcases the incorporation of living components into synthetic materials to enhance self-healing properties.
Article
Polymer Science
Ronny G. Huamani-Palomino, Bryan M. Cordova, Elvis Renzo Pichilingue L., Tiago Venancio, Ana C. Valderrama
Summary: This research successfully synthesized a functional alginate-based material through oxidation and reductive amination processes, confirming the successful attachment of cysteine molecules to the alginate backbone. The preferential impact of guluronic acid residue over mannuronic acid residue in the functionalization process of alginate was observed.
Review
Polymer Science
Mohd Nor Faiz Norrrahim, Noor Azilah Mohd Kasim, Victor Feizal Knight, Keat Khim Ong, Siti Aminah Mohd Noor, Norhana Abdul Halim, Noor Aisyah Ahmad Shah, Siti Hasnawati Jamal, Nurjahirah Janudin, Muhammad Syukri Mohamad Misenan, Muhammad Zamharir Ahmad, Mohd Hanif Yaacob, Wan Md Zin Wan Yunus
Summary: This article presents the application of nanocellulose in anti-microbial membrane filters and key advancements in surface modifications, demonstrating its unique advantages in filtering microbes.
Article
Multidisciplinary Sciences
Zenghao Wang, Haotian Bai, Wen Yu, Zhiqiang Gao, Weijian Chen, Zhiwen Yang, Chuanwei Zhu, Yiming Huang, Fengting Lv, Shu Wang
Summary: Researchers have developed a living material composed of conjugated polymers and bacterial biofilm for lactate detection and cancer cell counting. This conductive material optimizes bioelectronic processes and allows wireless transfer of electrical signals to a portable smartphone for analysis.
Article
Multidisciplinary Sciences
Baoshan Tang, Hasita Veluri, Yida Li, Zhi Gen Yu, Moaz Waqar, Jin Feng Leong, Maheswari Sivan, Evgeny Zamburg, Yong-Wei Zhang, John Wang, Aaron V-Y Thean
Summary: This study reports the wafer-scale integration of solution-processed 2D MoS2 memristor arrays, demonstrating significant progress in achieving high density and reliability. The research also showcases the feasibility of MoS2 memristors for future analog memory applications and neuromorphic computing.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Uidon Jeong, Dokyung Jeong, Seokran Go, Hyunbum Park, Geun-ho Kim, Namyoon Kim, Jaehwang Jung, Wookrae Kim, Myungjun Lee, Changhoon Choi, Doory Kim
Summary: The recent development of super-resolution fluorescence microscopy has greatly improved the resolution of light microscopy to tens of nanometers. However, applying this technique to semiconductor materials has been challenging due to limitations in conventional surface functionalization methods for labeling. In this study, a novel approach for highly dense material-specific fluorophore labeling on silicon-based materials has been developed and demonstrated for super-resolution microscopy imaging of semiconductor line patterns. This new method shows the ability to selectively and sensitively probe different-sized silicon and silica line patterned arrays, including edge structures, in three dimensions, which cannot be achieved by conventional metrology systems. Furthermore, it has shown high sensitivity in detecting nanoparticle defects, indicating its potential as a semiconductor defect inspection tool.
CHEMISTRY OF MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Jiawen Niu, Chenlu Liu, Xiaopeng Yang, Wenlong Liang, Yufu Wang
Summary: Micro-nano robots have promising applications in biomedicine and the design of their motor is crucial. Living cells such as bacteria with flagella, sperm, and algal cells are commonly used as motors. Scientists have also developed biomimetic motors with functionalized cell membranes. This paper provides a comprehensive review of micro-nano robots utilizing living cells and functionalized biological cell membranes, discusses their potential practical applications, and addresses potential challenges for future development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yixin Zhang, Le You, Pu Deng, Xiaocheng Jiang, Huan-Hsuan Hsu
Summary: Exoelectrogens have the ability to reduce extracellular electron acceptors and form conductive nanomaterials integrated with their cell bodies. In this study, we designed and fabricated a biohybrid electronic material using bioreduced graphene oxide as the linker, enabling interaction between the exoelectrogen community and external electronics. This material can be effectively applied in microbial fuel cells and as building blocks for various electronic components. By replacing exoelectrogens with photosynthetic organelles and cells, the resulting materials showed significant improvements in photocurrent intensities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Yixin Zhang, Le You, Pu Deng, Xiaocheng Jiang, Huan-Hsuan Hsu
Summary: Utilizing exoelectrogens and bioreduced graphene oxide (B-rGO) as linkers, a biohybrid electronic material was designed and fabricated to enhance interaction between exoelectrogen community and external electronics. This material can also serve as a basic building block for constructing various electronic components with other microorganisms. Studies show that photosynthetic organelles and cells can replace exoelectrogens as active bioreducing components, leading to significantly increased photocurrent intensities in formed materials.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Ahmed Saad, Carolina Penaloza Arias, Min Wang, Osama ElKashty, Davide Brambilla, Faleh Tamimi, Marta Cerruti
Summary: This study aims to create a tight seal between PEEK and epithelial tissues by mimicking the surface chemistry of teeth, using collagen I as a mediator. The results showed that both collagen-modified PEEK and titanium had higher adsorption of BM proteins and better cell viability and spreading compared to controls. This work introduces a versatile and biomimetic surface modification technique that may enhance PEEK-epithelial tissue sealing and expand its applications in percutaneous implants, making it competitive with titanium.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Oliwia Jeznach, Dorota Kolbuk, Mateusz Marzec, Andrzej Bernasik, Pawel Sajkiewicz
Summary: This study investigated the impact of reaction parameters on the properties of electrospun fibers and cell response through aminolysis. The concentration of NH2 groups increased with reaction time and concentration, and different polymers required different conditions. Aminolysis was not limited to the surface and resulted in global molecular weight reduction. Despite minimal changes in water contact angle, aminolysis improved cell shape.
Article
Biochemistry & Molecular Biology
Ryan S. O'Neill, Afeez K. Sodeinde, Frances C. Welsh, Carey J. Fagerstrom, Brian J. Galletta, Nasser M. Rusan
Summary: Centrosomes are organelles that play a crucial role in cell division by organizing microtubules and ensuring spindle formation and chromosome segregation. This study investigates a duplication of the Spd-2 gene in Drosophila willistoni, which results in two isoforms, Spd-2A and Spd-2B, with different functions in neural and germ cells. The findings suggest that cell-type-specific differences in translation or protein stability contribute to the functional divergence of centrosome proteins.
Article
Engineering, Electrical & Electronic
Ozgur Yasin Keskin, Mustafa Erol
Summary: This study presents a new environmentally friendly matrix material for temperature sensors. Sodium silicate solution and graphite were utilized as the matrix and conductive materials, respectively. The performance of sensors with different graphite contents was investigated, showing negative temperature coefficient behavior and high linearity, sensitivity, and stability.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Immunology
Jonathan Greenbaum, Xu Lin, Kuan-Jui Su, Rui Gong, Hui Shen, Jie Shen, Hong-Mei Xiao, Hong-Wen Deng
Summary: The study conducted a systematic multi-omics analysis on a large sample of peri- and early post-menopausal women, revealing potential crosstalk between gut microbiome and serum metabolome that may be involved in the regulation of bone mineral density. Identified bacteria species and serum metabolites showed associations with bone mineral density, providing novel insights into the interrelationships between gut microbiome and serum metabolome that may play a role in skeletal remodeling processes, although further replication and validation are needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Wei Chen, Zheng Wang, Lin Wang, Xiaoyuan Chen
Summary: Smart attachable systems, based on chemical engineering, offer lightweight and miniaturized solutions for body performance evaluation, disease diagnostics, and drug delivery. They have advantages such as being easy to control, battery-free, and functionally diverse. These systems find applications in real-time monitoring, point-of-care sampling, biomarker detection, and controlled release, with potential for improving human lives in clinical and industrial fields.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Wei Chen, Jacob Wainer, Si Won Ryoo, Xiaoyue Qi, Rong Chang, Jason Li, Seung Ho Lee, Seokkee Min, Adam Wentworth, Joy E. Collins, Siddartha Tamang, Keiko Ishida, Alison Hayward, Robert Langer, Giovanni Traverso
Summary: Oral drug administration remains the preferred route for patients and health care providers, but delivering macromolecules through this route is challenging. In this study, a delivery system combining physical and nonphysical drug delivery enhancement modes was developed and tested in a large animal model. Inspired by a thorny-headed intestinal worm, a dynamic omnidirectional mucoadhesive microneedle system was created, which showed prolonged fixation on the gastric mucosa. The incorporation of sodium N-[8-(2-hydroxybenzoyl)amino] caprylate along with semaglutide demonstrated enhanced absorption in swine, and a targeted capsule system was developed to deploy intact microneedle-containing systems, enabling drug delivery in a privileged region of the gastrointestinal tract.
Article
Chemistry, Multidisciplinary
Qilin Li, Rengui Xu, Huiling Fan, Jiarong Xu, Yunruo Xu, Peng Cao, Yan Zhang, Tao Liang, Yang Zhang, Wei Chen, Zheng Wang, Lin Wang, Xiaoyuan Chen
Summary: This study developed a mushroom-inspired micro-needle platform for the delivery of COVID-19 vaccines and on-site recording of vaccination information. The system can be easily pressed into the skin and detached, acting as a tattoo to record vaccination counts. It showed promising results in terms of immunogenicity and offers a convenient and efficient method for vaccine delivery and storage.
Article
Chemistry, Multidisciplinary
Yan Deng, Cheng Yang, Yuanyuan Zhu, Wenyu Liu, Heli Li, Liping Wang, Wei Chen, Zheng Wang, Lin Wang
Summary: An oriented antibacterial sericin microneedle (OASM) was designed for improved wound healing. The microneedles, inspired by lamprey teeth, provide both penetration and directional traction. Sericin, derived from silkworm cocoons, improves skin repair via hair follicle regeneration and angiogenesis. Additionally, zinc oxide nanoparticles enhance the antibacterial properties of the microneedles, showing promising clinical translational potential.
Article
Biotechnology & Applied Microbiology
Haoming Huang, Dian Hu, Zhuo Chen, Jiarong Xu, Rengui Xu, Yusheng Gong, Zhengming Fang, Ting Wang, Wei Chen
Summary: Our newly developed STAMP system was able to significantly reduce blood glucose levels and attenuate pancreatic injury in T1DM mice independent of adjuvants. The slowly degrading Schistosoma japonicum eggs in the skin continuously released egg antigen for at least 2 weeks, ensuring localized and safe antigen stimulation. This phenomenon should be attributed to the shift of Th2 immune response to reduce Th1 polarization.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yuan Liu, Ting Huang, Zhiyong Qian, Wei Chen
Summary: Microneedles are a promising medical technology for various applications, but their clinical and commercial translation is hindered by challenges in manufacturing, cost, comfort, and contamination. Recent innovations in biomaterials and chemical engineering have led to the development of hydrogel-forming microneedles, enabling precise drug delivery and sampling. This review summarizes the latest developments in these microneedles and discusses the challenges and prospects for their clinical application.
CHINESE CHEMICAL LETTERS
(2023)
Review
Nanoscience & Nanotechnology
Yajie Yu, Bin Lv, Juntao Wu, Wei Chen
Summary: Mussel biomimetic materials have been widely used in the treatment of musculoskeletal disorders, but there is a lack of comprehensive discussion on their applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Jun Dai, Simin Wei, Jiarong Xu, Huiying Xue, Zhaojun Chen, Meng Wu, Wei Chen, Xiaoding Lou, Fan Xia, Shixuan Wang
Summary: A microneedle-based device combined with aggregation-induced emission (AIE) photosensitizers (PSs) was constructed to achieve enhanced metronomic photodynamic therapy (mPDT) for cancer. The strong anti-photobleaching property of the AIE PS allows for superior photosensitivity even after prolonged light exposure. The delivery of the AIE PS to the tumor through the microneedle device provides better treatment outcomes and convenience.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Rengui Xu, Honglian Guo, Xiuli Chen, Jiarong Xu, Yusheng Gong, Peng Cao, Chunyu Wei, Fei Xiao, Di Wu, Wei Chen, Lin Wang, Zheng Wang
Summary: This study proposes a self-heating and controllable microneedle system to treat deep-seated subcutaneous tumors. The system has the features of deep penetration, synergistic thermal therapy, on-demand self-service, and achieves a high tumor growth inhibition rate.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Qiying Lv, Xiaoye Li, Xin Tian, Da-an Fu, Huan Liu, Jia Liu, Yu Song, Bo Cai, Jian Wang, Qiangfei Su, Wei Chen, Meizhen Zou, Fei Xiao, Shuai Wang, Zheng Wang, Lin Wang
Summary: A simple and feasible method was proposed to prepare an implantable hydrogel-based supercapacitor. The use of a amine-modified reduced graphene oxide and methacrylic anhydride co-modified sericin (SrMA/A-rGO) in a multinetwork conductive electrode provided high specific capacitance and excellent biocompatibility and biodegradability. The supercapacitor showed potential as a power storage unit for medical implants.
ADVANCED ENERGY MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xiuli Chen, Yusheng Gong, Wei Chen
Summary: The temporal-spatial precision of interventions for neurological disorders has gained attention in recent years. Collaborative efforts from various disciplines have led to advancements in localized drug delivery, precise neuromodulation, and biological signal detection for closed-loop control. This review highlights the clinical potential of these interventions in both central and peripheral nervous systems, discusses challenges related to biosafety and scaled production, and presents future perspectives. These intelligent precision intervention systems are expected to have significant clinical value for patients with neurological disorders.
Article
Chemistry, Multidisciplinary
Yusheng Gong, Shuai Tong, Xixuan Li, Xiuli Chen, Yushuang Liu, Nan Li, Jiarong Xu, Rengui Xu, Yusong Guo, Fei Xiao, Xiaoyuan Chen, Wei Chen
Summary: Mucosa-interfacing systems based on bioinspired engineering design have shown significant potential in disease monitoring and treatment, but are limited by restricted molecular transfer and insufficient capture/detachment capability. Inspired by the structure of the small intestine, a trigonometric function-based periodic pattern was integrated onto a microneedle patch, improving sample enrichment and molecular transfer. Mathematical modeling and finite element analysis were used to optimize parameters, and the system demonstrated applicability and clinical translation potential through in vitro and in vivo tests.
Article
Engineering, Environmental
Jiarong Xu, Qi Zeng, Xiuli Chen, Honglian Guo, Yusheng Gong, Rengui Xu, Peng Cao, Chunyu Wei, Fei Xiao, Dawei Jiang, Wei Chen
Summary: In this study, an iron (III) cross-linked alginate microneedle patch (ICAMP) has been developed for long-term treatment of dry skin. The microneedles can be dissolved by exposure to light, allowing controlled release of the drug. This new method provides a regulated way to treat dry skin, especially under intense light radiation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yusheng Gong, Shuai Tong, Xixuan Li, Xiuli Chen, Yushuang Liu, Nan Li, Jiarong Xu, Rengui Xu, Yusong Guo, Fei Xiao, Xiaoyuan Chen, Wei Chen
Summary: Mucosa-interfacing systems based on bioinspired engineering design show significant potential for sampling and drug delivery, but face limitations in contact area and capture/detachment capability. This study fabricates trigonometric function-based periodic patterns on microneedle patches, inspired by the villi structure of the small intestine, to enhance sample enrichment and molecular transfer. Mathematical modeling and finite element analysis are used to optimize parameters. The engineered microneedles demonstrate applicability in varying mucosa tissues and gain support from preliminary testing with healthy volunteers, showing promise for clinical translation.
Review
Medicine, Research & Experimental
Bo Cai, Yusheng Gong, Zheng Wang, Lin Wang, Wei Chen
Summary: Living organisms have a significant impact on human health, and utilizing them for disease treatment faces challenges such as limited biocompatibility, poor biosafety, inconvenience for personal handling, and low patient compliance. Microneedle arrays, as promising biomedical devices with functional diversity and minimal invasion, show great potential in treating a broad spectrum of diseases.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
